{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:45:23Z","timestamp":1778309123292,"version":"3.51.4"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T00:00:00Z","timestamp":1284595200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1001104","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T19:50:04Z","timestamp":1284666604000},"page":"e1001104","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":72,"title":["Role of Acetyl-Phosphate in Activation of the Rrp2-RpoN-RpoS Pathway in Borrelia burgdorferi"],"prefix":"10.1371","volume":"6","author":[{"given":"Haijun","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa J.","family":"Caimano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Radolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Gheradini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. Frank","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.en.36.010191.003103","article-title":"Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe.","volume":"36","author":"RS Lane","year":"1991","journal-title":"Annu Rev Entomol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1365-2958.2007.05860.x","article-title":"Analysis of the RpoS regulon in <italic>Borrelia burgdorferi<\/italic> in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.","volume":"65","author":"MJ Caimano","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1073\/pnas.0408536102","article-title":"<italic>Borrelia burgdorferi<\/italic> \u03c3<sup>54<\/sup> is required for mammalian infection and vector transmission but not for tick colonization.","volume":"102","author":"MA Fisher","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1099\/mic.0.2008\/019992-0","article-title":"Transcriptional interplay among the regulators Rrp2, RpoN, and RpoS in <italic>Borrelia burgdorferi<\/italic>.","volume":"154","author":"Z Ouyang","year":"2008","journal-title":"Microbiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1128\/IAI.72.11.6433-6445.2004","article-title":"RpoS is not central to the general stress response in <italic>Borrelia burgdorferi<\/italic> but does control expression of one or more essential virulence determinants.","volume":"72","author":"MJ Caimano","year":"2004","journal-title":"Infect Immun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2958.2007.05813.x","article-title":"Insights into the complex regulation of rpoS in <italic>Borrelia burgdorferi<\/italic>.","volume":"65","author":"MN Burtnick","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1365-2958.2007.05716.x","article-title":"Temperature-induced regulation of RpoS by a small RNA in <italic>Borrelia burgdorferi<\/italic>.","volume":"64","author":"MC Lybecker","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1073\/pnas.231442498","article-title":"Expression of <italic>Borrelia burgdorferi<\/italic> OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway.","volume":"98","author":"A H\u00fcbner","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20031960","article-title":"Essential role for OspA\/B in the life cycle of the Lyme disease spirochete.","volume":"199","author":"XF Yang","year":"2004","journal-title":"J Exp Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1073\/pnas.0306845101","article-title":"Outer-surface protein C of the Lyme disease spirochete: A protein induced in ticks for infection of mammals.","volume":"101","author":"D Grimm","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates <italic>Borrelia burgdorferi<\/italic> invasion of Ixodes scapularis salivary glands.","volume":"113","author":"U Pal","year":"2004","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1128\/IAI.01950-05","article-title":"<italic>Borrelia burgdorferi<\/italic> OspC protein required exclusively in a crucial early stage of mammalian infection.","volume":"74","author":"K Tilly","year":"2006","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1128\/IAI.00410-08","article-title":"Outer Surface Protein A Protects Lyme Disease Spirochetes from Acquired Host Immunity in the Tick Vector.","volume":"76","author":"JM Battisti","year":"2008","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1128\/JB.01653-06","article-title":"Evidence that RpoS (\u03c3<sup>S<\/sup>) in <italic>Borrelia burgdorferi<\/italic> is controlled directly by RpoN (\u03c3<sup>54<\/sup>\/\u03c3<sup>N<\/sup>).","volume":"189","author":"AH Smith","year":"2007","journal-title":"J Bacteriol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1128\/JB.01721-08","article-title":"Rrp2, a \u03c3<sup>54<\/sup>-dependent transcriptional activator of <italic>Borrelia burgdorferi<\/italic>, activates <italic>rpoS<\/italic> in an enhancer-independent manner.","volume":"191","author":"JS Blevins","year":"2009","journal-title":"J Bacteriol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2000.tb09074.x","article-title":"The biology of enhancer-dependent transcriptional regulation in bacteria: insights from genome sequences.","volume":"186","author":"DJ Studholme","year":"2000","journal-title":"FEMS Microbiol Letts"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.","volume":"390","author":"CM Fraser","year":"1997","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1073\/pnas.1834315100","article-title":"The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi.","volume":"100","author":"XF Yang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1128\/jb.175.14.4267-4273.1993","article-title":"Prokaryotic enhancer-binding proteins reflect eukaryote-like modularity: the puzzle of nitrogen regulatory protein C.","volume":"175","author":"AK North","year":"1993","journal-title":"J Bacteriol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1128\/IAI.00467-08","article-title":"Essential role of the response regulator Rrp2 in the infectious cycle of <italic>Borrelia burgdorferi<\/italic>.","volume":"76","author":"BK Boardman","year":"2008","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1369-5274(00)00070-9","article-title":"Two-component and phosphorelay signal transduction.","volume":"3","author":"JA Hoch","year":"2000","journal-title":"Curr