{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:48:09Z","timestamp":1792086489685,"version":"4.4.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myocardial infarction (MI) induces cardiac remodeling and lead to heart failure. Some patients experience reverse remodeling, characterized by improved LV function. MicroRNAs (miRNAs) regulate gene expression and play a crucial role in remodeling processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to investigate the role of miRNAs in cardiac reverse remodeling after MI and identify candidate miRNAs that could predict better response to cardiac rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study enrolled 39 patients following their first MI. For final analysis, 10 patients meeting echocardiographic criteria for LVRR at 8-week follow-up (absolute LVEF increase\u2009\u2265\u200910% or LVESV reduction\u2009\u2265\u200915%) were matched with 10 patients with stable LV status (SLVS). All patients completed a cardiac rehabilitation program. Expression of 375 circulating miRNAs was quantified \u2013 those with higher baseline accumulation in the LVRR group were identified as candidate biomarkers and their target genes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty patients (mean age 57\u2009\u00b1\u20099 years) were analyzed. At baseline, the SLVS group exhibited significantly higher LVEF compared to the LVRR group (53% vs. 44%, p\u2009=\u20090.013). Baseline regional contractility impairment in all LVRR patients was reversed in 70% of them at follow-up. Fourteen miRNAs (-15b-5p, \u221224-3p, -29c-3p, -99b-5p, \u2212127-3p, -146a-5p, -199a-3p, \u2212361-5p, \u2212502-5p, \u2212625-5p, -376c-3p, -18b-5p, \u2212342-5p, and \u2212429) were identified as candidate LVRR biomarkers. Enrichment analysis linked their targets to PI3K-Akt, MAPK, FoxO, and HIF-1 pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identifies 14 candidate miRNAs as LVRR biomarkers post-MI. These findings highlight the biological relevance of non-coding RNA and support the need for further research and validation in large, non-pooled cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec006\">\n                    <jats:title>Unstructured abstract<\/jats:title>\n                    <jats:p>Myocardial infarction triggers adverse cardiac remodeling, though some patients achieve left ventricular reverse remodeling (LVRR), marked by functional and structural recovery. This pilot study investigated 39 patients to identify circulating microRNAs (miRNAs) that predict positive responses to cardiac rehabilitation. Comparing 10 LVRR responders against 10 stable patients, we quantified 375 miRNAs via RT-qPCR. At baseline, the stable group had higher ejection fractions (53% vs. 44%, p = 0.013), but 70% of LVRR patients reversed regional contractility impairment by the 8-week follow-up. We identified 14 potential biomarkers, including novel candidates (miR-502-5p, miR-376c-3p, and miR-18b-5p), whose target genes enrich pathways like PI3K-Akt, MAPK, and FoxO. These findings bridge the gap between preclinical data and clinical settings, highlighting the therapeutic potential of non-coding RNAs in cardiac reverse remodeling and necessitating further validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0360414","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:46Z","timestamp":1792085206000},"page":"e0360414","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating microRNAs as potential candidate biomarkers of left ventricular reverse remodeling after myocardial infarction: A pilot study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-1448","authenticated-orcid":true,"given":"Roksana","family":"Gozdowska","sequence":"first","affiliation":[{"name":"Hypertension and Internal Diseases, Mazovian Brodnowski Hospital, Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Konopka","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Sports Cardiology and Noninvasive Cardiovascular Imaging, Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hojka-Osi\u0144ska","sequence":"additional","affiliation":[{"name":"Bioinformatics Facility, International Institute of Molecular and Cell Biology","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Jas","sequence":"additional","affiliation":[{"name":"Hypertension and Internal Diseases, Mazovian Brodnowski Hospital, Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Czarzasta","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Experimental and Clinical Physiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Cudnoch-J\u0119drzejewska","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Experimental and Clinical Physiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Braksator","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Sports Cardiology and Noninvasive Cardiovascular Imaging, Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-511X","authenticated-orcid":true,"given":"Dominika","family":"Klimczak-Tomaniak","sequence":"additional","affiliation":[{"name":"Hypertension and Internal Diseases, Mazovian Brodnowski Hospital, Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Cardiology"]},{"name":"Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Heart Failure and Cardiac Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Kuch","sequence":"additional","affiliation":[{"name":"Hypertension and Internal Diseases, Mazovian Brodnowski Hospital, Medical University of