{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:27:14Z","timestamp":1779244034278,"version":"3.51.4"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T00:00:00Z","timestamp":1336608000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002688","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T21:10:36Z","timestamp":1336684236000},"page":"e1002688","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein"],"prefix":"10.1371","volume":"8","author":[{"given":"Peter T.","family":"Beernink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutamas","family":"Shaughnessy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolando","family":"Pajon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily M.","family":"Braga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Ram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M.","family":"Granoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/649209","article-title":"Changes in <italic>Neisseria meningitidis<\/italic> disease epidemiology in the United States, 1998\u20132007: implications for prevention of meningococcal disease.","volume":"50","author":"AC Cohn","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1574-6976.2006.00060.x","article-title":"A surveillance network for meningococcal disease in Europe.","volume":"31","author":"CL Trotter","year":"2007","journal-title":"FEMS Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/infdis\/171.6.1481","article-title":"Antibodies to polysialic acid and its N-propyl derivative: binding properties and interaction with human embryonal brain glycopeptides.","volume":"171","author":"J Hayrinen","year":"1995","journal-title":"J Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(83)90340-9","article-title":"Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis.","volume":"2","author":"J Finne","year":"1983","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1574-6976.2006.00053.x","article-title":"Vaccination against meningococcal disease in Europe: review and recommendations for the use of conjugate vaccines.","volume":"31","author":"CL Trotter","year":"2007","journal-title":"FEMS Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1086\/648966","article-title":"Review of meningococcal group B vaccines.","volume":"50","author":"DM Granoff","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1473-3099(09)70324-X","article-title":"Serogroup B meningococcal vaccines-an unfinished story.","volume":"10","author":"M Sadarangani","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20021911","article-title":"Vaccination against <italic>Neisseria meningitidis<\/italic> using three variants of the lipoprotein GNA1870.","volume":"197","author":"V Masignani","year":"2003","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/IAI.72.4.2088-2100.2004","article-title":"Vaccine potential of the <italic>Neisseria meningitidis<\/italic> 2086 lipoprotein.","volume":"72","author":"LD Fletcher","year":"2004","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1097\/INF.0b013e3181f59f6d","article-title":"Immunogenicity of two investigational serogroup B meningococcal vaccines in the first year of life: a randomized comparative trial.","volume":"29","author":"MD Snape","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1086\/656741","article-title":"Multicenter, open-label, randomized phase II controlled trial of an investigational recombinant meningococcal serogroup B vaccine with and without outer membrane vesicles, administered in infancy.","volume":"51","author":"J Findlow","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.vaccine.2010.06.083","article-title":"Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease.","volume":"28","author":"HQ Jiang","year":"2010","journal-title":"Vaccine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7752","DOI":"10.1016\/j.vaccine.2011.07.124","article-title":"An experimental outer membrane vesicle vaccine from <italic>N. meningitidis<\/italic> serogroup B strains that induces serum bactericidal activity to multiple serogroups.","volume":"29","author":"VB Pinto","year":"2011","journal-title":"Vaccine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.vaccine.2010.12.039","article-title":"A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.","volume":"29","author":"PB Keiser","year":"2011","journal-title":"Vaccine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4049\/jimmunol.177.1.501","article-title":"The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance.","volume":"177","author":"G Madico","year":"2006","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1128\/IAI.01191-08","article-title":"Binding of complement factor H (fH) to <italic>Neisseria meningitidis<\/italic> is specific for human fH and inhibits complement activation by rat and rabbit sera.","volume":"77","author":"DM Granoff","year":"2009","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.4049\/jimmunol.1003470","article-title":"A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination.","volume":"186","author":"PT Beernink","year":"2011","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1302","DOI":"10.1371\/journal.pntd.0001302","article-title":"Meningococcal factor h binding proteins in epidemic strains from Africa: implications for vaccine development.","volume":"5","author":"R Pajon","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1016\/j.vaccine.2011.04.095","article-title":"Immunogenicity of a meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and over-expressed factor H binding protein in infant rhesus monkeys.","volume":"29","author":"O Koeberling","year":"2011","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/CVI.00542-10","article-title":"A critical threshold of meningococcal factor H binding protein expression is required for increased breadth of protective antibodies elicited by native outer membrane vesicle vaccines.","volume":"18","author":"O Koeberling","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/CVI.00403-08","article-title":"Meningococcal outer membrane vesicle vaccines derived from mutant strains engineered to express factor H binding proteins