{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:59:26Z","timestamp":1790704766021,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016182","name":"Universidade Federal de Mato Grosso do Sul","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100016182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>In Brazil, regional disparities in cardiovascular disease (CVD) mortality persist, with no population-based study having examined CVD mortality at the municipal level in the Central-West region. This study analysed the epidemiological profile, temporal trends, spatial distribution, and socioeconomic correlates of CVD mortality in Campo Grande, Mato Grosso do Sul, Brazil (2013\u20132022). A population-based ecological study used data from the Brazilian Mortality Information System. Five CVD groups were analysed: ischaemic heart disease (IHD), heart failure (HF), arrhythmias (ARR), cardiomyopathies (CMP), and inflammatory heart diseases (INF). Temporal trends were assessed using Poisson, Prais-Winsten, and Joinpoint regression. Spatial distribution was examined through Kernel Density Estimation and Local Indicators of Spatial Association (LISA). Socioeconomic correlates were assessed using Spearman\u2019s correlation with neighbourhood-level indicators. Of 59,392 registered deaths, 8,148 (13.7%) were CVD-related. IHD was the dominant cause (79.5%), with males accounting for 59.3% of deaths (IRR 1.59; 95% CI 1.46\u20131.74) and individuals aged \u226560 years representing 75.2%. Overall crude CVD mortality increased by 26.1% over the study period, with an estimated mean annual increase of 2.5% (APC\u2009+\u20092.5%\/year; 95% CI 1.7\u20133.3; p\u2009&lt;\u20090.001) and significant acceleration after 2019. A striking proportion of IHD deaths occurred outside hospital settings (67.3%), with home deaths alone surpassing hospital deaths (43.9% vs. 32.7%). Spatial analysis identified significant high-high mortality clusters in central-western neighbourhoods and low-low clusters in eastern neighbourhoods (13 and 5 neighbourhoods, respectively; Global Moran\u2019s I\u2009=\u20090.555, p\u2009&lt;\u20090.001), with cluster patterns varying by disease group. Socioeconomic correlates showed a consistent pattern across most CVD groups, with higher mortality in more socioeconomically advantaged neighbourhoods, except for inflammatory heart disease, which showed the opposite pattern. This first municipal-level CVD mortality analysis in Central-West Brazil identified significant spatiotemporal heterogeneity and a high burden of out-of-hospital IHD deaths, providing actionable evidence for geographically targeted cardiovascular prevention strategies.<\/jats:p>","DOI":"10.1371\/journal.pone.0359337","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:23:52Z","timestamp":1790702632000},"page":"e0359337","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular disease mortality in a Central-West Brazilian capital: A spatial, temporal, and ecological analysis"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2339-5744","authenticated-orcid":true,"given":"Jo\u00e3o Vitor","family":"Barrio","sequence":"first","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul","place":["Campo Grande, Mato 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Kingdom"],"department":["Faculty of Epidemiology and Population Health"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elizabeth Ara\u00fajo","family":"Ajalla","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul","place":["Campo Grande, Mato Grosso do Sul, Brazil"],"department":["Faculdade de Medicina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Du Bocage","family":"Santos-Pinto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul","place":["Campo Grande, Mato Grosso do Sul, Brazil"],"department":["Faculdade de Medicina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-5278","authenticated-orcid":true,"given":"Everton","family":"Falc\u00e3o de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul","place":["Campo Grande, Mato Grosso do Sul, Brazil"],"department":["Faculdade de Medicina"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Universidade Federal de Mato Grosso do Sul","place":["Campo Grande, Mato Grosso do Sul, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"22","key":"pone.0359337.ref001","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jacc.2025.08.015","article-title":"Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990-2023","volume":"86","author":"Global Burden of Cardiovascular Diseases and Risks 2023 Collaborators","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"pone.0359337.ref002","first-page":"100960","article-title":"Cardiovascular disease in the Americas: the epidemiology of cardiovascular disease and its risk factors","volume":"42","author":"P 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