{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:51:44Z","timestamp":1790481104257,"version":"4.1.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T00:00:00Z","timestamp":1254441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000607","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T18:07:09Z","timestamp":1254420429000},"page":"e1000607","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":118,"title":["Induction of IFN-\u03b2 and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7"],"prefix":"10.1371","volume":"5","author":[{"given":"Stephane","family":"Daffis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul S.","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy J.","family":"Szretter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.cyto.2008.07.009","article-title":"Innate immune response to viral infection.","volume":"43","author":"S Koyama","year":"2008","journal-title":"Cytokine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1084\/jem.20061377","article-title":"Antiviral defense: interferons and beyond.","volume":"203","author":"DB Stetson","year":"2006","journal-title":"J Exp Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense.","volume":"25","author":"DB Stetson","year":"2006","journal-title":"Immunity"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10156-008-0596-1","article-title":"Pathogen recognition by innate receptors.","volume":"14","author":"Y Kumagai","year":"2008","journal-title":"J Infect Chemother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-065X.2007.00562.x","article-title":"Recognition of viruses by innate immunity.","volume":"220","author":"O Takeuchi","year":"2007","journal-title":"Immunol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.coi.2008.01.002","article-title":"MDA5\/RIG-I and virus recognition.","volume":"20","author":"O Takeuchi","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.","volume":"25","author":"K Honda","year":"2006","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/intimm\/dxh318","article-title":"Regulation of the type I IFN induction: a current view.","volume":"17","author":"K Honda","year":"2005","journal-title":"Int Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.","volume":"6","author":"K Honda","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1073\/pnas.0607038104","article-title":"IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.","volume":"104","author":"DJ Lenschow","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.biochi.2007.03.006","article-title":"ISG20, an actor of the innate immune response.","volume":"89","author":"G Degols","year":"2007","journal-title":"Biochimie"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.1128\/JVI.01282-07","article-title":"Identification and characterization of interferon-induced proteins that inhibit alphavirus replication.","volume":"81","author":"Y Zhang","year":"2007","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1128\/JVI.00489-06","article-title":"PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.","volume":"80","author":"MA Samuel","year":"2006","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses.","volume":"434","author":"K Honda","year":"2005","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1128\/JVI.80.6.2913-2923.2006","article-title":"West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling.","volume":"80","author":"BL Fredericksen","year":"2006","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/JVI.01305-07","article-title":"Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1.","volume":"82","author":"BL Fredericksen","year":"2008","journal-title":"J Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1128\/JVI.00935-08","article-title":"Toll-like receptor 3 has a protective role against West Nile virus infection.","volume":"82","author":"S Daffis","year":"2008","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.immuni.2008.11.012","article-title":"Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing.","volume":"30","author":"T Town","year":"2009","journal-title":"Immunity"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.4049\/jimmunol.177.10.7114","article-title":"Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.","volume":"177","author":"JP Wang","year":"2006","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1084\/jem.20051720","article-title":"Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.","volume":"203","author":"T Querec","year":"2006","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1371\/journal.ppat.0030106","article-title":"Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.","volume":"3","author":"S Daffis","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1128\/JVI.00918-08","article-title":"Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection.","volume":"82","author":"S Daffis","year":"2008","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.sbi.2007.12.002","article-title":"The enhanceosome.","volume":"18","author":"D Panne","year":"2008","journal-title":"Curr Opin Struct Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2007.05.019","article-title":"An atomic model of the interferon-beta enhanceosome.","volume":"129","author":"D Panne","year":"2007","journal-title":"Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0092-8674(95)90136-1","article-title":"Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome.","volume":"83","author":"D Thanos","year":"1995","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"13350","DOI":"10.1128\/JVI.79.21.13350-13361.2005","article-title":"Alpha\/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival.","volume":"79","author":"MA Samuel","year":"2005","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.1128\/JVI.00316-07","article-title":"Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production.","volume":"81","author":"N Bourne","year":"2007","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/eji.200838814","article-title":"The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.","volume":"39","author":"C Steinberg","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1093\/emboj\/17.22.6660","article-title":"Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.","volume":"17","author":"I Marie","year":"1998","journal-title":"Embo J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0014-5793(98)01514-2","article-title":"Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7.","volume":"441","author":"M Sato","year":"1998","journal-title":"FEBS Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1128\/JVI.01122-06","article-title":"Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion.","volume":"80","author":"MA Samuel","year":"2006","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ana.20959","article-title":"West Nile virus neuroinvasive disease.","volume":"60","author":"LE Davis","year":"2006","journal-title":"Ann Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.virusres.2008.02.008","article-title":"DC-SIGN enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells induces production of IFN-alpha and TNF-alpha.","volume":"135","author":"BE Martina","year":"2008","journal-title":"Virus Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.","volume":"322","author":"K Hildner","year":"2008","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/eji.200636767","article-title":"Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.","volume":"37","author":"F Schmitz","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.immuni.2007.06.009","article-title":"The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.","volume":"27","author":"P Tailor","year":"2007","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction.","volume":"13","author":"M Sato","year":"2000","journal-title":"Immunity"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"14295","DOI":"10.1074\/jbc.M800501200","article-title":"Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response.","volume":"283","author":"A