{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:41:22Z","timestamp":1773279682135,"version":"3.50.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T00:00:00Z","timestamp":1151020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.0020058","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T18:30:17Z","timestamp":1150741817000},"page":"e58","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Antibody-Independent Control of \u03b3-Herpesvirus Latency via B Cell Induction of Anti-Viral T Cell Responses"],"prefix":"10.1371","volume":"2","author":[{"given":"Kelly B","family":"McClellan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivaprakash","family":"Gangappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel H","family":"Speck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert W.","family":"Virgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2006,6,23]]},"reference":[{"key":"ppat-0020058-b001","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1172\/JCI200417803","article-title":"Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.","volume":"113","year":"2004","journal-title":"J Clin Invest"},{"key":"ppat-0020058-b002","first-page":"818","article-title":"Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68.","volume":"145","year":"1994","journal-title":"Am J Pathol"},{"key":"ppat-0020058-b003","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/scbi.1998.0118","article-title":"The role of Kaposi's sarcoma-associated herpesvirus (KSHV\/HHV-8) in lymphoproliferative diseases.","volume":"9","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"ppat-0020058-b004","unstructured":"RickinsonABKieffE 2001 Epstein-Barr Virus. In: KnipeDMHowleyP Fields virology Philadelphia Lippincott Williams & Wilkins pp. 2575 2627"},{"key":"ppat-0020058-b005","unstructured":"MoorePSChangY 2001 Kaposi's Sarcoma-associated herpesvirus. In: KnipeDMHowleyP Fields virology Philadelphia Lippincott Williams & Wilkins pp. 2803 2833"},{"key":"ppat-0020058-b006","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1172\/JCI11540","article-title":"IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site.","volume":"107","year":"2001","journal-title":"J Clin Invest"},{"key":"ppat-0020058-b007","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/nm1297-1346","article-title":"Murine gammaherpesvirus 68 causes severe large vessel arteritis in mice lacking interferon-gamma responsiveness: A new model for virus induced vascular disease.","volume":"3","year":"1997","journal-title":"Nat Med"},{"key":"ppat-0020058-b008","doi-asserted-by":"crossref","first-page":"7696","DOI":"10.1128\/JVI.77.13.7696-7701.2003","article-title":"Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection.","volume":"77","year":"2003","journal-title":"J Virol"},{"key":"ppat-0020058-b009","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1074-7613(00)80493-8","article-title":"Is EBV persistence in vivo a model for B cell homeostasis?","volume":"5","year":"1996","journal-title":"Immunity"},{"key":"ppat-0020058-b010","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.1128\/JVI.76.14.7125-7132.2002","article-title":"Immune control of the number and reactivation phenotype of cells latently infected with a gamma-herpesvirus.","volume":"76","year":"2002","journal-title":"J Virol"},{"key":"ppat-0020058-b011","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1128\/JVI.73.6.4651-4661.1999","article-title":"B cells regulate murine gammaherpesvirus 68 latency.","volume":"73","year":"1999","journal-title":"J Virol"},{"key":"ppat-0020058-b012","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1084\/jem.20011825","article-title":"Identification of the in vivo role of a viral bcl-2.","volume":"195","year":"2002","journal-title":"J Exp Med"},{"key":"ppat-0020058-b013","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1128\/JVI.74.16.7451-7461.2000","article-title":"The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.","volume":"74","year":"2000","journal-title":"J Virol"},{"key":"ppat-0020058-b014","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1128\/JVI.77.9.5118-5126.2003","article-title":"Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes.","volume":"77","year":"2003","journal-title":"J Virol"},{"key":"ppat-0020058-b015","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1128\/JVI.73.4.3273-3283.1999","article-title":"Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells.","volume":"73","year":"1999","journal-title":"J Virol"},{"key":"ppat-0020058-b016","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1099\/0022-1317-73-12-3275","article-title":"Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo.","volume":"73","year":"1992","journal-title":"J Gen Virol"},{"key":"ppat-0020058-b017","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.4049\/jimmunol.170.7.3828","article-title":"Differential gamma-herpesvirus distribution in