{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:47:45Z","timestamp":1792086465502,"version":"4.4.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72374180"],"award-info":[{"award-number":["72374180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province","award":["2020E10004"],"award-info":[{"award-number":["2020E10004"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lifestyle modifications are recommended by American Gastroenterological Association (AGA) for managing gastroesophageal reflux disease (GERD), a significant health issue; but evidence is scarce. This study aims to investigate the longitudinal association between healthy lifestyle behaviors and the risk of GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 306,543 participants aged between 38 and 73 years without GERD at baseline from the UK Biobank. A summarized healthy lifestyle score (range, 0\u20137) was calculated using seven items: never smoking, healthy sleep, moderate body mass index (BMI), regular physical exercise, moderate alcohol intake, healthy diet, and moderate tea\/coffee intake. Multivariable Cox regression was performed to examine the associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      During a mean follow-up of 12.7 years, 27,943 (9.1%) GERD cases were identified. Each healthy lifestyle, except for moderate alcohol intake (hazard ratios [HR], 1.00; 95% confidence interval [CI]: 0.98\u20131.03) was associated with a lower risk of GERD. Relative to participants with less than 2 of summarized healthy lifestyle score, those with 2, 3, 4, and 5\u20137 of this score showed a significantly lower risk of GERD, with the HR of 0.94 (95% CI: 0.90\u20130.98), 0.83 (0.80\u20130.86), 0.74 (0.71\u20130.77), 0.63 (0.60\u20130.66), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      for trend &lt;0.001). Stratified analysis shows that the above associations were more pronounced among participants who were younger (&lt; 60 years), female and employed (all\n                      <jats:italic>P<\/jats:italic>\n                      for interaction &lt;0.05). Sensitivity analyses demonstrated similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the importance of adherence to healthy lifestyle behaviors in reducing the prevalence of GERD in the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0360299","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:32Z","timestamp":1792085192000},"page":"e0360299","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healthy lifestyle as a protective factor against the risk of gastroesophageal reflux disease: Prospective population cohort analysis"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7413-240X","authenticated-orcid":true,"given":"Lei","family":"Peng","sequence":"first","affiliation":[{"name":"Shandong University","place":["Jinan, Shandong, China"],"department":["Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"],"department":["Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Shandong University","place":["Jinan, Shandong, China"],"department":["Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"],"department":["Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"],"department":["Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xucheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"],"department":["Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Jia","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"],"department":["Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George O.","family":"Agogo","sequence":"additional","affiliation":[{"name":"U.S. Centers for Disease Control and Prevention (CDC)","place":["Nairobi, Kenya"],"department":["Division of Global Health Protection"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoju","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Medical College","place":["Jinan, Shandong, China"],"department":["Department of Physiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong University","place":["Jinan, Shandong, China"],"department":["Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"],"department":["Center for Clinical Big Data and Analytics 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Richter","year":"2018","journal-title":"Gastroenterology"},{"key":"pone.0360299.ref004","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9270(03)00010-8","article-title":"The economic and quality-of-life impact of symptomatic gastroesophageal reflux disease","volume":"98","author":"JJ Ofman","year":"2003","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"pone.0360299.ref005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.14309\/ajg.0000000000001538","article-title":"ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease","volume":"117","author":"PO Katz","year":"2022","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"pone.0360299.ref006","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/gut.2009.200063","article-title":"Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study","volume":"59","author":"J 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Population-Based Study","volume":"77","author":"C-Y Hsu","year":"2015","journal-title":"Psychosom Med"},{"issue":"1","key":"pone.0360299.ref024","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.atherosclerosis.2014.04.031","article-title":"Self-reported habitual snoring and risk of cardiovascular disease and all-cause mortality","volume":"235","author":"D Li","year":"2014","journal-title":"Atherosclerosis"},{"issue":"11","key":"pone.0360299.ref025","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006071","article-title":"Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study","volume":"4","author":"Y Leng","year":"2014","journal-title":"BMJ Open"},{"key":"pone.0360299.ref026","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jad.2024.01.122","article-title":"Associations between sleep-behavioral traits and healthspan: A one-sample Mendelian randomization study based on 388,909 participants of the UK-Biobank","volume":"350","author":"ML Sambou","year":"2024","journal-title":"J Affect Disord"},{"key":"pone.0360299.ref027","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jama.2019.9879","article-title":"Association of lifestyle and genetic risk with incidence of dementia","volume":"322","author":"I Lourida","year":"2019","journal-title":"JAMA"},{"issue":"8","key":"pone.0360299.ref028","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jamacardio.2018.1717","article-title":"Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study","volume":"3","author":"MA Said","year":"2018","journal-title":"JAMA Cardiol"},{"key":"pone.0360299.ref029","article-title":"Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study","volume":"368","author":"Y Li","year":"2020","journal-title":"BMJ"},{"issue":"3","key":"pone.0360299.ref030","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.05.056","article-title":"Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin","volume":"157","author":"P