{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:23:37Z","timestamp":1762251817692},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002462","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T21:40:39Z","timestamp":1324590039000},"page":"e1002462","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["CNS Recruitment of CD8+ T Lymphocytes Specific for a Peripheral Virus Infection Triggers Neuropathogenesis during Polymicrobial Challenge"],"prefix":"10.1371","volume":"7","author":[{"given":"Christine M.","family":"Matullo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"O'Regan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn F.","family":"Rall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ana.410340203","article-title":"The attraction of adhesion molecules.","volume":"34","author":"JP Antel","year":"1993","journal-title":"Ann Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.272.5258.60","article-title":"Lymphocyte homing and homeostasis.","volume":"272","author":"EC Butcher","year":"1996","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0952-7915(93)90063-X","article-title":"Homing of naive, memory and effector lymphocytes.","volume":"5","author":"CR Mackay","year":"1993","journal-title":"Curr Opin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.virol.2005.06.023","article-title":"Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection.","volume":"340","author":"TJ Chapman","year":"2005","journal-title":"Virology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrmicro928","article-title":"Developing animal models for polymicrobial diseases.","volume":"2","author":"LO Bakaletz","year":"2004","journal-title":"Nat Rev Micro"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(05)70155-0","article-title":"Human polymicrobial infections.","volume":"365","author":"KA Brogden","year":"2005","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1073\/pnas.94.9.4659","article-title":"A transgenic mouse model for measles virus infection of the brain.","volume":"94","author":"GF Rall","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1128\/JVI.73.3.1795-1801.1999","article-title":"Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and CNS disease.","volume":"73","author":"DMP Lawrence","year":"1999","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1128\/JVI.76.9.4497-4506.2002","article-title":"Immune-mediated protection from measles virus-induced central nervous system disease is noncytolytic and gamma-interferon dependent.","volume":"76","author":"CE Patterson","year":"2002","journal-title":"J Virol"},{"key":"ref10","first-page":"593","article-title":"Lymphocytic choriomeningitis virus.","author":"P Borrow","year":"1997"},{"key":"ref11","first-page":"575","article-title":"Lymphocytic choriomeningitis virus.","author":"MJ Buchmeier","year":"1999"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/JVI.01459-06","article-title":"Quantitating the magnitude of the LCMV-specific CD8 T cell response: it&apos;s even bigger than we thought.","volume":"81","author":"D Masopust","year":"2007","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.2741\/3021","article-title":"Lymphocytic choriomeningitis infection of the central nervous system.","volume":"13","author":"SS Kang","year":"2008","journal-title":"Front Biosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1128\/JVI.00727-09","article-title":"Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation.","volume":"84","author":"CM Matullo","year":"2010","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2 deficient mice lack mature lymphocytes owing to the inability to initiate V(D)J rearrangement.","volume":"68","author":"Y Shinkai","year":"1992","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/369031a0","article-title":"Cytotoxicity mediated by T cells and NK cells is greatly impaired in perforin-deficient mice.","volume":"369","author":"D Kagi","year":"1994","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/JVI.74.4.1908-1918.2000","article-title":"Measles virus spread between neurons requires cell contact but not CD46 expression, syncytium formation or extracellular virus production.","volume":"74","author":"DMP Lawrence","year":"2000","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0065-2776(08)60197-2","article-title":"The virology and immunobiology of LCMV infection.","volume":"30","author":"M Buchmeier","year":"1980","journal-title":"Adv Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0165-5728(93)90230-V","article-title":"Trafficking of activated CTL into the CNS: use of a transgenic model.","volume":"46","author":"MBA Oldstone","year":"1993","journal-title":"J Neuroimmunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.4049\/jimmunol.171.6.3102","article-title":"Measles virus infection induces chemokine synthesis by neurons.","volume":"171","author":"CE Patterson","year":"2003","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.4049\/jimmunol.176.7.4235","article-title":"CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system.","volume":"176","author":"JE Christensen","year":"2006","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1523\/JNEUROSCI.0123-04.2004","article-title":"Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3.","volume":"24","author":"JE Christensen","year":"2004","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1158\/0008-5472.CAN-05-3526","article-title":"Intratumor CD4 T-cell accumulation requires stronger priming than for expansion and lymphokine secretion.","volume":"66","author":"NT Joncker","year":"2006","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/ijc.21472","article-title":"Antigen-independent accumulation of activated effector\/memory T lymphocytes