{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:49:33Z","timestamp":1791280173816,"version":"4.1.0"},"reference-count":99,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T00:00:00Z","timestamp":1224201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000175","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T21:37:58Z","timestamp":1224193078000},"page":"e1000175","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":202,"title":["Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans"],"prefix":"10.1371","volume":"4","author":[{"given":"Eric A.","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti","family":"Kawli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Wah","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1128\/9781555817671","article-title":"The innate immune response to infection.","author":"SHE Kaufmann","year":"2004"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition.","volume":"20","author":"CA Janeway Jr.","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: a renewed sense of self.","volume":"296","author":"P Matzinger","year":"2002","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0952-7915(99)80003-X","article-title":"The Toll-receptor family and control of innate immunity.","volume":"11","author":"EB Kopp","year":"1999","journal-title":"Curr Opin Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0952-7915(99)00045-X","article-title":"Toll signaling pathways in the innate immune response.","volume":"12","author":"KV Anderson","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0960-9822(01)00241-X","article-title":"A reverse genetic analysis of components of the Toll signaling pathway in <italic>Caenorhabditis elegans<\/italic>.","volume":"11","author":"N Pujol","year":"2001","journal-title":"Curr Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"14086","DOI":"10.1073\/pnas.0603424103","article-title":"A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.","volume":"103","author":"M Shapira","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1371\/journal.pgen.0020183","article-title":"p38 MAPK regulates expression of immune response genes and contributes to longevity in <italic>C. elegans<\/italic>.","volume":"2","author":"ER Troemel","year":"2006","journal-title":"PLoS Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1101\/gr.50823006","article-title":"Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of <italic>C. elegans<\/italic> with <italic>M. nematophilum<\/italic>.","volume":"16","author":"D O'Rourke","year":"2006","journal-title":"Genome Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0960-9822(02)00928-4","article-title":"Inducible antibacterial defense system in <italic>C. elegans<\/italic>.","volume":"12","author":"GV Mallo","year":"2002","journal-title":"Curr Biol"},{"key":"ref11","first-page":"1","article-title":"Signaling in the immune response.","author":"JJ Ewbank","year":"2006","journal-title":"WormBook"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1462-5822.2005.00523.x","article-title":"<italic>Caenorhabditis elegans<\/italic> as a model for innate immunity to pathogens.","volume":"7","author":"MJ Gravato-Nobre","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1073759","article-title":"A conserved p38 MAP kinase pathway in <italic>Caenorhabditis elegans<\/italic> innate immunity.","volume":"297","author":"DH Kim","year":"2002","journal-title":"Science"},{"key":"ref14","first-page":"96","article-title":"Genetic and genomic dissection of host-pathogen interactions using a <italic>P. aeruginosa-C. elegans<\/italic> pathogenesis model.","volume":"31","author":"M-W Tan","year":"2001","journal-title":"Pediatric Pulmonol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.1080147","article-title":"Long-lived <italic>C. elegans daf-2<\/italic> mutants are resistant to bacterial pathogens.","volume":"300","author":"DA Garsin","year":"2003","journal-title":"Science"},{"key":"ref16","article-title":"Genes that act downstream of DAF-16 to influence the lifespan of <italic>Caenorhabditis elegans<\/italic>.","author":"CT Murphy","year":"2003","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1073\/pnas.96.26.15020","article-title":"Identification of transforming growth factor-beta- regulated genes in caenorhabditis elegans by differential hybridization of arrayed cDNAs.","volume":"96","author":"M Mochii","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/bj3610221","article-title":"<italic>abf-1<\/italic> and <italic>abf-2<\/italic>, ASABF-type antimicrobial peptide genes in <italic>Caenorhabditis elegans<\/italic>.","volume":"361","author":"Y Kato","year":"2002","journal-title":"Biochem J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-4838(98)00237-4","article-title":"Amoebapore homologs of <italic>Caenorhabditis elegans<\/italic>.","volume":"1429","author":"L Banyai","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1462-5822.2008.01124.x","article-title":"Resistance to antimicrobial peptides contributes to persistence of <italic>Salmonella typhimurium<\/italic> in the <italic>C. elegans<\/italic> intestine.","volume":"10","author":"RA