{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:41:32Z","timestamp":1792777292866,"version":"4.5.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Lens dislocation (ectopia lentis) is a recognized anterior-segment manifestation of fibrillinopathy. This exploratory phenotype-first study compared macular optical coherence tomography angiography (OCTA) parameters between participants with and without documented lens dislocation and descriptively reviewed available archived clinical\n                      <jats:italic>FBN1<\/jats:italic>\n                      reports.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective, availability-based study included 16 participants classified by verified current or historical lens-dislocation status. Participant-level superficial capillary plexus (SCP) vessel density was calculated by averaging valid bilateral measurements or using the single valid eye. Five OCTA endpoints were compared using two-sided Mann\u2013Whitney U tests; Benjamini\u2013Hochberg q values were used as a multiplicity sensitivity analysis. Seven archived clinical\n                      <jats:italic>FBN1<\/jats:italic>\n                      reports from lens-dislocation-positive (LD+) participants were summarized without variant reclassification. No genotype\u2013OCTA association was assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 7 LD+ and 9 lens-dislocation-negative (LD\u2212) participants; 15 participants (6 LD+ and 9 LD\u2212) contributed quantitative OCTA data. Foveal SCP vessel density was lower in LD+ participants (median [IQR], 19.38% [18.68\u201320.04] vs 30.20% [29.20\u201331.85]; p\u2009=\u20090.036), but the finding was not retained after multiplicity sensitivity analysis (q\u2009=\u20090.180). Whole-image, parafoveal, and perifoveal vessel-density comparisons were not significant (p\u2009=\u20090.328, 0.272, and 0.238; q\u2009=\u20090.410 each), and OD-only foveal avascular zone area did not differ (n\u2009=\u200914; p\u2009=\u20090.606; q\u2009=\u20090.606). Six of seven archived reports documented an\n                      <jats:italic>FBN1<\/jats:italic>\n                      variant; one was negative within its assay scope.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The unadjusted foveal signal was not robust to multiplicity analysis, and other OCTA endpoints did not differ significantly. Marked between-group differences in spherical equivalent and axial length, the small sample, and heterogeneous routine-care genetic reports limit interpretation. These findings are hypothesis-generating and do not establish OCTA as a diagnostic or prognostic test or demonstrate an individual-level genotype\u2013OCTA association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0361193","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:32:41Z","timestamp":1792776761000},"page":"e0361193","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lens dislocation, OCTA, and archived FBN1 reports: An exploratory study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-0795","authenticated-orcid":true,"given":"Muhammer \u00d6zg\u00fcr","family":"\u00c7evik","sequence":"first","affiliation":[{"name":"Adiyaman University Faculty of Medicine","place":["Adiyaman, T\u00fcrkiye"],"department":["Department of Medical Genetics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metehan","family":"Simsek","sequence":"additional","affiliation":[{"name":"Beyoglu Eye Training and Research Hospital","place":["Istanbul, T\u00fcrkiye"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadik Gorkem","family":"Cevik","sequence":"additional","affiliation":[{"name":"Beyoglu Eye Training and Research Hospital","place":["Istanbul, T\u00fcrkiye"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Perente","sequence":"additional","affiliation":[{"name":"Beyoglu Eye Training and Research Hospital","place":["Istanbul, T\u00fcrkiye"],"department":["Department of Ophthalmology"]},{"name":"Bursa Y\u00fcksek \u0130htisas Training and Research Hospital","place":["Bursa, T\u00fcrkiye"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"pone.0361193.ref001","doi-asserted-by":"crossref","first-page":"1302285","DOI":"10.3389\/fcell.2023.1302285","article-title":"The extracellular matrix glycoprotein fibrillin-1 in health and disease","volume":"11","author":"L Li","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"pone.0361193.ref002","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3126\/jnhls.v2i1.55802","article-title":"Marfan\u2019s syndrome with rhegmatogenous retinal detachment: a case report and literature review","volume":"2","author":"K Subedi","year":"2023","journal-title":"J Nat Heart Lung Soc Nep"},{"issue":"9","key":"pone.0361193.ref003","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.9.9.5","article-title":"Retinal and Choroidal Vasculature in Patients with Marfan Syndrome","volume":"9","author":"M Di 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