distinct anatomical locations and cell subsets during persistent infection in mice.","volume":"170","year":"2003","journal-title":"J Immunol"},{"key":"ppat-0020058-b018","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1128\/JVI.77.15.8310-8321.2003","article-title":"Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo.","volume":"77","year":"2003","journal-title":"J Virol"},{"key":"ppat-0020058-b019","doi-asserted-by":"crossref","first-page":"14668","DOI":"10.1128\/JVI.79.23.14668-14679.2005","article-title":"Murine gammaherpesvirus 68 infection induces lymphoproliferative disease and lymphoma in BALB \u03b22 microglobulin deficient mice.","volume":"79","year":"2005","journal-title":"J Virol"},{"key":"ppat-0020058-b020","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.102.7.779","article-title":"Herpesvirus infection accelerates atherosclerosis in the apolipoprotein E-deficient mouse.","volume":"102","year":"2000","journal-title":"Circulation"},{"key":"ppat-0020058-b021","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1128\/JVI.78.13.6836-6845.2004","article-title":"Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gamma-herpesvirus latency.","volume":"78","year":"2004","journal-title":"J Virol"},{"key":"ppat-0020058-b022","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1084\/jem.192.7.943","article-title":"Control of gammaherpesvirus latency by latent antigen-specific CD8(+) T cells.","volume":"192","year":"2000","journal-title":"J Exp Med"},{"key":"ppat-0020058-b023","doi-asserted-by":"crossref","first-page":"14149","DOI":"10.1128\/JVI.79.22.14149-14160.2005","article-title":"Alpha\/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency.","volume":"79","year":"2005","journal-title":"J Virol"},{"key":"ppat-0020058-b024","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/JVI.80.1.192-200.2006","article-title":"Gamma interferon blocks gammaherpesvirus reactivation from latency.","volume":"80","year":"2006","journal-title":"J Virol"},{"key":"ppat-0020058-b025","doi-asserted-by":"crossref","first-page":"11460","DOI":"10.1128\/JVI.76.22.11460-11468.2002","article-title":"Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice.","volume":"76","year":"2002","journal-title":"J Virol"},{"key":"ppat-0020058-b026","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.4049\/jimmunol.168.8.3958","article-title":"Antibody-mediated control of persistent \u03b3-herpesvirus infection.","volume":"168","year":"2002","journal-title":"J Immunol"},{"key":"ppat-0020058-b027","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.184.3.863","article-title":"Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.","volume":"184","year":"1996","journal-title":"J Exp Med"},{"key":"ppat-0020058-b028","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.1128\/JVI.78.13.6827-6835.2004","article-title":"An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.","volume":"78","year":"2004","journal-title":"J Virol"},{"key":"ppat-0020058-b029","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1073\/pnas.96.9.5135","article-title":"CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma.","volume":"96","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"ppat-0020058-b030","doi-asserted-by":"crossref","first-page":"12519","DOI":"10.1128\/JVI.78.22.12519-12528.2004","article-title":"Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.","volume":"78","year":"2004","journal-title":"J Virol"},{"key":"ppat-0020058-b031","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1084\/jem.187.12.1941","article-title":"Lung epithelial cells are a major site of murine gammaherpesvirus persistence.","volume":"187","year":"1998","journal-title":"J Exp Med"},{"key":"ppat-0020058-b032","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1242\/jeb.200.14.2057","article-title":"Trafficking of adoptively transferred B lymphocytes in B-lymphocyte-deficient mice.","volume":"200","year":"1997","journal-title":"J Exp Biol"},{"key":"ppat-0020058-b033","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.4049\/jimmunol.167.3.1575","article-title":"Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection.","volume":"167","year":"2001","journal-title":"J Immunol"},{"key":"ppat-0020058-b034","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/334676a0","article-title":"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.","volume":"334","year":"1988","journal-title":"Nature"},{"key":"ppat-0020058-b035","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/350423a0","article-title":"A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.","volume":"350","year":"1991","journal-title":"Nature"},{"key":"ppat-0020058-b036","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.1128\/JVI.70.10.6775-6780.1996","article-title":"Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.","volume":"70","year":"1996","journal-title":"J