{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:16:58Z","timestamp":1791397018545,"version":"4.3.3"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T00:00:00Z","timestamp":1238716800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000359","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T22:19:15Z","timestamp":1238710755000},"page":"e1000359","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Anthrax Lethal Toxin Impairs IL-8 Expression in Epithelial Cells through Inhibition of Histone H3 Modification"],"prefix":"10.1371","volume":"5","author":[{"given":"Benoit","family":"Raymond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Batsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Boutillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Leduc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Balloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00efse","family":"Raoust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Muchardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre L.","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lhousseine","family":"Touqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","article-title":"Anthrax.","volume":"55","author":"M Mock","year":"2001","journal-title":"Annu Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/infdis\/115.5.481","article-title":"Role of the lymphatics in the pathogenesis of anthrax.","volume":"115","author":"RE Lincoln","year":"1965","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/path.1700730219","article-title":"The pathogenesis of anthrax following the administration of spores by the respiratory route.","volume":"73","author":"JM Ross","year":"1957","journal-title":"J Pathol Bacteriol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0264-410X(91)90237-Z","article-title":"Anthrax vaccines: past, present and future.","volume":"9","author":"PC Turnbull","year":"1991","journal-title":"Vaccine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-5793(92)80909-Z","article-title":"Interleukin-8, a chemotactic and inflammatory cytokine.","volume":"307","author":"M Baggiolini","year":"1992","journal-title":"FEBS Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression.","volume":"72","author":"E Hoffmann","year":"2002","journal-title":"J Leukoc Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications.","volume":"403","author":"BD Strahl","year":"2000","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1093\/emboj\/18.17.4779","article-title":"The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3\/HMG-14 kinase.","volume":"18","author":"S Thomson","year":"1999","journal-title":"EMBO J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1093\/emboj\/19.14.3714","article-title":"Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation.","volume":"19","author":"AL Clayton","year":"2000","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1242\/jcs.114.19.3433","article-title":"The nucleus, a site for signal termination by sequestration and inactivation of p42\/p44 MAP kinases.","volume":"114","author":"V Volmat","year":"2001","journal-title":"J Cell Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.it.2006.07.002","article-title":"Anthrax toxins: A paradigm of bacterial immune suppression.","volume":"27","author":"CT Baldari","year":"2006","journal-title":"Trends Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1473-3099(04)00940-5","article-title":"Immune system paralysis by anthrax lethal toxin: the roles of innate and adaptive immunity.","volume":"4","author":"T Fukao","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1371\/journal.ppat.0030187","article-title":"Edema Toxin impairs Anthracidal Phospholipase A2 Expression by Alveolar Macrophages.","volume":"3","author":"B Raymond","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","article-title":"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.","volume":"280","author":"NS Duesbery","year":"1998","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1998.9040","article-title":"Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine\/threonine phosphorylation of MAPKs in cultured macrophages.","volume":"248","author":"G Vitale","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1128\/IAI.72.11.6382-6389.2004","article-title":"Cytokine response to infection with <italic>Bacillus anthracis<\/italic> spores.","volume":"72","author":"AK Pickering","year":"2004","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1128\/IAI.00446-06","article-title":"<italic>Bacillus anthracis<\/italic> spores stimulate cytokine and chemokine innate immune responses in human alveolar macrophages through multiple mitogen-activated protein kinase pathways.","volume":"74","author":"K Chakrabarty","year":"2006","journal-title":"Infect immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.4049\/jimmunol.174.8.4934","article-title":"Anthrax edema toxin cooperates with lethal toxin to impair cytokine production during infection of dendritic cells.","volume":"174","author":"JN Tournier","year":"2005","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0092-8674(00)81063-6","article-title":"Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.","volume":"84","author":"JE Brownell","year":"1996","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0092-8674(91)90385-C","article-title":"Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors.","volume":"65","author":"LC