Moayyedi","year":"2019","journal-title":"Gastroenterology"},{"issue":"2","key":"pone.0360299.ref031","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/ndt\/gfw470","article-title":"The association between proton pump inhibitor use and the risk of adverse kidney outcomes: a systematic review and meta-analysis","volume":"33","author":"S Nochaiwong","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"pone.0360299.ref032","doi-asserted-by":"crossref","first-page":"101585","DOI":"10.1016\/j.canep.2019.101585","article-title":"Duration of use of proton pump inhibitors and the risk of gastric and oesophageal cancer","volume":"62","author":"N Brusselaers","year":"2019","journal-title":"Cancer Epidemiol"},{"key":"pone.0360299.ref033","article-title":"Association between infection of Helicobacter pylori and the risk of reflux oesophagitis occurrence or recurrence: a systematic review and meta-analysis","volume":"3","author":"A Li","year":"2025","journal-title":"EGastro"},{"key":"pone.0360299.ref034","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1053\/j.gastro.2025.09.012","article-title":"AGA Clinical Practice Guideline on Surveillance of Barrett\u2019s Esophagus","volume":"169","author":"S Wani","year":"2025","journal-title":"Gastroenterology"},{"issue":"1","key":"pone.0360299.ref035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000509208","article-title":"Combined Healthy Lifestyle Is Inversely Associated with Upper Gastrointestinal Disorders among Iranian Adults","volume":"39","author":"P Saneei","year":"2021","journal-title":"Dig Dis"},{"issue":"4","key":"pone.0360299.ref036","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/gut.43.4.537","article-title":"Effect of chronic and acute cigarette smoking on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow","volume":"43","author":"K Dua","year":"1998","journal-title":"Gut"},{"issue":"4","key":"pone.0360299.ref037","first-page":"431","article-title":"The effect of cigarette smoking on salivation and esophageal acid clearance","volume":"114","author":"PJ Kahrilas","year":"1989","journal-title":"J Lab Clin Med"},{"issue":"1","key":"pone.0360299.ref038","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/gut.31.1.4","article-title":"Mechanisms of acid reflux associated with cigarette smoking","volume":"31","author":"PJ Kahrilas","year":"1990","journal-title":"Gut"},{"issue":"1","key":"pone.0360299.ref039","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/gut.47.1.26","article-title":"No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study","volume":"47","author":"J Lagergren","year":"2000","journal-title":"Gut"},{"issue":"12","key":"pone.0360299.ref040","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1136\/gut.2004.043265","article-title":"Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux","volume":"53","author":"M Nilsson","year":"2004","journal-title":"Gut"},{"issue":"4","key":"pone.0360299.ref041","first-page":"377","article-title":"The effect of raw onions on acid reflux and reflux symptoms","volume":"85","author":"ML Allen","year":"1990","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"pone.0360299.ref042","doi-asserted-by":"crossref","first-page":"21","DOI":"10.32394\/rpzh.2021.0145","article-title":"Risk factors for gastroesophageal reflux disease symptoms related to lifestyle and diet","volume":"72","author":"A Taraszewska","year":"2021","journal-title":"Rocz Panstw Zakl Hig"},{"issue":"5","key":"pone.0360299.ref043","first-page":"297","article-title":"Risk factors for gastroesophageal reflux disease: the role of diet","volume":"9","author":"M Jarosz","year":"2014","journal-title":"Prz Gastroenterol"},{"issue":"2","key":"pone.0360299.ref044","first-page":"104","article-title":"Abnormal lower esophageal sphincter pressure responses in patients with orange juice-induced heartburn","volume":"81","author":"JP Cranley","year":"1986","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"pone.0360299.ref045","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5056\/jnm.2010.16.2.131","article-title":"Are rice and spicy diet good for functional gastrointestinal disorders?","volume":"16","author":"S Gonlachanvit","year":"2010","journal-title":"J Neurogastroenterol Motil"},{"issue":"1","key":"pone.0360299.ref046","article-title":"Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach","volume":"3","author":"D Liu","year":"2025","journal-title":"eGastroenterology"},{"issue":"5","key":"pone.0360299.ref047","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1249\/01.MSS.0000064937.99001.56","article-title":"Esophageal reflux in conditioned runners, cyclists, and weightlifters","volume":"35","author":"KL Collings","year":"2003","journal-title":"Med Sci Sports Exerc"},{"issue":"8","key":"pone.0360299.ref048","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/j.1572-0241.2004.30515.x","article-title":"Esophagogastric junction morphology predicts susceptibility to exercise-induced reflux","volume":"99","author":"JE Pandolfino","year":"2004","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"pone.0360299.ref049","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1249\/00149619-200404000-00010","article-title":"Gastroesophageal reflux in athletes","volume":"3","author":"K Parmelee-Peters","year":"2004","journal-title":"Curr Sports Med Rep"},{"issue":"14","key":"pone.0360299.ref050","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.3748\/wjg.15.1690","article-title":"Body weight, lifestyle, dietary habits and gastroesophageal reflux disease","volume":"15","author":"D Festi","year":"2009","journal-title":"World J Gastroenterol"},{"key":"pone.0360299.ref051","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4414\/smw.2007.11887","article-title":"The relationship between gastroesophageal reflux disease and the level of physical activity","volume":"137","author":"P J\u00f3\u017ak\u00f3w","year":"2007","journal-title":"Swiss Med Wkly"},{"issue":"2","key":"pone.0360299.ref052","article-title":"The Effect of Ramelteon on Heartburn Symptoms of Patients With Gastroesophageal Reflux Disease and Chronic Insomnia: A Pilot Study","volume":"50","author":"LK Jha","year":"2016","journal-title":"J Clin Gastroenterol"},{"issue":"7","key":"pone.0360299.ref053","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.3390\/ijms19072033","article-title":"Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett\u2019s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives","volume":"19","author":"J Majka","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"4","key":"pone.0360299.ref054","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cgh.2008.11.021","article-title":"A systematic review of the definitions, prevalence, and response to treatment of nocturnal gastroesophageal reflux disease","volume":"7","author":"LB Gerson","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"pone.0360299.ref055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.2004.02237.x","article-title":"Review article: impact of night-time reflux on lifestyle - unrecognized issues in reflux disease","author":"R 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