{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:33:26Z","timestamp":1762101206496},"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002242","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T04:39:57Z","timestamp":1315543197000},"page":"e1002242","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["Protease-Sensitive Conformers in Broad Spectrum of Distinct PrPSc Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate"],"prefix":"10.1371","volume":"7","author":[{"given":"Chae","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Haldiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janis","family":"Blevins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-Sun","family":"Sy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri G.","family":"Safar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/209794a0","article-title":"Experimental transmission of a kuru-like syndrome to chimpanzees.","volume":"209","author":"DC Gajdusek","year":"1966","journal-title":"Nature"},{"key":"ref2","first-page":"187","article-title":"Transmission and replication of prions.","author":"SB Prusiner","year":"2004"},{"key":"ref3","first-page":"143","article-title":"Familial Creutzfeldt-Jakob disease and other familial dementias: an inquiry into possible models of virus-induced familial diseases.","author":"CL Masters","year":"1979"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.161.3839.388","article-title":"Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee.","volume":"161","author":"CJ Gibbs Jr","year":"1968","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie.","volume":"216","author":"SB Prusiner","year":"1982","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1073\/pnas.90.23.10962","article-title":"Conversion of \u03b1-helices into \u03b2-sheets features in the formation of the scrapie prion proteins.","volume":"90","author":"K-M Pan","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"20276","DOI":"10.1016\/S0021-9258(20)80725-X","article-title":"Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.","volume":"268","author":"J Safar","year":"1993","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1021\/bi00245a003","article-title":"Secondary structure analysis of the scrapie-associated protein PrP 27\u201330 in water by infrared spectroscopy.","volume":"30","author":"BW Caughey","year":"1991","journal-title":"Biochemistry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0092-8674(85)90333-2","article-title":"A cellular gene encodes scrapie PrP 27\u201330 protein.","volume":"40","author":"B Oesch","year":"1985","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.biochem.78.082907.145410","article-title":"Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.","volume":"78","author":"B Caughey","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1021\/bi900108v","article-title":"Prion diseases and their biochemical mechanisms.","volume":"48","author":"NJ Cobb","year":"2009","journal-title":"Biochemistry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"14083","DOI":"10.1074\/jbc.C110.113464","article-title":"Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors.","volume":"285","author":"JI Kim","year":"2010","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1128\/JVI.68.12.7859-7868.1994","article-title":"Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy.","volume":"68","author":"RA Bessen","year":"1994","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1126\/science.274.5295.2079","article-title":"Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity.","volume":"274","author":"GC Telling","year":"1996","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/2654","article-title":"Eight prion strains have PrP<sup>Sc<\/sup> molecules with different conformations.","volume":"4","author":"J Safar","year":"1998","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1110\/ps.39201","article-title":"Strain-specified relative conformational stability of the scrapie prion protein.","volume":"10","author":"D Peretz","year":"2001","journal-title":"Protein Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1126\/science.1183218","article-title":"Darwinian evolution of prions in cell culture.","volume":"327","author":"J Li","year":"2010","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-59745-234-2_17","article-title":"Transgenic mouse models of prion diseases.","volume":"459","author":"GC Telling","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nrmicro1492","article-title":"Pathogenesis of prion diseases: current status and future outlook.","volume":"4","author":"A Aguzzi","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbadis.2006.12.006","article-title":"The prion strain phenomenon: molecular basis and unprecedented features.","volume":"1772","author":"R Morales","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/bmb\/66.1.213","article-title":"Sporadic and familial CJD: classification and characterisation.","volume":"66","author":"P Gambetti","year":"2003","journal-title":"Br Med Bull"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/386232a0","article-title":"Typing prion isoforms.","volume":"386","author":"P Parchi","year":"1997","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/383685a0","article-title":"Molecular analysis of prion strain variation and the aetiology of \u201cnew variant\u201d CJD.","volume":"383","author":"J Collinge","year":"1996","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/9030","article-title":"Strain-specific prion-protein conformation determined by metal ions.","volume":"1","author":"JDF Wadsworth","year":"1999","journal-title":"Nat Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"40429","DOI":"10.1074\/jbc.M308550200","article-title":"Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.","volume":"278","author":"WQ Zou","year":"2003","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1138718","article-title":"A general model of prion strains and their pathogenicity.","volume":"318","author":"J