{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:43:09Z","timestamp":1791546189665,"version":"4.3.4"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T00:00:00Z","timestamp":1192752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.0030148","type":"journal-article","created":{"date-parts":[[2007,10,15]],"date-time":"2007-10-15T11:01:11Z","timestamp":1192446071000},"page":"e148","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":350,"title":["Genome Sequence of Babesia bovis and Comparative Analysis of Apicomplexan Hemoprotozoa"],"prefix":"10.1371","volume":"3","author":[{"given":"Kelly A","family":"Brayton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey O. T","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hannick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell S","family":"Kappmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn J","family":"Berens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby L","family":"Bidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy C","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Fadrosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Feldblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A","family":"Forberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Khouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hean","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Norimine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Radune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger K","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R","family":"Wortman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry F","family":"McElwain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishvanath M","family":"Nene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,10,19]]},"reference":[{"issue":"Suppl","key":"ppat-0030148-b001","first-page":"S247","article-title":"Babesiosis of cattle.","volume":"129","year":"2004","journal-title":"Parasitology"},{"issue":"Suppl 40","key":"ppat-0030148-b002","first-page":"131","article-title":"Identity of the causal agents of human babesiosis in Europe.","volume":"296","year":"2006","journal-title":"Int J Med Microbiol"},{"key":"ppat-0030148-b003","doi-asserted-by":"crossref","unstructured":"SmithTKilborneFL 1893 Investigations into the nature, causation and prevention of Southern cattle fever Washington (D.C.) Washington Government Printing Office 177 304","DOI":"10.5962\/bhl.title.124068"},{"key":"ppat-0030148-b004","unstructured":"McCoskerPJ 1981 The global importance of babesiosis. In: RisticMKreierJP Babesiosis New York Academic Press 1 24"},{"key":"ppat-0030148-b005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.vetpar.2006.01.042","article-title":"Live vaccines against bovine babesiosis.","volume":"138","year":"2006","journal-title":"Vet Parasitol"},{"issue":"Pt 2","key":"ppat-0030148-b006","first-page":"147","article-title":"Phylogeny and evolution of the piroplasms.","volume":"108","year":"1994","journal-title":"Parasitology"},{"key":"ppat-0030148-b007","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.1110418","article-title":"Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.","volume":"309","year":"2005","journal-title":"Science"},{"key":"ppat-0030148-b008","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0169-4758(99)01566-5","article-title":"Can Babesia infections be used as a model for cerebral malaria?","volume":"15","year":"1999","journal-title":"Parasitol Today"},{"key":"ppat-0030148-b009","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.vetpar.2005.07.002","article-title":"Cellular adhesive phenomena in apicomplexan parasites of red blood cells.","volume":"132","year":"2005","journal-title":"Vet Parasitol"},{"key":"ppat-0030148-b010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1126\/science.1110439","article-title":"Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes.","volume":"309","year":"2005","journal-title":"Science"},{"key":"ppat-0030148-b011","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature01097","article-title":"Genome sequence of the human malaria parasite Plasmodium falciparum.","volume":"419","year":"2002","journal-title":"Nature"},{"key":"ppat-0030148-b012","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0166-6851(92)90041-H","article-title":"Chromosomes of Babesia bovis and Babesia bigemina.","volume":"52","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b013","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0020-7519(97)00099-4","article-title":"Babesia bovis: genome size, number of chromosomes and telomeric probe hybridisation.","volume":"27","year":"1997","journal-title":"Int J Parasitol"},{"key":"ppat-0030148-b014","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/22964","article-title":"The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.","volume":"400","year":"1999","journal-title":"Nature"},{"key":"ppat-0030148-b015","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1093\/nar\/gki818","article-title":"Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ppat-0030148-b016","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00930816","article-title":"Purine salvage and metabolism in Babesia bovis.","volume":"76","year":"1990","journal-title":"Parasitol Res"},{"key":"ppat-0030148-b017","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.vetpar.2006.01.040","article-title":"Expressed sequence tag (EST) analysis of the erythrocytic stages of Babesia bovis.","volume":"138","year":"2006","journal-title":"Vet Parasitol"},{"key":"ppat-0030148-b018","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0014-4894(86)90024-X","article-title":"Babesia bovis: increased percentage parasitized erythrocytes in cultures and assessment of growth by incorporation of [3H]hypoxanthine.","volume":"62","year":"1986","journal-title":"Exp Parasitol"},{"key":"ppat-0030148-b019","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molbiopara.2003.08.013","article-title":"An amino acid substitution