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Xu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1128\/IAI.73.8.4488-4493.2005","article-title":"Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection.","volume":"73","author":"RC Larocque","year":"2005","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1073\/pnas.2628026100","article-title":"ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients.","volume":"100","author":"J Bina","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature00778","article-title":"Host-induced epidemic spread of the cholera bacterium.","volume":"417","author":"DS 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Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1128\/JB.184.20.5533-5544.2002","article-title":"Mechanism of ToxT-dependent transcriptional activation at the Vibrio cholerae tcpA promoter.","volume":"184","author":"RR Hulbert","year":"2002","journal-title":"J Bacteriol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1128\/AEM.64.6.2240-2246.1998","article-title":"New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria.","volume":"64","author":"JB Andersen","year":"1998","journal-title":"Appl Environ Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1128\/AEM.65.9.4108-4117.1999","article-title":"Distribution of bacterial growth activity in flow-chamber biofilms.","volume":"65","author":"C Sternberg","year":"1999","journal-title":"Appl Environ 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Schaechter","year":"1958","journal-title":"J Gen Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0022-2836(74)90449-5","article-title":"Differential rate of ribosomal protein synthesis in Escherichia coli B\/r.","volume":"84","author":"PP Dennis","year":"1974","journal-title":"J Mol Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0300-9084(02)00010-X","article-title":"Kinetic properties of rrn promoters in Escherichia coli.","volume":"84","author":"X Zhang","year":"2002","journal-title":"Biochimie"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1128\/jb.176.17.5560-5564.1994","article-title":"Growth rate-dependent control of the rrnB P1 core promoter in Escherichia coli.","volume":"176","author":"MS Bartlett","year":"1994","journal-title":"J Bacteriol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/IAI.00409-09","article-title":"Bicarbonate Induces Vibrio cholerae virulence gene expression by enhancing ToxT activity.","volume":"77","author":"BH Abuaita","year":"2009","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF02233563","article-title":"Ionic constituents and osmolality of gastric and small-intestinal fluids after eating.","volume":"11","author":"JS Fordtran","year":"1966","journal-title":"Am J Dig Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/j.1365-2958.2006.05053.x","article-title":"The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT.","volume":"59","author":"JH Withey","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1128\/JB.181.14.4250-4256.1999","article-title":"A Vibrio cholerae LysR homolog, AphB, cooperates with AphA at the tcpPH promoter to activate expression of the ToxR virulence cascade.","volume":"181","author":"G Kovacikova","year":"1999","journal-title":"J Bacteriol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1073\/pnas.88.12.5403","article-title":"Regulatory cascade controls virulence in Vibrio cholerae.","volume":"88","author":"VJ DiRita","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1073\/pnas.95.2.730","article-title":"TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae.","volume":"95","author":"CC Hase","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1046\/j.1365-2958.2002.03229.x","article-title":"Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter.","volume":"46","author":"G Kovacikova","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(87)90430-2","article-title":"Cholera toxin transcriptional activator toxR is a transmembrane DNA binding protein.","volume":"48","author":"VL Miller","year":"1987","journal-title":"Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0955-0674(02)00314-9","article-title":"Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.","volume":"14","author":"JE Ferrell Jr","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1365-2958.2007.06098.x","article-title":"Regulatory interplay between pap operons in uropathogenic Escherichia coli.","volume":"67","author":"M Totsika","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.micro.62.081307.163002","article-title":"Bistability, epigenetics, and bet-hedging in bacteria.","volume":"62","author":"JW Veening","year":"2008","journal-title":"Annu Rev Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2958.2006.05249.x","article-title":"Bistability in bacteria.","volume":"61","author":"D Dubnau","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1128\/JB.181.8.2584-2592.1999","article-title":"Analysis of an autoregulatory loop controlling ToxT, cholera toxin, and toxin-coregulated pilus production in Vibrio cholerae.","volume":"181","author":"RR Yu","year":"1999","journal-title":"J Bacteriol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1365-2958.2005.04897.x","article-title":"Characterization of functional domains of the Vibrio cholerae virulence regulator ToxT.","volume":"58","author":"MG Prouty","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1116739","article-title":"Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.","volume":"310","author":"DT Hung","year":"2005","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1073\/pnas.0611643104","article-title":"Virstatin inhibits dimerization of the transcriptional activator ToxT.","volume":"104","author":"EA Shakhnovich","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrmicro1932","article-title":"Carbon catabolite repression in bacteria: many ways to make the most out of nutrients.","volume":"6","author":"B Gorke","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1073\/pnas.94.1.265","article-title":"Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae.","volume":"94","author":"K Skorupski","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1128\/JB.186.19.6374-6382.2004","article-title":"Transcriptional regulation of Vibrio cholerae hemagglutinin\/protease by the cyclic AMP receptor protein