into human and murine tumors.","volume":"118","author":"NT Joncker","year":"2006","journal-title":"Int J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","article-title":"Cloning of a new cytokine that induces IFN-gamma production by T cells.","volume":"378","author":"H Okamura","year":"1995","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0","article-title":"Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18.","volume":"32","author":"RE Berg","year":"2002","journal-title":"Eur J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.coi.2006.03.010","article-title":"The role of CD8 T cells in innate immunity and in antigen non-specific protection.","volume":"18","author":"RE Berg","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/eji.200636766","article-title":"IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells.","volume":"37","author":"AE Denton","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/eji.200535387","article-title":"TCR-independent cytokine stimulation induces non-MHC restricted T cell activity and is negatively regulated by HLA class I.","volume":"36","author":"M vonGeldern","year":"2006","journal-title":"Eur J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens.","volume":"166","author":"G Lertmemongkolchai","year":"2001","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.4049\/jimmunol.170.4.2221","article-title":"Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis.","volume":"170","author":"J Nitcheu","year":"2003","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1073\/pnas.86.5.1684","article-title":"Immunological function of the blood-cerebrospinal fluid barrier.","volume":"86","author":"JA Nathanson","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0041-1345(00)02024-8","article-title":"Antigen presentation by murine endothelial cells.","volume":"33","author":"FM Marelli-Berg","year":"2001","journal-title":"Transplant Proc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1086\/503569","article-title":"Impact of hepatitis C virus coinfection on response to highly active antiretroviral therapy and outcome in HIV-infected individuals: a nationwide cohort study.","volume":"42","author":"N Weis","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.micro.57.030502.090843","article-title":"Measles virus 1998-2002: progress and controversy.","volume":"57","author":"GF Rall","year":"2003","journal-title":"Ann Rev Micro"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrmicro1089","article-title":"Endemic Burkitt&apos;s lymphoma: a polymicrobial disease?","volume":"3","author":"R Rochford","year":"2005","journal-title":"Nat Rev Micro"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11910-001-0029-3","article-title":"T cells, cytokines, and autoantigens in multiple sclerosis.","volume":"1","author":"B Gran","year":"2001","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ana.21705","article-title":"Specific central nervous system recruitment of HLA-G+ regulatory T cells in multiple sclerosis.","volume":"66","author":"YH Huang","year":"2009","journal-title":"Ann Neurol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbadis.2006.03.001","article-title":"Innate immunity in amyotrophic lateral sclerosis.","volume":"1762","author":"K Moisse","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.nbd.2009.10.005","article-title":"Inflammation in ALS and SMA: sorting out the good from the evil.","volume":"37","author":"D Papadimitriou","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1212\/WNL.0b013e3181d865a1","article-title":"Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis.","volume":"74","author":"SA Sargsyan","year":"2010","journal-title":"Neurology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1600-0404.1997.tb00210.x","article-title":"Absence of seven human herpesviruses, including HHV-6, by PCR in CSF and blood from patients with multiple sclerosis and optic neuritis.","volume":"95","author":"C Martin","year":"1997","journal-title":"Acta Neurol Scand"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/17482960902835988","article-title":"No evidence of HIV pol gene in spinal cord tissue on sporadic ALS by real time RT-PCR.","volume":"11","author":"YJ Kim","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/1531-8249(20010201)49:2<249::AID-ANA46>3.0.CO;2-3","article-title":"Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients.","volume":"49","author":"MP Walker","year":"2001","journal-title":"Ann Neurol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2003.12.009","article-title":"Neuroinflammation, COX-2, and ALS - a dual role?","volume":"187","author":"C Consilvio","year":"2004","journal-title":"Exper Neurol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.clineuro.2005.11.006","article-title":"Neuroinflammation in multiple sclerosis: evidence for autoimmune dysregulation, not simple autimmune reaction.","volume":"108","author":"N Grigoriadis","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-1-14","article-title":"Microglia and neuroinflammation: a pathological perspective.","volume":"1","author":"WJ Streit","year":"2004","journal-title":"J Neuroinflammation"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1474-4422(05)70023-5","article-title":"Infectious causes of multiple sclerosis.","volume":"4","author":"DH Gilden","year":"2005","journal-title":"Lancet Neurol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:06:26Z","timestamp":1593407186000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002462"}},"subtitle":[],"editor":[{"given":"Robert E.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,22]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002462","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,22]]}}}