Alegado","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/gb-2007-8-9-r194","article-title":"Genome-wide investigation reveals pathogen-specific and shared signatures in the response of <italic>Caenorhabditis elegans<\/italic> to infection.","volume":"8","author":"D Wong","year":"2007","journal-title":"Genome Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni1060","article-title":"TLR-independent control of innate immunity in <italic>Caenorhabditis elegans<\/italic> by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.","volume":"5","author":"C Couillault","year":"2004","journal-title":"Nat Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1371\/journal.pone.0000077","article-title":"GATA transcription factor required for immunity to bacterial and fungal pathogens.","volume":"1","author":"S Kerry","year":"2006","journal-title":"PLoS ONE"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/21548331.1976.11706983","article-title":"Pseudomonas: the compromised host.","volume":"11","author":"RE Wood","year":"1976","journal-title":"Hosp Pract"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1128\/CMR.17.1.57-71.2004","article-title":"Infection control in cystic fibrosis.","volume":"17","author":"L Saiman","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/CMR.15.2.194-222.2002","article-title":"Lung infections associated with cystic fibrosis.","volume":"15","author":"JB Lyczak","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2958.1997.3291701.x","article-title":"The global activator GacA of <italic>Pseudomonas aeruginosa<\/italic> PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase.","volume":"24","author":"C Reimmann","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1073\/pnas.97.16.8815","article-title":"Plants and animals share functionally common bacterial virulence factors.","volume":"97","author":"LG Rahme","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0065-2911(08)60306-9","article-title":"Occurrence, biochemistry and physiology of phenazine pigment production.","volume":"27","author":"JM Turner","year":"1986","journal-title":"Adv Microb Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.molmed.2004.10.002","article-title":"The role of pyocyanin in <italic>Pseudomonas aeruginosa<\/italic> infection.","volume":"10","author":"GW Lau","year":"2004","journal-title":"Trends Mol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1172\/JCI109138","article-title":"The effect of complement depletion on lung clearance of bacteria.","volume":"62","author":"GN Gross","year":"1978","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0090-1229(92)90065-V","article-title":"Effect of <italic>Pseudomonas aeruginosa<\/italic> elastase and alkaline protease on serum complement and isolated components C1q and C3.","volume":"62","author":"YQ Hong","year":"1992","journal-title":"Clin Immunol Immunopathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0882-4010(02)00197-3","article-title":"Elastase-producing <italic>Pseudomonas aeruginosa<\/italic> degrade plasma proteins and extracellular products of human skin and fibroblasts, and inhibit fibroblast growth.","volume":"34","author":"A Schmidtchen","year":"2003","journal-title":"Microb Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1073\/pnas.0307553101","article-title":"<italic>Pseudomonas aeruginosa<\/italic> regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients.","volume":"101","author":"MC Wolfgang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1128\/JB.187.15.5267-5277.2005","article-title":"Cystic fibrosis sputum supports growth and cues key aspects of <italic>Pseudomonas aeruginosa<\/italic> physiology.","volume":"187","author":"KL Palmer","year":"2005","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1073\/pnas.0409588102","article-title":"Profiling early infection responses: <italic>Pseudomonas aeruginosa<\/italic> eludes host defenses by suppressing antimicrobial peptide gene expression.","volume":"102","author":"Y Apidianakis","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1242\/dev.02185","article-title":"Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in <italic>C. elegans<\/italic>.","volume":"133","author":"F Pauli","year":"2006","journal-title":"Development"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1126\/science.1062013","article-title":"Common and contrasting themes of plant and animal diseases.","volume":"292","author":"BJ Staskawicz","year":"2001","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1128\/MCB.02070-06","article-title":"Specificity and complexity of the <italic>Caenorhabditis elegans<\/italic> innate immune response.","volume":"27","author":"S Alper","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1126\/science.7604262","article-title":"Common virulence factors for bacterial pathogenicity in plants and animals.","volume":"268","author":"LG Rahme","year":"1995","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"13245","DOI":"10.1073\/pnas.94.24.13245","article-title":"Use of model plant hosts to identify <italic>Pseudomonas aeruginosa<\/italic> virulence factors.","volume":"94","author":"LG Rahme","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1073\/pnas.96.5.2408","article-title":"<italic>Pseudomonas