{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:47Z","timestamp":1792512947147,"version":"4.5.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000116","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T22:29:49Z","timestamp":1217543389000},"page":"e1000116","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Histidine-Rich Glycoprotein Protects from Systemic Candida Infection"],"prefix":"10.1371","volume":"4","author":[{"given":"Victoria","family":"Rydeng\u00e5rd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oonagh","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Lundqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Kacprzyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Chalupka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi","family":"Jahnen-Dechent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Malmsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Schmidtchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00062752-200201000-00004","article-title":"Cathelicidins: a family of endogenous antimicrobial peptides.","volume":"9","author":"RI Lehrer","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/0968051907088275","article-title":"Review: Human antimicrobial proteins effectors of innate immunity.","volume":"13","author":"J Harder","year":"2007","journal-title":"J Endotoxin Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms.","volume":"415","author":"M Zasloff","year":"2002","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1189\/jlb.0403147","article-title":"Cathelicidins, multifunctional peptides of the innate immunity.","volume":"75","author":"M Zanetti","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1172\/JCI18761","article-title":"What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses?","volume":"111","author":"P Elsbach","year":"2003","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nri1180","article-title":"Defensins: antimicrobial peptides of innate immunity.","volume":"3","author":"T Ganz","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4049\/jimmunol.167.2.623","article-title":"Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity.","volume":"167","author":"AM Cole","year":"2001","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrmicro1098","article-title":"Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?","volume":"3","author":"KA Brogden","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0024-3205(02)01740-X","article-title":"Direct antimicrobial properties of substance P.","volume":"71","author":"K Kowalska","year":"2002","journal-title":"Life Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1021\/bi00187a034","article-title":"Structure, synthesis, and activity of dermaseptin b, a novel vertebrate defensive peptide from frog skin: relationship with adenoregulin.","volume":"33","author":"A Mor","year":"1994","journal-title":"Biochemistry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1074\/jbc.M607848200","article-title":"Preservation of antimicrobial properties of complement peptide C3a, from invertebrates to humans.","volume":"282","author":"M Pasupuleti","year":"2007","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"16879","DOI":"10.1073\/pnas.0406678101","article-title":"Activation of the complement system generates antibacterial peptides.","volume":"101","author":"EA Nordahl","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/08977190701344120","article-title":"Antimicrobial peptides derived from growth factors.","volume":"25","author":"M Malmsten","year":"2007","journal-title":"Growth Factors"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1038\/sj.emboj.7601422","article-title":"The contact system\u2013a novel branch of innate immunity generating antibacterial peptides.","volume":"25","author":"IM Frick","year":"2006","journal-title":"Embo J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"34832","DOI":"10.1074\/jbc.M507249200","article-title":"Domain 5 of high molecular weight kininogen is antibacterial.","volume":"280","author":"EA Nordahl","year":"2005","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/j.bbamem.2007.06.020","article-title":"Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions.","volume":"1768","author":"L Kacprzyk","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1111\/j.1742-4658.2006.05246.x","article-title":"Zinc potentiates the antibacterial effects of histidine-rich peptides against Enterococcus faecalis.","volume":"273","author":"V Rydeng\u00e5rd","year":"2006","journal-title":"Febs J"},{"key":"ref18","first-page":"1125","article-title":"[Human serum proteins with high affinity for carboxymethylcellulose. I. Isolation of lysozyme, C1q and 2 hitherto unknown -globulins].","volume":"353","author":"H Haupt","year":"1972","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1515\/bchm2.1972.353.2.1133","article-title":"[Human serum proteins with high affinity to carboxymethylcellulose. II. Physico-chemical and immunological characterization of a histidine-rich 3,8S- 2 -glycoportein (CM-protein I)].","volume":"353","author":"N Heimburger","year":"1972","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1440-1711.2005.01320.x","article-title":"Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems.","volume":"83","author":"AL Jones","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1182\/blood.V62.5.1016.1016","article-title":"Histidine-rich glycoprotein is present in human platelets and is released following thrombin stimulation.","volume":"62","author":"LL Leung","year":"1983","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1538-7836.2005.01238.x","article-title":"Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG).","volume":"3","author":"N Tsuchida-Straeten","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bss0700179","article-title":"Cystatins.","author":"M Abrahamson","year":"2003","journal-title":"Biochem Soc Symp"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1074\/jbc.273.10.5493","article-title":"Histidine-proline-rich glycoprotein as a plasma pH sensor. Modulation of its interaction with glycosaminoglycans by ph and metals.","volume":"273","author":"DB Borza","year":"1998","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1158\/0008-5472.CAN-04-0440","article-title":"Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities.","volume":"64","author":"F Donate","year":"2004","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1158\/0008-5472.CAN-03-1941","article-title":"A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization.","volume":"64","author":"AK Olsson","year":"2004","journal-title":"Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1742-4658.2006.05586.x","article-title":"Histidine-rich glycoprotein exerts antibacterial activity.","volume":"274","author":"V Rydeng\u00e5rd","year":"2007","journal-title":"Febs J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system.","volume":"6","author":"MG Netea","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/srin.2001.22723","article-title":"Antimicrobial proteins and peptides in host defense.","volume":"16","author":"T Ganz","year":"2001","journal-title":"Semin Respir