Warsaw","place":["Warsaw, Poland"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"pone.0360414.ref001","doi-asserted-by":"crossref","first-page":"3920195","DOI":"10.1155\/2017\/3920195","article-title":"A Review of the molecular mechanisms underlying the development and progression of cardiac remodeling","volume":"2017","author":"L Schirone","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"pone.0360414.ref002","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00696.2015","article-title":"Myocardial reverse remodeling: How far can we rewind?","volume":"310","author":"PG Rodrigues","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"pone.0360414.ref003","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacc.2020.05.075","article-title":"Heart Failure with recovered left ventricular ejection fraction: JACC scientific expert panel","volume":"76","author":"JE Wilcox","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"pone.0360414.ref004","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1159\/000526986","article-title":"Prediction of Left Ventricular Reverse Remodelling: A Mini Review on Clinical Aspects","volume":"147","author":"M Chud\u00fd","year":"2022","journal-title":"Cardiology"},{"key":"pone.0360414.ref005","author":"B Ko\u0144","year":"2023"},{"issue":"1","key":"pone.0360414.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2015.10.044","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane Systematic Review and Meta-Analysis","volume":"67","author":"L Anderson","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"pone.0360414.ref007","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2011.07.017","article-title":"Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials","volume":"162","author":"PR Lawler","year":"2011","journal-title":"Am Heart J"},{"issue":"3","key":"pone.0360414.ref008","doi-asserted-by":"crossref","first-page":"415","DOI":"10.33963\/KP.a2022.0035","article-title":"Survival analysis of patients with acute coronary syndrome receiving comprehensive coordinated care after myocardial infarction (KOS-Zawa\u0142)","volume":"80","author":"G Kubielas","year":"2022","journal-title":"Kardiol Pol"},{"issue":"4","key":"pone.0360414.ref009","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s12265-024-10498-7","article-title":"The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling","volume":"17","author":"H Gao","year":"2024","journal-title":"J Cardiovasc Transl Res"},{"issue":"4","key":"pone.0360414.ref010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.14797\/mdcvj.1381","article-title":"Role of Imaging and Biomarkers in Identifying, Monitoring, and Promoting Myocardial Recovery","volume":"20","author":"E Meekers","year":"2024","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"pone.0360414.ref011","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gde.2021.05.007","article-title":"RNA interference therapeutics for cardiac regeneration","volume":"70","author":"J Huntington","year":"2021","journal-title":"Curr Opin Genet Dev"},{"issue":"3","key":"pone.0360414.ref012","first-page":"400","article-title":"MicroRNAs in Heart Failure Pathogenesis and Progression: Mechanistic Control, Biomarker Potential, and Translational Perspectives","volume":"16","author":"D Zivalj","year":"2026","journal-title":"Life (Basel)"},{"key":"pone.0360414.ref013","doi-asserted-by":"crossref","first-page":"1429858","DOI":"10.3389\/fcvm.2024.1429858","article-title":"Unveiling the role of long non-coding RNA MALAT1: A comprehensive review on myocardial infarction","volume":"11","author":"R Eshraghi","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"pone.0360414.ref014","doi-asserted-by":"crossref","first-page":"650566","DOI":"10.3389\/fphys.2021.650566","article-title":"Non-coding RNAs in Cardiac Regeneration","volume":"12","author":"T Yuan","year":"2021","journal-title":"Front Physiol"},{"issue":"38","key":"pone.0360414.ref015","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"RA Byrne","year":"2023","journal-title":"Eur Heart J"},{"issue":"1","key":"pone.0360414.ref016","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/eurjpc\/zwab007","article-title":"Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: why and how: a position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology","volume":"29","author":"D Hansen","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"pone.0360414.ref017","doi-asserted-by":"crossref","first-page":"901","DOI":"10.33963\/KP.a2021.0066","article-title":"Comprehensive cardiac rehabilitation as the keystone in the secondary prevention of cardiovascular disease","volume":"79","author":"A Jegier","year":"2021","journal-title":"Kardiol Pol"},{"issue":"1","key":"pone.0360414.ref018","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"RM Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"1","key":"pone.0360414.ref019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"16","author":"J-U Voigt","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"2","key":"pone.0360414.ref020","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/bioinformatics\/btr645","article-title":"MSnbase-an R\/Bioconductor package for isobaric tagged mass spectrometry data visualization, processing and quantitation","volume":"28","author":"L Gatto","year":"2012","journal-title":"Bioinformatics"},{"issue":"1","key":"pone.0360414.ref021","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.jproteome.0c00313","article-title":"MSnbase, efficient and elegant r-based processing and visualization of raw mass spectrometry