{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:56:35Z","timestamp":1792032995754,"version":"4.4.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.0030188","type":"journal-article","created":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T23:54:42Z","timestamp":1196726082000},"page":"e188","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":112,"title":["The Legionella pneumophila IcmSW Complex Interacts with Multiple Dot\/Icm Effectors to Facilitate Type IV Translocation"],"prefix":"10.1371","volume":"3","author":[{"given":"Eric D","family":"Cambronne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"ppat-0030188-b001","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrmicro753","article-title":"The versatile bacterial type IV secretion systems.","volume":"1","year":"2003","journal-title":"Nat Rev Microbiol"},{"key":"ppat-0030188-b002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2958.1993.tb01092.x","article-title":"Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila.","volume":"7","year":"1993","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b003","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.1073\/pnas.89.20.9607","article-title":"Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages.","volume":"89","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b004","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.279.5352.873","article-title":"Conjugative transfer by the virulence system of Legionella pneumophila.","volume":"279","year":"1998","journal-title":"Science"},{"key":"ppat-0030188-b005","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2958.1998.00841.x","article-title":"Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake.","volume":"28","year":"1998","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b006","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI110744","article-title":"Intracellular multiplication of Legionnaires' disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin.","volume":"71","year":"1983","journal-title":"J Clin Invest"},{"key":"ppat-0030188-b007","first-page":"307","article-title":"Symbiotic interactions between Legionella pneumophila and human leukocytes.","volume":"14","year":"1983","journal-title":"Int Rev Cytol Suppl"},{"key":"ppat-0030188-b008","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1128\/IAI.63.9.3609-3620.1995","article-title":"Association of Legionella pneumophila with the macrophage endoplasmic reticulum.","volume":"63","year":"1995","journal-title":"Infect Immun"},{"key":"ppat-0030188-b009","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/jcs.114.24.4637","article-title":"How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane.","volume":"114","year":"2001","journal-title":"J Cell Sci"},{"key":"ppat-0030188-b010","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncb883","article-title":"Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites.","volume":"4","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ppat-0030188-b011","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1093\/emboj\/20.21.5962","article-title":"The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot\/Icm transporter.","volume":"20","year":"2001","journal-title":"Embo J"},{"key":"ppat-0030188-b012","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.1094226","article-title":"Legionella effectors that promote nonlytic release from protozoa.","volume":"303","year":"2004","journal-title":"Science"},{"key":"ppat-0030188-b013","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.0304916101","article-title":"Multiple substrates of the Legionella pneumophila Dot\/Icm system identified by interbacterial protein transfer.","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b014","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1067025","article-title":"A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.","volume":"295","year":"2002","journal-title":"Science"},{"key":"ppat-0030188-b015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1365-2958.2003.03400.x","article-title":"The Legionella pneumophila LidA protein: a translocated substrate of the Dot\/Icm system associated with maintenance of bacterial integrity.","volume":"48","year":"2003","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b016","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1365-2958.2005.04595.x","article-title":"A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot\/Icm system.","volume":"56","year":"2005","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b017","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1073\/pnas.0501315102","article-title":"Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b018","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1128\/JB.187.22.7716-7726.2005","article-title":"Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer.","volume":"187","year":"2005","journal-title":"J Bacteriol"},{"key":"ppat-0030188-b019","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2006.05.013","article-title":"Targeting of host rab GTPase function by the intravacuolar pathogen Legionella pneumophila.","volume":"11","year":"2006","journal-title":"Dev Cell"},{"key":"ppat-0030188-b020","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/IAI.02060-05","article-title":"Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells.","volume":"74","year":"2006","journal-title":"Infect Immun"},{"key":"ppat-0030188-b021","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1365-2958.2004.04435.x","article-title":"The Legionella IcmS-IcmW protein complex is important for Dot\/Icm-mediated protein translocation.","volume":"55","year":"2005","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b022","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1073\/pnas.0611030104","article-title":"Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.","volume":"104","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b023","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/IAI.01278-06","article-title":"The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome.","volume":"75","year":"2007","journal-title":"Infect Immun"},{"key":"ppat-0030188-b024","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb1463","article-title":"The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.","volume":"8","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ppat-0030188-b025","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2958.2005.04539.x","article-title":"IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system.","volume":"56","year":"2005","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b026","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/j.1365-2958.2007.05604.x","article-title":"The response regulator PmrA is a major regulator of the icm\/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii.","volume":"63","year":"2007","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b027","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.290.5493.979","article-title":"VirB\/D4-dependent protein translocation from Agrobacterium into plant cells.","volume":"290","year":"2000","journal-title":"Science"},{"key":"ppat-0030188-b028","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1046\/j.1365-2958.2001.02582.x","article-title":"The carboxy-terminus of VirE2 from Agrobacterium tumefaciens is required for its transport to host cells by the virB-encoded type IV transport system.","volume":"41","year":"2001","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b029","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1073\/pnas.0406241102","article-title":"Positive charge is an important feature of the C-terminal transport signal of the VirB\/D4-translocated proteins of Agrobacterium.