{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:06:35Z","timestamp":1791291995973,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T00:00:00Z","timestamp":1316044800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002120","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T04:30:32Z","timestamp":1316147432000},"page":"e1002120","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":114,"title":["A Salmonella Small Non-Coding RNA Facilitates Bacterial Invasion and Intracellular Replication by Modulating the Expression of Virulence Factors"],"prefix":"10.1371","volume":"7","author":[{"given":"Hao","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gia-Phong","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elton","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,15]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Surveillance for foodborne-disease outbreaks\u2013United States, 1993\u20131997.","volume":"49","author":"SJ Olsen","year":"2000","journal-title":"MMWR CDC Surveill Summ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1128\/CMR.17.1.14-56.2004","article-title":"Pathogenicity islands in bacterial pathogenesis.","volume":"17","author":"H Schmidt","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nature05272","article-title":"Protein delivery into eukaryotic cells by type III secretion machines.","volume":"444","author":"JE Galan","year":"2006","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1462-5822.2006.00706.x","article-title":"Manipulating cellular transport and immune responses: dynamic interactions between intracellular <italic>Salmonella enterica<\/italic> and its host cells.","volume":"8","author":"GL Abrahams","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.cellbio.17.1.53","article-title":"<italic>Salmonella<\/italic> interactions with host cells: type III secretion at work.","volume":"17","author":"JE Galan","year":"2001","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1462-5822.2003.00294.x","article-title":"Functions and effectors of the <italic>Salmonella<\/italic> pathogenicity island 2 type III secretion system.","volume":"5","author":"SR Waterman","year":"2003","journal-title":"Cell Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.62.2.379-433.1998","article-title":"Type III protein secretion systems in bacterial pathogens of animals and plants.","volume":"62","author":"CJ Hueck","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mib.2006.12.002","article-title":"Adaptation to the host environment: regulation of the SPI1 type III secretion system in <italic>Salmonella enteric<\/italic>a serovar Typhimurium.","volume":"10","author":"JR Ellermeier","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1099\/mic.0.2006\/002758-0","article-title":"SipA, SopA, SopB, SopD and SopE2 effector proteins of <italic>Salmonella enterica<\/italic> serovar Typhimurium are synthesized at late stages of infection in mice.","volume":"153","author":"MN Giacomodonato","year":"2007","journal-title":"Microbiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1128\/IAI.67.11.5690-5698.1999","article-title":"<italic>Salmonella typhimurium<\/italic> virulence genes are induced upon bacterial invasion into phagocytic and nonphagocytic cells.","volume":"67","author":"CG Pfeifer","year":"1999","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1462-5822.2002.00170.x","article-title":"The invasion-associated type III secretion system of <italic>Salmonella enterica<\/italic> serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells.","volume":"4","author":"O Steele-Mortimer","year":"2002","journal-title":"Cell Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2180-9-73","article-title":"Characterization of the expression of <italic>Salmonella<\/italic> Type III secretion system factor PrgI, SipA, SipB, SopE2, SpaO, and SptP in cultures and in mice.","volume":"9","author":"H Gong","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1099\/mic.0.032318-0","article-title":"Differential expression of <italic>Salmonella<\/italic> type III secretion system factors InvJ, PrgJ, SipC, SipD, SopA and SopB in cultures and in mice.","volume":"156","author":"H Gong","year":"2010","journal-title":"Microbiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1101\/sqb.2006.71.064","article-title":"The expanding universe of noncoding RNAs.","volume":"71","author":"GJ Hannon","year":"2006","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.1072249","article-title":"An expanding universe of noncoding RNAs.","volume":"296","author":"G Storz","year":"2002","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mib.2007.03.004","article-title":"Small noncoding RNAs controlling pathogenesis.","volume":"10","author":"A Toledo-Arana","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.chom.2010.06.008","article-title":"Regulatory RNA in bacterial pathogens.","volume":"8","author":"K Papenfort","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1101\/sqb.2006.71.033","article-title":"Regulating bacterial transcription with small RNAs.","volume":"71","author":"G Storz","year":"2006","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2958.2008.06505.x","article-title":"A rough guide to the non-coding RNA world of <italic>Salmonella<\/italic>.","volume":"71","author":"J Vogel","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.mib.2004.02.015","article-title":"Controlling mRNA stability and translation with small, noncoding RNAs.","volume":"7","author":"G Storz","year":"2004","journal-title":"Curr Opin Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mib.2007.03.007","article-title":"CsrB sRNA family: sequestration of RNA-binding regulatory proteins.","volume":"10","author":"P Babitzke","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.mib.2007.03.008","article-title":"6S RNA: a small RNA regulator of transcription.","volume":"10","author":"KM Wassarman","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/nar\/gkn050","article-title":"Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence.","volume":"36","author":"G Padalon-Brauch","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/j.1365-2958.2007.05991.x","article-title":"A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the <italic>Salmonella<\/italic> core genome.","volume":"66","author":"V Pfeiffer","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1000163","DOI":"10.1371\/journal.pgen.1000163","article-title":"Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq.","volume":"4","author":"A Sittka","year":"2008","journal-title":"PLoS Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1365-2958.1998.00976.x","article-title":"The