{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:57:09Z","timestamp":1791223029802,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      End-stage renal disease (ESRD) is a major global non-communicable condition associated with substantial morbidity and mortality. The current investigation aimed to report the association of\n                      <jats:italic>GSTM1<\/jats:italic>\n                      ,\n                      <jats:italic>GSTT1<\/jats:italic>\n                      genotypes and single nucleotide polymorphisms (SNPs) in\n                      <jats:italic>GSTP1<\/jats:italic>\n                      (rs1695) and\n                      <jats:italic>TP53<\/jats:italic>\n                      (rs1042522) genes with ESRD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinically confirmed ESRD patients (n\u2009=\u2009305) and healthy controls (n\u2009=\u2009305) were enrolled from District Multan in Punjab, Pakistan, during 30-10-2023 till 28-02-2024, following their informed verbal consent. Multiplex and T-ARMS PCR based approaches were used to document the genotype at GSTs and SNPs of targeted genes and their associations with ESRD were analyzed individually as well as in combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant association of absence of\n                      <jats:italic>GSTM1,<\/jats:italic>\n                      presence of\n                      <jats:italic>GSTT1,<\/jats:italic>\n                      presence of \u201cG\u201d polymorphic allele at rs1695 in\n                      <jats:italic>GSTP1,<\/jats:italic>\n                      and the presence of \u201cC\u201d polymorphic allele at rs1042522 in\n                      <jats:italic>TP53<\/jats:italic>\n                      gene was observed with ESRD during the present study. Participants having age ranging between 26\u201340 years, males and smokers suffered more from ESRD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Genetic variations in the studied GSTs, along with rs1695 in\n                      <jats:italic>GSTP1<\/jats:italic>\n                      and rs1042522 in the\n                      <jats:italic>TP53<\/jats:italic>\n                      gene, may influence the progression of ESRD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0359809","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:28:31Z","timestamp":1791221311000},"page":"e0359809","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of GST 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