{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:54:57Z","timestamp":1792000497989,"version":"4.4.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009752","name":"Futurum - Akademin f\u00f6r H\u00e4lsa och V\u00e5rd, Region J\u00f6nk\u00f6pings l\u00e4ns","doi-asserted-by":"publisher","award":["963747"],"award-info":[{"award-number":["963747"]}],"id":[{"id":"10.13039\/501100009752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n Postoperative recovery after subcutaneous venous port implantation is generally considered uncomplicated; however, patient-reported recovery outcomes in patients with cancer remain poorly characterized. The impact of patient-controlled sedation (PCS) on postoperative recovery has not been established.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess early postoperative recovery using the Quality of Recovery-15 (QoR-15) questionnaire in a prespecified substudy of the PACSPI-2 randomised clinical trial and to compare recovery between patients receiving local anaesthesia alone and those receiving local anaesthesia combined with patient-controlled sedation.<\/jats:p>\n <\/jats:sec>\n \n Design and setting<\/jats:title>\n Prespecified substudy of a randomised, open-label clinical trial conducted at two Swedish anaesthesia departments.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n Three hundred thirty-four adult patients with cancer.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Local anaesthesia (LA) alone or LA combined with propofol-alfentanil PCS during SVP implantation.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Primary outcome was difference of postoperative total QoR-15 scores between groups. The primary endpoint of the parent PACSPI-2 trial was maximal intraprocedural pain.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There was no overall difference in total postoperative QoR-15 scores between the treatment groups (P\u2009=\u20090.61). Total QoR-15 scores changed significantly over time (P\u2009<\u20090.001) in both groups. By postoperative day 1 (POD 1), mean QoR-15 scores had increased from baseline in both groups (mean difference 2.9 and 3.1, respectively; P\u2009=\u20090.02 for both), although these changes were below the published minimal clinically important difference (MCID) of 6. Before discharge, the LA\u2009+\u2009PCS group showed its largest within-group improvement in QoR-15 (mean difference 5.6, P\u2009<\u20090.001), primarily driven by the \u201cEmotional state\u201d and \u201cPsychological support\u201d dimensions, however no significant between group differences were observed. Median pain scores on POD 1 were 3 (IQR 2\u20135) in both groups, with NRS\u2009\u2265\u20094 reported by 49% in the LA and 48% in the LA\u2009+\u2009PCS group.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Early postoperative recovery after subcutaneous venous port implantation was generally good and did not differ between the LA and LA\u2009+\u2009PCS group. A transient within-group improvement in emotional and psychological recovery domains was observed before discharge in the LA\u2009+\u2009PCS group. Pain on POD 1 remained common in both groups. These findings were based on secondary analyses and should therefore be considered exploratory.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n European Union Clinical Trials Registry: EudraCT: 2021-003821-31, ClinicalTrials.gov:\n NCT05688384<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0360479","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:28:55Z","timestamp":1791998935000},"page":"e0360479","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of recovery (QoR-15) after patient-controlled sedation during venous port implantation: A prespecified substudy of the PACSPI-2 randomised clinical trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-4004","authenticated-orcid":true,"given":"Stefanie","family":"Seifert","sequence":"first","affiliation":[{"name":"Ryhov County Hospital","place":["J\u00f6nk\u00f6ping, Sweden"],"department":["Department of Anaesthesia and Intensive Care Medicine"]},{"name":"Link\u00f6ping University","place":["Link\u00f6ping, Sweden"],"department":["Department of Biomedical and Clinical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University Hospital","place":["Link\u00f6ping, Sweden"],"department":["Department of Anaesthesia and Intensive Care"]},{"name":"Link\u00f6ping University","place":["Link\u00f6ping, Sweden"],"department":["Department of Medical and Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josip","family":"Azman","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University Hospital","place":["Link\u00f6ping, Sweden"],"department":["Department of Anaesthesia and Intensive Care"]},{"name":"Link\u00f6ping University Hospital","place":["Link\u00f6ping, Sweden"],"department":["Pain and Rehabilitation Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Futurum, Academy of Health and Care","place":["J\u00f6nk\u00f6ping, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Chew","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University","place":["Link\u00f6ping, Sweden"],"department":["Department of Biomedical and Clinical Sciences"]},{"name":"Karolinska University Hospital","place":["Stockholm, Sweden"],"department":["Department of Perioperative Medicine and Intensive Care"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Hammarskj\u00f6ld","sequence":"additional","affiliation":[{"name":"Ryhov County Hospital","place":["J\u00f6nk\u00f6ping, Sweden"],"department":["Department of Anaesthesia and Intensive Care Medicine"]},{"name":"Link\u00f6ping University","place":["Link\u00f6ping, Sweden"],"department":["Department of Biomedical and Clinical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Taxbro","sequence":"additional","affiliation":[{"name":"Ryhov County Hospital","place":["J\u00f6nk\u00f6ping, Sweden"],"department":["Department of Anaesthesia and Intensive Care Medicine"]},{"name":"Link\u00f6ping University","place":["Link\u00f6ping, Sweden"],"department":["Department of Biomedical and Clinical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"pone.0360479.ref001","unstructured":"World Health Organization. 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