{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:16Z","timestamp":1790791096536,"version":"4.1.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Full-thickness macular hole (FTMH) is a vitreoretinal condition affecting the foveal center that causes central vision loss and metamorphopsia. Despite high surgical success in achieving closure, functional visual recovery remains unpredictable. Identifying reliable optical coherence tomography (OCT) biomarkers that predict postoperative outcomes could improve patient counselling and surgical decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate the predictive value of baseline structural OCT biomarkers for visual acuity (VA) outcomes at 3, 6, 12, and 24 months following FTMH surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We will search PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception for studies evaluating baseline OCT parameters as predictors of postoperative VA outcomes following FTMH surgery, with minimum follow-up of 3 months. Data will be synthesized using random-effects meta-analyses. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review will synthesize current evidence on OCT biomarkers\u2019 predictive value for FTMH surgical outcomes. The findings will clarify their clinical utility and may inform individualized prognostic counselling and surgical decision-making, including which patients are most likely to benefit from surgery and which surgical techniques may be most effective given specific OCT profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0359108","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:29:05Z","timestamp":1790789345000},"page":"e0359108","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-0006","authenticated-orcid":true,"given":"Sahar","family":"Khademioore","sequence":"first","affiliation":[{"name":"McMaster University","place":["Hamilton, ON, Canada"],"department":["Department of Health Research Methods, Evidence, and Impact"]},{"name":"St Joseph\u2019s Healthcare","place":["Hamilton, ON, Canada"],"department":["Thomas Kevill Advanced Vitreoretinal Imaging (AVI) Lab"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-7211","authenticated-orcid":true,"given":"Jo\u00e3o Pedro","family":"Lima","sequence":"additional","affiliation":[{"name":"McMaster University","place":["Hamilton, ON, Canada"],"department":["Department of Health Research Methods, Evidence, and Impact"]},{"name":"St Joseph\u2019s Healthcare","place":["Hamilton, ON, Canada"],"department":["Thomas Kevill Advanced Vitreoretinal Imaging (AVI) Lab"]},{"name":"McMaster University","place":["Hamilton, ON, Canada"],"department":["Department of Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena","family":"Zeraatkar","sequence":"additional","affiliation":[{"name":"McMaster University","place":["Hamilton, ON, Canada"],"department":["Department of Health Research Methods, Evidence, and Impact"]},{"name":"McMaster University","place":["Hamilton, ON, Canada"],"department":["Department of Anesthesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1033-3315","authenticated-orcid":true,"given":"Sadia","family":"Mahmood","sequence":"additional","affiliation":[{"name":"McMaster University","place":["Hamilton, ON, Canada"],"department":["Department of Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Khademioureh","sequence":"additional","affiliation":[{"name":"University of Alberta","place":["Edmonton, Alberta, Canada"],"department":["School of Public Health"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-5091","authenticated-orcid":true,"given":"Charles C.","family":"Wykoff","sequence":"additional","affiliation":[{"name":"Retina Consultants of Texas","place":["Houston, Texas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic","place":["Cleveland, Ohio, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-1264","authenticated-orcid":true,"given":"Tien-Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"Beijing Visual Science and Translational Eye Research Institute, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University","place":["Beijing, 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