Paun","year":"2008","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"17005","DOI":"10.1074\/jbc.M412584200","article-title":"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.","volume":"280","author":"A Schoenemeyer","year":"2005","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"23382","DOI":"10.1074\/jbc.M101216200","article-title":"Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.","volume":"276","author":"BJ Barnes","year":"2001","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature03308","article-title":"Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.","volume":"434","author":"A Takaoka","year":"2005","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1073\/pnas.0611559104","article-title":"Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.","volume":"104","author":"H Yanai","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/bj3560525","article-title":"Inhibitor of nuclear factor-kappaB induction by cAMP antagonizes interleukin-1-induced human macrophage-colony-stimulating-factor expression.","volume":"356","author":"PJ Kamthong","year":"2001","journal-title":"Biochem J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/en.2004-0809","article-title":"Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.","volume":"146","author":"M Lappas","year":"2005","journal-title":"Endocrinology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri1865","article-title":"The many paths to p38 mitogen-activated protein kinase activation in the immune system.","volume":"6","author":"JD Ashwell","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.4049\/jimmunol.166.9.5688","article-title":"Endotoxin-induced maturation of MyD88-deficient dendritic cells.","volume":"166","author":"T Kaisho","year":"2001","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.4049\/jimmunol.164.8.4277","article-title":"TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C\/EBP beta.","volume":"164","author":"H Liu","year":"2000","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1038\/sj.emboj.7601220","article-title":"Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.","volume":"25","author":"SK Saha","year":"2006","journal-title":"Embo J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nature04374","article-title":"Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.","volume":"439","author":"G Oganesyan","year":"2006","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1074-7613(00)80497-5","article-title":"Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.","volume":"5","author":"Y Xu","year":"1996","journal-title":"Immunity"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1093\/emboj\/19.18.4976","article-title":"Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.","volume":"19","author":"M Bonnard","year":"2000","journal-title":"Embo J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"36211","DOI":"10.1074\/jbc.M806576200","article-title":"TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.","volume":"283","author":"R Yoshida","year":"2008","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.20051395","article-title":"Production of type I interferons: plasmacytoid dendritic cells and beyond.","volume":"202","author":"C Asselin-Paturel","year":"2005","journal-title":"J Exp Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.23.021704.115633","article-title":"IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.","volume":"23","author":"YJ Liu","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.","volume":"303","author":"SS Diebold","year":"2004","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0092-8674(05)80086-8","article-title":"Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.","volume":"75","author":"T Matsuyama","year":"1993","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1073\/pnas.90.24.11503","article-title":"Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.","volume":"90","author":"H Ruffner","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.cr.7310018","article-title":"IRF family proteins and type I interferon induction in dendritic cells.","volume":"16","author":"P Tailor","year":"2006","journal-title":"Cell Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1073\/pnas.0307336101","article-title":"Negative regulation of IFN-alpha\/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells.","volume":"101","author":"K Honda","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"15989","DOI":"10.1073\/pnas.0508327102","article-title":"Negative regulation of Toll-like-receptor signaling by IRF-4.","volume":"102","author":"H Negishi","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"820","DOI":"10.4049\/jimmunol.182.2.820","article-title":"TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.","volume":"182","author":"C Richez","year":"2009","journal-title":"J Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.4049\/jimmunol.178.11.6876","article-title":"Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.","volume":"178","author":"K Yasuda","year":"2007","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e1000500","DOI":"10.1371\/journal.ppat.1000500","article-title":"NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.","volume":"5","author":"AK Pandey","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1084\/jem.20060792","article-title":"Essential role of IPS-1 in innate immune responses against RNA viruses.","volume":"203","author":"H Kumar","year":"2006","journal-title":"J Exp Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/JVI.01080-07","article-title":"Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.","volume":"82","author":"YM Loo","year":"2008","journal-title":"J Virol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.4049\/jimmunol.179.7.4711","article-title":"Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.","volume":"179","author":"S Koyama","year":"2007","journal-title":"J Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.micinf.2005.06.014","article-title":"Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation.","volume":"8","author":"TH Chang","year":"2006","journal-title":"Microbes Infect"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1073\/pnas.0603082103","article-title":"Essential role of mda-5 in type I IFN responses to polyriboinosinic\u2236polyribocytidylic acid and encephalomyocarditis picornavirus.","volume":"103","author":"L Gitlin","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1084\/jem.20040528","article-title":"Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection.","volume":"199","author":"AK Perry","year":"2004","journal-title":"J Exp Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3201\/eid0704.017408","article-title":"Partial genetic characterization of West Nile virus strains, New York State, 2000.","volume":"7","author":"GD Ebel","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1128\/JVI.77.4.2578-2586.2003","article-title":"B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus.","volume":"77","author":"MS Diamond","year":"2003","journal-title":"J Virol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1089\/jir.2006.26.804","article-title":"Blocking monoclonal antibodies specific for mouse IFN-alpha\/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection.","volume":"26","author":"KC Sheehan","year":"2006","journal-title":"J Interferon Cytokine Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:00:53Z","timestamp":1588996853000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000607"}},"subtitle":[],"editor":[{"given":"Ganes","family":"Sen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,10,2]]},"references-count":73,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2009,10,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000607","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1165228.628169","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,2]]}}}