{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:15Z","timestamp":1791354075320,"version":"4.3.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002079","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T17:13:06Z","timestamp":1308330786000},"page":"e1002079","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Molecular Interactions that Enable Movement of the Lyme Disease Agent from the Tick Gut into the Hemolymph"],"prefix":"10.1371","volume":"7","author":[{"given":"Lili","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarojini","family":"Adusumilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanya","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang O.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.8503006","article-title":"The biological and social phenomenon of Lyme disease.","volume":"260","author":"AG Barbour","year":"1993","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease.","volume":"345","author":"AC Steere","year":"2001","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01200454","article-title":"Transmission of Lyme disease spirochetes (Borrelia burgdorferi).","volume":"7","author":"J Piesman","year":"1989","journal-title":"Exp Appl Acarol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1128\/JB.184.11.3122-3125.2002","article-title":"Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding.","volume":"184","author":"S Narasimhan","year":"2002","journal-title":"J Bacteriol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/651172","article-title":"BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts.","volume":"201","author":"M Kumar","year":"2010","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1286-4579(01)01435-6","article-title":"Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis.","volume":"3","author":"RD Gilmore Jr","year":"2001","journal-title":"Microbes Infect"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1128\/IAI.00372-10","article-title":"Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi.","volume":"78","author":"H Xu","year":"2010","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.4049\/jimmunol.164.10.5344","article-title":"Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission.","volume":"164","author":"E Fikrig","year":"2000","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding.","volume":"53","author":"AM De Silva","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2004.10.027","article-title":"TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi.","volume":"119","author":"U Pal","year":"2004","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host.","volume":"436","author":"N Ramamoorthi","year":"2005","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from Borrelia burgdorferi.","volume":"30","author":"BP Guo","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2958.1998.01127.x","article-title":"Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31.","volume":"30","author":"WS Probert","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1128\/IAI.63.9.3467-3472.1995","article-title":"Adherence of Borrelia burgdorferi to the proteoglycan decorin.","volume":"63","author":"BP Guo","year":"1995","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1099\/mic.0.2006\/003350-0","article-title":"Regulated synthesis of the Borrelia burgdorferi inner-membrane lipoprotein IpLA7 (P22, P22-A) during the Lyme disease spirochaete&apos;s mammal-tick infectious cycle.","volume":"153","author":"K von Lackum","year":"2007","journal-title":"Microbiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/IAI.67.1.30-35.1999","article-title":"Influence of outer surface protein A antibody on Borrelia burgdorferi within feeding ticks.","volume":"67","author":"AM de Silva","year":"1999","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands.","volume":"113","author":"U Pal","year":"2004","journal-title":"J Clin Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0.","volume":"340","author":"JD Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1172\/JCI39401","article-title":"Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.","volume":"119","author":"SM Dunham-Ems","year":"2009","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1603\/0022-2585-38.1.99","article-title":"Contrasts in tick innate immune responses to Borrelia burgdorferi challenge: immunotolerance in Ixodes scapularis versus immunocompetence in Dermacentor variabilis (Acari: Ixodidae).","volume":"38","author":"R Johns","year":"2001","journal-title":"J Med Entomol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.1073\/pnas.1000268107","article-title":"The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission.","volume":"107","author":"RD Gilmore Jr","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1574-6968.2000.tb09415.x","article-title":"Enhancement of OspC expression by Borrelia burgdorferi in the presence of tick hemolymph.","volume":"193","author":"RH Johns","year":"2000","journal-title":"FEMS Microbiol Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/IAI.02035-05","article-title":"Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity.","volume":"74","author":"X Li","year":"2006","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20031960","article-title":"Essential role for OspA\/B in the life cycle of the Lyme disease spirochete.","volume":"199","author":"XF Yang","year":"2004","journal-title":"J Exp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1128\/IAI.00632-07","article-title":"Role of outer surface protein D in the Borrelia burgdorferi life cycle.","volume":"75","author":"X Li","year":"2007","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1084\/jem.20070962","article-title":"Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis.","volume":"205","author":"U Pal","year":"2008","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1128\/JB.187.16.5776-5781.2005","article-title":"Role of Borrelia burgdorferi linear plasmid 25 in infection of Ixodes scapularis ticks.","volume":"187","author":"KO Strother","year":"2005","journal-title":"J Bacteriol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1128\/IAI.72.10.5938-5946.2004","article-title":"Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.","volume":"72","author":"D Grimm","year":"2004","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1089\/vbz.2005.5.237","article-title":"Plasmid requirements for infection of ticks by Borrelia burgdorferi.","volume":"5","author":"KO Strother","year":"2005","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1046\/j.1365-2958.2003.03452.x","article-title":"A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host.","volume":"48","author":"JE Purser","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1073\/pnas.0502565102","article-title":"bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector.","volume":"102","author":"AT Revel","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.4049\/jimmunol.166.12.7398","article-title":"Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody.","volume":"166","author":"U Pal","year":"2001","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.chom.2007.06.001","article-title":"A tick antioxidant facilitates the Lyme disease agent&apos;s successful migration from the mammalian host to the arthropod vector.","volume":"2","author":"S Narasimhan","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nprot.2006.94","article-title":"Isolating and engineering human antibodies using yeast surface display.","volume":"1","author":"G Chao","year":"2006","journal-title":"Nat Protoc"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T03:31:24Z","timestamp":1592623884000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002079"}},"subtitle":[],"editor":[{"given":"David L.","family":"Sacks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,6,9]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002079","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11762961.12854063","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,9]]}}}