{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:11:28Z","timestamp":1792707088773,"version":"4.5.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000719","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T19:44:37Z","timestamp":1262893477000},"page":"e1000719","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":381,"title":["Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics"],"prefix":"10.1371","volume":"6","author":[{"given":"Deborah L.","family":"Diamond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Syder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie-Anne","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Proll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A.","family":"Gritsenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Katze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJM199212313272702","article-title":"The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team.","volume":"327","author":"MJ Alter","year":"1992","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.addr.2007.03.021","article-title":"Modulation of host metabolism as a target of new antivirals.","volume":"59","author":"M Ikeda","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.drudis.2007.01.009","article-title":"Emerging host cell targets for hepatitis C therapy.","volume":"12","author":"Y He","year":"2007","journal-title":"Drug Discov Today"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1371\/journal.ppat.0030108","article-title":"Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.","volume":"3","author":"J Ye","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1478-3231.2008.01950.x","article-title":"Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data.","volume":"S2","author":"F Negro","year":"2009","journal-title":"Liver Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1128\/JVI.77.7.4160-4168.2003","article-title":"Hepatitis C virus RNA replication occurs on a detergent-resistant membrane that cofractionates with caveolin 2.","volume":"77","author":"ST Shi","year":"2003","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1073\/pnas.0409834102","article-title":"Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids.","volume":"102","author":"SB Kapadia","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molcel.2005.04.004","article-title":"Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication.","volume":"18","author":"C Wang","year":"2005","journal-title":"Mol Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nchembio742","article-title":"Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.","volume":"1","author":"H Sakamoto","year":"2005","journal-title":"Nat Chem Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2006.05.085","article-title":"Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model.","volume":"346","author":"T Umehara","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ncb1631","article-title":"The lipid droplet is an important organelle for hepatitis C virus production.","volume":"9","author":"Y Miyanari","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1073\/pnas.0700760104","article-title":"Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low density lipoproteins.","volume":"104","author":"H Huang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1128\/JVI.02053-07","article-title":"Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion.","volume":"82","author":"P Gastaminza","year":"2008","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1074\/jbc.M706160200","article-title":"Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.","volume":"283","author":"H Yao","year":"2008","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/hep.22197","article-title":"Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin.","volume":"47","author":"Y Nahmias","year":"2008","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1128\/JVI.02530-07","article-title":"Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection.","volume":"82","author":"H Aizaki","year":"2008","journal-title":"J Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1000269","DOI":"10.1371\/journal.ppat.1000269","article-title":"Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes.","volume":"5","author":"KA Walters","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1114016","article-title":"Complete replication of hepatitis C virus in cell culture.","volume":"309","author":"BD Lindenbach","year":"2005","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1074\/mcp.M500045-MCP200","article-title":"Quantitative Proteome Analysis of Human Plasma following in Vivo Lipopolysaccharide Administration Using 16O\/18O Labeling and the Accurate Mass and Time Tag Approach.","volume":"4","author":"WJ Qian","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/hep.21751","article-title":"Proteomic Profiling of Human Liver Biopsies: Hepatitis C Virus-Induced Fibrosis and Mitochondrial Dysfunction.","volume":"46","author":"DL Diamond","year":"2007","journal-title":"Hepatology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1128\/JVI.79.12.7558-7569.2005","article-title":"Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients.","volume":"79","author":"JM Jacobs","year":"2005","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1021\/ac0011336","article-title":"Packed capillary reversed-phase liquid chromatography with high-performance electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for proteomics.","volume":"73","author":"Y Shen","year":"2001","journal-title":"Anal Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1021\/ac701727r","article-title":"Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses.","volume":"80","author":"EA Livesay","year":"2008","journal-title":"Anal Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1021\/ac070080q","article-title":"Capillary LC coupled with high-mass measurement accuracy mass spectrometry for metabolic profiling.","volume":"79","author":"J Ding","year":"2007","journal-title":"Anal Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/pmic.200500500","article-title":"PRISM: A data management system for high-throughput proteomics.","volume":"60","author":"GR Kiebel","year":"2006","journal-title":"Proteomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2105-10-87","article-title":"Decon2LS: An open-source software package for automated processing and visualization of high resolution Mass Spectrometry Data.","volume":"10","author":"N Jaitly","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1093\/bioinformatics\/btm281","article-title":"VIPER: an advanced software package to support high-throughput LC-MS peptide identification.","volume":"23","author":"ME Monroe","year":"2007","journal-title":"Bioinformatics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1021\/ac052197p","article-title":"Robust algorithm for alignment of liquid chromatography-mass spectrometry analyses in an accurate mass and time tag data analysis pipeline.","volume":"78","author":"N Jaitly","year":"2006","journal-title":"Anal Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1021\/ac001404c","article-title":"Protelytic 180 Labeling for Comparative Proteomics: Model Studies with Two Serotypes of Adenovirus.","volume":"73","author":"X Yao","year":"2001","journal-title":"Anal Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry.","volume":"75","author":"AI Nesvizhskii","year":"2003","journal-title":"Anal Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/pr060594q","article-title":"Chemometrics in metabonomics.","volume":"6","author":"J Trygg","year":"2007","journal-title":"J Proteome Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1371\/journal.pcbi.0030059","article-title":"The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics.","volume":"3","author":"H Yu","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1371\/journal.ppat.0040032","article-title":"The landscape of human proteins interacting with viruses and other