{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T18:37:45Z","timestamp":1792780665703,"version":"4.5.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French National Cancer Institute","award":["2024-075"],"award-info":[{"award-number":["2024-075"]}],"id":[{"id":"https:\/\/ror.org\/03m8vkq32","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Supportive cancer care (SCC) is essential for comprehensive oncology care. It addresses treatment-related adverse effects, reduces long-term sequelae and improves patients\u2019 quality of life. Patient-partner (PP) programmes positively impact psychological well-being, patient empowerment and supportive care. Nevertheless, access to SCC remains inconsistent, fragmented and unequally distributed, while PPs are rarely integrated into routine cancer care pathways. Anal cancer is a predominantly localised cancer with high survival rates. Treatment is associated with acute toxicity and often severe long-term sequelae. This interventional public health research study aims to implement and evaluate an innovative enhanced care pathway combining systematic SCC and structured PP support for all individuals diagnosed with anal cancer living in France. The study will assess the intervention\u2019s clinical, organisational, and social effects, and will identify the conditions required for its long-term sustainability and transferability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and design<\/jats:title>\n                    <jats:p>This is a longitudinal mixed-methods case study conducted in two French Comprehensive Cancer Centres. The intervention entails introducing a systematic, coordinated, and repeated SCC offer together with a structured PP support programme for all patients diagnosed with anal cancer and over 12 months following diagnosis. One centre will implement the enhanced care pathway, while the other will initially provide standard care before progressively adopting the intervention during the transferability phase. Quantitative data will include patient-reported outcomes, clinical information and implementation indicators. Qualitative data exploring implementation processes, organisational changes and contextual determinants, will be collected through observations, semi-structured interviews, focus groups and PP activity logs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The study\u2019s results will provide essential scientific knowledge on the implementation of programmes providing equitable SCC and PP support access to people living with anal cancer. Specifically, by combining implementation research, participatory approaches and mixed-methods evaluation, the project aims to identify the organisational conditions for the sustainable implementation of such programmes for this population, and their successful transferability to other populations living with cancer and to other healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0359705","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:40:46Z","timestamp":1792777246000},"page":"e0359705","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysing the implementation and transferability of an enhanced care pathway integrating systematic supportive cancer care and patient-partner support for people living with anal cancer: Protocol for a mixed-methods study in two French cancer centres"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-7433","authenticated-orcid":true,"given":"S\u00e9verine","family":"Carillon","sequence":"first","affiliation":[{"name":"SESSTIM (Economic and Social Sciences of Health and Medical Information Processing), INSERM, IRD, Aix-Marseille University","place":["Marseille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Faure","sequence":"additional","affiliation":[{"name":"SESSTIM (Economic and Social Sciences of Health and Medical Information Processing), INSERM, IRD, Aix-Marseille University","place":["Marseille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maguy","family":"Del Rio","sequence":"additional","affiliation":[{"name":"Montpellier Cancer Institute (ICM)","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lemanski","sequence":"additional","affiliation":[{"name":"Montpellier Cancer Institute (ICM)","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Tyran","sequence":"additional","affiliation":[{"name":"Institut Paoli-Calmettes (IPC)","place":["Marseille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"de Montgolfier","sequence":"additional","affiliation":[{"name":"SESSTIM (Economic and Social Sciences of Health and Medical Information