{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:57:58Z","timestamp":1791568678957,"version":"4.3.4"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation of the First Hospital of Lanzhou University","award":["ldyyyn2023-16"],"award-info":[{"award-number":["ldyyyn2023-16"]}],"id":[{"id":"https:\/\/ror.org\/05d2xpa49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Foundation of the First Hospital of Lanzhou University","award":["ldyyyn2023-16"],"award-info":[{"award-number":["ldyyyn2023-16"]}],"id":[{"id":"https:\/\/ror.org\/05d2xpa49","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antiphospholipid syndrome is an autoimmune disorder characterized by recurrent thrombotic events and\/or adverse pregnancy outcomes. Although three classification criteria\u2014the 1999 Sapporo criteria, the Revised Sapporo criteria, and the 2023 ACR\/EULAR antiphospholipid syndrome classification\u2014have been developed primarily for research purposes to standardize patient selection, clinicians sometimes apply these criteria to aid in diagnostic decision-making. However, direct head-to-head studies comparing these three criteria remain scarce, and a comprehensive systematic review with network meta-analysis of their classification performance is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary objective is to conduct a traditional meta-analysis to evaluate and compare the performance (sensitivity, specificity, positive likelihood ratio [PLR], negative likelihood ratio [NLR]) of each individual classification criterion. Secondary objectives include: 1) Conducting a Bayesian network meta-analysis (NMA) to compare and rank the three criteria using superiority index (SI); and 2) Exploring sources of heterogeneity through predefined subgroup analyses (primary vs. secondary APS, thrombotic vs. obstetric APS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adhering to the PRISMA-P statement, this protocol has been registered in PROSPERO (CRD420251074199). A comprehensive literature search will be performed in electronic databases (PubMed\/MEDLINE, Embase, the Cochrane Library, Web of Science) and gray literature sources (ClinicalTrials.gov, abstracts from international congresses including ACR, EULAR) from their inception to October 2025. Eligible studies are classification performance studies (cross-sectional, cohort, or case-control) that assess at least one of the three criteria against the reference standard (expert clinical diagnosis by rheumatologists\/APS specialists, based on comprehensive evaluation of clinical history, persistent antiphospholipid antibodies [aPLs] testing, and exclusion of alternative causes). The quality of included studies will be assessed using the QUADAS-2 tool. Bayesian NMA will be conducted in R version 4.3.0 with the RStan package, adopting a random-effects ANOVA model. Heterogeneity will be assessed via Cochrane\u2019s Q test and the inconsistency index (I\u00b2), while publication bias will be evaluated using Deeks\u2019 funnel plot asymmetry test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0359310","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:33:22Z","timestamp":1791567202000},"page":"e0359310","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systematic review and network meta-analysis of performance of the Sapporo criteria, the Revised Sapporo criteria, and the 2023 ACR\/EULAR APS classification criteria for patients with antiphospholipid syndrome: A protocol"],"prefix":"10.1371","volume":"21","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"The Second People\u2019s Hospital of Gansu Province","place":["Lanzhou, Gansu, China"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqi","family":"Yin","sequence":"additional","affiliation":[{"name":"General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group","place":["Fushun, Liaoning, China"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Wuhan University","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbin","family":"Tao","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University","place":["Lanzhou, Gansu, China"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Chi","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Occupational and Environmental Health","place":["Kitakyushu, Fukuoka, Japan"],"department":["Second Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8398-9867","authenticated-orcid":true,"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian Women and Children\u2019s Medical Group","place":["Dalian, Liaoning, China"],"department":["Department of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"pone.0359310.ref001","article-title":"Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management","volume":"380","author":"JS Knight","year":"2023","journal-title":"BMJ"},{"issue":"2","key":"pone.0359310.ref002","doi-asserted-by":"crossref","first-page":"020504","DOI":"10.11613\/BM.2024.020504","article-title":"Antiphospholipid antibodies in patients with antiphospholipid syndrome","volume":"34","author":"S 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