Collinge","year":"2007","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/38925","article-title":"The same prion strain causes vCJD and BSE.","volume":"389","author":"AF Hill","year":"1997","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1073\/pnas.91.7.2839","article-title":"Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism.","volume":"91","author":"L Monari","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ana.410390613","article-title":"Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease.","volume":"39","author":"P Parchi","year":"1996","journal-title":"Ann Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1073\/pnas.0409651102","article-title":"Diagnosis of human prion disease.","volume":"102","author":"JG Safar","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1000029","DOI":"10.1371\/journal.ppat.1000029","article-title":"Beyond PrP9res) type 1\/type 2 dichotomy in Creutzfeldt-Jakob disease.","volume":"4","author":"E Uro-Coste","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(05)70225-8","article-title":"Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease.","volume":"4","author":"M Polymenidou","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1212\/WNL.53.9.2173","article-title":"Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain.","volume":"53","author":"G Puoti","year":"1999","journal-title":"Neurology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.2002.tb00417.x","article-title":"Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes.","volume":"12","author":"GG Kovacs","year":"2002","journal-title":"Brain Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/ana.20127","article-title":"Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: UK cases 1991\u20132002.","volume":"55","author":"MW Head","year":"2004","journal-title":"Ann Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1212\/01.wnl.0000167188.65787.a0","article-title":"Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles.","volume":"65","author":"V Lewis","year":"2005","journal-title":"Neurology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.pmed.0030014","article-title":"Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease.","volume":"3","author":"G Schoch","year":"2006","journal-title":"PLoS Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1093\/brain\/awp196","article-title":"Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.","volume":"132","author":"I Cali","year":"2009","journal-title":"Brain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20081235","article-title":"Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin.","volume":"416","author":"S Cronier","year":"2008","journal-title":"Biochem J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1099\/vir.0.80947-0","article-title":"Prion clearance in bigenic mice.","volume":"86","author":"JG Safar","year":"2005","journal-title":"J Gen Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nbt748","article-title":"Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.","volume":"20","author":"JG Safar","year":"2002","journal-title":"Nat Biotechnol"},{"key":"ref42","article-title":"Protein Stability and Folding: Theory and Practice","year":"1995"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1021\/bi00193a027","article-title":"Scrapie amyloid (prion) protein has the conformational characteristics of an aggregated molten globule folding intermediate.","volume":"33","author":"J Safar","year":"1994","journal-title":"Biochemistry"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/brain\/awh249","article-title":"Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies.","volume":"127","author":"M Pocchiari","year":"2004","journal-title":"Brain"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1128\/JVI.61.12.3688-3693.1987","article-title":"Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins.","volume":"61","author":"RJ Kascsak","year":"1987","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1073\/pnas.95.15.8812","article-title":"Prion protein expression in different species: Analysis with a panel of new mAbs.","volume":"95","author":"G Zanusso","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/labinvest.2009.30","article-title":"Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease.","volume":"89","author":"EM Choi","year":"2009","journal-title":"Lab Invest"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1099\/vir.0.18996-0","article-title":"Improved conformation-dependent immunoassay: suitability for human prion detection with enhanced sensitivity.","volume":"84","author":"A Bellon","year":"2003","journal-title":"J Gen Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/BJ20061264","article-title":"Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay.","volume":"401","author":"AM Thackray","year":"2007","journal-title":"Biochem J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1537-2995.2008.01954.x","article-title":"Human platelets as a substrate source for the in vitro amplification of the abnormal prion protein (PrP) associated with variant Creutzfeldt-Jakob disease.","volume":"49","author":"M Jones","year":"2009","journal-title":"Transfusion"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/JVI.78.4.2088-2099.2004","article-title":"Mutant PrP<sup>Sc<\/sup> conformers induced by a synthetic peptide and several prion strains.","volume":"78","author":"P Tremblay","year":"2004","journal-title":"J Virol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1006\/jmbi.1997.1328","article-title":"A conformational transition at the N-terminus of the prion protein features in formation of the scrapie isoform.","volume":"273","author":"D Peretz","year":"1997","journal-title":"J Mol Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1056\/NEJMoa030351","article-title":"Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease.","volume":"349","author":"M Glatzel","year":"2003","journal-title":"N Engl J Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0140-6736(01)05403-4","article-title":"Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay.","volume":"358","author":"JD Wadsworth","year":"2001","journal-title":"Lancet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1073\/pnas.0812770106","article-title":"Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.","volume":"106","author":"H Wille","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/labinvest.3700676","article-title":"A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule.","volume":"87","author":"S Notari","year":"2007","journal-title":"Lab Invest"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/bmb\/66.1.241","article-title":"Molecular and clinical classification of human prion disease.","volume":"66","author":"JD Wadsworth","year":"2003","journal-title":"Br Med Bull"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"30557","DOI":"10.1074\/jbc.M801877200","article-title":"Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease.","volume":"283","author":"S Notari","year":"2008","journal-title":"J Biol Chem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","article-title":"Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects.","volume":"46","author":"P Parchi","year":"1999","journal-title":"Ann Neurol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"12030","DOI":"10.1128\/JVI.01057-10","article-title":"Distinct stability states of disease-associated human prion protein identified by conformation-dependent immunoassay.","volume":"84","author":"YP Choi","year":"2011","journal-title":"J Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1099\/vir.0.026948-0","article-title":"Comparison of the level, distribution and form of disease-associated prion protein in variant and sporadic Creutzfeldt-Jakob diseased brain using conformation-dependent immunoassay and Western blot.","volume":"92","author":"YP Choi","year":"2011","journal-title":"J Gen Virol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"12868","DOI":"10.1021\/bi025958g","article-title":"Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes.","volume":"41","author":"S Tzaban","year":"2002","journal-title":"Biochemistry"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e12723","DOI":"10.1371\/journal.pone.0012723","article-title":"A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrP.","volume":"5","author":"L Pirisinu","year":"2011","journal-title":"PLoS ONE"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.1004688107","article-title":"Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties.","volume":"107","author":"MT Bishop","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"15710","DOI":"10.1021\/bi0615442","article-title":"Isolation and characterization of a proteinase K-sensitive PrP(Sc) fraction.","volume":"45","author":"MA Pastrana","year":"2006","journal-title":"Biochemistry"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e1000736","DOI":"10.1371\/journal.ppat.1000736","article-title":"Protease-sensitive synthetic prions.","volume":"6","author":"DW Colby","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJM200105173442006","article-title":"Shattuck Lecture \u2014 Neurodegenerative diseases and prions.","volume":"344","author":"SB Prusiner","year":"2001","journal-title":"N Engl J Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2007.01.005","article-title":"Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.","volume":"53","author":"GR Mallucci","year":"2007","journal-title":"Neuron"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/ana.21420","article-title":"A novel human disease with abnormal prion protein sensitive to protease.","volume":"63","author":"P Gambetti","year":"2008","journal-title":"Ann Neurol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.2204","article-title":"In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrP(Sc).","volume":"213","author":"M Jones","year":"2007","journal-title":"J Pathol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature04922","article-title":"The physical basis of how prion conformations determine strain phenotypes.","volume":"442","author":"M Tanaka","year":"2006","journal-title":"Nature"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"19105","DOI":"10.1073\/pnas.0608970103","article-title":"Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.","volume":"103","author":"G Legname","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","article-title":"WHO infection control guidelines for transmissible spongiform encephalopathies.","year":"1999"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/brain\/awl159","article-title":"Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease.","volume":"129","author":"SJ Collins","year":"2006","journal-title":"Brain"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ana.21430","article-title":"Rapidly progressive dementia.","volume":"64","author":"MD Geschwind","year":"2008","journal-title":"Ann Neurol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"10168","DOI":"10.1073\/pnas.97.18.10168","article-title":"Genetic influence on the structural variations of the abnormal prion protein.","volume":"97","author":"P Parchi","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1021\/bi991967m","article-title":"Aggregation and fibrillization of the recombinant human prion protein huPrP90\u2013231.","volume":"39","author":"W Swietnicki","year":"2000","journal-title":"Biochemistry"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1073\/pnas.0604021103","article-title":"Human prions and plasma lipoproteins.","volume":"103","author":"JG Safar","year":"2006","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T01:58:40Z","timestamp":1638583120000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002242"}},"subtitle":[],"editor":[{"given":"David","family":"Westaway","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,8]]},"references-count":78,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002242","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,8]]}}}