Opin Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/MMBR.00020-06","article-title":"Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases.","volume":"70","author":"T Mascher","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biochem.69.1.183","article-title":"Two component signal transduction.","volume":"69","author":"AM Stock","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1074\/jbc.M410104200","article-title":"Functional characterization in vitro of all twocomponent signal transduction systems from <italic>Escherichia coli<\/italic>.","volume":"280","author":"K Yamamoto","year":"2005","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1073\/pnas.85.15.5492","article-title":"Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.","volume":"85","author":"AJ Ninfa","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0966-842X(03)00176-8","article-title":"Making informed decisions: regulatory interactions between two-component systems.","volume":"11","author":"JE Bijlsma","year":"2003","journal-title":"Trends Micro"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.genet.41.042007.170548","article-title":"Specificity in two-component signal transduction pathways.","volume":"41","author":"MT Laub","year":"2007","journal-title":"Annu Rev Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1128\/jb.174.7.2053-2058.1992","article-title":"Is cross regulation by phosphorylation of two-component response regulator proteins important in bacteria?","volume":"174","author":"BL Wanner","year":"1992","journal-title":"J Bacteriol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1128\/jb.175.10.2793-2798.1993","article-title":"Is acetyl phosphate a global signal in Escherichia coli?","volume":"175","author":"WR McCleary","year":"1993","journal-title":"J Bacteriol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1073\/pnas.89.2.718","article-title":"Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.","volume":"89","author":"GS Lukat","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jcb.240510110","article-title":"Gene regulation by phosphate in enteric bacteria.","volume":"51","author":"BL Wanner","year":"1993","journal-title":"J Cell Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1128\/MMBR.69.1.12-50.2005","article-title":"The acetate switch.","volume":"69","author":"AJ Wolfe","year":"2005","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.mib.2010.01.002","article-title":"Physiologically relevant small phosphodonors link metabolism to signal transduction.","volume":"13","author":"AJ Wolfe","year":"2010","journal-title":"Current Opinion in Microbiology"},{"key":"ref34","article-title":"Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of <italic>Borrelia burgdorferi<\/italic> core cellular functions.","author":"EA Rogers","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1128\/IAI.70.4.2139-2150.2002","article-title":"Clonal Polymorphism of <italic>Borrelia burgdorferi<\/italic> Strain B31 MI: Implications for Mutagenesis in an Infectious Strain Background.","volume":"70","author":"AF Elias","year":"2002","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1365-2958.2007.05593.x","article-title":"Artificial regulation of ospC expression in <italic>Borrelia burgdorferi<\/italic>","volume":"63","author":"MA Gilbert","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1128\/IAI.65.4.1165-1171.1997","article-title":"Cell-density-dependent expression of <italic>Borrelia burgdorferi<\/italic> lipoproteins in vitro.","volume":"65","author":"KJ Indest","year":"1997","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1046\/j.1365-2958.2000.02104.x","article-title":"Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent <italic>Borrelia burgdorferi<\/italic>.","volume":"37","author":"X Yang","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1073\/pnas.92.7.2909","article-title":"Induction of an outer surface protein on <italic>Borrelia burgdorferi<\/italic> during tick feeding.","volume":"92","author":"TG Schwan","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1172\/JCI2325","article-title":"A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state.","volume":"101","author":"DR Akins","year":"1998","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1128\/JB.187.22.7845-7852.2005","article-title":"Alternate sigma factor RpoS is required for the in vivo-specific repression of <italic>Borrelia burgdorferi<\/italic> plasmid lp54-borne ospA and lp6.6 genes.","volume":"187","author":"MJ Caimano","year":"2005","journal-title":"J Bacteriol"},{"key":"ref42","article-title":"Cultivation of <italic>Borrelia burgdorferi<\/italic> in dialysis membrane chambers in rat peritonea. Curr Protoc Microbiol 12.","volume":"12C.3","author":"M Caimano","year":"2005","journal-title":"Unit"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.genet.36.041602.134359","article-title":"Genetics of motility and chemotaxis of a fascinating gruop of bacteria: the spirochetes.","volume":"36","author":"NW Charon","year":"2002","journal-title":"Annu Rev Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1073\/pnas.092010499","article-title":"Asymetrical flagellar rotation in <italic>Borrelia burgdorferi<\/italic> nonchemotactic mutants.","volume":"99","author":"C Li","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/IAI.67.7.3181-3187.1999","article-title":"Effects of environmental pH on membrane proteins in <italic>Borrelia burgdorferi<\/italic>.","volume":"67","author":"JA Carroll","year":"1999","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1128\/JB.187.9.3100-3109.2005","article-title":"Phosphorylation-Independent Activity of Atypical Response Regulators of <italic>Helicobacter pylori<\/italic>.","volume":"187","author":"J Schar","year":"2005","journal-title":"J Bacteriol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1099\/mic.0.2008\/020677-0","article-title":"Phosphorylation-independent activation of the atypical response regulator NblR.","volume":"154","author":"D Ruiz","year":"2008","journal-title":"Microbiology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2958.2007.05785.x","article-title":"An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.","volume":"65","author":"JS