in the Babesia bovis dihydrofolate reductase-thymidylate synthase gene is correlated to cross-resistance against pyrimethamine and WR99210.","volume":"133","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b020","doi-asserted-by":"crossref","first-page":"D284","DOI":"10.1093\/nar\/gkh016","article-title":"TransportDB: a relational database of cellular membrane transport systems.","volume":"32","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ppat-0030148-b021","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/37132","article-title":"A plastid organelle as a drug target in apicomplexan parasites.","volume":"390","year":"1997","journal-title":"Nature"},{"key":"ppat-0030148-b022","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF00280323","article-title":"The evolutionary origin of the 35 kb circular DNA of Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry.","volume":"243","year":"1994","journal-title":"Mol Gen Genet"},{"key":"ppat-0030148-b023","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.gene.2003.08.008","article-title":"Apicoplast genome of the coccidian Eimeria tenella.","volume":"321","year":"2003","journal-title":"Gene"},{"key":"ppat-0030148-b024","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.275.5305.1485","article-title":"A plastid of probable green algal origin in Apicomplexan parasites.","volume":"275","year":"1997","journal-title":"Science"},{"key":"ppat-0030148-b025","first-page":"57","article-title":"The apicoplast: a review of the derived plastid of apicomplexan parasites.","volume":"7","year":"2005","journal-title":"Curr Issues Mol Biol"},{"key":"ppat-0030148-b026","doi-asserted-by":"crossref","first-page":"23612","DOI":"10.1074\/jbc.M201748200","article-title":"Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme.","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"ppat-0030148-b027","doi-asserted-by":"crossref","first-page":"12352","DOI":"10.1073\/pnas.95.21.12352","article-title":"Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum.","volume":"95","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030148-b028","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.285.5433.1573","article-title":"Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.","volume":"285","year":"1999","journal-title":"Science"},{"key":"ppat-0030148-b029","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2958.2005.04699.x","article-title":"Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum.","volume":"57","year":"2005","journal-title":"Mol Microbiol"},{"key":"ppat-0030148-b030","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/emboj\/19.8.1794","article-title":"Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway.","volume":"19","year":"2000","journal-title":"EMBO J"},{"key":"ppat-0030148-b031","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.1078599","article-title":"Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum.","volume":"299","year":"2003","journal-title":"Science"},{"key":"ppat-0030148-b032","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrmicro843","article-title":"Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast.","volume":"2","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ppat-0030148-b033","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/j.1365-2958.2006.05343.x","article-title":"The cell biology of secondary endosymbiosis\u2013how parasites build, divide and segregate the apicoplast.","volume":"61","year":"2006","journal-title":"Mol Microbiol"},{"key":"ppat-0030148-b034","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1073\/pnas.0603391103","article-title":"Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii.","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030148-b035","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/j.1460-2075.1994.tb06333.x","article-title":"A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially encoded proteins.","volume":"13","year":"1994","journal-title":"EMBO J"},{"key":"ppat-0030148-b036","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/nar\/30.7.1575","article-title":"An efficient algorithm for large-scale detection of protein families.","volume":"30","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ppat-0030148-b037","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1365-2958.2005.04993.x","article-title":"Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription.","volume":"59","year":"2006","journal-title":"Mol Microbiol"},{"key":"ppat-0030148-b038","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1128\/IAI.64.7.2618-2626.1996","article-title":"A Babesia bovis 225-kilodalton spherical-body protein: localization to the cytoplasmic face of infected erythrocytes after merozoite invasion.","volume":"64","year":"1996","journal-title":"Infect Immun"},{"key":"ppat-0030148-b039","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0166-6851(92)90129-8","article-title":"Neutralization-sensitive merozoite surface antigens of Babesia bovis encoded by members of a polymorphic gene family.","volume":"55","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0166-6851(97)00125-4","article-title":"Characterization of a variant erythrocyte surface antigen (VESA1) expressed by Babesia bovis during antigenic variation.","volume":"89","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b041","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1097-2765(00)80411-6","article-title":"The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface.","volume":"5","year":"2000","journal-title":"Mol Cell"},{"key":"ppat-0030148-b042","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.4049\/jimmunol.164.4.2037","article-title":"Selection of Babesia bovis-infected erythrocytes for adhesion to endothelial cells coselects for altered variant erythrocyte surface antigen isoforms.","volume":"164","year":"2000","journal-title":"J Immunol"},{"key":"ppat-0030148-b043","first-page":"1","article-title":"Evidence for distinct prototype sequences within the Plasmodium