Processing), INSERM, IRD, Aix-Marseille University","place":["Marseille, France"]},{"name":"Paris Est Creteil","place":["University, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the SOS \u2013 PP Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"pone.0359705.ref001","author":"INCa - Institut National du Cancer","year":"2023"},{"key":"pone.0359705.ref002","author":"Multinational Association of Supportive Care in Cancer"},{"issue":"4","key":"pone.0359705.ref003","first-page":"1883","article-title":"Supportive\/palliative care in cancer patients: quo vadis?","volume":"24","author":"J Klastersky","year":"2016","journal-title":"Support Care Cancer"},{"key":"pone.0359705.ref004","author":"European Society for Medical Oncology"},{"issue":"5","key":"pone.0359705.ref005","article-title":"The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis","volume":"31","author":"C Cuthbert","year":"2023","journal-title":"Support Care Cancer"},{"issue":"7","key":"pone.0359705.ref006","first-page":"5601","article-title":"Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials","volume":"30","author":"P Machado","year":"2022","journal-title":"Support Care Cancer"},{"key":"pone.0359705.ref007","doi-asserted-by":"crossref","first-page":"806344","DOI":"10.3389\/fneur.2022.806344","article-title":"Quality of Life and Role of Palliative and Supportive Care for Patients With Brain Metastases and Caregivers: A Review","volume":"13","author":"A Wu","year":"2022","journal-title":"Front Neurol"},{"issue":"8","key":"pone.0359705.ref008","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMoa1000678","article-title":"Early palliative care for patients with metastatic non-small-cell lung cancer","volume":"363","author":"JS Temel","year":"2010","journal-title":"N Engl J Med"},{"issue":"10334","key":"pone.0359705.ref009","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0140-6736(22)00242-2","article-title":"Management of common clinical problems experienced by survivors of cancer","volume":"399","author":"J Emery","year":"2022","journal-title":"Lancet"},{"issue":"25","key":"pone.0359705.ref010","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1200\/JCO.2010.29.5618","article-title":"Integrating supportive and palliative care in the trajectory of cancer: establishing goals and models of care","volume":"28","author":"E Bruera","year":"2010","journal-title":"J Clin Oncol"},{"issue":"7","key":"pone.0359705.ref011","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archinternmed.2011.87","article-title":"The optimal delivery of palliative care: a national comparison of the outcomes of consultation teams vs inpatient units","volume":"171","author":"D Casarett","year":"2011","journal-title":"Arch Intern Med"},{"issue":"3","key":"pone.0359705.ref012","first-page":"290","article-title":"Edmonton Regional Palliative Care Program: Impact on Patterns of Terminal Cancer Care","volume":"161","author":"E Bruera","year":"1999","journal-title":"CMAJ"},{"key":"pone.0359705.ref013","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.critrevonc.2018.09.002","article-title":"Supporting Supportive Care in Cancer: The ethical importance of promoting a holistic conception of quality of life","volume":"131","author":"D Carrieri","year":"2018","journal-title":"Crit Rev Oncol Hematol"},{"key":"pone.0359705.ref014","unstructured":"INCa - Institut National du Cancer Inc. Soins oncologiques de support des patients adultes atteints de cancer\/ R\u00e9f\u00e9rentiel organisationnel national\/ avis d\u2019experts. 2021."},{"issue":"7","key":"pone.0359705.ref015","first-page":"2111","article-title":"Supportive Care Organization in France: a national in-depth survey among patients and oncologists","volume":"25","author":"F Scott\u00e9","year":"2017","journal-title":"Support Care Cancer"},{"issue":"4","key":"pone.0359705.ref016","first-page":"5","article-title":"Les soins oncologiques de support: une ressource in\u00e9galement mobilis\u00e9e face au cancer","volume":"41","author":"H Kane","year":"2023","journal-title":"Sciences sociales et sant\u00e9"},{"key":"pone.0359705.ref017","author":"Ligue nationale, contre le cancer","year":"2022"},{"issue":"6","key":"pone.0359705.ref018","article-title":"Supportive care structures and fundings in French Comprehensive Cancer Centers: a national survey","volume":"33","author":"C Dancoisne","year":"2025","journal-title":"Support Care Cancer"},{"key":"pone.0359705.ref019","author":"Ligue contre le cancer","year":"2022"},{"issue":"2","key":"pone.0359705.ref020","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/hex.13710","article-title":"Accompanying