{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:46:28Z","timestamp":1790397988368,"version":"4.1.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:00:00Z","timestamp":1300320000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1001319","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T18:04:44Z","timestamp":1300385084000},"page":"e1001319","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":143,"title":["Sheep and Goat BSE Propagate More Efficiently than Cattle BSE in Human PrP Transgenic Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Danielle","family":"Padilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00e9ringue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Andreoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Jaumain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Reine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Gutierrez-Adan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Pintado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Laude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Maria","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie.","volume":"216","author":"SB Prusiner","year":"1982","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/2151043a0","article-title":"Self-replication and scrapie.","volume":"215","author":"JS Griffith","year":"1967","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/vr.121.18.419","article-title":"A novel progressive spongiform encephalopathy in cattle.","volume":"121","author":"GA Wells","year":"1987","journal-title":"Vet Rec"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/39057","article-title":"Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent.","volume":"389","author":"ME Bruce","year":"1997","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/38925","article-title":"The same prion strain causes vCJD and BSE.","volume":"389","author":"AF Hill","year":"1997","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0966-842X(02)02477-0","article-title":"BSE - a wolf in sheep&apos;s clothing?","volume":"10","author":"M Baylis","year":"2002","journal-title":"Trends Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/vr.133.14.339","article-title":"Transmission of bovine spongiform encephalopathy to sheep and goats.","volume":"133","author":"JD Foster","year":"1993","journal-title":"Vet Rec"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/vr.157.7.206","article-title":"Natural transmission of BSE between sheep within an experimental flock.","volume":"157","author":"SJ Bellworthy","year":"2005","journal-title":"Vet Rec"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/vr.162.4.130-c","article-title":"Oral transmission of BSE to VRQ\/VRQ sheep in an experimental flock.","volume":"162","author":"SJ Bellworthy","year":"2008","journal-title":"Vet Rec"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1099\/vir.0.005983-0","article-title":"Three serial passages of bovine spongiform encephalopathy in sheep do not significantly affect discriminatory test results.","volume":"90","author":"M Stack","year":"2009","journal-title":"J Gen Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/423498a","article-title":"Prion diseases: BSE in sheep bred for resistance to infection.","volume":"423","author":"F Houston","year":"2003","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/vr.156.16.523-b","article-title":"BSE agent signatures in a goat.","volume":"156","author":"M Eloit","year":"2005","journal-title":"Vet Rec"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jcpa.2005.10.003","article-title":"Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies.","volume":"134","author":"M Jeffrey","year":"2006","journal-title":"J Comp Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/vr.142.5.103","article-title":"Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update.","volume":"142","author":"GA Wells","year":"1998","journal-title":"Vet Rec"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1086\/431602","article-title":"Highly bovine spongiform encephalopathy-sensitive transgenic mice confirm the essential restriction of infectivity to the nervous system in clinically diseased cattle.","volume":"192","author":"A Buschmann","year":"2005","journal-title":"J Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/vr.156.13.401","article-title":"Pathogenesis of experimental bovine spongiform encephalopathy: preclinical infectivity in tonsil and observations on the distribution of lingual tonsil in slaughtered cattle.","volume":"156","author":"GA Wells","year":"2005","journal-title":"Vet Rec"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1099\/vir.0.82647-0","article-title":"Progression of prion infectivity in asymptomatic cattle after oral bovine spongiform encephalopathy challenge.","volume":"88","author":"JC Espinosa","year":"2007","journal-title":"J Gen Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1136\/vr.138.22.546","article-title":"Detection of BSE infectivity in brain and spleen of experimentally infected sheep.","volume":"138","author":"JD Foster","year":"1996","journal-title":"Vet Rec"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/vr.156.7.197","article-title":"Tissue distribution of bovine spongiform encephalopathy infectivity in Romney sheep up to the onset of clinical disease after oral challenge.","volume":"156","author":"SJ Bellworthy","year":"2005","journal-title":"Vet Rec"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1138718","article-title":"A general model of prion strains and their pathogenicity.","volume":"318","author":"J Collinge","year":"2007","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0034-5288(18)34700-3","article-title":"The relative susceptibility of sheep, goats and mice to two types of the goat scrapie agent.","volume":"7","author":"IH Pattison","year":"1966","journal-title":"Res Vet Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(89)90608-9","article-title":"Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.","volume":"59","author":"M Scott","year":"1989","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(90)90134-Z","article-title":"Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.","volume":"63","author":"SB Prusiner","year":"1990","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(02)00726-2","article-title":"A change in the conformation of prions accompanies the emergence of a new prion strain.","volume":"34","author":"D Peretz","year":"2002","journal-title":"Neuron"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/383685a0","article-title":"Molecular analysis of prion strain variation and the aetiology of \u2018new variant\u2019 CJD.","volume":"383","author":"J Collinge","year":"1996","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.96.26.15137","article-title":"Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.","volume":"96","author":"MR Scott","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1128\/JVI.79.9.5259-5271.2005","article-title":"Transmission barriers for bovine, ovine, and human prions in transgenic mice.","volume":"79","author":"MR Scott","year":"2005","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1371\/journal.ppat.0020012","article-title":"Efficient transmission and characterization of Creutzfeldt-Jakob disease strains in bank voles.","volume":"2","author":"R