{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:47:04Z","timestamp":1791157624550,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002358","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T21:03:02Z","timestamp":1320354182000},"page":"e1002358","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":86,"title":["ChemR23 Dampens Lung Inflammation and Enhances Anti-viral Immunity in a Mouse Model of Acute Viral Pneumonia"],"prefix":"10.1371","volume":"7","author":[{"given":"Benjamin","family":"Bondue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Vosters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"de Nadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Glineur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"De Henau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souphalone","family":"Luangsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Van Gool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Communi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"De Vuyst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Desmecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Parmentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0140-6736(98)10263-5","article-title":"Respiratory syncytial virus infection.","volume":"354","author":"EA Simoes","year":"1999","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1067\/mpd.2000.107525","article-title":"Respiratory syncytial virus pneumonia in the hospital setting: length of stay, charges, and mortality.","volume":"137","author":"TS Howard","year":"2000","journal-title":"J Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults.","volume":"352","author":"AR Falsey","year":"2005","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.rmed.2007.07.015","article-title":"A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD.","volume":"101","author":"AF Hutchinson","year":"2007","journal-title":"Respir Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI115362","article-title":"Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.","volume":"88","author":"BS Graham","year":"1991","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.4049\/jimmunol.162.7.4207","article-title":"CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness.","volume":"162","author":"J Schwarze","year":"1999","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.4049\/jimmunol.175.7.4735","article-title":"Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted mice.","volume":"175","author":"TL Garvey","year":"2005","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1128\/JVI.00375-08","article-title":"Role of T cells in virus control and disease after infection with pneumonia virus of mice.","volume":"82","author":"S Frey","year":"2008","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.4049\/jimmunol.163.5.2816","article-title":"Respiratory syncytial virus stimulates neutrophil degranulation and chemokine release.","volume":"163","author":"P Jaovisidha","year":"1999","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.imlet.2008.03.013","article-title":"Pneumonia virus of mice: severe respiratory infection in a natural host.","volume":"118","author":"HF Rosenberg","year":"2008","journal-title":"Immunol Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1164\/rccm.200410-1384SO","article-title":"Pulmonary dendritic cells.","volume":"172","author":"K Vermaelen","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00109-007-0212-3","article-title":"Emerging role of dendritic cells in respiratory viral infection.","volume":"85","author":"MH Grayson","year":"2007","journal-title":"J Mol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.4049\/jimmunol.171.12.6466","article-title":"Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody.","volume":"171","author":"C Asselin-Paturel","year":"2003","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1084\/jem.20040035","article-title":"Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen.","volume":"200","author":"HJ de Heer","year":"2004","journal-title":"J Exp Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1615\/CritRevImmunol.v25.i6.20","article-title":"The phenotype and function of lung dendritic cells.","volume":"25","author":"TJ Webb","year":"2005","journal-title":"Crit Rev Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1084\/jem.20071365","article-title":"Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells.","volume":"205","author":"CH GeurtsvanKessel","year":"2008","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.immuni.2008.09.002","article-title":"Antigen-presentation properties of plasmacytoid dendritic cells.","volume":"29","author":"JA Villadangos","year":"2008","journal-title":"Immunity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1141","article-title":"Plasmacytoid dendritic cells in immunity.","volume":"5","author":"M Colonna","year":"2004","journal-title":"Nat Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9790","DOI":"10.1128\/JVI.00530-07","article-title":"Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo.","volume":"81","author":"NA Jewell","year":"2007","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.4049\/jimmunol.182.2.871","article-title":"Plasmacytoid dendritic cells are dispensable during primary influenza virus infection.","volume":"182","author":"AI Wolf","year":"2009","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20052359","article-title":"Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus.","volume":"203","author":"JJ Smit","year":"2006","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.4049\/jimmunol.177.9.6263","article-title":"Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection.","volume":"177","author":"H Wang","year":"2006","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.4049\/jimmunol.173.7.4433","article-title":"Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.","volume":"173","author":"EA Moseman","year":"2004","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jaci.2006.03.041","article-title":"Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation.","volume":"118","author":"H