from antigenic variant groups 1 and 2.","volume":"16","author":"O Koeberling","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1086\/597806","article-title":"Meningococcal factor H-binding protein variants expressed by epidemic capsular group A, W-135, and X strains from Africa.","volume":"199","author":"PT Beernink","year":"2009","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/589308","article-title":"Bactericidal antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed factor H-binding protein and genetically attenuated endotoxin.","volume":"198","author":"O Koeberling","year":"2008","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/0140-6736(91)91961-S","article-title":"Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway.","volume":"338","author":"G Bjune","year":"1991","journal-title":"Lancet"},{"key":"ref25","first-page":"67","article-title":"Production, characterization and control of MenB-vaccine \u201cFolkehelsa\u201d: an outer membrane vesicle vaccine against group B meningococcal disease.","volume":"14","author":"JH Fredriksen","year":"1991","journal-title":"NIPH Ann"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1128\/IAI.69.10.5981-5990.2001","article-title":"Modification of lipid A biosynthesis in <italic>Neisseria meningitidis<\/italic> lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity.","volume":"69","author":"P van der Ley","year":"2001","journal-title":"Infect Immun"},{"key":"ref27","first-page":"113","article-title":"Teasing apart structural determinants of \u2018toxicity\u2019 and \u2018adjuvanticity\u2019: implications for meningococcal vaccine development.","volume":"10","author":"L Steeghs","year":"2004","journal-title":"J Endotoxin Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1086\/432102","article-title":"Protective antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed genome-derived neisserial antigen 1870.","volume":"192","author":"VC Hou","year":"2005","journal-title":"J Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1128\/IAI.05182-11","article-title":"Complement-mediated bactericidal activity of anti-Factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding.","volume":"79","author":"S Giuntini","year":"2011","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.4049\/jimmunol.172.9.5606","article-title":"Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a <italic>Neisseria meningitidis<\/italic> candidate vaccine.","volume":"172","author":"JA Welsch","year":"2004","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1574-695X.1997.tb01006.x","article-title":"Epitope specificity of murine and human bactericidal antibodies against PorA P1.7,16 induced with experimental meningococcal group B vaccines.","volume":"17","author":"EM Rouppe van der Voort","year":"1997","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1128\/IAI.70.11.6021-6031.2002","article-title":"Sequential immunization with vesicles prepared from heterologous <italic>Neisseria meningitidis<\/italic> strains elicits broadly protective serum antibodies to group B strains.","volume":"70","author":"GR Moe","year":"2002","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1128\/CVI.00103-10","article-title":"Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor h binding.","volume":"17","author":"PT Beernink","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.vaccine.2010.12.075","article-title":"Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and Neisserial heparin binding antigen.","volume":"29","author":"DM Vu","year":"2011","journal-title":"Vaccine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e1001027","DOI":"10.1371\/journal.ppat.1001027","article-title":"The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement.","volume":"6","author":"LA Lewis","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.vaccine.2009.12.027","article-title":"Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates.","volume":"28","author":"R Pajon","year":"2010","journal-title":"Vaccine"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/IAI.00849-10","article-title":"Effect of factor H-binding protein sequence variation on factor H binding and survival of <italic>Neisseria meningitidis<\/italic> in human blood.","volume":"79","author":"KY Dunphy","year":"2011","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1016\/j.vaccine.2010.05.006","article-title":"Design and evaluation in mice of a broadly protective meningococcal group B native outer membrane vesicle vaccine.","volume":"28","author":"WD Zollinger","year":"2010","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"91ra62","DOI":"10.1126\/scitranslmed.3002234","article-title":"Rational design of a meningococcal antigen inducing broad protective immunity.","volume":"3","author":"M Scarselli","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1128\/IAI.00033-08","article-title":"Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines.","volume":"76","author":"PT Beernink","year":"2008","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"I113","DOI":"10.1016\/j.vaccine.2008.11.058","article-title":"Microbial complement inhibitors as vaccines.","volume":"26","author":"S Meri","year":"2008","journal-title":"Vaccine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/ni0706-681","article-title":"Interpreting flow cytometry data: a guide for the perplexed.","volume":"7","author":"LA Herzenberg","year":"2006","journal-title":"Nat Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1128\/CDLI.5.6.845-855.1998","article-title":"Proposed standardization of <italic>Neisseria meningitidis<\/italic> PorA variable-region typing nomenclature.","volume":"5","author":"CT Sacchi","year":"1998","journal-title":"Clin Diagn Lab Immunol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T11:11:20Z","timestamp":1642245080000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002688"}},"subtitle":[],"editor":[{"given":"H. Steven","family":"Seifert","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,10]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002688","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,10]]}}}