patients in clinical oncology teams: Reported activities and perceived effects","volume":"26","author":"M Pomey","year":"2023","journal-title":"Health Expectations"},{"issue":"1","key":"pone.0359705.ref021","first-page":"97","article-title":"Peer support opportunities across the cancer care continuum: a systematic scoping review of recent peer-reviewed literature","volume":"27","author":"SD Kowitt","year":"2019","journal-title":"Support Care Cancer"},{"issue":"3","key":"pone.0359705.ref022","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5737\/23688076303186192","article-title":"Les patients-partenaires dans les soins du cancer: une strat\u00e9gie novatrice dans le d\u00e9pistage de la d\u00e9tresse?","volume":"30","author":"J Rivest","year":"2020","journal-title":"Can Oncol Nurs J"},{"issue":"1","key":"pone.0359705.ref023","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/s12885-023-10856-9","article-title":"An exploratory cross-sectional study of the effects of ongoing relationships with accompanying patients on cancer care experience, self-efficacy, and psychological distress","volume":"23","author":"M-P Pomey","year":"2023","journal-title":"BMC Cancer"},{"issue":"11","key":"pone.0359705.ref024","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1016\/j.pec.2022.07.008","article-title":"Peer support interventions on quality of life, depression, anxiety, and self-efficacy among patients with cancer: A systematic review and meta-analysis","volume":"105","author":"S Zhang","year":"2022","journal-title":"Patient Educ Couns"},{"key":"pone.0359705.ref025","doi-asserted-by":"crossref","first-page":"102256","DOI":"10.1016\/j.ejon.2022.102256","article-title":"The integration of accompanying patients into clinical teams in oncology: perceptions of accompanying patients and nurses","volume":"62","author":"AM Ferville","year":"2022","journal-title":"Eur J Oncol Nurs"},{"issue":"3","key":"pone.0359705.ref026","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3917\/spub.233.0285","article-title":"Comment int\u00e9grer un patient partenaire dans une \u00e9quipe de soins?","volume":"35","author":"N Tourniaire","year":"2023","journal-title":"Sant\u00e9 Publique"},{"issue":"3","key":"pone.0359705.ref027","first-page":"924","article-title":"International trends in anal cancer incidence rates","volume":"46","author":"F Islami","year":"2017","journal-title":"Int J Epidemiol"},{"key":"pone.0359705.ref028","doi-asserted-by":"crossref","first-page":"109542","DOI":"10.1016\/j.radonc.2023.109542","article-title":"Treatment, outcome, and prognostic factors in non-metastatic anal cancer: The French nationwide cohort study FFCD-ANABASE","volume":"183","author":"V Vendrely","year":"2023","journal-title":"Radiother Oncol"},{"issue":"9","key":"pone.0359705.ref029","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.annonc.2021.06.015","article-title":"Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\u2606","volume":"32","author":"S Rao","year":"2021","journal-title":"Ann Oncol"},{"key":"pone.0359705.ref030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.radonc.2021.12.050","article-title":"Evaluation of prognostic factors after primary chemoradiotherapy of anal cancer: A multicenter study of the German Cancer Consortium-Radiation Oncology Group (DKTK-ROG)","volume":"167","author":"D Martin","year":"2022","journal-title":"Radiother Oncol"},{"issue":"6","key":"pone.0359705.ref031","first-page":"475","article-title":"Improving our understanding of the quality of life of patients with metastatic or recurrent\/persistent anal cancer: a systematic review","volume":"33","author":"SC Sodergren","year":"2025","journal-title":"Support Care Cancer"},{"issue":"9","key":"pone.0359705.ref032","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00384-019-03342-x","article-title":"Quality of life in patients treated for anal carcinoma\u2014a systematic literature review","volume":"34","author":"A Sterner","year":"2019","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"pone.0359705.ref033","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12029-019-00233-w","article-title":"Sexual Function, Quality of Life, and Mood After Radiation Therapy in Patients with Anal Cancer","volume":"51","author":"D Yerramilli","year":"2020","journal-title":"J Gastrointest Cancer"},{"issue":"8","key":"pone.0359705.ref034","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.canrad.2021.09.007","article-title":"Toxicit\u00e9 sexuelle induite par la radioth\u00e9rapie","volume":"25","author":"C