data","volume":"20","author":"L Gatto","year":"2021","journal-title":"J Proteome Res"},{"issue":"11","key":"pone.0360414.ref022","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"S Xu","year":"2024","journal-title":"Nat Protoc"},{"key":"pone.0360414.ref023","author":"G Cs\u00e1rdi","year":"2025"},{"key":"pone.0360414.ref024","volume-title":"ggraph: An implementation of grammar of graphics for graphs and networks","author":"T Pedersen","year":"2024"},{"key":"pone.0360414.ref025","doi-asserted-by":"crossref","first-page":"619583","DOI":"10.3389\/fbioe.2020.619583","article-title":"Bringing MicroRNAs to Light: Methods for MicroRNA Quantification and Visualization in Live Cells","volume":"8","author":"T Siddika","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"issue":"3","key":"pone.0360414.ref026","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3390\/ijms27031488","article-title":"Dynamic microRNA Signatures as Biomarkers for Cardiac Ischemia and Remodeling","volume":"27","author":"M Rodr\u00edguez-Serrano","year":"2026","journal-title":"Int J Mol Sci"},{"issue":"4","key":"pone.0360414.ref027","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/stem.1026","article-title":"Role of microRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells","volume":"30","author":"NM Kane","year":"2012","journal-title":"Stem Cells"},{"issue":"13","key":"pone.0360414.ref028","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1111\/jcmm.15251","article-title":"Analysis of extracellular vesicle miRNA profiles in heart failure","volume":"24","author":"JG Oh","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"2","key":"pone.0360414.ref029","article-title":"Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury","volume":"311","author":"KM Park","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"pone.0360414.ref030","first-page":"57","article-title":"MiR-199a-3p promotes repair of myocardial infarction by targeting NACC2","volume":"16","author":"X-Z Wang","year":"2023","journal-title":"Int J Clin Exp Pathol"},{"issue":"7429","key":"pone.0360414.ref031","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11739","article-title":"Functional screening identifies miRNAs inducing cardiac regeneration","volume":"492","author":"A Eulalio","year":"2012","journal-title":"Nature"},{"issue":"8","key":"pone.0360414.ref032","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.116.309589","article-title":"Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction","volume":"120","author":"P Lesizza","year":"2017","journal-title":"Circ Res"},{"issue":"6","key":"pone.0360414.ref033","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31083\/ph.2020.0383","article-title":"MicroRNA-342-5p protects against myocardial ischemia-reperfusion injury by targeting the GPRC5A pathway","volume":"75","author":"W Chen","year":"2020","journal-title":"Pharmazie"},{"issue":"4","key":"pone.0360414.ref034","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1089\/humc.2019.087","article-title":"MiR-625-5p inhibits cardiac hypertrophy through targeting STAT3 and CaMKII","volume":"30","author":"K Cai","year":"2019","journal-title":"Hum Gene Ther Clin Dev"},{"key":"pone.0360414.ref035","doi-asserted-by":"crossref","first-page":"36904","DOI":"10.1038\/srep36904","article-title":"Integrated microRNA and messenger RNA analysis in aortic stenosis","volume":"6","author":"S Coffey","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0360414.ref036","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12967-017-1255-z","article-title":"Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure","volume":"15","author":"M Abu-Halima","year":"2017","journal-title":"J Transl Med"},{"issue":"1","key":"pone.0360414.ref037","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","article-title":"Inhibition of miR-15 protects against cardiac ischemic injury","volume":"110","author":"TG Hullinger","year":"2012","journal-title":"Circ Res"},{"issue":"6","key":"pone.0360414.ref038","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/cdd.2014.200","article-title":"miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury","volume":"22","author":"K Wang","year":"2015","journal-title":"Cell Death Differ"},{"issue":"5","key":"pone.0360414.ref039","article-title":"Dysregulated miR-361-5p\/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease","volume":"9","author":"H-W Wang","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pone.0360414.ref040","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12872-021-01891-0","article-title":"Dysregulation of serum miR-361-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients","volume":"21","author":"W Zhang","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"issue":"3","key":"pone.0360414.ref041","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1084\/jem.20101547","article-title":"miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes","volume":"208","author":"L Qian","year":"2011","journal-title":"J Exp Med"},{"key":"pone.0360414.ref042","doi-asserted-by":"crossref","first-page":"7042105","DOI":"10.1155\/2018\/7042105","article-title":"MicroRNA miR-24-3p reduces apoptosis and regulates Keap1-Nrf2 pathway in mouse cardiomyocytes responding to ischemia\/reperfusion injury","volume":"2018","author":"X Xiao","year":"2018","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"pone.0360414.ref043","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"GL