{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:35:34Z","timestamp":1780104934897,"version":"3.54.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000005","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T01:13:40Z","timestamp":1204852420000},"page":"e1000005","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Methylated DNA Recognition during the Reversal of Epigenetic Silencing Is Regulated by Cysteine and Serine Residues in the Epstein-Barr Virus Lytic Switch Protein"],"prefix":"10.1371","volume":"4","author":[{"given":"Questa H.","family":"Karlsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Schelcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Verrall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Petosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tibs.2005.12.008","article-title":"Genomic DNA methylation: the mark and its mediators.","volume":"31","author":"RJ Klose","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1101\/gad.2.9.1136","article-title":"Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.","volume":"2","author":"F Watt","year":"1988","journal-title":"Genes Dev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/ng1424","article-title":"The EBV lytic switch protein, Z, preferentially binds to and activates the methylated viral genome.","volume":"36","author":"PM Bhende","year":"2004","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.1128\/JVI.79.12.7338-7348.2005","article-title":"BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.","volume":"79","author":"PM Bhende","year":"2005","journal-title":"J Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on.","volume":"4","author":"LS Young","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1473-3099(03)00543-7","article-title":"Epstein-Barr virus-recent advances.","volume":"3","author":"KF Macsween","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref7","first-page":"205","article-title":"The switch between EBV latency and replication.","volume":"62","author":"G Miller","year":"1989","journal-title":"Yale J Biol Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/rmv.441","article-title":"Latent and lytic Epstein-Barr virus replication strategies.","volume":"15","author":"T Tsurumi","year":"2005","journal-title":"Rev Med Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1128\/JVI.64.3.1227-1232.1990","article-title":"Autoregulation of Epstein-Barr Virus putative lytic switch gene BZLF1.","volume":"64","author":"E Flemington","year":"1990","journal-title":"Journal of Virology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1128\/JVI.65.5.2237-2244.1991","article-title":"Pathways of activation of the Epstein-Barr virus productive cycle.","volume":"65","author":"AJ Sinclair","year":"1991","journal-title":"J Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1093\/emboj\/19.12.3080","article-title":"The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators.","volume":"19","author":"R Feederle","year":"2000","journal-title":"EMBO J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"13298","DOI":"10.1128\/JVI.79.21.13298-13309.2005","article-title":"A redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication.","volume":"79","author":"P Wang","year":"2005","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13822","DOI":"10.1128\/JVI.79.21.13822-13828.2005","article-title":"Mutation of a single amino acid residue in the basic region of the Epstein-Barr virus (EBV) lytic cycle switch protein Zta (BZLF1) prevents reactivation of EBV from latency.","volume":"79","author":"C Schelcher","year":"2005","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1099\/vir.0.82881-0","article-title":"A comprehensive library of mutations of Epstein Barr virus.","volume":"88","author":"YF Chiu","year":"2007","journal-title":"J Gen Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molcel.2006.01.006","article-title":"Structural Basis of Lytic Cycle Activation by the Epstein-Barr Virus ZEBRA Protein.","volume":"21","author":"C Petosa","year":"2006","journal-title":"Mol Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijbiomac.2004.04.003","article-title":"Structural analysis of cation-pi interactions in DNA binding proteins.","volume":"34","author":"M Gromiha","year":"2004","journal-title":"Int J Biol Macromol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0014-5793(99)01122-9","article-title":"Strong hydrophobic nature of cysteine residues in proteins.","volume":"458","author":"N Nagano","year":"1999","journal-title":"FEBS Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1101\/gad.198501","article-title":"The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor.","volume":"15","author":"A Prokhortchouk","year":"2001","journal-title":"Genes Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1128\/JVI.00215-07","article-title":"Atypical bZIP domain of viral transcription factor contributes to stability of dimer formation and transcriptional function.","volume":"81","author":"C Schelcher","year":"2007","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/sj.onc.1209205","article-title":"EBV EBNA 2 stimulates CDK9-dependent transcription and RNA polymerase II phosphorylation on serine 5.","volume":"25","author":"SJ Bark-Jones","year":"2006","journal-title":"Oncogene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1128\/JVI.75.11.5381-5384.2001","article-title":"Biophysical analysis of natural variants of the multimerization region of Epstein-Barr virus lytic-switch protein BZLF1.","volume":"75","author":"MR Hicks","year":"2001","journal-title":"Journal of Virology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1128\/JVI.77.14.8173-8177.2003","article-title":"The zipper region of Epstein-Barr virus bZIP transcription factor Zta is necessary but not sufficient to direct DNA binding.","volume":"77","author":"MR Hicks","year":"2003","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models.","volume":"47 (Pt 2)","author":"TA Jones","year":"1991","journal-title":"Acta Crystallogr A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1016\/S0021-9258(18)42522-7","article-title":"C-C-A-G-G-C-m5C-T-G-G. Helical fine structure, hydration, and comparison with C-C-A-G-G-C-C-T-G-G.","volume":"267","author":"U Heinemann","year":"1992","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1107\/S0907444998017363","article-title":"Further additions to MolScript version 1.4, including reading and contouring of electron-density maps.","volume":"55","author":"RM Esnouf","year":"1999","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0076-6879(97)77028-9","article-title":"Raster3D: Photorealistic Molecular Graphics.","volume":"277","author":"EA Merritt","year":"1997","journal-title":"Methods in Enzymology"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T10:17:37Z","timestamp":1630837057000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000005"}},"subtitle":[],"editor":[{"given":"Bill","family":"Sugden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,3,7]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000005","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,7]]}}}