{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:47:38Z","timestamp":1792086458785,"version":"4.4.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anesthetic technique may influence postoperative quality of recovery (QoR). Remimazolam may offer hemodynamic stability and favorable early recovery characteristics, but its effect on patient-reported QoR compared with propofol remains unclear. This is particularly relevant in minor orthopedic surgery, where QoR is a principal outcome. This randomized controlled trial compared postoperative QoR between propofol-based and remimazolam-based total intravenous anesthesia (TIVA) using the QoR-40 questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Eighty adult patients undergoing elective arthroscopic meniscectomy were randomly assigned to propofol-based or remimazolam-based TIVA; 71 patients completed the QoR-40 questionnaire and were included in the final analysis (36 in the Propofol group, 35 in the Remimazolam group). The primary outcome was the global QoR-40 score on postoperative day (POD) 1. Secondary outcomes included intraoperative hemodynamic variables, anesthetic and analgesic requirements, postoperative recovery profiles, pain scores, and postoperative nausea and vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Global QoR-40 scores on POD 1 did not differ significantly between the Propofol and Remimazolam groups (166.1\u2009\u00b1\u200916.8 vs. 170.6\u2009\u00b1\u200913.6; mean difference \u22124.5, 95% CI \u221211.8 to 2.7; P\u2009=\u20090.218). In an exploratory analysis, the emotional-state domain scores were higher in the Remimazolam group (37.0\u2009\u00b1\u20094.3 vs. 39.2\u2009\u00b1\u20092.5; mean difference \u22122.2, 95% CI \u22123.9 to \u22120.6; P\u2009=\u20090.009). The Remimazolam group had a longer time to full alertness (18 [15\u201324] vs. 37 [31\u201345] min; P\u2009&lt;\u20090.001) and longer post-anesthesia care unit stay (30 [30\u201339] vs. 38 [30\u201350] min; P\u2009=\u20090.008). Intraoperative hypotension requiring ephedrine occurred more frequently in the Propofol group (44.4% vs. 17.1%; P\u2009=\u20090.013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Global QoR-40 scores on POD 1 did not differ significantly between propofol-based and remimazolam-based TIVA in adults undergoing elective arthroscopic meniscectomy, although remimazolam was associated with greater intraoperative hemodynamic stability at the cost of slower return to full alertness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0360759","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:01Z","timestamp":1792085161000},"page":"e0360759","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of recovery after arthroscopic meniscectomy with remimazolam or propofol anesthesia: A randomized controlled trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3445-1905","authenticated-orcid":true,"given":"Eunah","family":"Cho","sequence":"first","affiliation":[{"name":"Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine","place":["Seoul, Republic of Korea"],"department":["Department of Anesthesiology and Pain Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Yan","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Republic of Korea"],"department":["Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"],"department":["Department of Anesthesiology and Pain Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2641-0070","authenticated-orcid":true,"given":"Seokyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"],"department":["Department of Anesthesiology and Pain Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"2","key":"pone.0360759.ref001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/bja\/aet014","article-title":"Measurement of quality of recovery using the QoR-40: a quantitative systematic review","volume":"111","author":"BF Gornall","year":"2013","journal-title":"Br J 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