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Singer","year":"1998","journal-title":"Genetics"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1101\/gr.090233.108","article-title":"High-resolution DNA-binding specificity analysis of yeast transcription factors.","volume":"19","author":"C Zhu","year":"2009","journal-title":"Genome Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/genetics\/150.4.1443","article-title":"Regulators of pseudohyphal differentiation in <italic>Saccharomyces cerevisiae<\/italic> identified through multicopy suppressor analysis in ammonium permease mutant strains.","volume":"150","author":"MC Lorenz","year":"1998","journal-title":"Genetics"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1432-1033.1997.t01-2-00449.x","article-title":"Identification and characterization of the genes for mitochondrial ribosomal proteins of <italic>Saccharomyces cerevisiae<\/italic>.","volume":"245","author":"M Kitakawa","year":"1997","journal-title":"Eur J Biochem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s002940050221","article-title":"The yeast ORF <italic>YDL202w<\/italic> codes for the mitochondrial ribosomal protein YmL11.","volume":"31","author":"DM Bui","year":"1997","journal-title":"Curr Genet"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/MCB.19.1.173","article-title":"The beta subunit of eukaryotic translation initiation factor 2 binds mRNA through the lysine repeats and a region comprising the C2-C2 motif.","volume":"19","author":"JP Laurino","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1128\/MCB.11.11.5767","article-title":"<italic>CDC55<\/italic>, a <italic>Saccharomyces cerevisiae<\/italic> gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase.","volume":"11","author":"AM Healy","year":"1991","journal-title":"Mol Cell Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1128\/MCB.17.2.620","article-title":"Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore\/spindle checkpoint in <italic>Saccharomyces cerevisiae<\/italic>.","volume":"17","author":"Y Wang","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cell.2006.03.038","article-title":"Downregulation of PP2A (Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.","volume":"125","author":"E Queralt","year":"2006","journal-title":"Cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1083\/jcb.201103076","article-title":"Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis.","volume":"193","author":"F Bizzari","year":"2011","journal-title":"J Cell Biol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/mmy.39.1.55.66","article-title":"Fungal beta(1,3)-D-glucan synthesis.","volume":"39","author":"CM Douglas","year":"2001","journal-title":"Med Mycol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"12907","DOI":"10.1073\/pnas.91.26.12907","article-title":"The <italic>Saccharomyces cerevisiae FKS1<\/italic> (<italic>ETG1<\/italic>) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.","volume":"91","author":"CM Douglas","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrmicro2319","article-title":"Antibiotic resistance and its cost: is it possible to reverse resistance?","volume":"8","author":"DI Andersson","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/genetics\/154.3.985","article-title":"Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria.","volume":"154","author":"BR Levin","year":"2000","journal-title":"Genetics"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1128\/AAC.01460-09","article-title":"Compensation of fitness costs and reversibility of antibiotic resistance mutations.","volume":"54","author":"P Schulz zur Wiesch","year":"2010","journal-title":"Antimicrob Agents Chemotherapy"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/j.1558-5646.2011.01223.x","article-title":"Escaping an evolutionary lobster trap: drug resistance and compensatory mutation in a fluctuating environment.","volume":"65","author":"MM Tanaka","year":"2011","journal-title":"Evolution"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4161\/viru.3.1.18886","article-title":"Resistance to echinocandins comes at a cost: The impact of <italic>FKS1<\/italic> hotspot mutations on <italic>Candida albicans<\/italic> fitness and virulence.","volume":"3","author":"R Ben-Ami","year":"2012","journal-title":"Virulence"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1021\/jm980403y","article-title":"Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.","volume":"42","author":"SM Roe","year":"1999","journal-title":"J Med Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"8324","DOI":"10.1073\/pnas.91.18.8324","article-title":"Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.","volume":"91","author":"L Whitesell","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1128\/MCB.20.24.9262-9270.2000","article-title":"Role of <italic>HSP90<\/italic> in salt stress tolerance via stabilization and regulation of calcineurin.","volume":"20","author":"J Imai","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nrmicro1680","article-title":"Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.","volume":"5","author":"WJ Steinbach","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref93","first-page":"115","article-title":"Calcineurin. Structure, function, and inhibition.","volume":"30","author":"CS Hemenway","year":"1999","journal-title":"Cell Biochem Biophys"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1432-1033.1995.tb20770.x","article-title":"Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae.","volume":"231","author":"SB Inoue","year":"1995","journal-title":"Eur J Biochem"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1534\/genetics.167.1.35","article-title":"Analysis of beta-1,3-glucan assembly in <italic>Saccharomyces cerevisiae<\/italic> using a synthetic interaction network and altered sensitivity to caspofungin.","volume":"167","author":"G Lesage","year":"2004","journal-title":"Genetics"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1128\/MCB.15.10.5671","article-title":"Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase.","volume":"15","author":"P Mazur","year":"1995","journal-title":"Mol Cell Biol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1128\/MCB.18.2.1013","article-title":"Temperature-induced expression of yeast <italic>FKS2<\/italic> is under the dual control of protein kinase C and calcineurin.","volume":"18","author":"C Zhao","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/AAC.48.5.1788-1796.2004","article-title":"Mechanisms of azole resistance in petite mutants of <italic>Candida glabrata<\/italic>.","volume":"48","author":"S Brun","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1128\/AAC.00182-07","article-title":"A <italic>Candida albicans<\/italic> petite mutant strain with uncoupled oxidative phosphorylation overexpresses <italic>MDR1<\/italic> and has diminished susceptibility to fluconazole and voriconazole.","volume":"51","author":"S