falciparum Pf60 multigene family.","volume":"87","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b044","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrmicro1392","article-title":"Plasmodium post-genomics: better the bug you know?","volume":"4","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ppat-0030148-b045","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1073\/pnas.0406656102","article-title":"Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030148-b046","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ijpara.2006.05.007","article-title":"Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum.","volume":"36","year":"2006","journal-title":"Int J Parasitol"},{"key":"ppat-0030148-b047","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1093\/emboj\/17.18.5418","article-title":"Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum.","volume":"17","year":"1998","journal-title":"EMBO J"},{"key":"ppat-0030148-b048","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(01)00275-4","article-title":"Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion.","volume":"115","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b049","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.","volume":"305","year":"2001","journal-title":"J Mol Biol"},{"key":"ppat-0030148-b050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0166-6851(94)00200-7","article-title":"Genetic and antigenic characterization of Babesia bovis merozoite spherical body protein Bb-1.","volume":"69","year":"1995","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b051","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0166-6851(92)90058-R","article-title":"A Babesia bovis 225-kilodalton protein located on the cytoplasmic side of the erythrocyte membrane has sequence similarity with a region of glycogen phosphorylase.","volume":"52","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b052","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0166-6851(93)90216-K","article-title":"Cloning and characterisation of cDNA clones encoding two Babesia bovis proteins with homologous amino- and carboxy-terminal domains.","volume":"59","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b053","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0001-706X(93)90031-6","article-title":"Molecular variation and diversity in candidate vaccine antigens from Babesia.","volume":"53","year":"1993","journal-title":"Acta Trop"},{"key":"ppat-0030148-b054","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1128\/IAI.73.9.5388-5394.2005","article-title":"Sequence variation and immunologic cross-reactivity among Babesia bovis merozoite surface antigen 1 proteins from vaccine strains and vaccine breakthrough isolates.","volume":"73","year":"2005","journal-title":"Infect Immun"},{"key":"ppat-0030148-b055","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1128\/IAI.73.11.7180-7189.2005","article-title":"Merozoite surface antigen 2 proteins of Babesia bovis vaccine breakthrough isolates contain a unique hypervariable region composed of degenerate repeats.","volume":"73","year":"2005","journal-title":"Infect Immun"},{"key":"ppat-0030148-b056","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1128\/IAI.70.7.3566-3575.2002","article-title":"The Babesia bovis merozoite surface antigen 2 locus contains four tandemly arranged and expressed genes encoding immunologically distinct proteins.","volume":"70","year":"2002","journal-title":"Infect Immun"},{"key":"ppat-0030148-b057","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0166-6851(02)00311-0","article-title":"Organization, transcription, and expression of rhoptry associated protein genes in the Babesia bigemina rap-1 locus.","volume":"127","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b058","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molbiopara.2004.02.006","article-title":"A Babesia bovis merozoite protein with a domain architecture highly similar to the thrombospondin-related anonymous protein (TRAP) present in Plasmodium sporozoites.","volume":"136","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b059","doi-asserted-by":"crossref","first-page":"12194","DOI":"10.1073\/pnas.0500925102","article-title":"Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030148-b060","doi-asserted-by":"crossref","first-page":"40169","DOI":"10.1074\/jbc.M509631200","article-title":"Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"ppat-0030148-b061","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cell.2005.01.036","article-title":"Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum.","volume":"121","year":"2005","journal-title":"Cell"},{"key":"ppat-0030148-b062","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00253-006-0452-0","article-title":"Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug.","volume":"72","year":"2006","journal-title":"Appl Microbiol Biotechnol"},{"key":"ppat-0030148-b063","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1128\/IAI.72.9.5515-5521.2004","article-title":"The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites.","volume":"72","year":"2004","journal-title":"Infect Immun"},{"key":"ppat-0030148-b064","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1128\/IAI.64.5.1832-1838.1996","article-title":"Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva.","volume":"64","year":"1996","journal-title":"Infect Immun"},{"key":"ppat-0030148-b065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0166-6851(02)00013-0","article-title":"Characterization of a polymorphic Theileria annulata surface protein (TaSP) closely related to PIM of Theileria parva: implications for use in diagnostic tests and subunit vaccines.","volume":"120","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b066","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1073\/pnas.0511273103","article-title":"Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes.","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030148-b067","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00436-004-1226-1","article-title":"Molecular