{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:22:07Z","timestamp":1791354127842,"version":"4.3.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T00:00:00Z","timestamp":1290556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1001205","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T15:40:44Z","timestamp":1290613244000},"page":"e1001205","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":110,"title":["Tick Histamine Release Factor Is Critical for Ixodes scapularis Engorgement and Transmission of the Lyme Disease Agent"],"prefix":"10.1371","volume":"6","author":[{"given":"Jianfeng","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanya","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.2741\/3201","article-title":"Targeting the tick-pathogen interface for novel control strategies.","volume":"13","author":"J de la Fuente","year":"2008","journal-title":"Front Biosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.idc.2007.12.006","article-title":"Biology of ticks.","volume":"22","author":"JF Anderson","year":"2008","journal-title":"Infect Dis Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJMra072023","article-title":"A critical appraisal of \u201cchronic Lyme disease\u201d.","volume":"357","author":"HM Feder Jr","year":"2007","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.idc.2008.03.007","article-title":"Prevention of lyme disease and other tick-borne infections.","volume":"22","author":"RP Clark","year":"2008","journal-title":"Infect Dis Clin North Am"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2217\/fmb.09.17","article-title":"Human Lyme disease vaccines: past and future concerns.","volume":"4","author":"DT Nardelli","year":"2009","journal-title":"Future Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJM199807233390401","article-title":"Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group.","volume":"339","author":"AC Steere","year":"1998","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11259-007-0069-5","article-title":"Tick vaccines and the transmission of tick-borne pathogens.","volume":"31","author":"J de la Fuente","year":"2007","journal-title":"Vet Res Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/280491a0","article-title":"Immunisation of guinea pigs and cattle against ticks.","volume":"280","author":"JR Allen","year":"1979","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.4049\/jimmunol.181.8.5209","article-title":"Cutting edge: Immunity against a \u201csilent\u201d salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed.","volume":"181","author":"M Kotsyfakis","year":"2008","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1371\/journal.ppat.0020027","article-title":"An antivector vaccine protects against a lethal vector-borne pathogen.","volume":"2","author":"M Labuda","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.4049\/jimmunol.127.5.2163","article-title":"Cutaneous basophil responses and immune resistance of guinea pigs to ticks: passive transfer with peritoneal exudate cells or serum.","volume":"127","author":"SJ Brown","year":"1981","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.en.41.010196.000245","article-title":"Host immunity to ticks.","volume":"41","author":"SK Wikel","year":"1996","journal-title":"Annu Rev Entomol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1371\/journal.pone.0000451","article-title":"Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission.","volume":"2","author":"S Narasimhan","year":"2007","journal-title":"PLoS ONE"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding.","volume":"53","author":"AM De Silva","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1017\/S0031182004004834","article-title":"Tick immunobiology.","volume":"129","author":"M Brossard","year":"2004","journal-title":"Parasitology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4269\/ajtmh.1990.42.352","article-title":"Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini).","volume":"42","author":"J Piesman","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.2741\/3363","article-title":"The role of saliva in tick feeding.","volume":"14","author":"IM Francischetti","year":"2009","journal-title":"Front Biosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1371\/journal.pmed.0050043","article-title":"Salivating for knowledge: potential pharmacological agents in tick saliva.","volume":"5","author":"JW Hovius","year":"2008","journal-title":"PLoS Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2005.11.005","article-title":"An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks.","volume":"36","author":"JM Ribeiro","year":"2006","journal-title":"Insect Biochem Mol Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S0031182000000950","article-title":"Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae\u2013studies in vivo and in vitro.","volume":"80","author":"DH Kemp","year":"1980","journal-title":"Parasitology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80359-7","article-title":"Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure.","volume":"3","author":"GC Paesen","year":"1999","journal-title":"Mol Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0965-1748(03)00097-3","article-title":"The American dog tick, Dermacentor variabilis, encodes a functional histamine release factor homolog.","volume":"33","author":"A Mulenga","year":"2003","journal-title":"Insect Biochem Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.chom.2007.06.001","article-title":"A tick antioxidant facilitates the Lyme disease agent&apos;s successful migration from the mammalian host to the arthropod vector.","volume":"2","author":"S Narasimhan","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1182\/blood-2007-07-104364","article-title":"Distinct characteristics of signal transduction events by histamine-releasing factor\/translationally controlled tumor protein (HRF\/TCTP)-induced priming and activation of human basophils.","volume":"111","author":"BM Vonakis","year":"2008","journal-title":"Blood"},{"key":"ref25","first-page":"381","article-title":"Vector-host interactions in disease transmission.","volume":"2","author":"PA Nuttall","year":"2000","journal-title":"J Mol Microbiol Biotechnol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.chom.2009.10.006","article-title":"Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent.","volume":"6","author":"J Dai","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host.","volume":"436","author":"N Ramamoorthi","year":"2005","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1357-2725(03)00213-9","article-title":"The translationally controlled tumour protein (TCTP).","volume":"36","author":"UA Bommer","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1126\/science.7542803","article-title":"Molecular identification of an IgE-dependent histamine-releasing factor.","volume":"269","author":"SM MacDonald","year":"1995","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.1073\/pnas.201191498","article-title":"Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo.","volume":"98","author":"SM MacDonald","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2583.2003.00400.x","article-title":"Dynamics of Rickettsia-tick interactions: identification and characterization of differentially expressed mRNAs in uninfected and infected Dermacentor variabilis.","volume":"12","author":"A Mulenga","year":"2003","journal-title":"Insect Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10493-005-3261-8","article-title":"The molecular and biological analysis of ixodid ticks histamine release factors.","volume":"37","author":"A Mulenga","year":"2005","journal-title":"Exp Appl Acarol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijpara.2008.09.006","article-title":"Histamine release factor from Dermanyssus gallinae (De Geer): characterization and in vitro assessment as a protective antigen.","volume":"39","author":"K Bartley","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S0031182000050617","article-title":"In vitro feeding of Dermacentor andersoni (Stiles): effects of histamine and other mediators.","volume":"86 (Pt 3)","author":"SH Paine","year":"1983","journal-title":"Parasitology"},{"key":"ref35","first-page":"1131","article-title":"Tick histamine-binding proteins and related lipocalins: potential as therapeutic agents.","volume":"6","author":"BJ Mans","year":"2005","journal-title":"Curr Opin Investig Drugs"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1172\/JCI39401","article-title":"Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.","volume":"119","author":"SM Dunham-Ems","year":"2009","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1073\/pnas.0307669100","article-title":"Disruption of Ixodes scapularis anticoagulation by using RNA interference.","volume":"101","author":"S Narasimhan","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S1074-7613(02)00325-4","article-title":"Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation.","volume":"16","author":"J Anguita","year":"2002","journal-title":"Immunity"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1001205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:22:23Z","timestamp":1711963343000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1001205"}},"subtitle":[],"editor":[{"given":"Jenifer","family":"Coburn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,24]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1001205","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,24]]}}}