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b030","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1365-2958.2006.05050.x","article-title":"A C-terminal translocation signal is necessary, but not sufficient for type IV secretion of the Helicobacter pylori CagA protein.","volume":"59","year":"2006","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b031","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1073\/pnas.0406796102","article-title":"A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b032","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1073\/pnas.0406239101","article-title":"A C-terminal translocation signal required for Dot\/Icm-dependent delivery of the Legionella RalF protein to host cells.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b033","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1111\/j.1462-5822.2007.00899.x","article-title":"Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila.","volume":"9","year":"2007","journal-title":"Cell Microbiol"},{"key":"ppat-0030188-b034","article-title":"A translocated bacterial protein protects vascular endothelial cells from apoptosis.","volume":"2","year":"2006","journal-title":"PLoS Pathog"},{"key":"ppat-0030188-b035","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1074\/jbc.M410820200","article-title":"The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site.","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"ppat-0030188-b036","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1046\/j.1365-2958.2000.02176.x","article-title":"Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth.","volume":"38","year":"2000","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b037","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/MMBR.68.4.771-795.2004","article-title":"Process of protein transport by the type III secretion system.","volume":"68","year":"2004","journal-title":"Microbiol Mol Biol Rev"},{"key":"ppat-0030188-b038","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1046\/j.1365-2958.1999.01410.x","article-title":"Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth.","volume":"32","year":"1999","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b039","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1365-2958.2006.05446.x","article-title":"Identification of the core transmembrane complex of the Legionella Dot\/Icm type IV secretion system.","volume":"62","year":"2006","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b040","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1365-2958.2006.05243.x","article-title":"The Legionella pneumophila IcmS-LvgA protein complex is important for Dot\/Icm-dependent intracellular growth.","volume":"61","year":"2006","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b041","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2958.1994.tb02191.x","article-title":"Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells.","volume":"14","year":"1994","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b042","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.molcel.2006.01.026","article-title":"A common structural motif in the binding of virulence factors to bacterial secretion chaperones.","volume":"21","year":"2006","journal-title":"Mol Cell"},{"key":"ppat-0030188-b043","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1097-2765(02)00529-4","article-title":"Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens.","volume":"9","year":"2002","journal-title":"Mol Cell"},{"key":"ppat-0030188-b044","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nature03992","article-title":"Chaperone release and unfolding of substrates in type III secretion.","volume":"437","year":"2005","journal-title":"Nature"},{"key":"ppat-0030188-b045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/35102073","article-title":"Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion.","volume":"414","year":"2001","journal-title":"Nature"},{"key":"ppat-0030188-b046","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1107\/S0907444904017597","article-title":"Structure of the Yersinia pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2.","volume":"60","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ppat-0030188-b047","doi-asserted-by":"crossref","first-page":"16490","DOI":"10.1073\/pnas.0605974103","article-title":"Secretion signal recognition by YscN, the Yersinia type III secretion ATPase.","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat-0030188-b048","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2958.2005.04667.x","article-title":"Genetic analysis of the Legionella pneumophila DotB ATPase reveals a role in type IV secretion system protein export.","volume":"57","year":"2005","journal-title":"Mol Microbiol"},{"key":"ppat-0030188-b049","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1128\/JB.01742-06","article-title":"A pair of highly conserved two-component systems participates in the regulation of the hypervariable FIR proteins in different Legionella species.","volume":"189","year":"2007","journal-title":"J Bacteriol"},{"key":"ppat-0030188-b050","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1462-5822.2006.00703.x","article-title":"Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila.","volume":"8","year":"2006","journal-title":"Cell Microbiol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0030188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:29:59Z","timestamp":1708388999000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.0030188"}},"subtitle":[],"editor":[{"given":"Ralph R","family":"Isberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,12,7]]},"references-count":50,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2007,12,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.0030188","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,7]]}}}