genetic characterization and subcellular localization of a putative Theileria annulata membrane protein.","volume":"94","year":"2004","journal-title":"Parasitol Res"},{"key":"ppat-0030148-b068","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molbiopara.2006.01.004","article-title":"A novel 78-kDa fatty acyl-CoA synthetase (ACS1) of Babesia bovis stimulates memory CD4+ T lymphocyte responses in B. bovis-immune cattle.","volume":"147","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b069","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1128\/IAI.72.5.2947-2955.2004","article-title":"Erythrocyte invasion by Babesia bovis merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 1.","volume":"72","year":"2004","journal-title":"Infect Immun"},{"key":"ppat-0030148-b070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijpara.2005.09.002","article-title":"Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes.","volume":"36","year":"2006","journal-title":"Int J Parasitol"},{"key":"ppat-0030148-b071","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0166-6851(99)00064-X","article-title":"Evidence for localisation of a Theileria parasite AT hook DNA-binding protein to the nucleus of immortalised bovine host cells.","volume":"101","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b072","first-page":"231","article-title":"Evidence for a common protective antigenic determinant on sporozoites of several Theileria parva strains.","volume":"52","year":"1984","journal-title":"Immunology"},{"key":"ppat-0030148-b073","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-3024.1994.tb00328.x","article-title":"Theileria annulata sporozoite surface antigen (SPAG-1) contains neutralizing determinants in the C terminus.","volume":"16","year":"1994","journal-title":"Parasite Immunol"},{"key":"ppat-0030148-b074","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1016\/j.vaccine.2004.09.039","article-title":"Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge.","volume":"23","year":"2005","journal-title":"Vaccine"},{"key":"ppat-0030148-b075","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature01099","article-title":"Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.","volume":"419","year":"2002","journal-title":"Nature"},{"key":"ppat-0030148-b076","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.1998.tb11046.x","article-title":"Babesia bovis immunity. In vitro and in vivo evidence for IL-10 regulation of IFN-gamma and iNOS.","volume":"849","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"ppat-0030148-b077","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.7355284","article-title":"Babesia bovis: continuous cultivation in a microaerophilous stationary phase culture.","volume":"207","year":"1980","journal-title":"Science"},{"key":"ppat-0030148-b078","unstructured":"AusubelFMBrentRKingstonREMooreDDSeidmanJG 2006 Current protocols in molecular biology New York John Wiley & Sons"},{"key":"ppat-0030148-b079","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0166-6851(01)00363-2","article-title":"Phat\u2013a gene finding program for Plasmodium falciparum.","volume":"118","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ppat-0030148-b080","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1093\/bioinformatics\/bth315","article-title":"TigrScan and GlimmerHMM: two open source ab initio eukaryotic gene-finders.","volume":"20","year":"2004","journal-title":"Bioinformatics"},{"key":"ppat-0030148-b081","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1093\/nar\/gkg527","article-title":"GlimmerM, Exonomy and Unveil: three ab initio eukaryotic genefinders.","volume":"31","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ppat-0030148-b082","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/geno.1997.4984","article-title":"A tool for analyzing and annotating genomic sequences.","volume":"46","year":"1997","journal-title":"Genomics"},{"issue":"Suppl 1","key":"ppat-0030148-b083","first-page":"S9.1","article-title":"JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regions.","volume":"7","year":"2006","journal-title":"Genome Biol"},{"key":"ppat-0030148-b084","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2105-3-19","article-title":"Visualizing the genome: techniques for presenting human genome data and annotations.","volume":"3","year":"2002","journal-title":"BMC Bioinformatics"},{"key":"ppat-0030148-b085","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/nar\/25.5.955","article-title":"tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.","volume":"25","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ppat-0030148-b086","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool.","volume":"215","year":"1990","journal-title":"J Mol Biol"},{"key":"ppat-0030148-b087","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gki442","article-title":"InterProScan: protein domains identifier.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ppat-0030148-b088","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0.","volume":"340","year":"2004","journal-title":"J Mol Biol"},{"key":"ppat-0030148-b089","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1093\/nar\/gkg770","article-title":"Improving the Arabidopsis genome annotation using maximal transcript alignment assemblies.","volume":"31","year":"2003","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0030148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T08:47:19Z","timestamp":1708246039000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0030148"}},"subtitle":[],"editor":[{"given":"Jane","family":"Carlton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,10,19]]},"references-count":89,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2007,10,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.0030148","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1092807.547734","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,19]]}}}