Besnard","year":"2021","journal-title":"Cancer\/Radioth\u00e9rapie"},{"issue":"2","key":"pone.0359705.ref035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1468-0009.2012.00665.x","article-title":"Uncovering the benefits of participatory research: implications of a realist review for health research and practice","volume":"90","author":"J Jagosh","year":"2012","journal-title":"Milbank Q"},{"key":"pone.0359705.ref036","volume-title":"Community-based participatory research for health: advancing social and health equity","author":"N. Wallerstein","year":"2017","edition":"3"},{"key":"pone.0359705.ref037","doi-asserted-by":"crossref","DOI":"10.4000\/books.irdeditions.48278","volume-title":"La recherche interventionnelle en sant\u00e9 des populations","author":"F Alla","year":"2024"},{"key":"pone.0359705.ref038","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4000\/books.irdeditions.48317","article-title":"Les approches m\u00e9thodologiques en RISP","volume-title":"La recherche interventionnelle en sant\u00e9 des populations: Concepts, m\u00e9thodes, applications","author":"F Alla","year":"2024"},{"issue":"1","key":"pone.0359705.ref039","first-page":"35","article-title":"D\u00e9veloppement territorial du partenariat en sant\u00e9 dans l\u2019accompagnement de patients sous th\u00e9rapie orale: PACTO","volume":"10","author":"M Del Rio","year":"2024","journal-title":"Innov Ther Oncol"},{"issue":"1","key":"pone.0359705.ref040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1684\/ito.2025.499","article-title":"D\u00e9cider ensemble pour aller plus loin, plus vite, plus haut! Application de la d\u00e9mocratie sanitaire \u00e0 l\u2019Institut du cancer de Montpellier","volume":"11","author":"C Guillaumon","year":"2025","journal-title":"Innovations & Th\u00e9rapeutiques en Oncologie"},{"key":"pone.0359705.ref041","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1475-9276-12-18","article-title":"Patient-centred access to health care: conceptualising access at the interface of health systems and populations","volume":"12","author":"J-F Levesque","year":"2013","journal-title":"Int J Equity Health"},{"issue":"1","key":"pone.0359705.ref042","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12939-021-01416-3","article-title":"Assessing healthcare access using the Levesque\u2019s conceptual framework- a scoping review","volume":"20","author":"A Cu","year":"2021","journal-title":"Int J Equity Health"},{"issue":"1","key":"pone.0359705.ref043","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13012-018-0784-z","article-title":"Engaging patients to improve quality of care: a systematic review","volume":"13","author":"Y Bombard","year":"2018","journal-title":"Implement Sci"},{"issue":"5","key":"pone.0359705.ref044","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/pon.5869","article-title":"Empowerment in cancer patients: Does peer support make a difference? A systematic review","volume":"31","author":"E Ziegler","year":"2022","journal-title":"Psychooncology"},{"issue":"7","key":"pone.0359705.ref045","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1177\/02692163211015574","article-title":"Early, integrated palliative rehabilitation improves quality of life of patients with newly diagnosed advanced cancer: The Pal-Rehab randomized controlled trial","volume":"35","author":"L Nottelmann","year":"2021","journal-title":"Palliat Med"},{"key":"pone.0359705.ref046","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1748-5908-4-50","article-title":"Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science","volume":"4","author":"LJ Damschroder","year":"2009","journal-title":"Implement Sci"},{"key":"pone.0359705.ref047","author":"P Craig","year":"2018"},{"issue":"5","key":"pone.0359705.ref048","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/heapol\/czq077","article-title":"Process-oriented fidelity research assists in evaluation, adjustment and scaling-up of community-based interventions","volume":"26","author":"D P\u00e9rez","year":"2011","journal-title":"Health Policy Plan"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0359705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:40:54Z","timestamp":1792777254000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0359705"}},"subtitle":[],"editor":[{"given":"Emma","family":"Campbell","sequence":"first","affiliation":[{"name":"PLOS: Public Library of Science","place":["UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":48,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0359705","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]}}}