pathogens.","volume":"4","author":"MD Dyer","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/cmb.2008.04TT","article-title":"Bottlenecks and hubs in inferred networks are important for virulence in Salmonella typhimurium.","volume":"16","author":"JE McDermott","year":"2009","journal-title":"J Comput Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hep.21318","article-title":"HepatoProteomics: applying proteomic technologies to the study of liver function and disease.","volume":"44","author":"DL Diamond","year":"2006","journal-title":"Hepatology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.","volume":"7","author":"RJ DeBerardinis","year":"2008","journal-title":"Cell Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.","volume":"104","author":"RJ DeBerardinis","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1128\/JVI.77.19.10689-10694.2003","article-title":"Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.","volume":"77","author":"LJ Stuyver","year":"2003","journal-title":"J Virol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"30409","DOI":"10.1074\/jbc.R200006200","article-title":"The key role of anaplerosis and cataplerosis for citric acid cycle function.","volume":"277","author":"OE Owen","year":"2002","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"20621","DOI":"10.1074\/jbc.M706494200","article-title":"Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line.","volume":"283","author":"H Yoo","year":"2008","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1128\/JVI.76.15.7453-7459.2002","article-title":"Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway.","volume":"76","author":"KD Tardif","year":"2002","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1128\/JVI.77.6.3578-3585.2003","article-title":"Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK.","volume":"77","author":"N Pavio","year":"2003","journal-title":"J Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.bbagen.2006.09.009","article-title":"NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis.","volume":"1760","author":"AT Miccheli","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nm1539","article-title":"Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.","volume":"13","author":"PA Lang","year":"2007","journal-title":"Nat Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1462-5822.2007.01070.x","article-title":"Ceramide enrichment of the plasma membrane induces CD81 internalization and inhibits hepatitis C virus entry.","volume":"10","author":"C Voisset","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/msb.2008.66","article-title":"Hepatitis C virus infection protein network.","volume":"4","author":"B de Chassey","year":"2008","journal-title":"Mol Syst Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1371\/journal.ppat.0020132","article-title":"Dynamics of the cellular metabolome during human cytomegalovirus infection.","volume":"2","author":"J Munger","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/nbt.1500","article-title":"Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy.","volume":"26","author":"J Munger","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7571","DOI":"10.1128\/JVI.00288-07","article-title":"Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production.","volume":"81","author":"EY Chan","year":"2007","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"9283","DOI":"10.1128\/JVI.00814-09","article-title":"Dynamic Host Energetics and Cytoskeletal Proteomes in HIV-1-Infected Human Primary CD4 Cells: Analysis by Multiplexed Label-free Mass Spectrometry.","volume":"83","author":"EY Chan","year":"2009","journal-title":"J Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1128\/JVI.01819-07","article-title":"Proteomic studies reveal coordinated changes in T-cell expression patterns upon infection with human immunodeficiency virus type 1.","volume":"82","author":"JH Ringrose","year":"2008","journal-title":"J Virol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1128\/JVI.79.15.10053-10058.2005","article-title":"Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells.","volume":"79","author":"AB van 't Wout","year":"2005","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/hep.21679","article-title":"Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress.","volume":"46","author":"C Piccoli","year":"2007","journal-title":"Hepatology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1158\/0008-5472.CAN-06-3137","article-title":"Adaptation of energy metabolism in breast cancer brain metastases.","volume":"67","author":"EI Chen","year":"2007","journal-title":"Cancer Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1126\/science.1056843","article-title":"Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.","volume":"291","author":"L Abu-Elheiga","year":"2001","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fj.01-0568com","article-title":"Cold elicits the simultaneous induction of fatty acid synthesis and beta-oxidation in murine brown adipose tissue: prediction from differential gene expression and confirmation in vivo.","volume":"16","author":"XX Yu","year":"2002","journal-title":"FASEB J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.ijo.0802861","article-title":"Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity.","volume":"Suppl 4","author":"AG Dulloo","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jhep.2008.12.029","article-title":"HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters.","volume":"50","author":"D Kasai","year":"2009","journal-title":"J Hepatol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/MMBR.64.2.239-280.2000","article-title":"Translational control of viral gene expression in eukaryotes.","volume":"64","author":"M Gale Jr","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019.","volume":"438","author":"J Kr\u00fctzfeldt","year":"2005","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.","volume":"3","author":"C Esau","year":"2006","journal-title":"Cell Metab"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.","volume":"309","author":"CL Jopling","year":"2005","journal-title":"Science"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/pmic.200800275","article-title":"Global analysis of cellular protein translation by pulsed SILAC.","volume":"9","author":"B Schwanh\u00e4usser","year":"2009","journal-title":"Proteomics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1073\/pnas.0511136103","article-title":"The HIV lipidome: A raft with an unusual composition.","volume":"103","author":"B Br\u00fcgger","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.4049\/jimmunol.170.9.4840","article-title":"Phosphatidylserine on HIV Envelope Is a Cofactor for Infection of Monocytic Cells.","volume":"170","author":"MK Callahan","year":"2003","journal-title":"J Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1073\/pnas.0409834102","article-title":"Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids.","volume":"102","author":"SB Kapadia","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.antiviral.2007.02.002","article-title":"Suppression of virus replication via down-modulation of mitochondrial short chain enoyl-CoA hydratase in human glioblastoma cells.","volume":"75","author":"M Takahashi","year":"2007","journal-title":"Antiviral Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.mib.2009.06.003","article-title":"Virus-host interactions: from systems biology to translational research.","volume":"12","author":"X Peng","year":"2009","journal-title":"Curr Opin Microbiol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T21:01:24Z","timestamp":1558731684000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000719"}},"subtitle":[],"editor":[{"given":"Guangxiang George","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,1,8]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000719","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1628956.1129054","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,8]]}}}