{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:42:39Z","timestamp":1792464159659,"version":"4.5.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002162","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T21:20:50Z","timestamp":1311888050000},"page":"e1002162","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Structural Basis of Chemokine Sequestration by CrmD, a Poxvirus-Encoded Tumor Necrosis Factor Receptor"],"prefix":"10.1371","volume":"7","author":[{"given":"Xiaoguang","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic.","volume":"392","author":"M Baggiolini","year":"1998","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors.","volume":"18","author":"D Rossi","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","article-title":"Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.","volume":"22","author":"A Rot","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation.","volume":"354","author":"IF Charo","year":"2006","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood.V90.3.909","article-title":"Chemokines.","volume":"90","author":"BJ Rollins","year":"1997","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1146\/annurev.immunol.24.021605.090529","article-title":"Chemokine: receptor structure, interactions, and antagonism.","volume":"25","author":"SJ Allen","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0076-6879(09)05404-4","article-title":"Chapter 4. Interactions of chemokines with glycosaminoglycans.","volume":"461","author":"DJ Hamel","year":"2009","journal-title":"Methods Enzymol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1073\/pnas.032497699","article-title":"Structural diversity of heparan sulfate binding domains in chemokines.","volume":"99","author":"H Lortat-Jacob","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.immunol.21.120601.141049","article-title":"Poxviruses and immune evasion.","volume":"21","author":"BT Seet","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri980","article-title":"Viral mimicry of cytokines, chemokines and their receptors.","volume":"3","author":"A Alcami","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nri1964","article-title":"Tuning inflammation and immunity by chemokine sequestration: decoys and more.","volume":"6","author":"A Mantovani","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/viro.1996.8423","article-title":"The T1\/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues.","volume":"229","author":"KA Graham","year":"1997","journal-title":"Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1006\/viro.1997.8730","article-title":"Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.","volume":"236","author":"CA Smith","year":"1997","journal-title":"Virology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.4049\/jimmunol.160.2.624","article-title":"Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus.","volume":"160","author":"A Alcami","year":"1998","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/viro.1998.9340","article-title":"Functional comparisons among members of the poxvirus T1\/35kDa family of soluble CC-chemokine inhibitor glycoproteins.","volume":"250","author":"AS Lalani","year":"1998","journal-title":"Virology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1074\/jbc.M109884200","article-title":"Comprehensive mapping of poxvirus vCCI chemokine-binding protein. Expanded range of ligand interactions and unusual dissociation kinetics.","volume":"277","author":"JM Burns","year":"2002","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.ppat.0040005","article-title":"Structure and function of A41, a vaccinia virus chemokine binding protein.","volume":"4","author":"MW Bahar","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1128\/JVI.02111-07","article-title":"An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain.","volume":"82","author":"MB Ruiz-Arguello","year":"2008","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1084\/jem.191.3.573","article-title":"A broad spectrum secreted chemokine binding protein encoded by a herpesvirus.","volume":"191","author":"CM Parry","year":"2000","journal-title":"J Exp Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1128\/JVI.74.15.6741-6747.2000","article-title":"Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action.","volume":"74","author":"V van Berkel","year":"2000","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0092-8674(02)01007-3","article-title":"Structural basis of chemokine sequestration by a herpesvirus decoy receptor.","volume":"111","author":"JM Alexander","year":"2002","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1096\/fj.03-0485fje","article-title":"The gammaherpesvirus chemokine binding protein can inhibit the interaction of chemokines with glycosaminoglycans.","volume":"18","author":"LM Webb","year":"2004","journal-title":"Faseb J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1084\/jem.20071677","article-title":"Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor.","volume":"204","author":"JM Alexander-Brett","year":"2007","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/JVI.71.6.4356-4363.1997","article-title":"The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines.","volume":"71","author":"AS Lalani","year":"1997","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.2336648100","article-title":"Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors.","volume":"100","author":"BT Seet","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"16642","DOI":"10.1073\/pnas.0407233101","article-title":"Human cytomegalovirus encodes a highly specific RANTES decoy receptor.","volume":"101","author":"D Wang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/emboj\/cdg092","article-title":"Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins.","volume":"22","author":"NA Bryant","year":"2003","journal-title":"Embo J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1462-5822.2004.00423.x","article-title":"Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes.","volume":"6","author":"JB Johnston","year":"2004","journal-title":"Cell Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jmb.2007.06.082","article-title":"Structure of CrmE, a virus-encoded tumour necrosis factor receptor.","volume":"372","author":"SC Graham","year":"2007","journal-title":"J Mol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.0510462103","article-title":"A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.","volume":"103","author":"A Alejo","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4419-1601-3_13","article-title":"Chemokine