Mahadevan","year":"1991","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni748","article-title":"p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment.","volume":"3","author":"S Saccani","year":"2002","journal-title":"Nat Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1093\/emboj\/cdg273","article-title":"MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.","volume":"22","author":"A Soloaga","year":"2003","journal-title":"EMBO J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-5793(03)00451-4","article-title":"MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation.","volume":"546","author":"AL Clayton","year":"2003","journal-title":"FEBS Lett"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ni1423","article-title":"An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses.","volume":"8","author":"L Arbibe","year":"2007","journal-title":"Nat Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1462-5822.2005.00606.x","article-title":"Inhibition of mitogen-activated protein kinase signaling by <italic>Bacillus anthracis<\/italic> lethal causes destabilization of interleukin-8 mRNA.","volume":"8","author":"S Batty","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1462-5822.2007.01098.x","article-title":"Potential dissemination of Bacillus anthracis utilizing human lung epithelial cells.","volume":"10","author":"BH Russell","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1128\/IAI.00282-08","article-title":"<italic>In vivo<\/italic> demonstration and quantification of intracellular Bacillus anthracis in lung epithelial cells.","volume":"76","author":"BH Russell","year":"2008","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1371\/journal.ppat.0030076","article-title":"Primary involvement of pharynx and peyer&apos;s patch in inhalational and intestinal anthrax.","volume":"3","author":"IJ Glomski","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.micinf.2008.07.042","article-title":"Inhaled non-capsulated Bacillus anthracis in A\/J mice: nasopharynx and alveolar space as dual portals of entry, delayed dissemination, and specific organ targeting.","volume":"10","author":"IJ Glomski","year":"2008","journal-title":"Microbes Infect"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/IAI.00985-07","article-title":"Detection of Bacillus anthracis spore germination in vivo by bioluminescence imaging.","volume":"76","author":"P Sanz","year":"2008","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/IAI.00633-08","article-title":"Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model.","volume":"77","author":"CL Loving","year":"2009","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1128\/IAI.00046-07","article-title":"Human lung innate immune response to <italic>Bacillus anthracis<\/italic> spore infection.","volume":"75","author":"K Chakrabarty","year":"2007","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"C1402","DOI":"10.1152\/ajpcell.00582.2004","article-title":"ATR\/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis&apos; three sites of entry: implications for the pathogenesis of anthrax infection.","volume":"288","author":"G Bonuccelli","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1128\/IAI.68.12.7010-7017.2000","article-title":"Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease.","volume":"68","author":"E Cario","year":"2000","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1183\/09031936.00141005","article-title":"Legionella pneumophila-induced NF-kappaB- and MAPK-dependent cytokine release by lung epithelial cells.","volume":"29","author":"B Schmeck","year":"2007","journal-title":"Eur Respir J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1128\/IAI.74.1.469-480.2006","article-title":"Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection.","volume":"74","author":"CK Cote","year":"2006","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1128\/IAI.59.10.3472-3477.1991","article-title":"Contribution of individual toxin components to virulence of Bacillus anthracis.","volume":"59","author":"C Pezard","year":"1991","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1128\/IAI.73.9.5420-5425.2005","article-title":"Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.","volume":"73","author":"V Balloy","year":"2005","journal-title":"Infect Immun"},{"key":"ref39","first-page":"L134","article-title":"Isolation and culture of alveolar type II cells.","volume":"258","author":"LG Dobbs","year":"1990","journal-title":"Am J Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1165\/ajrcmb.14.4.8600933","article-title":"Isolation and primary culture of murine alveolar type II cells.","volume":"14","author":"M Corti","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/intimm\/12.5.613","article-title":"<italic>In vivo<\/italic> identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB\/Rel complexes.","volume":"12","author":"J Feuillard","year":"2000","journal-title":"Int Immunol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T09:55:57Z","timestamp":1710237357000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000359"}},"subtitle":[],"editor":[{"given":"Steven R.","family":"Blanke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,4,3]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000359","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,3]]}}}