Semenza","year":"2012","journal-title":"Cell"},{"issue":"9","key":"pone.0360414.ref044","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1111\/j.1582-4934.2012.01523.x","article-title":"MicroRNA-24 regulates cardiac fibrosis after myocardial infarction","volume":"16","author":"J Wang","year":"2012","journal-title":"J Cell Mol Med"},{"issue":"6","key":"pone.0360414.ref045","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.111.039008","article-title":"MicroRNA-24 regulates vascularity after myocardial infarction","volume":"124","author":"J Fiedler","year":"2011","journal-title":"Circulation"},{"issue":"7","key":"pone.0360414.ref046","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/mt.2013.89","article-title":"Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction","volume":"21","author":"M Meloni","year":"2013","journal-title":"Mol Ther"},{"issue":"3","key":"pone.0360414.ref047","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00617.2018","article-title":"HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility","volume":"316","author":"AL Williams","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"35","key":"pone.0360414.ref048","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"E van Rooij","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pone.0360414.ref049","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/CIRCGENETICS.111.959841","article-title":"Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction","volume":"4","author":"MR Zile","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"issue":"3","key":"pone.0360414.ref050","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/cvr\/cvq053","article-title":"Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury","volume":"87","author":"Y Ye","year":"2010","journal-title":"Cardiovasc Res"},{"key":"pone.0360414.ref051","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yjmcc.2024.05.010","article-title":"MiR-127-3p enhances macrophagic proliferation via disturbing fatty acid profiles and oxidative phosphorylation in atherosclerosis","volume":"193","author":"Y Liu","year":"2024","journal-title":"J Mol Cell Cardiol"},{"key":"pone.0360414.ref052","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehy563.P4751","article-title":"Suppression of miR-127-3p prevents cardiac fibrosis","volume":"39","author":"Q Zhou","year":"2018","journal-title":"Eur Heart J"},{"issue":"6","key":"pone.0360414.ref053","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1536\/ihj.23-379","article-title":"MicroRNA-127-3p inhibits cardiomyocyte inflammation and apoptosis after acute myocardial infarction via targeting CDKN3","volume":"64","author":"S Zhu","year":"2023","journal-title":"Int Heart J"},{"issue":"9","key":"pone.0360414.ref054","first-page":"1081","article-title":"miR-146a targets Fos expression in human cardiac cells","volume":"8","author":"X Palomer","year":"2015","journal-title":"Dis Model Mech"},{"issue":"3","key":"pone.0360414.ref055","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/cvr\/cvac104","article-title":"Impaired regulation of MMP2\/16-MLCK3 by miR-146a-5p increased susceptibility to myocardial ischaemic injury in aging mice","volume":"119","author":"M Dong","year":"2023","journal-title":"Cardiovasc Res"},{"key":"pone.0360414.ref056","doi-asserted-by":"crossref","first-page":"2923441","DOI":"10.1155\/2021\/2923441","article-title":"MicroRNA-146a Serves as a Biomarker for Adverse Prognosis of ST-Segment Elevation Myocardial Infarction","volume":"2021","author":"S Xiao","year":"2021","journal-title":"Cardiovasc Ther"},{"issue":"8","key":"pone.0360414.ref057","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3390\/diagnostics12081946","article-title":"miR-146a-5p, miR-223-3p and miR-142-3p as Potential Predictors of Major Adverse Cardiac Events in Young Patients with Acute ST Elevation Myocardial Infarction-Added Value over Left Ventricular Myocardial Work Indices","volume":"12","author":"AI Sc\u0103rl\u0103tescu","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"4","key":"pone.0360414.ref058","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1096\/fj.14-267054","article-title":"The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1\u03b1 expression in human endothelial cells through a negative feedback loop","volume":"29","author":"S Bartoszewska","year":"2015","journal-title":"FASEB J"},{"key":"pone.0360414.ref059","doi-asserted-by":"crossref","first-page":"22775","DOI":"10.1038\/srep22775","article-title":"miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells","volume":"6","author":"A Janaszak-Jasiecka","year":"2016","journal-title":"Sci Rep"},{"issue":"11","key":"pone.0360414.ref060","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.3390\/cancers15112903","article-title":"HIF-1-Induced hsa-miR-429: Understanding Its Direct Targets as the Key to Developing Cancer Diagnostics and Therapies","volume":"15","author":"S Bartoszewska","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"10","key":"pone.0360414.ref061","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41401-024-01296-7","article-title":"CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p\/SULF1\/Wnt\/\u03b2-catenin signaling pathway","volume":"45","author":"D-N Ji","year":"2024","journal-title":"Acta Pharmacol Sin"},{"issue":"6","key":"pone.0360414.ref062","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3892\/ijmm.2016.2558","article-title":"Downregulation of microRNA-429 protects cardiomyocytes against hypoxia-induced apoptosis by increasing Notch1 