{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:30:26Z","timestamp":1789885826064,"version":"4.0.1"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002150","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T21:06:30Z","timestamp":1311282390000},"page":"e1002150","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency"],"prefix":"10.1371","volume":"7","author":[{"given":"Justin M.","family":"Richner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Clyde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Pezda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson Yee Hin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Renuka","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Covarrubias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Coscoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Glaunsinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1097-2765(04)00091-7","article-title":"Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover.","volume":"13","author":"B Glaunsinger","year":"2004","journal-title":"Mol Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0603144103","article-title":"Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation.","volume":"103","author":"W Kamitani","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0021-9258(18)69588-2","article-title":"Poliovirus protein: source of amino acids and time course of synthesis.","volume":"235","author":"JE Darnell Jr","year":"1960","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/MCB.4.10.2198","article-title":"Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.","volume":"4","author":"MG Katze","year":"1984","journal-title":"Mol Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(81)90449-9","article-title":"A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription.","volume":"23","author":"SJ Plotch","year":"1981","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1369-5274(00)00106-5","article-title":"Regulation of host cell translation by viruses and effects on cell function.","volume":"3","author":"SR Thompson","year":"2000","journal-title":"Curr Opin Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"11620","DOI":"10.1128\/JVI.00702-07","article-title":"Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain.","volume":"81","author":"MG Wathelet","year":"2007","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1128\/JVI.74.22.10401-10406.2000","article-title":"Toward a comprehensive phylogeny for mammalian and avian herpesviruses.","volume":"74","author":"DJ McGeoch","year":"2000","journal-title":"J Virol"},{"key":"ref9","first-page":"468","article-title":"Isolation of five strains of herpesviruses from two species of free living small rodents.","volume":"24","author":"D Blaskovic","year":"1980","journal-title":"Acta Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5894","DOI":"10.1128\/JVI.71.8.5894-5904.1997","article-title":"Complete sequence and genomic analysis of murine gammaherpesvirus 68.","volume":"71","author":"HW Virgin","year":"1997","journal-title":"J Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12026-010-8172-z","article-title":"Prospects of a novel vaccination strategy for human gamma-herpesviruses.","volume":"48","author":"TT Wu","year":"2010","journal-title":"Immunol Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1128\/JVI.79.8.5227-5231.2005","article-title":"Ex vivo stimulation of B cells latently infected with gammaherpesvirus 68 triggers reactivation from latency.","volume":"79","author":"JM Moser","year":"2005","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1128\/JVI.01400-09","article-title":"Toll-like receptor agonists synergistically increase proliferation and activation of B cells by epstein-barr virus.","volume":"84","author":"S Iskra","year":"2010","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"11725","DOI":"10.1073\/pnas.0905316106","article-title":"Toll-like receptor signaling controls reactivation of KSHV from latency.","volume":"106","author":"SM Gregory","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1073\/pnas.0611128104","article-title":"Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.","volume":"104","author":"M Rowe","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1128\/JVI.01051-09","article-title":"Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm.","volume":"83","author":"S Covarrubias","year":"2009","journal-title":"J Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1128\/JVI.70.4.2075-2085.1996","article-title":"Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.","volume":"70","author":"R Martinez","year":"1996","journal-title":"J Virol"},{"issue":"Pt 11","key":"ref18","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1099\/0022-1317-78-11-2953","article-title":"The human cytomegalovirus UL98 gene encodes the conserved herpesvirus alkaline nuclease.","volume":"78","author":"AK Sheaffer","year":"1997","journal-title":"J Gen Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10282","DOI":"10.1128\/JVI.78.19.10282-10290.2004","article-title":"Identification of candidate gammaherpesvirus 68 genes required for virus replication by signature-tagged transposon mutagenesis.","volume":"78","author":"NJ Moorman","year":"2004","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1099\/0022-1317-3-3-337","article-title":"A new DNA-exonuclease in cells infected with herpes virus: partial purification and properties of the enzyme.","volume":"3","author":"JM Morrison","year":"1968","journal-title":"J Gen Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jmb.2009.06.034","article-title":"A bridge crosses the active-site canyon of the Epstein-Barr