{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:53:47Z","timestamp":1792788827390,"version":"4.5.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["RS-2022NR070832 and RS-2023-00276320"],"award-info":[{"award-number":["RS-2022NR070832 and RS-2023-00276320"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug-coated balloon (DCB) therapy for in-stent restenosis (ISR) relies on efficient drug transfer during balloon\u2013artery contact. Surface micro-patterning has been proposed to enhance transfer efficiency without altering the antiproliferative drug. This study evaluated a linear micro-patterned DCB (LMDCB) compared with a comparator paclitaxel-coated DCB in a porcine coronary ISR model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      ISR\n                      <jats:bold>was induced by bare-metal stent implantation followed by a 4-week maturation period.<\/jats:bold>\n                      In two prespecified cohorts (1 month: 10 animals, 20 segments; 3 months: 4 animals, 8 segments), paired ISR segments within each animal were treated with LMDCB or a comparator paclitaxel-coated DCB (3.0 \u00b5g\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ). Endpoints included quantitative coronary angiography (QCA), optical coherence tomography (OCT), and histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1 month, LMDCB demonstrated a larger minimum lumen diameter (2.3\u2009\u00b1\u20090.2 mm vs 1.9\u2009\u00b1\u20090.4 mm; p\u2009=\u20090.019) and lower percent diameter stenosis (13.3\u2009\u00b1\u20094.8% vs 23.7\u2009\u00b1\u20099.3%; p\u2009=\u20090.003). OCT showed lower mean neointimal thickness (0.2\u2009\u00b1\u20090.1 mm vs 0.3\u2009\u00b1\u20090.1 mm; p\u2009=\u20090.008). Histology showed lower neointimal area (2.4\u2009\u00b1\u20090.7 mm\n                      <jats:sup>2<\/jats:sup>\n                      vs 2.9\u2009\u00b1\u20091.1 mm\n                      <jats:sup>2<\/jats:sup>\n                      ; p\u2009=\u20090.011) and percent area stenosis (36.6\u2009\u00b1\u200910.4% vs 44.4\u2009\u00b1\u200917.8%; p\u2009=\u20090.013), with comparable vascular healing indices. In the independent 3-month cohort, QCA and OCT findings were similar between groups. Exploratory histology in a limited subset suggested a larger lumen and lower percent area stenosis with LMDCB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this porcine coronary ISR model, LMDCB was associated with reduced neointimal proliferation and improved luminal dimensions at 1 month compared with a comparator paclitaxel-coated DCB, without impaired vascular healing. In a separate 3-month cohort, imaging findings were comparable between devices, while histology remained exploratory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0359232","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:27:16Z","timestamp":1790357236000},"page":"e0359232","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surface micro-patterned drug-coated balloon enhances early biological efficacy in a porcine coronary in-stent restenosis model"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2641-9606","authenticated-orcid":true,"given":"Seunghwan","family":"Kim","sequence":"first","affiliation":[{"name":"Inje University College of Medicine","place":["Busan, Korea"],"department":["Division of Cardiology, Haeundae Paik Hospital"]},{"name":"Yonsei University College of Medicine","place":["Seoul, 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