expression","volume":"37","author":"H Xu","year":"2016","journal-title":"Int J Mol Med"},{"issue":"4","key":"pone.0360414.ref063","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/ejhf.332","article-title":"Signature of circulating microRNAs in patients with acute heart failure","volume":"18","author":"ES Ovchinnikova","year":"2016","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"pone.0360414.ref064","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12872-021-02211-2","article-title":"Identification of key miRNAs and mRNAs related to coronary artery disease by meta-analysis","volume":"21","author":"L Liu","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"issue":"6","key":"pone.0360414.ref065","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2459\/JCM.0000000000000233","article-title":"The prognostic value of circulating microRNAs in heart failure: Preliminary results from a genome-wide expression study","volume":"16","author":"HA Cakmak","year":"2015","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"1","key":"pone.0360414.ref066","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.atherosclerosis.2009.10.032","article-title":"Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways","volume":"210","author":"H Jiang","year":"2010","journal-title":"Atherosclerosis"},{"issue":"1","key":"pone.0360414.ref067","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11010-021-04260-9","article-title":"Modulation of endothelium function by fatty acids","volume":"477","author":"R Mallick","year":"2022","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"pone.0360414.ref068","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"I Papandreou","year":"2006","journal-title":"Cell Metab"},{"issue":"1","key":"pone.0360414.ref069","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"SJ Kierans","year":"2021","journal-title":"J Physiol"},{"issue":"1","key":"pone.0360414.ref070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12192-017-0827-4","volume":"23","author":"H Zhu","year":"2018","journal-title":"Cell Stress Chaperones"},{"issue":"3","key":"pone.0360414.ref071","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/CIRCRESAHA.117.310183","article-title":"PI3K and calcium signaling in cardiovascular disease","volume":"121","author":"A Ghigo","year":"2017","journal-title":"Circ Res"},{"key":"pone.0360414.ref072","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-physiol-021909-135931","article-title":"The FoxO family in cardiac function and dysfunction","volume":"72","author":"SM Ronnebaum","year":"2010","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"pone.0360414.ref073","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1038\/s41467-024-52739-y","article-title":"Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation","volume":"15","author":"S Li","year":"2024","journal-title":"Nat Commun"},{"key":"pone.0360414.ref074","doi-asserted-by":"crossref","first-page":"5278218","DOI":"10.1155\/2017\/5278218","article-title":"Kaempferide Protects against Myocardial Ischemia\/Reperfusion Injury through Activation of the PI3K\/Akt\/GSK-3\u03b2 Pathway","volume":"2017","author":"D Wang","year":"2017","journal-title":"Mediators Inflamm"},{"issue":"1","key":"pone.0360414.ref075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Q Zhang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"pone.0360414.ref076","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3390\/ijms25031469","article-title":"Trials and Tribulations of MicroRNA Therapeutics","volume":"25","author":"AA Seyhan","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"3","key":"pone.0360414.ref077","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/ejhf.3139","article-title":"Efficacy and safety of CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: Rationale and design of the HF-REVERT trial","volume":"26","author":"J Bauersachs","year":"2024","journal-title":"Eur J Heart Fail"},{"issue":"19","key":"pone.0360414.ref078","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2174\/1389557523666230328125031","article-title":"The Role of MiR-29 in the Mechanism of Fibrosis","volume":"23","author":"M Wang","year":"2023","journal-title":"Mini Rev Med Chem"},{"issue":"5","key":"pone.0360414.ref079","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jid.2018.11.007","article-title":"A microRNA-29 mimic (Remlarsen) represses extracellular matrix expression and fibroplasia in the skin","volume":"139","author":"CL Gallant-Behm","year":"2019","journal-title":"J Invest Dermatol"},{"issue":"16","key":"pone.0360414.ref080","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMoa1912387","article-title":"Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol","volume":"382","author":"KK Ray","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"pone.0360414.ref081","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"D Adams","year":"2018","journal-title":"N Engl J Med"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0360414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:59Z","timestamp":1792085219000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0360414"}},"subtitle":[],"editor":[{"given":"Reza","family":"Eshraghi","sequence":"first","affiliation":[{"name":"Isfahan University of Medical Sciences","place":["IRAN, ISLAMIC REPUBLIC OF"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":81,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0360414","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]}}}