Virol"},{"key":"ppat-0020058-b037","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1128\/JVI.72.1.882-885.1998","article-title":"Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells.","volume":"72","year":"1998","journal-title":"J Virol"},{"key":"ppat-0020058-b038","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.4049\/jimmunol.170.3.1443","article-title":"A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes.","volume":"170","year":"2003","journal-title":"J Immunol"},{"key":"ppat-0020058-b039","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.1128\/JVI.72.11.9208-9216.1998","article-title":"Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: Failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT mice.","volume":"72","year":"1998","journal-title":"J Virol"},{"key":"ppat-0020058-b040","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1073\/pnas.0307320101","article-title":"The limits of protection by \u201cmemory\u201d T cells in Ig-\/-mice persistently infected with a gamma-herpesvirus.","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0020058-b041","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1084\/jem.194.11.1649","article-title":"Splenic T zone development is B cell dependent.","volume":"194","year":"2001","journal-title":"J Exp Med"},{"key":"ppat-0020058-b042","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.20020890","article-title":"Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells.","volume":"196","year":"2002","journal-title":"J Exp Med"},{"key":"ppat-0020058-b043","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.4049\/jimmunol.163.6.3403","article-title":"Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection.","volume":"163","year":"1999","journal-title":"J Immunol"},{"key":"ppat-0020058-b044","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/08828240152716637","article-title":"Factors controlling levels of CD8+ T-cell lymphocytosis associated with murine gamma-herpesvirus infection.","volume":"14","year":"2001","journal-title":"Viral Immunol"},{"key":"ppat-0020058-b045","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4049\/jimmunol.163.3.1481","article-title":"Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infection.","volume":"163","year":"1999","journal-title":"J Immunol"},{"key":"ppat-0020058-b046","doi-asserted-by":"crossref","first-page":"9650","DOI":"10.1128\/JVI.73.11.9650-9654.1999","article-title":"Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome.","volume":"73","year":"1999","journal-title":"J Virol"},{"key":"ppat-0020058-b047","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.185.9.1641","article-title":"Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: Role for a viral superantigen?","volume":"185","year":"1997","journal-title":"J Exp Med"},{"key":"ppat-0020058-b048","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1128\/JVI.75.9.4435-4438.2001","article-title":"Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection.","volume":"75","year":"2001","journal-title":"J Virol"},{"key":"ppat-0020058-b049","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1128\/JVI.73.9.7866-7869.1999","article-title":"Turnover of T cells in murine gammaherpesvirus 68-infected mice.","volume":"73","year":"1999","journal-title":"J Virol"},{"key":"ppat-0020058-b050","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1128\/JVI.72.2.943-949.1998","article-title":"Kinetic analysis of the specific host response to a murine gammaherpesvirus.","volume":"72","year":"1998","journal-title":"J Virol"},{"key":"ppat-0020058-b051","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.4049\/jimmunol.164.4.1820","article-title":"Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus.","volume":"164","year":"2000","journal-title":"J Immunol"},{"key":"ppat-0020058-b052","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1658936","article-title":"Antibody-mediated clearance of alphavirus infection from neurons.","volume":"254","year":"1991","journal-title":"Science"},{"key":"ppat-0020058-b053","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1128\/JVI.65.12.6772-6781.1991","article-title":"Monoclonal antibodies to reovirus reveal structure\/function relationships between capsid proteins and genetics of susceptibility to antibody action.","volume":"65","year":"1991","journal-title":"J Virol"},{"key":"ppat-0020058-b054","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1128\/JVI.68.10.6719-6729.1994","article-title":"Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases.","volume":"68","year":"1994","journal-title":"J Virol"},{"key":"ppat-0020058-b055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0264-410X(98)00190-X","article-title":"Murine gamma-herpesvirus 68 glycoprotein 150 protects against virus-induced mononucleosis: A model system for gamma-herpesvirus vaccination.","volume":"17","year":"1999","journal-title":"Vaccine"},{"key":"ppat-0020058-b056","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1128\/JVI.77.4.2522-2529.2003","article-title":"Effective