{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:19:25Z","timestamp":1791674365066,"version":"4.3.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002125","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T16:51:51Z","timestamp":1310662311000},"page":"e1002125","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":139,"title":["E6 and E7 from Beta Hpv38 Cooperate with Ultraviolet Light in the Development of Actinic Keratosis-Like Lesions and Squamous Cell Carcinoma in Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Daniele","family":"Viarisio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Mueller-Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kloz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Aengeneyndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Kopp-Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann-Josef","family":"Gr\u00f6ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Gheit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Flechtenmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Gissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Tommasino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ijc.1571","article-title":"Estimates of the world-wide prevalence of cancer for 25 sites in the adult population.","volume":"97","author":"P Pisani","year":"2002","journal-title":"Int J Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nm0597-510","article-title":"Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens.","volume":"3","author":"HN Ananthaswamy","year":"1997","journal-title":"Nat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1011-1344(01)00198-1","article-title":"The epidemiology of UV induced skin cancer.","volume":"63","author":"BK Armstrong","year":"2001","journal-title":"J Photochem Photobiol B"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJM199212033272307","article-title":"Nonmelanoma cancers of the skin.","volume":"327","author":"DS Preston","year":"1992","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(84)92221-9","article-title":"Cancer, warts, and sunshine in renal transplant patients. A case-control study.","volume":"1","author":"J Boyle","year":"1984","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/scbi.1999.0143","article-title":"Papillomaviruses in non-melanoma skin cancer: epidemiological aspects.","volume":"9","author":"NB Kiviat","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1440-0960.1976.tb00798.x","article-title":"The skin and immunosuppression.","volume":"17","author":"BK Walder","year":"1976","journal-title":"Australas J Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/S0140-6736(71)90602-7","article-title":"Skin cancer and immunosuppression.","volume":"2","author":"BK Walder","year":"1971","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/oxfordjournals.jncimonographs.a003483","article-title":"Chapter 8: human papillomavirus and skin cancer.","volume":"31","author":"H Pfister","year":"2003","journal-title":"J Natl Cancer Inst Monogr"},{"key":"ref10","first-page":"269","article-title":"The cutaneous human papillomavirus types and non-melanoma-skin cancer. Papillomavirus Research: From Natural History to Vaccine and Beyond","author":"V Bouvard","year":"2006"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1128\/JCM.38.6.2087-2096.2000","article-title":"Persistence of human papillomavirus DNA in benign and (pre)malignant skin lesions from renal transplant recipients.","volume":"38","author":"RJ Berkhout","year":"2000","journal-title":"J Clin Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/1523-1747.ep12320803","article-title":"High frequency of detection of epidermodysplasia verruciformis-associated human papillomavirus DNA in biopsies from malignant and premalignant skin lesions from renal transplant recipients.","volume":"105","author":"LM de Jong-Tieben","year":"1995","journal-title":"J Invest Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1096-9071(200007)61:3<289::AID-JMV2>3.0.CO;2-Z","article-title":"Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals.","volume":"61","author":"CA Harwood","year":"2000","journal-title":"J Med Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1158\/1055-9965.EPI-07-0405","article-title":"Seroreactivity to cutaneous human papillomaviruses among patients with nonmelanoma skin cancer or benign skin lesions.","volume":"17","author":"K Andersson","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2133.2008.08621.x","article-title":"Serological association of beta and gamma human papillomaviruses with squamous cell carcinoma of the skin.","volume":"159","author":"T Waterboer","year":"2008","journal-title":"Br J Dermatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/ijc.22885","article-title":"A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition.","volume":"121","author":"D Casabonne","year":"2007","journal-title":"Int J Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/jnci\/djj092","article-title":"Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin.","volume":"98","author":"MR Karagas","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"c2986","DOI":"10.1136\/bmj.c2986","article-title":"Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study.","volume":"341","author":"MR Karagas","year":"2010","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1158\/0008-5472.CAN-10-0352","article-title":"Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma.","volume":"70","author":"JN Bavinck","year":"2010","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1101\/gad.182100","article-title":"Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins.","volume":"14","author":"S Jackson","year":"2000","journal-title":"Genes Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10408","DOI":"10.1128\/JVI.00902-08","article-title":"E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation.","volume":"82","author":"MP Underbrink","year":"2008","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1128\/JVI.77.3.2195-2206.2003","article-title":"The E6 and E7 proteins of cutaneous human papillomavirus type 38 display transforming properties.","volume":"77","author":"S Caldeira","year":"2003","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1096\/fj.07-8389com","article-title":"Impairment of the telomere\/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38.","volume":"22","author":"AS Gabet","year":"2008","journal-title":"Faseb J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/sj.embor.7400615","article-title":"Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.","volume":"7","author":"R Accardi","year":"2006","journal-title":"EMBO Rep"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1158\/0008-5472.CAN-04-3263","article-title":"Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8.","volume":"65","author":"ID Schaper","year":"2005","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1099\/vir.0.012872-0","article-title":"Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding.","volume":"90","author":"GP Marcuzzi","year":"2009","journal-title":"J Gen Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.1128\/JVI.00954-06","article-title":"E6\/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice.","volume":"80","author":"A Michel","year":"2006","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"14899","DOI":"10.1128\/JVI.79.23.14899-14908.2005","article-title":"Skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing E6 and E7 of human papillomavirus type 38.","volume":"79","author":"W Dong","year":"2005","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.cb.11.110195.001011","article-title":"Keratins and the skin.","volume":"11","author":"E Fuchs","year":"1995","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1128\/JVI.78.9.4797-4805.2004","article-title":"Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.","volume":"78","author":"I Helfrich","year":"2004","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/viro.1999.0106","article-title":"Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis.","volume":"267","author":"S Song","year":"2000","journal-title":"Virology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1128\/JVI.01818-07","article-title":"The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes.","volume":"82","author":"KM Bedard","year":"2008","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-009-0412-8","article-title":"The biological properties of E6 and E7 oncoproteins from human papillomaviruses.","volume":"40","author":"R Ghittoni","year":"2010","journal-title":"Virus Genes"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.0022-202X.2005.23733.x","article-title":"Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers.","volume":"125","author":"SJ Weissenborn","year":"2005","journal-title":"J Invest Dermatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/JVI.62.10.3655-3661.1988","article-title":"Involvement of human papillomavirus type 8 genes E6 and E7 in transformation and replication.","volume":"62","author":"T Iftner","year":"1988","journal-title":"J Virol"},{"key":"ref36","first-page":"2433","article-title":"Biological and biochemical activity of E7 genes of the cutaneous human papillomavirus type 5 and 8.","volume":"8","author":"T Yamashita","year":"1993","journal-title":"Oncogene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1128\/JVI.68.11.7051-7059.1994","article-title":"Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1.","volume":"68","author":"A Schmitt","year":"1994","journal-title":"J Virol"},{"key":"ref38","first-page":"167","article-title":"Two independently transforming functions of human papillomavirus 8.","volume":"144","author":"T Iftner","year":"1989","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1038\/jid.2008.73","article-title":"The human papillomavirus type 8 E2 protein induces skin tumors in transgenic mice.","volume":"128","author":"R Pfefferle","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8250","DOI":"10.1128\/MCB.14.12.8250","article-title":"Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.","volume":"14","author":"P Auewarakul","year":"1994","journal-title":"Mol Cell Biol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006005","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000}}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T05:20:06Z","timestamp":1592716806000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002125"}},"subtitle":[],"editor":[{"given":"Paul","family":"Lambert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002125","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}