binding proteins encoded by pathogens.","volume":"666","author":"A Alcami","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1756-0500-3-271","article-title":"SECRET domain of variola virus CrmB protein can be a member of poxviral type II chemokine-binding proteins family.","volume":"3","author":"DV Antonets","year":"2010","journal-title":"BMC research notes"},{"key":"ref33","first-page":"563","article-title":"Isolation and identification of a mouse poxvirus and its infectivity.","volume":"18","author":"X An","year":"2003","journal-title":"Virologica Sinica"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1073\/pnas.96.22.12379","article-title":"Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus.","volume":"96","author":"A Carfi","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1128\/JVI.00576-06","article-title":"Structural determinants of chemokine binding by an Ectromelia virus-encoded decoy receptor.","volume":"80","author":"PL Arnold","year":"2006","journal-title":"J Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"13985","DOI":"10.1073\/pnas.0602142103","article-title":"Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta.","volume":"103","author":"L Zhang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.1073\/pnas.171069398","article-title":"Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor.","volume":"98","author":"BT Seet","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"43270","DOI":"10.1074\/jbc.M106305200","article-title":"The viral CC chemokine-binding protein vCCI inhibits monocyte chemoattractant protein-1 activity by masking its CCR2B-binding site.","volume":"276","author":"CG Beck","year":"2001","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"27250","DOI":"10.1074\/jbc.M704706200","article-title":"Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus.","volume":"282","author":"A Frauenschuh","year":"2007","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1084\/jem.20072689","article-title":"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity.","volume":"205","author":"M Deruaz","year":"2008","journal-title":"J Exp Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.20050955","article-title":"Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity.","volume":"202","author":"P Smith","year":"2005","journal-title":"J Exp Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e8514","DOI":"10.1371\/journal.pone.0008514","article-title":"Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3.","volume":"4","author":"JM Dias","year":"2009","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.4049\/jimmunol.175.6.3737","article-title":"Syk is required for monocyte\/macrophage chemotaxis to CX3CL1 (Fractalkine).","volume":"175","author":"JC Gevrey","year":"2005","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.biochem.72.121801.161747","article-title":"Regulation of protein function by glycosaminoglycans--as exemplified by chemokines.","volume":"74","author":"TM Handel","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1042\/BST0340422","article-title":"The biological relevance of chemokine-proteoglycan interactions.","volume":"34","author":"AE Proudfoot","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.str.2004.08.014","article-title":"The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.","volume":"12","author":"JP Shaw","year":"2004","journal-title":"Structure"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1074\/jbc.M608796200","article-title":"Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin.","volume":"282","author":"JW Murphy","year":"2007","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1093\/emboj\/16.23.6996","article-title":"Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.","volume":"16","author":"MP Crump","year":"1997","journal-title":"Embo J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.1021\/bi970593z","article-title":"Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5.","volume":"36","author":"DR Pakianathan","year":"1997","journal-title":"Biochemistry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1021\/bi026087d","article-title":"Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding.","volume":"41","author":"A Bondue","year":"2002","journal-title":"Biochemistry"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pharmtox.42.091901.115838","article-title":"Structure, function, and inhibition of chemokines.","volume":"42","author":"EJ Fernandez","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1107\/S0108767303005488","article-title":"Multiparametric scaling of diffraction intensities.","volume":"59","author":"Z Otwinowski","year":"2003","journal-title":"Acta Crystallogr A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1107\/S0907444902011678","article-title":"Substructure solution with SHELXD.","volume":"58","author":"TR Schneider","year":"2002","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1524\/zkri.217.12.644.20662","article-title":"Macromolecular phasing with SHELXE.","volume":"217","author":"GM Sheldrick","year":"2002","journal-title":"Z Kristallogr"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1107\/S0021889804018047","article-title":"HKL2MAP, a graphical user interface for phasing with SHELX programs.","volume":"37","author":"T Pape","year":"2004","journal-title":"J Appl Crystallogr"},{"key":"ref56","first-page":"760","article-title":"Acta Crystallogr D Biol Crystallogr","volume":"50","year":"1994"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nprot.2008.91","article-title":"Automated macromolecular model building for X-ray crystallography using ARP\/wARP version 7.","volume":"3","author":"G Langer","year":"2008","journal-title":"Nat Protoc"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics.","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1107\/S0907444902016657","article-title":"PHENIX: building new software for automated crystallographic structure determination.","volume":"58","author":"PD Adams","year":"2002","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software.","volume":"40","author":"AJ McCoy","year":"2007","journal-title":"J Appl Crystallogr"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T12:41:41Z","timestamp":1686228101000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002162"}},"subtitle":[],"editor":[{"given":"R. Mark L","family":"Buller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,28]]},"references-count":60,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002162","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,28]]}}}