{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:46Z","timestamp":1790791126524,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82470726, 82270731"],"award-info":[{"award-number":["82470726, 82270731"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The High-Level Hospital Construction Project of Jiangsu Province","award":["LCZX202403"],"award-info":[{"award-number":["LCZX202403"]}]},{"name":"\u201cPaired Assistance Scientific Research Project by The Affiliated Hospital of Xuzhou Medical University","award":["SHJDBF2024104"],"award-info":[{"award-number":["SHJDBF2024104"]}],"id":[{"id":"https:\/\/ror.org\/02kstas42","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Open Project of Key Laboratory of Higher Education Institutions in Jiangsu Province","award":["XZSYSKF2023019"],"award-info":[{"award-number":["XZSYSKF2023019"]}]},{"name":"Xuzhou Medical leading Talent training Project","award":["XWRCHT20210038"],"award-info":[{"award-number":["XWRCHT20210038"]}]},{"name":"the New Technology project of Affiliated Hospital of Xuzhou Medical University","award":["2020301018"],"award-info":[{"award-number":["2020301018"]}],"id":[{"id":"https:\/\/ror.org\/02kstas42","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["82000703"],"award-info":[{"award-number":["82000703"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Chronic kidney disease (CKD) is commonly associated with vascular injury. To date, efficient tools for assessing microcirculatory changes in non-dialysis CKD patients remain limited. We conducted a retrospectively registered study to employed nailfold capillaroscopy as a non-invasive method to evaluate peripheral microcirculation in CKD. A total of 104 participants were enrolled, including 63 patients with non-dialysis CKD patients (CKD group) and 41 healthy controls (control group). Renal function assessment and nailfold microcirculation examinations were performed for all participants. We analyzed 20 microcirculatory parameters and further explored their associations with serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C, estimated glomerular filtration rate (eGFR), CKD stage, and hemoglobin (Hb) within the CKD group. Results showed that serum creatinine, cystatin C, and CKD stage were independently and positively associated with the capillary number integral, whereas eGFR and hemoglobin were independently and negatively associated with the capillary number integral. In addition, serum creatinine, cystatin C, and CKD stage were independently and negatively associated with the subpapillary venular plexus integral, while eGFR was independently and positively associated with the subpapillary venular plexus integral. In summary, our findings suggest that several key renal function parameters are independently associated with capillary number integral and subpapillary venular plexus integral. These findings indicate that renal dysfunction may be associated with reduced capillary number and impaired subpapillary venous plexus relaxation in patients with non-dialysis CKD.<\/jats:p>","DOI":"10.1371\/journal.pone.0359419","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:34:01Z","timestamp":1790789641000},"page":"e0359419","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of nailfold microcirculation in non-dialysis CKD: Capillaroscopic indicators correlated with renal dysfunction"],"prefix":"10.1371","volume":"21","author":[{"given":"Shulin","family":"Li","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]},{"name":"Clinical Research Center for Kidney Disease Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuf Abdulkarim","family":"Waheed","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Disheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4546-404X","authenticated-orcid":true,"given":"Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Nephrology"]},{"name":"Clinical Research Center for Kidney Disease Xuzhou Medical University","place":["Xuzhou, China"]},{"name":"Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Internal Medicine and Diagnostics"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"11","key":"pone.0359419.ref001","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Evaluation and management of chronic kidney disease: synopsis of the kidney disease: Improving global outcomes 2012 clinical practice guideline","volume":"158","author":"Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members","year":"2013","journal-title":"Ann Intern Med"},{"key":"pone.0359419.ref002","article-title":"Hypertension in chronic kidney disease: What lies behind the scene","author":"R Ameer","year":"2022","journal-title":"Journal of Clinical Hypertension"},{"issue":"1","key":"pone.0359419.ref003","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12916-021-02050-0","article-title":"Recent advances in diabetic kidney disease","volume":"19","author":"M Hanouneh","year":"2021","journal-title":"BMC Med"},{"issue":"3","key":"pone.0359419.ref004","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/ndt\/gfv041","article-title":"The vulnerable patient with chronic kidney disease","volume":"31","author":"G Schlieper","year":"2016","journal-title":"Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - 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