aeruginosa<\/italic> killing of <italic>Caenorhabditis elegans<\/italic> used to identify <italic>P. aeruginosa<\/italic> virulence factors.","volume":"96","author":"MW Tan","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.micro.60.080805.142251","article-title":"Subterfuge and manipulation: type III effector proteins of phytopathogenic bacteria.","volume":"60","author":"SR Grant","year":"2006","journal-title":"Annu Rev Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1371\/journal.ppat.0030003","article-title":"Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems.","volume":"3","author":"A Angot","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/mpat.2002.0504","article-title":"Role and activation of type III secretion system genes in <italic>Pseudomonas aeruginosa<\/italic>-induced Drosophila killing.","volume":"32","author":"MO Fauvarque","year":"2002","journal-title":"Microb Pathog"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1128\/IAI.71.5.2404-2413.2003","article-title":"Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in <italic>Pseudomonas aeruginosa<\/italic> pathogenesis.","volume":"71","author":"S Miyata","year":"2003","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00003246-200203000-00005","article-title":"Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by <italic>Pseudomonas aeruginosa<\/italic>.","volume":"30","author":"AR Hauser","year":"2002","journal-title":"Crit Care Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1128\/IAI.73.3.1695-1705.2005","article-title":"Activities of <italic>Pseudomonas aeruginosa<\/italic> effectors secreted by the Type III secretion system in vitro and during infection.","volume":"73","author":"VT Lee","year":"2005","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1128\/JB.187.11.3898-3902.2005","article-title":"Quorum sensing negatively controls type III secretion regulon expression in <italic>Pseudomonas aeruginosa<\/italic> PAO1.","volume":"187","author":"S Bleves","year":"2005","journal-title":"J Bacteriol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2958.2006.05412.x","article-title":"Transcriptional regulation of the <italic>Pseudomonas aeruginosa<\/italic> type III secretion system.","volume":"62","author":"TL Yahr","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.femsle.2004.11.018","article-title":"The <italic>Pseudomonas aeruginosa<\/italic> PA14 type III secretion system is expressed but not essential to virulence in the <italic>Caenorhabditis elegans<\/italic>-<italic>P. aeruginosa<\/italic> pathogenicity model.","volume":"242","author":"DW Wareham","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6026","DOI":"10.1128\/JB.00409-06","article-title":"Two GacA-dependent small RNAs modulate the quorum-sensing response in <italic>Pseudomonas aeruginosa<\/italic>.","volume":"188","author":"E Kay","year":"2006","journal-title":"J Bacteriol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-1097(03)00849-8","article-title":"Dueling quorum sensing systems in <italic>Pseudomonas aeruginosa<\/italic> control the production of the Pseudomonas quinolone signal (PQS).","volume":"230","author":"S McGrath","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1128\/JB.187.13.4372-4380.2005","article-title":"Regulation of Pseudomonas quinolone signal synthesis in <italic>Pseudomonas aeruginosa<\/italic>.","volume":"187","author":"DS Wade","year":"2005","journal-title":"J Bacteriol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.1128\/JB.184.23.6481-6489.2002","article-title":"Autolysis and autoaggregation in <italic>Pseudomonas aeruginosa<\/italic> colony morphology mutants.","volume":"184","author":"DA D'Argenio","year":"2002","journal-title":"J Bacteriol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1515\/BC.2007.100","article-title":"PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by <italic>Pseudomonas aeruginosa<\/italic> and Burkholderia thailandensis.","volume":"388","author":"F Lepine","year":"2007","journal-title":"Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/JB.01140-07","article-title":"<italic>Pseudomonas aeruginosa<\/italic> PqsA is an anthranilate-coenzyme A ligase.","volume":"190","author":"JP Coleman","year":"2008","journal-title":"J Bacteriol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1128\/JB.185.7.2066-2079.2003","article-title":"Identification, timing, and signal specificity of <italic>Pseudomonas aeruginosa<\/italic> quorum-controlled genes: a transcriptome analysis.","volume":"185","author":"M Schuster","year":"2003","journal-title":"J Bacteriol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1128\/JB.185.7.2080-2095.2003","article-title":"Microarray analysis of <italic>Pseudomonas aeruginosa<\/italic> quorum-sensing regulons: effects of growth phase and environment.","volume":"185","author":"VE Wagner","year":"2003","journal-title":"J Bacteriol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"44533","DOI":"10.1074\/jbc.M406207200","article-title":"Shared transcriptional signature in <italic>Caenorhabditis elegans<\/italic> Dauer larvae and long-lived <italic>daf-2<\/italic> mutants implicates detoxification system in longevity