{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:19:51Z","timestamp":1791415191931,"version":"4.3.3"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002508","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T18:09:55Z","timestamp":1327687795000},"page":"e1002508","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Identification of Genetic Determinants and Enzymes Involved with the Amidation of Glutamic Acid Residues in the Peptidoglycan of Staphylococcus aureus"],"prefix":"10.1371","volume":"8","author":[{"given":"Teresa A.","family":"Figueiredo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita G.","family":"Sobral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Madalena","family":"Ludovice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Manuel Feio","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhat K.","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Vollmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herm\u00ednia","family":"de Lencastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tomasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jmb.2006.07.066","article-title":"Structure, function and dynamics in the mur family of bacterial cell wall ligases.","volume":"362","author":"CA Smith","year":"2006","journal-title":"J Mol Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1365-2958.2004.04446.x","article-title":"Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of <italic>Staphylococcus aureus<\/italic>.","volume":"55","author":"A Bera","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1574-6976.2007.00094.x","article-title":"Peptidoglycan structure and architecture.","volume":"32","author":"W Vollmer","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"26268","DOI":"10.1016\/S0021-9258(19)74310-5","article-title":"The peptidoglycan composition of a <italic>Staphylococcus aureus<\/italic> mutant selected for reduced methicillin resistance.","volume":"268","author":"A Ornelas-Soares","year":"1993","journal-title":"J Biol Chem"},{"key":"ref5","first-page":"D214","article-title":"Ongoing and future developments at the Universal Protein Resource.","volume":"39","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/bioinformatics\/17.9.847","article-title":"InterProScan\u2013an integration platform for the signature-recognition methods in InterPro.","volume":"17","author":"EM Zdobnov","year":"2001","journal-title":"Bioinformatics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","article-title":"T-Coffee: A novel method for fast and accurate multiple sequence alignment.","volume":"302","author":"C Notredame","year":"2000","journal-title":"J Mol Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"W36","DOI":"10.1093\/nar\/gki410","article-title":"Protein structure prediction servers at University College London.","volume":"33","author":"K Bryson","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/1097-0134(20001101)41:2<238::AID-PROT80>3.0.CO;2-L","article-title":"The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase.","volume":"41","author":"MY Galperin","year":"2000","journal-title":"Proteins"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1128\/JB.188.7.2543-2553.2006","article-title":"Role of <italic>murF<\/italic> in cell wall biosynthesis: isolation and characterization of a <italic>murF<\/italic> conditional mutant of <italic>Staphylococcus aureus<\/italic>.","volume":"188","author":"RG Sobral","year":"2006","journal-title":"J Bacteriol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF02199440","article-title":"High-frequency transformation of <italic>Staphylococcus aureus<\/italic> by electroporation.","volume":"21","author":"GR Kraemer","year":"1990","journal-title":"Curr Microb"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1128\/jb.174.15.4952-4959.1992","article-title":"Isolation and characterization of a Tn<italic>551<\/italic>-autolysis mutant of <italic>Staphylococcus aureus<\/italic>.","volume":"174","author":"T Oshida","year":"1992","journal-title":"J Bacteriol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1099\/mic.0.25951-0","article-title":"Stable low-copy-number <italic>Staphylococcus aureus<\/italic> shuttle vectors.","volume":"149","author":"S Grkovic","year":"2003","journal-title":"Microbiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/107662903322286436","article-title":"Normally functioning <italic>murF<\/italic> is essential for the optimal expression of methicillin resistance in <italic>Staphylococcus aureus<\/italic>.","volume":"9","author":"RG Sobral","year":"2003","journal-title":"Microb Drug Resist"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1365-2958.2006.05340.x","article-title":"Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of <italic>Streptococcus pneumoniae<\/italic>.","volume":"61","author":"MI Crisostomo","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11248","DOI":"10.1016\/S0021-9258(19)49903-1","article-title":"Peptidoglycan composition of a highly methicillin-resistant <italic>Staphylococcus aureus<\/italic> strain. The role of penicillin binding protein 2A.","volume":"267","author":"BL de Jonge","year":"1992","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1128\/JB.00608-08","article-title":"The peptidoglycan sacculus of <italic>Myxococcus xanthus<\/italic> has unusual structural features and is degraded during glycerol-induced myxospore development.","volume":"191","author":"NK Bui","year":"2009","journal-title":"J Bacteriol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1574-6968.1991.tb04451.x","article-title":"One-step purification procedure for UDP-<italic>N<\/italic>-acetylmuramyl-peptide murein precursors from <italic>Bacillus cereus<\/italic>.","volume":"62","author":"U Kohlrausch","year":"1991","journal-title":"FEMS Microbiol Lett"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1371\/journal.ppat.0030102","article-title":"Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci.","volume":"3","author":"S Herbert","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref20","first-page":"783","article-title":"Biosynthesis of the peptidoglycan of bacterial cell walls. XI. Formation of the isoglutamine amide group in the cell walls of <italic>Staphylococcus aureus<\/italic>.","volume":"243","author":"G Siewert","year":"1968","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s000180050145","article-title":"The mechanism of glutamine-dependent amidotransferases.","volume":"54","author":"F Massiere","year":"1998","journal-title":"Cell Mol Life Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1128\/jb.176.5.1460-1467.1994","article-title":"The <italic>femC<\/italic> locus of <italic>Staphylococcus aureus<\/italic> required for methicillin resistance includes the glutamine synthetase operon.","volume":"176","author":"J Gustafson","year":"1994","journal-title":"J Bacteriol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/mdr.1999.5.163","article-title":"Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in <italic>Staphylococcus aureus<\/italic> strain COL that impact on the expression of resistance to methicillin.","volume":"5","author":"H De Lencastre","year":"1999","journal-title":"Microb Drug Resist"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/JB.01221-06","article-title":"Influence of wall teichoic acid on lysozyme resistance in <italic>Staphylococcus aureus<\/italic>.","volume":"189","author":"A Bera","year":"2007","journal-title":"J Bacteriol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mib.2004.12.008","article-title":"The role of peptidoglycan in pathogenesis.","volume":"8","author":"IG Boneca","year":"2005","journal-title":"Curr Opin Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/IAI.01597-06","article-title":"Modification of the structure of peptidoglycan is a strategy to avoid detection by nucleotide-binding oligomerization domain protein 1.","volume":"75","author":"MA Wolfert","year":"2007","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1128\/IAI.01576-06","article-title":"Muropeptide modification-amidation of peptidoglycan D-glutamate does not affect the proinflammatory activity of <italic>Staphylococcus aureus<\/italic>.","volume":"75","author":"D Kraus","year":"2007","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1021\/ja104533w","article-title":"Dynamics characterization of fully hydrated bacterial cell walls by solid-state NMR: evidence for cooperative binding of metal ions.","volume":"132","author":"T Kern","year":"2010","journal-title":"J Am Chem Soc"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T22:59:27Z","timestamp":1640559567000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002508"}},"subtitle":[],"editor":[{"given":"Ambrose","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,26]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002508","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,26]]}}}