{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:51:09Z","timestamp":1791827469358,"version":"4.3.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Program Management Unit for Human Resources & Institutional Development, Research and Innovation","award":["B17F640005"],"award-info":[{"award-number":["B17F640005"]}]},{"DOI":"10.13039\/501100007180","name":"Faculty of Science, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    SARS-CoV-2 infection is linked to hematologic abnormalities, but whether early hematopoietic compartments and their stromal niche are directly engaged remains unclear. We used in vitro exposure models to compare variant-associated responses of adult mesenchymal stromal cells (MSCs) and umbilical cord blood (UCB) CD34\u2009\u207a\u2009hematopoietic stem and progenitor cells (HSPCs). Adipose\u2013derived (AD) and bone marrow\u2013derived (BM) MSCs exposed to wild-type, Delta, or Omicron showed source- and variant-dependent nucleocapsid protein (NP) positivity, highest with Omicron in AD-MSCs; infectious virus in supernatants was undetectable. AD-MSCs expressed higher neuropilin-1 (NRP1) than BM-MSCs, and NRP1 knockdown reduced Omicron-associated NP signal, implicating an NRP1-linked entry process. SARS-CoV-2 exposure induced indoleamine-2,3-dioxygenase 1 (\n                    <jats:italic>IDO1<\/jats:italic>\n                    ), most prominently in AD-MSCs. In UCB CD34\u2009\u207a\u2009HSPCs, Omicron increased NP positivity enriched in long-term HSCs, reduced primitive fraction frequencies, increased colony formation, and promoted early erythroid progenitor accumulation; heat-inactivated virus did not. NanoString profiling revealed host-response activation and altered cell-cycle\/differentiation programs. These data indicate Omicron can engage stromal and early hematopoietic compartments and remodel stress-responsive hematopoiesis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0360439","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:27:41Z","timestamp":1791826061000},"page":"e0360439","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Omicron SARS-CoV-2 shows NRP1-linked susceptibility in adipose-derived MSCs and alters primitive cord blood CD34\u207a HSPCs"],"prefix":"10.1371","volume":"21","author":[{"given":"Kanit","family":"Bhukhai","sequence":"first","affiliation":[{"name":"Mahidol University","place":["Bangkok, Thailand"],"department":["Department of Physiology, Faculty of Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopmullee","family":"Tanhuad","sequence":"additional","affiliation":[{"name":"Mahidol 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