Nonno","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/JVI.01356-06","article-title":"Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice.","volume":"81","author":"JC Espinosa","year":"2007","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3201\/eid1508.081218","article-title":"Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie.","volume":"15","author":"JC Espinosa","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/352340a0","article-title":"Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease.","volume":"352","author":"MS Palmer","year":"1991","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s004390050204","article-title":"Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.","volume":"98","author":"O Windl","year":"1996","journal-title":"Hum Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/hmg\/6.10.1699","article-title":"Human prion diseases and bovine spongiform encephalopathy (BSE).","volume":"6","author":"J Collinge","year":"1997","journal-title":"Hum Mol Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1086\/317935","article-title":"Increased susceptibility to Kuru of carriers of the PRNP 129 methionine\/methionine genotype.","volume":"183","author":"HS Lee","year":"2001","journal-title":"J Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e1419","DOI":"10.1371\/journal.pone.0001419","article-title":"Prominent and persistent extraneural infection in human PrP transgenic mice infected with variant CJD.","volume":"3","author":"V Beringue","year":"2008","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3201\/eid1412.080941","article-title":"Transmission of atypical bovine prions to mice transgenic for human prion protein.","volume":"14","author":"V Beringue","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2353\/ajpath.2006.050766","article-title":"Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.","volume":"168","author":"HM Yull","year":"2006","journal-title":"Am J Pathol"},{"key":"ref38","first-page":"29","article-title":"Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation.","volume":"83","author":"H Fraser","year":"1973","journal-title":"J Comp Pathol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.bbadis.2006.10.009","article-title":"Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine\/murine and bovine\/murine prion protein chimeras.","volume":"1772","author":"L Kupfer","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1093\/emboj\/cdf653","article-title":"BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein.","volume":"21","author":"EA Asante","year":"2002","journal-title":"Embo J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1128\/JVI.02561-07","article-title":"Evaluation of the human transmission risk of an atypical bovine spongiform encephalopathy prion strain.","volume":"82","author":"Q Kong","year":"2008","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1474-4422(06)70413-6","article-title":"Predicting susceptibility and incubation time of human-to-human transmission of vCJD.","volume":"5","author":"MT Bishop","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1523\/JNEUROSCI.0693-07.2007","article-title":"A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission.","volume":"27","author":"V Beringue","year":"2007","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1099\/vir.0.82426-0","article-title":"Comparative titration of experimental ovine BSE infectivity in sheep and mice.","volume":"88","author":"L Gonzalez","year":"2007","journal-title":"J Gen Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1099\/vir.0.007500-0","article-title":"Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein.","volume":"90","author":"G Tamguney","year":"2009","journal-title":"J Gen Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e1000859","DOI":"10.1371\/journal.ppat.1000859","article-title":"The physical relationship between infectivity and prion protein aggregates is strain-dependent.","volume":"6","author":"P Tixador","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1126\/science.1183218","article-title":"Darwinian evolution of prions in cell culture.","volume":"327","author":"J Li","year":"2010","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3940(00)01047-8","article-title":"Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep.","volume":"284","author":"TG Baron","year":"2000","journal-title":"Neurosci Lett"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1053\/jcpa.2001.0465","article-title":"Oral inoculation of sheep with the agent of bovine spongiform encephalopathy (BSE). 1. Onset and distribution of disease-specific PrP accumulation in brain and viscera.","volume":"124","author":"M Jeffrey","year":"2001","journal-title":"J Comp Pathol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1099\/0022-1317-82-10-2319","article-title":"Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission.","volume":"82","author":"JD Foster","year":"2001","journal-title":"J Gen Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00705-002-0958-4","article-title":"Early detection of PrPres in BSE-infected bovine PrP transgenic mice.","volume":"148","author":"J Castilla","year":"2003","journal-title":"Arch Virol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1371\/journal.ppat.0020112","article-title":"Isolation from cattle of a prion strain distinct from that causing bovine spongiform encephalopathy.","volume":"2","author":"V Beringue","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1074\/jbc.M407006200","article-title":"Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.","volume":"280","author":"C Feraudet","year":"2005","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1099\/0022-1317-83-10-2607","article-title":"PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission.","volume":"83","author":"O Andreoletti","year":"2002","journal-title":"J Gen Virol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0021-9975(68)90006-6","article-title":"The sequential development of the brain lesion of scrapie in three strains of mice.","volume":"78","author":"H Fraser","year":"1968","journal-title":"J Comp Pathol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1523\/JNEUROSCI.5400-03.2004","article-title":"Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein.","volume":"24","author":"J Castilla","year":"2004","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1086\/512087","article-title":"Bovine spongiform encephalopathy agent in a prion protein (PrP)ARR\/ARR genotype sheep after peripheral challenge: complete immunohistochemical analysis of disease-associated PrP and transmission studies to ovine-transgenic mice.","volume":"195","author":"A Bencsik","year":"2007","journal-title":"J Infect Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1423-0410.2007.00904.x","article-title":"Reference materials for the evaluation of pre-mortem variant Creutzfeldt-Jakob disease diagnostic assays.","volume":"92","author":"JK Cooper","year":"2007","journal-title":"Vox Sang"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1001319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T04:21:54Z","timestamp":1712290914000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1001319"}},"subtitle":[],"editor":[{"given":"Umberto","family":"Agrimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,17]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1001319","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,17]]}}}