Infect"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"33115","DOI":"10.1074\/jbc.273.50.33115","article-title":"Apolipoprotein A-I binds and inhibits the human antibacterial\/cytotoxic peptide LL-37.","volume":"273","author":"Y Wang","year":"1998","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/yea.1241","article-title":"Candida glabrata is unusual with respect to its resistance to cationic antifungal proteins.","volume":"22","author":"EJ Helmerhorst","year":"2005","journal-title":"Yeast"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1128\/IAI.61.7.2978-2984.1993","article-title":"Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine.","volume":"61","author":"HG Boman","year":"1993","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/bj20031785","article-title":"Interactions of histatin 5 and histatin 5-derived peptides with liposome membranes: surface effects, translocation and permeabilization.","volume":"379","author":"AL Den Hertog","year":"2004","journal-title":"Biochem J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11745-004-1336-x","article-title":"What&apos;s so special about cholesterol?","volume":"39","author":"OG Mouritsen","year":"2004","journal-title":"Lipids"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1529\/biophysj.105.067652","article-title":"Universal behavior of membranes with sterols.","volume":"90","author":"J Henriksen","year":"2006","journal-title":"Biophys J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1128\/IAI.65.7.2898-2903.1997","article-title":"Effects of pH and salinity on the antimicrobial properties of clavanins.","volume":"65","author":"IH Lee","year":"1997","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/AAC.00490-06","article-title":"Enhanced membrane disruption and antibiotic action against pathogenic bacteria by designed histidine-rich peptides at acidic pH.","volume":"50","author":"AJ Mason","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/000155500750042925","article-title":"Degradation of antiproteinases, complement and fibronectin in chronic leg ulcers.","volume":"80","author":"A Schmidtchen","year":"2000","journal-title":"Acta Derm Venereol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/1523-1747.ep12342990","article-title":"Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha2-macroglobulin.","volume":"106","author":"F Grinnell","year":"1996","journal-title":"J Invest Dermatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1172\/JCI112435","article-title":"Interaction of histidine-rich glycoprotein with fibrinogen and fibrin.","volume":"77","author":"LL Leung","year":"1986","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1021\/bi952061t","article-title":"Domain structure and conformation of histidine-proline-rich glycoprotein.","volume":"35","author":"DB Borza","year":"1996","journal-title":"Biochemistry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/00220345930720020801","article-title":"In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.","volume":"72","author":"KT Miyasaki","year":"1993","journal-title":"J Dent Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/IAI.44.3.695-701.1984","article-title":"Growth-inhibitory and bactericidal effects of human parotid salivary histidine-rich polypeptides on Streptococcus mutans.","volume":"44","author":"BJ MacKay","year":"1984","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"18872","DOI":"10.1074\/jbc.274.27.18872","article-title":"Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death.","volume":"274","author":"SE Koshlukova","year":"1999","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1182\/blood.V96.8.2664","article-title":"Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents.","volume":"96","author":"O Levy","year":"2000","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0952-7915(98)80030-7","article-title":"Role of the bactericidal\/permeability-increasing protein in host defence.","volume":"10","author":"P Elsbach","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1007\/s00018-005-5373-z","article-title":"Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties.","volume":"62","author":"JL Gifford","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0167-4838(83)90365-5","article-title":"Physicochemical, immunochemical and functional comparison of human histidine-rich glycoprotein and autorosette inhibition factor.","volume":"742","author":"HR Lijnen","year":"1983","journal-title":"Biochim Biophys Acta"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0049-3848(85)90303-2","article-title":"Proteolysis of histidine-rich glycoprotein in plasma and in patients undergoing thrombolytic therapy.","volume":"40","author":"A Smith","year":"1985","journal-title":"Thromb Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.4049\/jimmunol.169.9.4745","article-title":"Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages.","volume":"169","author":"NN Gorgani","year":"2002","journal-title":"J Immunol"},{"key":"ref51","first-page":"27","article-title":"Immunomodulatory properties of defensins and cathelicidins.","volume":"306","author":"DM Bowdish","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0009-9120(91)80014-T","article-title":"Regulation of cytoplasmic pH in phagocytic cell function and dysfunction.","volume":"24","author":"S Grinstein","year":"1991","journal-title":"Clin Biochem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molimm.2005.06.018","article-title":"Clinical manifestations of mannan-binding lectin deficiency.","volume":"43","author":"S Thiel","year":"2006","journal-title":"Mol Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1196\/annals.1398.053","article-title":"Identification of histidine-rich glycoprotein, a potential autoantigen, in human and rat brain preparations.","volume":"1109","author":"C Ball-Rosen","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref55","first-page":"694","article-title":"Infections in systemic lupus erythematosus patients.","volume":"26","author":"NI Paton","year":"1997","journal-title":"Ann Acad Med Singapore"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0022-2836(70)90402-X","article-title":"A factor preventing the major head protein of bacteriophage T4 from random aggregation.","volume":"47","author":"UK Laemmli","year":"1970","journal-title":"J Mol Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0022-1759(91)90021-7","article-title":"Ultrasensitive assays for endogenous antimicrobial polypeptides.","volume":"137","author":"RI Lehrer","year":"1991","journal-title":"J Immunol Methods"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bbamem.2006.11.016","article-title":"Effects of topology, length, and charge on the activity of a kininogen-derived peptide on lipid membranes and bacteria.","volume":"1768","author":"L Ringstad","year":"2007","journal-title":"Biochim Biophys Acta"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T11:24:50Z","timestamp":1588850690000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000116"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,8,1]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000116","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,1]]}}}