Hammad","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.4049\/jimmunol.0900471","article-title":"An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.","volume":"183","author":"M Kool","year":"2009","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1689::AID-IMMU1689>3.0.CO;2-I","article-title":"ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.","volume":"28","author":"M Samson","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1182\/blood-2006-08-038844","article-title":"The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues.","volume":"109","author":"S Parolini","year":"2007","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.4049\/jimmunol.0901037","article-title":"Mouse ChemR23 Is Expressed in Dendritic Cell Subsets and Macrophages, and Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model.","volume":"183","author":"S Luangsay","year":"2009","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids.","volume":"198","author":"V Wittamer","year":"2003","journal-title":"J Exp Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"9956","DOI":"10.1074\/jbc.M313016200","article-title":"The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency.","volume":"279","author":"V Wittamer","year":"2004","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1084\/jem.20041310","article-title":"Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.","volume":"201","author":"W Vermi","year":"2005","journal-title":"J Exp Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4049\/jimmunol.175.1.487","article-title":"Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity.","volume":"175","author":"V Wittamer","year":"2005","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"34661","DOI":"10.1074\/jbc.M504868200","article-title":"Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades.","volume":"280","author":"BA Zabel","year":"2005","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"L426","DOI":"10.1152\/ajplung.00483.2005","article-title":"Differential resistance\/susceptibility patterns to pneumovirus infection among inbred mouse strains.","volume":"291","author":"DB Anh","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.virol.2006.02.017","article-title":"Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis.","volume":"349","author":"CA Bonville","year":"2006","journal-title":"Virology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1182\/blood-2009-01-199497","article-title":"Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6.","volume":"114","author":"KD Dyer","year":"2009","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1165\/rcmb.2007-0249OC","article-title":"Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant.","volume":"38","author":"J Levis","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1084\/jem.20080129","article-title":"Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.","volume":"206","author":"C Albanesi","year":"2009","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbrc.2009.01.071","article-title":"Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin.","volume":"380","author":"J Skrzeczynska-Moncznik","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.it.2010.05.004","article-title":"Trafficking properties of plasmacytoid dendritic cells in health and disease.","volume":"31","author":"S Sozzani","year":"2010","journal-title":"Trends Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nri1964","article-title":"Tuning inflammation and immunity by chemokine sequestration: decoys and more.","volume":"6","author":"A Mantovani","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"L350","DOI":"10.1152\/ajplung.00061.2004","article-title":"CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels.","volume":"288","author":"UA Maus","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/viro.1997.8719","article-title":"Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.","volume":"236","author":"M Diaz-Guerra","year":"1997","journal-title":"Virology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/smim.1998.0138","article-title":"Role of early cytokines, including alpha and beta interferons (IFN-alpha\/beta), in innate and adaptive immune responses to viral infections.","volume":"10","author":"CA Biron","year":"1998","journal-title":"Semin Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.4049\/jimmunol.0802982","article-title":"IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.","volume":"182","author":"AG Sikora","year":"2009","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.4049\/jimmunol.1002635","article-title":"Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway.","volume":"186","author":"S Davidson","year":"2011","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1099\/0022-1317-79-10-2411","article-title":"Pathogenesis of pneumovirus infections in mice: detection of pneumonia virus of mice and human respiratory syncytial virus mRNA in lungs of infected mice by in situ hybridization.","volume":"79","author":"PM Cook","year":"1998","journal-title":"J Gen Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.bbrc.2009.12.150","article-title":"Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis.","volume":"391","author":"J Kaur","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1210\/jc.2010-0042","article-title":"Chemerin, a novel adipokine in the regulation of angiogenesis.","volume":"95","author":"K Bozaoglu","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1152\/japplphysiol.00561.2002","article-title":"Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice.","volume":"94","author":"TD Flandre","year":"2003","journal-title":"J Appl Physiol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T22:43:43Z","timestamp":1686437023000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002358"}},"subtitle":[],"editor":[{"given":"Susan R.","family":"Ross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,11,3]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002358","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,3]]}}}