assurance.","volume":"279","author":"JJ McElwee","year":"2004","journal-title":"J Biol Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e1000105","DOI":"10.1371\/journal.ppat.1000105","article-title":"Anti-fungal innate immunity in <italic>C. elegans<\/italic> is enhanced by evolutionary diversification of antimicrobial peptides.","volume":"4","author":"N Pujol","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/382536a0","article-title":"A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in <italic>Caenorhabditis elegans<\/italic>.","volume":"382","author":"JZ Morris","year":"1996","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"49591","DOI":"10.1074\/jbc.M207866200","article-title":"Insulin receptor substrate and p55 orthologous adaptor proteins function in the <italic>Caenorhabditis elegans daf-2<\/italic>\/insulin-like signaling pathway.","volume":"277","author":"CA Wolkow","year":"2002","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1101\/gad.13.11.1438","article-title":"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in <italic>Caenorhabditis elegans<\/italic>.","volume":"13","author":"S Paradis","year":"1999","journal-title":"Genes Dev"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1101\/gad.12.16.2488","article-title":"<italic>Caenorhabditis elegans<\/italic> Akt\/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.","volume":"12","author":"S Paradis","year":"1998","journal-title":"Genes Dev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1534-5807(04)00095-4","article-title":"<italic>C. elegans<\/italic> SGK-1 is the critical component in the Akt\/PKB kinase complex to control stress response and life span.","volume":"6","author":"M Hertweck","year":"2004","journal-title":"Dev Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/S0960-9822(01)00595-4","article-title":"Regulation of <italic>C. elegans<\/italic> DAF-16 and its human ortholog FKHRL1 by the <italic>daf-2<\/italic> insulin-like signaling pathway.","volume":"11","author":"RY Lee","year":"2001","journal-title":"Curr Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/88850","article-title":"Regulation of the <italic>Caenorhabditis elegans<\/italic> longevity protein DAF-16 by insulin\/IGF-1 and germline signaling.","volume":"28","author":"K Lin","year":"2001","journal-title":"Nat Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1474-9728.2003.00043.x","article-title":"Transcriptional outputs of the <italic>Caenorhabditis elegans<\/italic> forkhead protein DAF-16.","volume":"2","author":"J McElwee","year":"2003","journal-title":"Aging Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bj3490629","article-title":"Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.","volume":"349","author":"T Furuyama","year":"2000","journal-title":"Biochem J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1096\/fasebj.13.11.1385","article-title":"The <italic>daf-2<\/italic> gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in <italic>Caenorhabditis elegans<\/italic>.","volume":"13","author":"Y Honda","year":"1999","journal-title":"Faseb J"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0891-5849(03)00102-3","article-title":"A stress-responsive glutathione S-transferase confers resistance to oxidative stress in <italic>Caenorhabditis elegans<\/italic>.","volume":"34","author":"B Leiers","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0960-9822(01)00594-2","article-title":"<italic>daf-16<\/italic> integrates developmental and environmental inputs to mediate aging in the nematode <italic>Caenorhabditis elegans<\/italic>.","volume":"11","author":"ST Henderson","year":"2001","journal-title":"Curr Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/20694","article-title":"Signals from the reproductive system regulate the lifespan of <italic>C. elegans<\/italic>.","volume":"399","author":"H Hsin","year":"1999","journal-title":"Nature"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1126\/science.1083701","article-title":"Regulation of aging and age-related disease by DAF-16 and heat-shock factor.","volume":"300","author":"AL Hsu","year":"2003","journal-title":"Science"},{"key":"ref76","first-page":"429","article-title":"Genetic analysis of <italic>Caenorhabditis elegans<\/italic> innate immunity.","volume":"415","author":"M Shapira","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cell.2006.01.039","article-title":"Germ-cell loss extends <italic>C. elegans<\/italic> life span through regulation of DAF-16 by <italic>kri-1<\/italic> and lipophilic-hormone signaling.","volume":"124","author":"JR Berman","year":"2006","journal-title":"Cell"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.277.5328.942","article-title":"<italic>daf-2<\/italic>, an insulin receptor-like gene that regulates longevity and diapause in <italic>Caenorhabditis elegans<\/italic>.","volume":"277","author":"KD Kimura","year":"1997","journal-title":"Science"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1101\/gad.867301","article-title":"Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse <italic>C. elegans<\/italic> insulin gene family.","volume":"15","author":"SB Pierce","year":"2001","journal-title":"Genes