Fraser","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1128\/JB.00564-07","article-title":"The intracellular concentration of acetyl phosphate in <italic>Escherichia coli<\/italic> is sufficient for direct phosphorylation of two-component response regulators.","volume":"189","author":"AH Klein","year":"2007","journal-title":"J Bacteriol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/IAI.63.11.4535-4539.1995","article-title":"Temperature-related differential expression of antigens in the Lyme disease spirochete, <italic>Borrelia burgdorferi<\/italic>.","volume":"63","author":"B Stevenson","year":"1995","journal-title":"Infect Immun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/JB.01109-06","article-title":"<italic>Borrelia burgdorferi<\/italic> alters its gene expression and antigenic profile in response to CO2 levels.","volume":"189","author":"JA Hyde","year":"2007","journal-title":"J Bacteriol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1365-2958.1994.tb01085.x","article-title":"Regulation of acetyl phosphate synthesis and degradation, and the control of flagellar expression in <italic>Escherichia coli<\/italic>.","volume":"12","author":"BM Pruss","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1128\/IAI.01018-09","article-title":"Characterization of a conditional <italic>bosR<\/italic> mutant in <italic>Borrelia burgdorferi<\/italic>.","volume":"78","author":"JA Hyde","year":"2010","journal-title":"Infect Immun"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1365-2958.2009.06945.x","article-title":"BosR (BB0647) governs virulence expression in <italic>Borrelia burgdorferi<\/italic>.","volume":"74","author":"Z Ouyang","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1365-2958.2009.06951.x","article-title":"The BosR regulatory protein of <italic>Borrelia burgdorferi<\/italic> interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete.","volume":"74","author":"JA Hyde","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/j.1365-2958.2009.06971.x","article-title":"Who is the BosR around here anyway?","volume":"74","author":"DS Samuels","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of <italic>Borrelia burgdorferi<\/italic> in Ixodes ticks during blood feeding.","volume":"53","author":"AM de Silva","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1128\/JCM.39.11.4145-4148.2001","article-title":"Use of quantitative PCR to measure density of <italic>Borrelia burgdorferi<\/italic> in the midgut and salivary glands of feeding tick vectors.","volume":"39","author":"J Piesman","year":"2001","journal-title":"J Clin Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2958.2007.05636.x","article-title":"Identification of an <italic>ospC<\/italic> operator critical for immune evasion of Borrelia burgdorferi.","volume":"64","author":"Q Xu","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref60","article-title":"Electrotransformation of the spirochete <italic>Borrelia burgdorferi<\/italic>.","volume":"253-259","author":"DS Samuels","year":"1995"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.69.1.446-455.2001","article-title":"Decreased infectivity in <italic>Borrelia burgdorferi<\/italic> strain B31 is associated with loss of linear plasmid 25 or 28-1.","volume":"69","author":"M Labandeira-Rey","year":"2001","journal-title":"Infect Immun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1128\/IAI.69.6.3670-3677.2001","article-title":"Analysis of mechanisms associated with loss of infectivity of clonal populations of <italic>Borrelia burgdorferi<\/italic> B31MI.","volume":"69","author":"JV McDowell","year":"2001","journal-title":"Infect Immun"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"13865","DOI":"10.1073\/pnas.97.25.13865","article-title":"Correlation between plasmid content and infectivity in <italic>Borrelia burgdorferi<\/italic>.","volume":"97","author":"JE Purser","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1128\/AEM.70.10.5973-5979.2004","article-title":"Genome-Wide Transposon Mutagenesis of <italic>Borrelia burgdorferi<\/italic> for Identification of Phenotypic Mutants.","volume":"70","author":"PE Stewart","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/IAI.63.6.2206-2212.1995","article-title":"High- and low-infectivity phenotypes of clonal populations of in vitro- cultured <italic>Borrelia burgdorferi<\/italic>.","volume":"63","author":"SJ Norris","year":"1995","journal-title":"Infect Immun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1128\/IAI.67.11.6008-6018.1999","article-title":"Identification, characterization, and expression of three new members of the <italic>Borrelia burgdorferi<\/italic> Mlp (2.9) lipoprotein gene family.","volume":"67","author":"X Yang","year":"1999","journal-title":"Infect Immun"},{"key":"ref67","first-page":"1872","article-title":"Characterization of the highly regulated antigen BBA05 in the enzootic cycle of <italic>Borrelia burgdorferi<\/italic>.","volume":"15","author":"H Xu","year":"2009","journal-title":"Infect Immun"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0092-8674(00)80995-2","article-title":"Cell Cycle Control by an Essential Bacterial Two-Component Signal Transduction Protein.","volume":"84","author":"KC Quon","year":"1996","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1371\/annotation\/88293342-3534-4b8b-8800-c63a8c86bf6d","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T00:00:00Z","timestamp":1292284800000}}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1001104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T20:55:18Z","timestamp":1591908918000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1001104"}},"subtitle":[],"editor":[{"given":"Jenifer","family":"Coburn","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,9,16]]},"references-count":68,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,9,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1001104","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/88293342-3534-4b8b-8800-c63a8c86bf6d","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,16]]}}}