{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:58:19Z","timestamp":1791035899479,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:00:00Z","timestamp":1144368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.0020027","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T20:13:05Z","timestamp":1143835985000},"page":"e27","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":156,"title":["An Antivector Vaccine Protects against a Lethal Vector-Borne Pathogen"],"prefix":"10.1371","volume":"2","author":[{"given":"Milan","family":"Labuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adama R","family":"Trimnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Li\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Kazim\u00edrov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian M","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lissina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie S","family":"Hails","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A","family":"Nuttall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"ppat-0020027-b001","doi-asserted-by":"crossref","first-page":"876","DOI":"10.4269\/ajtmh.1979.28.876","article-title":"Resistance to tickborne Francisella tularensis by tick-sensitized rabbits: Allergic kendusity.","volume":"28","year":"1979","journal-title":"Am J Trop Med Hyg"},{"key":"ppat-0020027-b002","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1751-0813.1964.tb08746.x","article-title":"Resistance of Droughtmaster cattle to tick infestation and babesiosis.","volume":"40","year":"1964","journal-title":"Aust Vet J"},{"key":"ppat-0020027-b003","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1099\/0022-1317-71-5-1039","article-title":"The effect of host resistance to tick infestation on the transmission of Thogoto virus by ticks.","volume":"71","year":"1990","journal-title":"J Gen Virol"},{"key":"ppat-0020027-b004","first-page":"93","article-title":"The protection of vertebrate animals from experimental tick-borne encephalitis with active and passive immunization against tick antigens.","volume":"8","year":"1990","journal-title":"Zh Mikrobiol Epidemiol Immunobiol"},{"key":"ppat-0020027-b005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/IAI.65.1.335-338.1997","article-title":"Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks.","volume":"65","year":"1997","journal-title":"Infect Immun"},{"key":"ppat-0020027-b006","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3201\/eid1101.040303","article-title":"Hypersensitivity to ticks and Lyme disease risk.","volume":"11","author":"Burke GS, Wikel SK, Spielman A, Telford SR, McKay K, Krause PJ, and the Tick-Borne Infection Study group","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ppat-0020027-b007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF02236193","article-title":"Transmission of Theileria parva bovis (Boleni strain) to cattle resistant to the brown ear tick Rhipicephalus appendiculatus (Neumann).","volume":"21","year":"1989","journal-title":"Trop Anim Health Prod"},{"key":"ppat-0020027-b008","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.290.5495.1351","article-title":"Protection against cutaneous Leishmaniasis resulting from bites of uninfected sand flies.","volume":"290","year":"2000","journal-title":"Science"},{"key":"ppat-0020027-b009","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1086\/344733","article-title":"Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity.","volume":"186","year":"2002","journal-title":"J Infect Dis"},{"key":"ppat-0020027-b010","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1073\/pnas.091447398","article-title":"Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship.","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0020027-b011","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cell.2004.10.009","article-title":"A role for insect galectins in parasite survival.","volume":"119","year":"2004","journal-title":"Cell"},{"key":"ppat-0020027-b012","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jmedent\/35.3.261","article-title":"Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice.","volume":"35","year":"1998","journal-title":"J Med Entomol"},{"key":"ppat-0020027-b013","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1126\/science.3616608","article-title":"A novel mode of arbovirus transmission involving a nonviraemic host.","volume":"237","year":"1987","journal-title":"Science"},{"key":"ppat-0020027-b014","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1126\/science.287.5452.485","article-title":"Transmission of vesicular stomatitis virus from infected to noninfected black flies co-feeding on nonviremic deer mice.","volume":"287","year":"2000","journal-title":"Science"},{"key":"ppat-0020027-b015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.173.1.49","article-title":"A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva.","volume":"173","year":"1991","journal-title":"J Exp Med"},{"key":"ppat-0020027-b016","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2567.2004.01975.x","article-title":"Characterization of the B-cell inhibitory protein factor in Ixodes ricinus tick saliva: A potential role in enhanced Borrelia burgdorferi transmission.","volume":"113","year":"2004","journal-title":"Immunology"},{"key":"ppat-0020027-b017","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host.","volume":"436","year":"2005","journal-title":"Nature"},{"key":"ppat-0020027-b018","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-Leishmania vaccine targeting vector antigens: Characterisation of a protective salivary protein.","volume":"194","year":"2001","journal-title":"J Exp Med"},{"key":"ppat-0020027-b019","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1016\/S0264-410X(02)00334-1","article-title":"Dual action ectoparasite vaccine targeting \u2018exposed' and \u2018concealed' antigens.","volume":"20","year":"2002","journal-title":"Vaccine"},{"key":"ppat-0020027-b020","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1016\/j.vaccine.2005.03.041","article-title":"A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine.","volume":"23","year":"2005","journal-title":"Vaccine"},{"key":"ppat-0020027-b021","first-page":"809","article-title":"Efficacy