Dev"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"19046","DOI":"10.1073\/pnas.0709613104","article-title":"Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of <italic>Caenorhabditis elegans<\/italic>.","volume":"104","author":"CT Murphy","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref81","article-title":"DAF-16-Dependent Suppression of Immunity during Reproduction in <italic>C. elegans<\/italic>.","author":"S Miyata","year":"2008","journal-title":"Genetics"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1073\/pnas.96.2.715","article-title":"Killing of <italic>Caenorhabditis elegans<\/italic> by <italic>Pseudomonas aeruginosa<\/italic> used to model mammalian bacterial pathogenesis.","volume":"96","author":"MW Tan","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1085\/jgp.200509355","article-title":"Oscillatory Ca2+ signaling in the isolated <italic>Caenorhabditis elegans<\/italic> intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma.","volume":"126","author":"MV Espelt","year":"2005","journal-title":"J Gen Physiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gene.2007.06.020","article-title":"Establishment of a tissue-specific RNAi system in <italic>C. elegans<\/italic>.","volume":"400","author":"H Qadota","year":"2007","journal-title":"Gene"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/jphysiol.2006.124883","article-title":"CRAC channel activity in <italic>C. elegans<\/italic> is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.","volume":"580","author":"C Lorin-Nebel","year":"2007","journal-title":"J Physiol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0012-1606(80)90475-3","article-title":"Mutants with altered muscle structure of <italic>Caenorhabditis elegans<\/italic>.","volume":"77","author":"RH Waterston","year":"1980","journal-title":"Dev Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cub.2008.02.079","article-title":"Distinct innate immune responses to infection and wounding in the <italic>C. elegans<\/italic> epidermis.","volume":"18","author":"N Pujol","year":"2008","journal-title":"Curr Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/45544","article-title":"Regulation of lifespan by sensory perception in <italic>Caenorhabditis elegans<\/italic>.","volume":"402","author":"J Apfeld","year":"1999","journal-title":"Nature"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1073\/pnas.96.13.7394","article-title":"Neurosecretory control of aging in <italic>Caenorhabditis elegans<\/italic>.","volume":"96","author":"M Ailion","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.2006412","article-title":"Control of larval development by chemosensory neurons in <italic>Caenorhabditis elegans<\/italic>.","volume":"251","author":"CI Bargmann","year":"1991","journal-title":"Science"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1462-5822.2007.00944.x","article-title":"Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions.","volume":"9","author":"P He","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cell.2005.12.042","article-title":"SMK-1, an essential regulator of DAF-16-mediated longevity.","volume":"124","author":"S Wolff","year":"2006","journal-title":"Cell"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cell.2008.01.030","article-title":"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in <italic>C. elegans<\/italic>.","volume":"132","author":"JM Tullet","year":"2008","journal-title":"Cell"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.1065768","article-title":"Regulation of life-span by germ-line stem cells in <italic>Caenorhabditis elegans<\/italic>.","volume":"295","author":"N Arantes-Oliveira","year":"2002","journal-title":"Science"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1748-1716.2007.01780.x","article-title":"FOXO transcription factors in ageing and cancer.","volume":"192","author":"EL Greer","year":"2008","journal-title":"Acta Physiol (Oxf)"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of <italic>Caenorhabditis elegans<\/italic>.","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gkl1019","article-title":"The Stanford Microarray Database: implementation of new analysis tools and open source release of software.","volume":"35","author":"J Demeter","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"P11","DOI":"10.1186\/gb-2004-5-5-p11","article-title":"AutoPrime: selecting primers for expressed sequences.","volume":"5","author":"G Wrobel","year":"2004","journal-title":"Genome Biology"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.devcel.2006.12.002","article-title":"RLE-1, an E3 ubiquitin ligase, regulates <italic>C. elegans<\/italic> aging by catalyzing DAF-16 polyubiquitination.","volume":"12","author":"W Li","year":"2007","journal-title":"Dev Cell"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T23:03:14Z","timestamp":1632006194000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000175"}},"subtitle":[],"editor":[{"given":"Frederick M.","family":"Ausubel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,10,17]]},"references-count":99,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000175","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,17]]}}}