and RpoS.","volume":"186","author":"AJ Silva","year":"2004","journal-title":"J Bacteriol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1099\/mic.0.2007\/006668-0","article-title":"The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio cholerae.","volume":"153","author":"W Liang","year":"2007","journal-title":"Microbiology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2958.2001.02518.x","article-title":"Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP-CRP at the Vibrio cholerae tcpPH promoter.","volume":"41","author":"G Kovacikova","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2958.2000.02111.x","article-title":"The Vibrio cholerae ToxR\/TcpP\/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoter.","volume":"38","author":"ES Krukonis","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0378-1119(95)00744-X","article-title":"Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and El Tor strains of Vibrio cholerae O1.","volume":"170","author":"MA Ogierman","year":"1996","journal-title":"Gene"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-1119(95)00610-X","article-title":"Regulation of tcp genes in classical and El Tor strains of Vibrio cholerae O1.","volume":"166","author":"S Thomas","year":"1995","journal-title":"Gene"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/MMBR.57.3.543-594.1993","article-title":"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.","volume":"57","author":"PW Postma","year":"1993","journal-title":"Microbiol Rev"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1073\/pnas.0915021107","article-title":"Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.","volume":"107","author":"MJ Lowden","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1073\/pnas.0802241105","article-title":"Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing.","volume":"105","author":"Z Liu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1152\/ajplegacy.1973.225.4.858","article-title":"Ion transport in rabbit ileal mucosa. IV. Bicarbonate secretion.","volume":"225","author":"J Dietz","year":"1973","journal-title":"Am J Physiol"},{"key":"ref72","first-page":"G10","article-title":"Cholera toxin stimulates secretion of immunoreactive intestinal mucin.","volume":"240","author":"JF Forstner","year":"1981","journal-title":"Am J Physiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2958.1992.tb01489.x","article-title":"Co-ordinate expression of virulence genes by ToxR in Vibrio cholerae.","volume":"6","author":"VJ DiRita","year":"1992","journal-title":"Mol Microbiol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04599","article-title":"Stochastic protein expression in individual cells at the single molecule level.","volume":"440","author":"L Cai","year":"2006","journal-title":"Nature"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1126\/science.1099390","article-title":"Bacterial persistence as a phenotypic switch.","volume":"305","author":"NQ Balaban","year":"2004","journal-title":"Science"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1128\/JB.186.24.8172-8180.2004","article-title":"Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli.","volume":"186","author":"I Keren","year":"2004","journal-title":"J Bacteriol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2958.1995.tb02259.x","article-title":"comK encodes the competence transcription factor, the key regulatory protein for competence development in Bacillus subtilis.","volume":"15","author":"D van Sinderen","year":"1995","journal-title":"Mol Microbiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2958.2005.04592.x","article-title":"Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop.","volume":"56","author":"H Maamar","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1128\/jb.176.7.1977-1984.1994","article-title":"Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation.","volume":"176","author":"JD Chung","year":"1994","journal-title":"J Bacteriol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.1086462","article-title":"Cannibalism by sporulating bacteria.","volume":"301","author":"JE Gonzalez-Pastor","year":"2003","journal-title":"Science"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/j.1365-2958.2005.04659.x","article-title":"Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis.","volume":"56","author":"JW Veening","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2958.2007.06040.x","article-title":"Bistability and biofilm formation in Bacillus subtilis.","volume":"67","author":"Y Chai","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1128\/IAI.62.4.1219-1227.1994","article-title":"Binding of Yersinia enterocolitica to purified, native small intestinal mucins from rabbits and humans involves interactions with the mucin carbohydrate moiety.","volume":"62","author":"M Mantle","year":"1994","journal-title":"Infect Immun"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/JCM.22.3.405-408.1985","article-title":"New medium for the production of cholera toxin by Vibrio cholerae O1 biotype El Tor.","volume":"22","author":"M Iwanaga","year":"1985","journal-title":"J Clin Microbiol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/IAI.67.3.1393-1404.1999","article-title":"Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae.","volume":"67","author":"KJ Fullner","year":"1999","journal-title":"Infect Immun"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1462-2920.2004.00605.x","article-title":"Mini-Tn7 transposons for site-specific tagging of bacteria with fluorescent proteins.","volume":"6","author":"L Lambertsen","year":"2004","journal-title":"Environ Microbiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-7012(01)00246-9","article-title":"A panel of Tn7-based vectors for insertion of the gfp marker gene or for delivery of cloned DNA into Gram-negative bacteria at a neutral chromosomal site.","volume":"45","author":"B Koch","year":"2001","journal-title":"J Microbiol Methods"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1073\/pnas.0308707101","article-title":"The Vibrio cholerae chitin utilization program.","volume":"101","author":"KL Meibom","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response.","volume":"98","author":"VG Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S 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