of vaccination against tick-borne encephalitis.","volume":"92","year":"1980","journal-title":"Wien Klin Wochenshr"},{"key":"ppat-0020027-b022","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/viro.1996.0261","article-title":"Importance of localized skin infection in tick-borne encephalitis virus transmission.","volume":"219","year":"1996","journal-title":"Virology"},{"key":"ppat-0020027-b023","doi-asserted-by":"crossref","first-page":"780","DOI":"10.4269\/ajtmh.1998.58.780","article-title":"Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.","volume":"58","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ppat-0020027-b024","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.2105\/AJPH.83.12.1746","article-title":"Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers.","volume":"83","year":"1993","journal-title":"Am J Pub Hlth"},{"key":"ppat-0020027-b025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1081-1206(10)63082-7","article-title":"Unusual manifestations of hypersensitivity after a tick bite: Report of two cases.","volume":"79","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ppat-0020027-b026","first-page":"596","article-title":"Infiltration of CD4+ CD8+ T cells, and expression of ICAM-1, Ia antigens, IL-1 alpha and TNF-alpha in the skin lesion of BALB\/c mice undergoing repeated infestations with nymphal Ixodes ricinus ticks.","volume":"82","year":"1994","journal-title":"Immunology"},{"key":"ppat-0020027-b027","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/viro.1997.8622","article-title":"Tick-borne encephalitis virus transmission between ticks cofeeding on specific immune natural rodent hosts.","volume":"235","year":"1997","journal-title":"Virology"},{"key":"ppat-0020027-b028","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2567.2004.02079.x","article-title":"Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells.","volume":"114","year":"2005","journal-title":"Immunology"},{"key":"ppat-0020027-b029","doi-asserted-by":"crossref","first-page":"S367","DOI":"10.1017\/S0031182003004657","article-title":"Anti-tick vaccines.","volume":"129","year":"2004","journal-title":"Parasitology"},{"key":"ppat-0020027-b030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0001-706X(00)00063-2","article-title":"Immunogenic influences on tick resistance in African cattle with particular reference to trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Gobra zebu (Bos indicus) cattle.","volume":"75","year":"2000","journal-title":"Acta Trop"},{"key":"ppat-0020027-b031","first-page":"311","article-title":"Acquired resistance to ticks. I. Passive transfer of resistance.","volume":"30","year":"1976","journal-title":"Immunology"},{"key":"ppat-0020027-b032","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0304-4017(01)00560-X","article-title":"The molecular revolution in the development of vaccines against ectoparasites.","volume":"101","year":"2001","journal-title":"Vet Parasit"},{"key":"ppat-0020027-b033","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1128\/JVI.72.4.3076-3081.1998","article-title":"Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein.","volume":"72","year":"1998","journal-title":"J Virol"},{"key":"ppat-0020027-b034","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1084\/jem.20030091","article-title":"Activation of virus-specific memory B cells in the absence of T cell help.","volume":"199","year":"2004","journal-title":"J Exp Med"},{"key":"ppat-0020027-b035","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1099\/0022-1317-79-4-689","article-title":"Immunological basis for protection in a murine model of tick-borne encephalitis by a recombinant adenovirus carrying the gene encoding the NS1 non-structural protein.","volume":"79","year":"1998","journal-title":"J Gen Virol"},{"key":"ppat-0020027-b036","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2915.1993.tb00674.x","article-title":"Enhancement of tick-borne encephalitis virus transmission by tick salivary gland extracts.","volume":"7","year":"1993","journal-title":"Med Vet Entomol"},{"key":"ppat-0020027-b037","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1017\/S0031182004005633","article-title":"Tick\u2013host interactions: Saliva-activated transmission.","volume":"129","year":"2004","journal-title":"Parasitology"},{"key":"ppat-0020027-b038","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.3344436","article-title":"Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity.","volume":"239","year":"1988","journal-title":"Science"},{"key":"ppat-0020027-b039","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4269\/ajtmh.1996.54.338","article-title":"La Crosse viremias in white-tailed deer and chipmunks exposed by injection or mosquito bite.","volume":"54","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ppat-0020027-b040","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/S0031182099005909","article-title":"Transmission of Orientia tsutsugamushi, the aetiological agent for scrub typhus, to co-feeding mites.","volume":"120","year":"2000","journal-title":"Parasitology"},{"key":"ppat-0020027-b041","doi-asserted-by":"crossref","first-page":"8871","DOI":"10.1073\/pnas.0503835102","article-title":"Nonviremic transmission of West Nile virus.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0020027-b042","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1590\/S0074-02762004000700008","article-title":"Effect of the Aedes fluviatilis saliva on the development of Plasmodium gallinaceum infection in Gallus (gallus) domesticus..","volume":"99","year":"2004","journal-title":"Mem. Inst Oswaldo Cruz"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0020027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T06:05:18Z","timestamp":1736316318000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0020027"}},"subtitle":[],"editor":[{"given":"Marianne","family":"Manchester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2006,4,7]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.0020027","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,7]]}}}