RcsB-RcsC regulatory system of <italic>Salmonella typhi<\/italic> differentially modulates the expression of invasion proteins, flagellin and Vi antigen in response to osmolarity.","volume":"29","author":"N Arricau","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1128\/IAI.58.6.1879-1885.1990","article-title":"Expression of <italic>Salmonella typhimurium<\/italic> genes required for invasion is regulated by changes in DNA supercoiling.","volume":"58","author":"JE Galan","year":"1990","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1128\/IAI.61.7.3084-3089.1993","article-title":"Osmolarity and growth phase overlap in regulation of <italic>Salmonella typhi<\/italic> adherence to and invasion of human intestinal cells.","volume":"61","author":"C Tartera","year":"1993","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1128\/IAI.62.9.3745-3752.1994","article-title":"Identification and characterization of a <italic>Salmonella typhimurium<\/italic> oxygen-regulated gene required for bacterial internalization.","volume":"62","author":"BD Jones","year":"1994","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.87.11.4304","article-title":"The ability of Salmonella to enter mammalian cells is affected by bacterial growth state.","volume":"87","author":"CA Lee","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/gut.28.10.1221","article-title":"Short chain fatty acids in human large intestine, portal, hepatic and venous blood.","volume":"28","author":"JH Cummings","year":"1987","journal-title":"Gut"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1637\/7094","article-title":"Interactions of butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro.","volume":"48","author":"F Van Immerseel","year":"2004","journal-title":"Avian Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible.","volume":"34","author":"J Kruger","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/nar\/gkl356","article-title":"Target prediction for small, noncoding RNAs in bacteria.","volume":"34","author":"B Tjaden","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1128\/IAI.71.3.1295-1305.2003","article-title":"HilE interacts with HilD and negatively regulates hilA transcription and expression of the <italic>Salmonella enterica<\/italic> serovar Typhimurium invasive phenotype.","volume":"71","author":"MA Baxter","year":"2003","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/nar\/gkl1040","article-title":"Translational control and target recognition by <italic>Escherichia coli<\/italic> small RNAs in vivo.","volume":"35","author":"JH Urban","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/IAI.57.1.1-7.1989","article-title":"Intracellular survival of wild-type <italic>Salmonella typhimurium<\/italic> and macrophage-sensitive mutants in diverse populations of macrophages.","volume":"57","author":"NA Buchmeier","year":"1989","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2958.2005.04737.x","article-title":"HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in <italic>Salmonella enterica<\/italic> serovar Typhimurium.","volume":"57","author":"CD Ellermeier","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2958.2006.05407.x","article-title":"The inflammation-associated <italic>Salmonella<\/italic> SopA is a HECT-like E3 ubiquitin ligase.","volume":"62","author":"Y Zhang","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nsmb1346","article-title":"Crystal structure of SopA, a <italic>Salmonella<\/italic> effector protein mimicking a eukaryotic ubiquitin ligase.","volume":"15","author":"J Diao","year":"2008","journal-title":"Nat Struct Mol Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mib.2009.11.008","article-title":"Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases.","volume":"13","author":"SW Hicks","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1128\/IAI.73.1.146-154.2005","article-title":"SipA, SopA, SopB, SopD, and SopE2 contribute to <italic>Salmonella enterica<\/italic> serotype typhimurium invasion of epithelial cells.","volume":"73","author":"M Raffatellu","year":"2005","journal-title":"Infect Immun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mib.2007.03.015","article-title":"Hfq structure, function and ligand binding.","volume":"10","author":"RG Brennan","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1365-2958.2003.03935.x","article-title":"The bacterial Sm-like protein Hfq: a key player in RNA transactions.","volume":"51","author":"P Valentin-Hansen","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1000037","DOI":"10.1371\/journal.ppat.1000037","article-title":"Deciphering interplay between <italic>Salmonella<\/italic> invasion effectors.","volume":"4","author":"RJ Cain","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e2178","DOI":"10.1371\/journal.pone.0002178","article-title":"Hierarchical effector protein transport by the <italic>Salmonella Typhimurium<\/italic> SPI-1 type III secretion system.","volume":"3","author":"B Winnen","year":"2008","journal-title":"PLoS ONE"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in <italic>Escherichia coli<\/italic> K-12 using PCR products.","volume":"97","author":"KA Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/IAI.70.2.451-461.2002","article-title":"The global regulator ArcA controls resistance to reactive nitrogen and oxygen intermediates in <italic>Salmonella enterica<\/italic> serovar Enteritidis.","volume":"70","author":"S Lu","year":"2002","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/IAI.01027-08","article-title":"The potassium transporter Trk and external potassium modulate <italic>Salmonella enterica<\/italic> protein secretion and virulence.","volume":"77","author":"J Su","year":"2009","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1128\/IAI.67.11.5651-5657.1999","article-title":"Analysis of virulence of clinical isolates of <italic>Salmonella enteritidis<\/italic> in vivo and in vitro.","volume":"67","author":"S Lu","year":"1999","journal-title":"Infect Immun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/35101614","article-title":"Complete genome sequence of <italic>Salmonella enterica<\/italic> serovar Typhimurium LT2.","volume":"413","author":"M McClelland","year":"2001","journal-title":"Nature"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:37:29Z","timestamp":1592959049000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002120"}},"subtitle":[],"editor":[{"given":"Denise M.","family":"Monack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,15]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002120","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,15]]}}}