vaccination against long-term gammaherpesvirus latency.","volume":"77","year":"2003","journal-title":"J Virol"},{"key":"ppat-0020058-b057","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.4049\/jimmunol.172.5.3078","article-title":"T cell reactivity during infectious mononucleosis and persistent gammaherpesvirus infection in mice.","volume":"172","year":"2004","journal-title":"J Immunol"},{"key":"ppat-0020058-b058","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.4049\/jimmunol.165.2.1074","article-title":"Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.","volume":"165","year":"2000","journal-title":"J Immunol"},{"key":"ppat-0020058-b059","doi-asserted-by":"crossref","first-page":"11304","DOI":"10.1128\/JVI.74.23.11304-11310.2000","article-title":"Ongoing viral replication is required for gammaherpesvirus 68-induced vascular damage.","volume":"74","year":"2000","journal-title":"J Virol"},{"key":"ppat-0020058-b060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni911","article-title":"Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections.","volume":"4","year":"2003","journal-title":"Nat Immunol"},{"key":"ppat-0020058-b061","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1084\/jem.186.5.673","article-title":"Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro.","volume":"186","year":"1997","journal-title":"J Exp Med"},{"key":"ppat-0020058-b062","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/viro.1999.9811","article-title":"Lymphotoxin-beta-deficient mice show defective antiviral immunity.","volume":"260","year":"1999","journal-title":"Virol"},{"key":"ppat-0020058-b063","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.155.4.1685","article-title":"Lymphotoxin-alpha-deficient mice\u2014Effects on secondary lymphoid organ development and humoral immune responsiveness.","volume":"155","year":"1995","journal-title":"J Immunol"},{"key":"ppat-0020058-b064","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1128\/JVI.74.6.2786-2792.2000","article-title":"Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis.","volume":"74","year":"2000","journal-title":"J Virol"},{"key":"ppat-0020058-b065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/35095584","article-title":"Epstein-Barr virus: Exploiting the immune system.","volume":"1","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"ppat-0020058-b066","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1128\/JVI.73.2.1075-1079.1999","article-title":"Non-antigen-specific B-cell activation following murine gammaherpesvirus infection is CD4 independent in vitro but CD4 dependent in vivo.","volume":"73","year":"1999","journal-title":"J Virol"},{"key":"ppat-0020058-b067","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1099\/0022-1317-80-10-2729","article-title":"Kinetic and phenotypic changes in murine lymphocytes infected with murine gammaherpesvirus-68 in vitro.","volume":"80","year":"1999","journal-title":"J Gen Virol"},{"key":"ppat-0020058-b068","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4049\/jimmunol.168.3.1204","article-title":"Mechanisms of central nervous system viral persistence: The critical role of antibody and B cells.","volume":"168","year":"2002","journal-title":"J Immunol"},{"key":"ppat-0020058-b069","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.171.9.4733","article-title":"Deficient CD4(+) T cell priming and regression of CD8+T cell functionality in virus-infected mice lacking a normal B cell compartment.","volume":"171","year":"2003","journal-title":"J Immunol"},{"key":"ppat-0020058-b070","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.4049\/jimmunol.130.4.1863","article-title":"SFR3-DR5, a monoclonal antibody with HLA-DR5 specificity.","volume":"130","year":"1983","journal-title":"J Immunol"},{"key":"ppat-0020058-b071","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.4049\/jimmunol.173.11.6627","article-title":"Following immunization antigen becomes concentrated in a limited number of APCs including B cells.","volume":"173","year":"2004","journal-title":"J Immunol"},{"key":"ppat-0020058-b072","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1128\/JVI.79.4.2573-2583.2005","article-title":"An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.","volume":"79","year":"2005","journal-title":"J Virol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0020058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T12:49:23Z","timestamp":1736426963000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0020058"}},"subtitle":[],"editor":[{"given":"Grant","family":"McFadden","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2006,6,23]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,6,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.0020058","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,23]]}}}