virus nuclease with DNase and RNase activities.","volume":"391","author":"M Buisson","year":"2009","journal-title":"J Mol Biol"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr111","article-title":"Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.","author":"C Bagneris","year":"2011"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/MCB.00600-10","article-title":"Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA.","volume":"30","author":"GR Kumar","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1000107","DOI":"10.1371\/journal.pbio.1000107","article-title":"Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destruction.","volume":"7","author":"YJ Lee","year":"2009","journal-title":"PLoS Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1128\/JVI.01946-07","article-title":"The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function.","volume":"82","author":"J Zuo","year":"2008","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"7396","DOI":"10.1128\/JVI.79.12.7396-7401.2005","article-title":"The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.","volume":"79","author":"B Glaunsinger","year":"2005","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1006\/viro.1998.9129","article-title":"The exonuclease activity of HSV-1 UL12 is required for in vivo function.","volume":"244","author":"JN Goldstein","year":"1998","journal-title":"Virology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1128\/JVI.74.15.6964-6974.2000","article-title":"Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome.","volume":"74","author":"H Adler","year":"2000","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/JVI.00297-09","article-title":"Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein.","volume":"83","author":"CM Collins","year":"2009","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1099\/vir.0.006569-0","article-title":"In vivo imaging of murid herpesvirus-4 infection.","volume":"90","author":"R Milho","year":"2009","journal-title":"J Gen Virol"},{"issue":"Pt 9","key":"ref31","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1099\/0022-1317-73-9-2347","article-title":"Virological and pathological features of mice infected with murine gamma-herpesvirus 68.","volume":"73","author":"NP Sunil-Chandra","year":"1992","journal-title":"J Gen Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"12498","DOI":"10.1128\/JVI.01152-08","article-title":"Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo.","volume":"82","author":"S Hwang","year":"2008","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chom.2010.06.014","article-title":"Viral latency and its regulation: lessons from the gamma-herpesviruses.","volume":"8","author":"SH Speck","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"Pt 12","key":"ref34","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1099\/0022-1317-73-12-3275","article-title":"Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo.","volume":"73","author":"NP Sunil-Chandra","year":"1992","journal-title":"J Gen Virol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/088282404322875467","article-title":"Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.","volume":"17","author":"JB Weinberg","year":"2004","journal-title":"Viral Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1128\/JVI.73.4.3273-3283.1999","article-title":"Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells.","volume":"73","author":"KE Weck","year":"1999","journal-title":"J Virol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.4049\/jimmunol.174.8.4972","article-title":"Early establishment of gamma-herpesvirus latency: implications for immune control.","volume":"174","author":"E Flano","year":"2005","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1099\/vir.0.18639-0","article-title":"Transcriptome profile of murine gammaherpesvirus-68 lytic infection.","volume":"84","author":"B Ebrahimi","year":"2003","journal-title":"J Gen Virol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.chom.2010.05.005","article-title":"Redefining the genetics of murine gammaherpesvirus 68 via transcriptome-based annotation.","volume":"7","author":"LS Johnson","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1128\/JVI.77.19.10488-10503.2003","article-title":"Transcription program of murine gammaherpesvirus 68.","volume":"77","author":"D Martinez-Guzman","year":"2003","journal-title":"J Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1128\/JVI.63.11.4834-4839.1989","article-title":"The herpes simplex virus virion host shutoff function.","volume":"63","author":"AD Kwong","year":"1989","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1128\/JVI.69.11.6779-6786.1995","article-title":"Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis.","volume":"69","author":"LI Strelow","year":"1995","journal-title":"J Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1128\/JVI.02409-07","article-title":"Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice.","volume":"82","author":"M Korom","year":"2008","journal-title":"J Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1128\/JVI.77.6.3768-3776.2003","article-title":"Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.","volume":"77","author":"L Samady","year":"2003","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1128\/JVI.77.17.9337-9345.2003","article-title":"Herpes simplex virus type 2 virion host shutoff protein regulates alpha\/beta interferon but not adaptive immune responses during primary infection in vivo.","volume":"77","author":"JA Murphy","year":"2003","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1128\/JVI.02047-07","article-title":"Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state.","volume":"82","author":"TJ Pasieka","year":"2008","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1111\/j.1742-4658.2009.07374.x","article-title":"Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus.","volume":"276","author":"SL Dahlroth","year":"2009","journal-title":"FEBS J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/gb-2009-10-8-234","article-title":"Virus-mediated mRNA decay by hyperadenylation.","volume":"10","author":"KJ Sokoloski","year":"2009","journal-title":"Genome Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.4049\/jimmunol.0903120","article-title":"EBV lytic-phase protein BGLF5 contributes to TLR9 downregulation during productive infection.","volume":"186","author":"M van Gent","year":"2011","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/vim.2005.18.445","article-title":"Immune mechanisms in murine gammaherpesvirus-68 infection.","volume":"18","author":"PG Stevenson","year":"2005","journal-title":"Viral Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.4049\/jimmunol.165.2.1074","article-title":"Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.","volume":"165","author":"E Flano","year":"2000","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e560","DOI":"10.1371\/journal.pone.0000560","article-title":"IgG fc receptors provide an alternative infection route for murine gamma-herpesvirus-68.","volume":"2","author":"GT Rosa","year":"2007","journal-title":"PLoS ONE"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-immunol-072710-081639","article-title":"Pathogenesis and host control of gammaherpesviruses: lessons from the mouse.","volume":"29","author":"E Barton","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref54","first-page":"51","article-title":"Pathogenesis of acute and persistent murine herpesvirus infection in mice.","volume":"29","author":"J Rajcani","year":"1985","journal-title":"Acta Virol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1128\/JVI.74.16.7451-7461.2000","article-title":"The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.","volume":"74","author":"LF van Dyk","year":"2000","journal-title":"J Virol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20071135","article-title":"A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.","volume":"205","author":"AG Evans","year":"2008","journal-title":"J Exp Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"9700","DOI":"10.1128\/JVI.77.17.9700-9709.2003","article-title":"Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosis.","volume":"77","author":"AI Macrae","year":"2003","journal-title":"J Virol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1128\/JVI.79.4.2261-2273.2005","article-title":"The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.","volume":"79","author":"J Herskowitz","year":"2005","journal-title":"J Virol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"10295","DOI":"10.1128\/JVI.77.19.10295-10303.2003","article-title":"The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency.","volume":"77","author":"NJ Moorman","year":"2003","journal-title":"J Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1128\/JVI.00133-10","article-title":"Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.","volume":"84","author":"CR Paden","year":"2010","journal-title":"J Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"7308","DOI":"10.1128\/JVI.77.13.7308-7318.2003","article-title":"Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes.","volume":"77","author":"S Marques","year":"2003","journal-title":"J Virol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chom.2008.12.013","article-title":"Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response.","volume":"5","author":"S Hwang","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.virol.2010.05.027","article-title":"Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.","volume":"405","author":"VL Tarakanova","year":"2010","journal-title":"Virology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1128\/JVI.00170-09","article-title":"The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication.","volume":"83","author":"R Feederle","year":"2009","journal-title":"J Virol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"9215","DOI":"10.1128\/JVI.78.17.9215-9223.2004","article-title":"Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection.","volume":"78","author":"TM Rickabaugh","year":"2004","journal-title":"J Virol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1099\/vir.0.19599-0","article-title":"Forced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68.","volume":"85","author":"JS May","year":"2004","journal-title":"J Gen Virol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1128\/JVI.73.8.6405-6414.1999","article-title":"Construction and transposon mutagenesis in Escherichia coli of a full-length infectious clone of pseudorabies virus, an alphaherpesvirus.","volume":"73","author":"GA Smith","year":"1999","journal-title":"J Virol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0022-1759(88)90310-9","article-title":"A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity.","volume":"115","author":"T Decker","year":"1988","journal-title":"J Immunol Methods"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T13:41:31Z","timestamp":1638106891000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002150"}},"subtitle":[],"editor":[{"given":"Samuel H.","family":"Speck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,21]]},"references-count":68,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002150","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,21]]}}}