{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:52:08Z","timestamp":1791827528132,"version":"4.3.4"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH-17-2-0029"],"award-info":[{"award-number":["W81XWH-17-2-0029"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite the increasing population of women with limb loss, data to sufficiently characterize potential gender-based differences are lacking, as scientific literature on this topic is often not specifically designed to assess the unique needs of women. Fragmentary information has indicated that women experience a variety of physical and psychological challenges that differ from those experienced by men, but this information has yet to be fully explored. This is the first exploratory needs assessment to combine population-specific physical and psychosocial assessments, as well as gap items that current measures do not capture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this national, cross-sectional, survey-based needs assessment, individuals with lower limb loss recruited across the Department of Veterans Affairs, Department of Defense, and civilian settings completed an online survey. Responses to the survey generated a subset of quantitative scores across several physical and psychosocial domains to compare outcomes between women and men with lower limb loss. Ordered beta regression and multiple linear regression models were used to test the association of gender with scale outcomes, while controlling for additional covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 229 individuals (130 women, 99 men) completed the needs assessment. Results highlighted decreased levels of aesthetic and functional satisfaction, body image, and social adjustment, as well as higher levels of anxiety, in women with limb loss compared with men. There were no differences in depression, activity restriction, or healthcare needs between women and men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An important contribution of this exploratory needs assessment was its ability to identify candidate constructs that may serve as building blocks for developing a clinically relevant patient-reported outcome measure for women with lower limb loss. Future research should build on these findings to develop and validate women-specific outcome measures, ultimately supporting limb loss care teams in providing optimal, individualized care for this underserved population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0359172","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:32:41Z","timestamp":1791826361000},"page":"e0359172","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying the unique needs of women with lower limb loss: A national, cross-sectional, survey-based needs assessment"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3605-2582","authenticated-orcid":true,"given":"Alexis N.","family":"Sidiropoulos","sequence":"first","affiliation":[{"name":"Prosthetics and Sensory Aids Service, Veterans Affairs New York Harbor Healthcare System","place":["New York, New York, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Disla","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, James J. Peters Veterans Affairs Medical Center","place":["New York, New York, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Pruziner","sequence":"additional","affiliation":[{"name":"National Veterans Sports Programs and Special Events","place":["Washington, District of Columbia, United States of America"],"department":["Department of Veterans Affairs"]},{"name":"Extremity Trauma and Amputation Center of Excellence","place":["Falls Church, Virginia, United States of America"]},{"name":"Walter Reed National Military Medical Center","place":["Bethesda, Maryland, United States of America"],"department":["Department of Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Bushnik","sequence":"additional","affiliation":[{"name":"Rusk Rehabilitation, New York University Langone Health","place":["New York, New York, United States of America"],"department":["Department of Rehabilitation Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"Moore","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["Storrs, Connecticut, United States of America"],"department":["Statistical Consulting Services, Center for Open Research Resources and Equipment"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Prosthetics and Sensory Aids Service, Veterans Affairs New York Harbor Healthcare System","place":["New York, New York, United States of America"]},{"name":"National Veterans Sports Programs and Special Events","place":["Washington, District of Columbia, United States of America"],"department":["Department of Veterans Affairs"]},{"name":"Extremity Trauma and Amputation Center of Excellence","place":["Falls Church, Virginia, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Klingbeil","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, James J. 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