{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:56:21Z","timestamp":1791222981092,"version":"4.1.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Society of Health Economics.","award":["202335"],"award-info":[{"award-number":["202335"]}]},{"name":"the Shenzhen Basic Research Program","award":["JCYJ20240813103813018"],"award-info":[{"award-number":["JCYJ20240813103813018"]}]},{"name":"Shenzhen Clinical Research Center for Respiratory Disease","award":["LCYSSQ20220823091203007"],"award-info":[{"award-number":["LCYSSQ20220823091203007"]}]},{"name":"Shenzhen Key Laboratory of Respiratory Diseases","award":["SYSPG20241211173920041"],"award-info":[{"award-number":["SYSPG20241211173920041"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Abnormal oxygenation may influence thrombosis, but evidence in catheterized critically ill patients remains limited. We examined whether the first arterial partial pressure of oxygen (PaO\n                    <jats:sub>2<\/jats:sub>\n                    ) measured within 24 hours after qualifying invasive venous catheter insertion was associated with documented acute upper-body deep or central venous thrombosis during hospitalization. This retrospective observational cohort study used the Medical Information Mart for Intensive Care IV database, version 2.2 (MIMIC-IV v2.2) (2008\u20132019). Adult intensive care unit admissions were included when a qualifying invasive venous catheter was present and an arterial PaO\n                    <jats:sub>2<\/jats:sub>\n                    measurement was obtained after insertion, within 24 hours, and while the catheter remained in situ. PaO\n                    <jats:sub>2<\/jats:sub>\n                    was analyzed continuously and categorically (\u226480, 81\u2013100, and &gt;100 mmHg). Logistic regression models sequentially adjusted for patient characteristics, laboratory measurements, catheter characteristics, measurement timing, inspired oxygen concentration, respiratory support, and non-respiratory organ dysfunction. Multiple imputation addressed missing covariate data, and patient-clustered robust standard errors accounted for repeated admissions. The cohort included 11,277 hospital admissions from 10,789 patients; 195 admissions (1.73%) had the primary outcome. In the unadjusted model, higher PaO\n                    <jats:sub>2<\/jats:sub>\n                    was associated with lower odds of the outcome (odds ratio [OR] per 10-mmHg increase, 0.970; 95% confidence interval [CI], 0.952\u20130.987), but this association attenuated after adjustment. In the fully adjusted model, PaO\n                    <jats:sub>2<\/jats:sub>\n                    was not associated with the outcome (OR, 1.008; 95% CI, 0.989\u20131.027; P\u2009=\u20090.430). Most secondary analyses supported the primary result, although the 60-minute sensitivity analysis yielded adjustment-dependent estimates. In the complete cohort, a single early post-insertion PaO\n                    <jats:sub>2<\/jats:sub>\n                    measurement was not independently associated with documented acute upper-body deep or central venous thrombosis. These findings do not support PaO\n                    <jats:sub>2<\/jats:sub>\n                    -based thrombosis risk stratification or modification of oxygen therapy for thrombosis prevention. Future studies should incorporate repeated oxygenation measurements and accurately timed, imaging-confirmed thrombotic outcomes.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0359719","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:18Z","timestamp":1791221358000},"page":"e0359719","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between early post-insertion arterial oxygen tension and documented acute upper-body deep or central venous thrombosis in critically ill adults: A retrospective MIMIC-IV cohort study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-6503","authenticated-orcid":true,"given":"Qing","family":"Cui","sequence":"first","affiliation":[{"name":"Shenzhen Clinical Research Center for Respiratory Disease, Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University)","place":["Shenzhen, China"],"department":["Department of Pulmonary and Critical Care Medicine, Shenzhen Key Laboratory of Respiratory Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1025-8546","authenticated-orcid":true,"given":"Anshuai","family":"Fang","sequence":"additional","affiliation":[{"name":"Shenzhen Clinical Research Center for Respiratory Disease, Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University)","place":["Shenzhen, China"],"department":["Department of Pulmonary and Critical Care Medicine, Shenzhen Key Laboratory of Respiratory Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital","place":["Shenzhen, Guangdong, China"],"department":["Department of Hepatobiliary Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8746-2470","authenticated-orcid":true,"given":"Qingtong","family":"Meng","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital","place":["Shenzhen, Guangdong, China"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital","place":["Shenzhen, Guangdong, China"],"department":["Department of Hepatobiliary Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-791X","authenticated-orcid":true,"given":"Yueming","family":"Peng","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital","place":["Shenzhen, Guangdong, China"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital","place":["Shenzhen, Guangdong, China"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"12","key":"pone.0359719.ref001","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1097\/CCM.0000000000003370","article-title":"Complication and Failures of Central Vascular Access Device in Adult Critical Care Settings","volume":"46","author":"M 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