{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:48:37Z","timestamp":1792086517464,"version":"4.4.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human cytomegalovirus (HCMV) infection causes life-threatening complications in transplant recipients. Despite a seroprevalence exceeding 90% in Peru, the influence of HLA diversity on HCMV immune recognition remains unexplored in the South American region. We aimed to characterize the HLA allele distribution in a Peruvian cohort and evaluate its impact on the predicted HCMV antigen-presentation landscape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HLA genotyping (loci A, B, C, DRB1, DQA1, DQB1) was performed in 562 kidney transplant candidates and related donors. Common allele groups (AF5%) were assigned 4-digit resolution proxies based on local prevalence. Linear T-cell epitopes from the immunodominant antigens 65 kDa phosphoprotein (pp65), Immediate early protein 1 (IE1), and Envelope glycoprotein B (gB) were predicted using high-performance algorithms. Allelic capacity to strongly bind antigenic peptides was quantified using the Predicted Strong Binder Density (PSBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 16 HLA-I and 10 HLA-II common allele groups; 92% of their 4-digit proxies are widely distributed in SAM, while C*15:12 emerged as a potentially endemic variant in Peru. Screening yielded 954 HLA-I candidate epitopes, including 169 that correspond to previously reported IEDB epitopes with potential for immunotherapy. PSBD analysis revealed distinct predicted antigen-presentation profiles across the common HLA variants identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings provide updated Peruvian HLA data and define regional HCMV antigen-presentation profiles based on predicted MHC-peptide binding affinity (PSBD). Further experimental validation of these high-confidence candidate epitopes and HLA-HCMV association studies will be necessary to determine their immunogenicity and potential utility for immune monitoring and future immunotherapeutic applications across South American populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0360632","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:27:24Z","timestamp":1792085244000},"page":"e0360632","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["HLA-driven variability in human cytomegalovirus immune recognition: Epitope predictions from a kidney transplant Cohort"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9599-6834","authenticated-orcid":true,"given":"Mirella Dara","family":"Moreno Rosado","sequence":"first","affiliation":[{"name":"Universidad Nacional Mayor de San Marcos, Av. Carlos Germ\u00e1n Amezaga","place":["Lima, Peru"],"department":["Facultad de Ciencias Biol\u00f3gicas"]},{"name":"Organization for Medical Innovation and Collaboration for Sciences (OMICS)","place":["Lima, Peru"],"department":["Pathogen Genetics Research Group (PATHO-GEN)"]},{"name":"Organization for Medical Innovation and Collaboration for Sciences (OMICS)","place":["Lima, Peru"],"department":["Immunology and Cancer Research Group (IMMUCA)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Chavez-Arias","sequence":"additional","affiliation":[{"name":"Universidad Cat\u00f3lica de Santa Mar\u00eda","place":["Arequipa, Peru"],"department":["Facultad de Medicina Humana"]},{"name":"\u00c1rea de Histocompatibilidad y Biolog\u00eda Molecular, Hospital Nacional Carlos Alberto Seguin Escobedo","place":["Arequipa, Peru"],"department":["Red Asistencial Arequipa, Seguro Social de Salud 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