{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:52:02Z","timestamp":1791298322141,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T00:00:00Z","timestamp":1238112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000355","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T22:47:30Z","timestamp":1238107650000},"page":"e1000355","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":96,"title":["Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes"],"prefix":"10.1371","volume":"5","author":[{"given":"Silvia","family":"Stockinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kernbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Westermayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Reutterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Soulat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Stengl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Frenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Waibler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadatsugu","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"R\u00fclicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kalinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors.","volume":"202","author":"S Pestka","year":"2004","journal-title":"Immunol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling.","volume":"4","author":"S Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri1684","article-title":"The yin and yang of type I interferon activity in bacterial infection.","volume":"5","author":"T Decker","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature04946","article-title":"Intracellular pattern recognition receptors in the host response.","volume":"442","author":"E Meylan","year":"2006","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.molmed.2005.07.006","article-title":"Interferon gene regulation: not all roads lead to Tolls.","volume":"11","author":"CA Jefferies","year":"2005","journal-title":"Trends Mol Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/j.1462-5822.2007.00965.x","article-title":"How important are Toll-like receptors for antimicrobial responses?","volume":"9","author":"S Carpenter","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/sj.icb.7100099","article-title":"The role of type I interferons in TLR responses.","volume":"85","author":"SJ Noppert","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature06013","article-title":"DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.","volume":"448","author":"A Takaoka","year":"2007","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.","volume":"6","author":"K Honda","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact.","volume":"3","author":"DE Levy","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0952-7915(02)00011-0","article-title":"Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.","volume":"15","author":"DE Levy","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nri1845","article-title":"Dendritic cells in a mature age.","volume":"6","author":"C Reis e Sousa","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2005.05.008","article-title":"Plasmacytoid dendritic cells\u2014virus experts of innate immunity.","volume":"17","author":"W Barchet","year":"2005","journal-title":"Semin Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.4049\/jimmunol.177.9.5785","article-title":"Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.","volume":"177","author":"K Matsui","year":"2006","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.R700009200","article-title":"Toll-like receptors and Type I interferons.","volume":"282","author":"S Uematsu","year":"2007","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"17005","DOI":"10.1074\/jbc.M412584200","article-title":"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.","volume":"280","author":"A Schoenemeyer","year":"2005","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature03308","article-title":"Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.","volume":"434","author":"A Takaoka","year":"2005","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1073\/pnas.0607181103","article-title":"Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.","volume":"103","author":"H Negishi","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/eji.200637009","article-title":"TLR pathways and IFN-regulatory factors: to each its own.","volume":"37","author":"M Colonna","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/eji.200636767","article-title":"Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.","volume":"37","author":"F Schmitz","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1128\/CMR.14.3.584-640.2001","article-title":"Listeria pathogenesis and molecular virulence determinants.","volume":"14","author":"JA Vazquez-Boland","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection.","volume":"200","author":"RM O'Connell","year":"2004","journal-title":"J Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.","volume":"200","author":"V Auerbuch","year":"2004","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20040769","article-title":"Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.","volume":"200","author":"JA Carrero","year":"2004","journal-title":"J Exp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.imbio.2008.07.020","article-title":"Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes.","volume":"213","author":"S Stockinger","year":"2008","journal-title":"Immunobiology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.it.2006.09.005","article-title":"Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens.","volume":"27","author":"JA Carrero","year":"2006","journal-title":"Trends Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrmicro1413","article-title":"Listeria monocytogenes: a multifaceted model.","volume":"4","author":"M Hamon","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.micinf.2007.05.005","article-title":"Listeriolysin O: a phagosome-specific lysin.","volume":"9","author":"P Schnupf","year":"2007","journal-title":"Microbes Infect"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.4049\/jimmunol.173.12.7416","article-title":"IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism.","volume":"173","author":"S Stockinger","year":"2004","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0167-5699(98)01319-X","article-title":"Neutrophil-Kupffer cell interaction in host defenses to systemic infections.","volume":"19","author":"SH Gregory","year":"1998","journal-title":"Immunol Today"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.4049\/jimmunol.169.11.6522","article-title":"Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes.","volume":"169","author":"S Stockinger","year":"2002","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2008.03.011","article-title":"Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.","volume":"28","author":"M Prinz","year":"2008","journal-title":"Immunity"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice.","volume":"8","author":"BE Clausen","year":"1999","journal-title":"Transgenic Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1084\/jem.20011666","article-title":"Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo.","volume":"195","author":"W Barchet","year":"2002","journal-title":"J Exp Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1074-7613(01)00126-1","article-title":"Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.","volume":"14","author":"A Le Bon","year":"2001","journal-title":"Immunity"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ni978","article-title":"Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon.","volume":"4","author":"A Le Bon","year":"2003","journal-title":"Nat Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.4049\/jimmunol.169.4.1665","article-title":"Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.","volume":"169","author":"MA Freudenberg","year":"2002","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.immuni.2008.09.017","article-title":"Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.","volume":"29","author":"SJ Kang","year":"2008","journal-title":"Immunity"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.immuni.2008.06.013","article-title":"Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells.","volume":"29","author":"T Aoshi","year":"2008","journal-title":"Immunity"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses.","volume":"434","author":"K Honda","year":"2005","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.immuni.2007.07.013","article-title":"Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.","volume":"27","author":"Y Kumagai","year":"2007","journal-title":"Immunity"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"18651","DOI":"10.1074\/jbc.M501289200","article-title":"Tissue-specific positive feedback requirements for production of type l interferon following virus infection.","volume":"280","author":"A Prakash","year":"2005","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"20416","DOI":"10.1073\/pnas.0808537105","article-title":"Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.","volume":"105","author":"S Scheu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1000208","DOI":"10.1371\/journal.ppat.1000208","article-title":"Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.","volume":"4","author":"G Fejer","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1462-5822.2006.00700.x","article-title":"Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes.","volume":"8","author":"MA Tam","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.4049\/jimmunol.178.5.3126","article-title":"Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria.","volume":"178","author":"G Mancuso","year":"2007","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(92)90188-I","article-title":"L. monocytogenes\u2013induced actin assembly requires the actA gene product, a surface protein.","volume":"68","author":"C Kocks","year":"1992","journal-title":"Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1258\/0023677021911740","article-title":"Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units.","volume":"36","author":"W Nicklas","year":"2002","journal-title":"Lab Anim"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.4049\/jimmunol.134.4.2658","article-title":"In vitro natural cell-mediated cytotoxicity against Candida albicans: macrophage precursors as effector cells.","volume":"134","author":"M Baccarini","year":"1985","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1462-5822.2007.01114.x","article-title":"Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence.","volume":"10","author":"B Reutterer","year":"2008","journal-title":"Cell Microbiol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T16:48:34Z","timestamp":1684946914000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000355"}},"subtitle":[],"editor":[{"given":"Dana J.","family":"Philpott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,3,27]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000355","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,27]]}}}