Cheng","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/jac\/46.2.191","article-title":"Modulation of fluconazole sensitivity by the interaction of mitochondria and erg3p in <italic>Saccharomyces cerevisiae<\/italic>.","volume":"46","author":"DP Kontoyiannis","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/AAC.45.4.1174-1183.2001","article-title":"Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in <italic>Candida glabrata<\/italic>.","volume":"45","author":"D Sanglard","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1128\/AAC.01271-10","article-title":"Loss of mitochondrial functions associated with azole resistance in <italic>Candida glabrata<\/italic> results in enhanced virulence in mice.","volume":"55","author":"S Ferrari","year":"2011","journal-title":"Antimicrob Agents Chemotherapy"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1099\/0022-1317-49-11-977","article-title":"In-vivo selection of an azole-resistant petite mutant of <italic>Candida glabrata<\/italic>.","volume":"49","author":"JP Bouchara","year":"2000","journal-title":"J Med Microbiol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jac\/dki200","article-title":"Biological consequences of petite mutations in <italic>Candida glabrata<\/italic>.","volume":"56","author":"S Brun","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1128\/IAI.01514-07","article-title":"<italic>Candida albicans<\/italic> uses multiple mechanisms to acquire the essential metabolite inositol during infection.","volume":"76","author":"YL Chen","year":"2008","journal-title":"Infect Immun"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cub.2009.03.017","article-title":"Hsp90 orchestrates temperature-dependent <italic>Candida albicans<\/italic> morphogenesis via Ras1-PKA signaling.","volume":"19","author":"RS Shapiro","year":"2009","journal-title":"Curr Biol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1128\/JB.182.6.1515-1522.2000","article-title":"Evolution of drug resistance in experimental populations of <italic>Candida albicans<\/italic>.","volume":"182","author":"LE Cowen","year":"2000","journal-title":"J Bacteriol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1128\/JB.183.10.2971-2978.2001","article-title":"Divergence in fitness and evolution of drug resistance in experimental populations of <italic>Candida albicans<\/italic>.","volume":"183","author":"LE Cowen","year":"2001","journal-title":"J Bacteriol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1128\/JCM.40.6.2228-2230.2002","article-title":"In vitro activity of caspofungin (MK-0991) against <italic>Candida albicans<\/italic> clinical isolates displaying different mechanisms of azole resistance.","volume":"40","author":"SP Bachmann","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/AAC.50.4.1148-1155.2006","article-title":"Overexpression of <italic>Candida albicans CDR1<\/italic>, <italic>CDR2<\/italic>, or <italic>MDR1<\/italic> does not produce significant changes in echinocandin susceptibility.","volume":"50","author":"K Niimi","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/jac\/dkl237","article-title":"Caspofungin activity against clinical isolates of azole cross-resistant <italic>Candida glabrata<\/italic> overexpressing efflux pump genes.","volume":"58","author":"B Posteraro","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0924-8579(03)00213-9","article-title":"Reversal of antifungal resistance mediated by ABC efflux pumps from <italic>Candida albicans<\/italic> functionally expressed in yeast.","volume":"22","author":"M Schuetzer-Muehlbauer","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1365-2958.2010.07503.x","article-title":"Cell wall integrity is linked to mitochondria and phospholipid homeostasis in <italic>Candida albicans<\/italic> through the activity of the post-transcriptional regulator Ccr4-Pop2.","volume":"79","author":"MJ Dagley","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1128\/EC.00115-06","article-title":"Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of <italic>Candida albicans<\/italic>: implications for antifungal drug target discovery.","volume":"5","author":"A Rodaki","year":"2006","journal-title":"Eukaryot Cell"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"34311","DOI":"10.1074\/jbc.M111.264671","article-title":"The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in <italic>Candida glabrata<\/italic>.","volume":"286","author":"S Borah","year":"2011","journal-title":"J Biol Chem"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"e1000752","DOI":"10.1371\/journal.ppat.1000752","article-title":"An extensive circuitry for cell wall regulation in <italic>Candida albicans<\/italic>.","volume":"6","author":"JR Blankenship","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of <italic>Candida albicans<\/italic> by the innate immune system.","volume":"6","author":"MG Netea","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408410903241444","article-title":"Epidemiology of invasive mycoses in North America.","volume":"36","author":"MA Pfaller","year":"2010","journal-title":"Crit Rev Microbiol"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"e1002257","DOI":"10.1371\/journal.ppat.1002257","article-title":"Hsp90 governs dispersion and drug resistance of fungal biofilms.","volume":"7","author":"N Robbins","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1128\/AAC.47.5.1565-1570.2003","article-title":"Fungicidal synergism of fluconazole and cyclosporine in <italic>Candida albicans<\/italic> is not dependent on multidrug efflux transporters encoded by the <italic>CDR1<\/italic>, <italic>CDR2<\/italic>, <italic>CaMDR1<\/italic>, and <italic>FLU1<\/italic> genes.","volume":"47","author":"O Marchetti","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1128\/AAC.00393-06","article-title":"Calcineurin promotes infection of the cornea by <italic>Candida albicans<\/italic> and can be targeted to enhance fluconazole therapy.","volume":"50","author":"C Onyewu","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1128\/AAC.01397-07","article-title":"Synergistic effect of calcineurin inhibitors and fluconazole against <italic>Candida albicans<\/italic> biofilms.","volume":"52","author":"P Uppuluri","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbiopara.2005.01.012","article-title":"<italic>Plasmodium falciparum<\/italic> calcineurin and its association with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin.","volume":"141","author":"R Kumar","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2958.2011.07584.x","article-title":"Calcineurin is required for <italic>Leishmania major<\/italic> stress response pathways and for virulence in the mammalian host.","volume":"80","author":"T Naderer","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"37964","DOI":"10.1074\/jbc.M110.155317","article-title":"Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from <italic>Plasmodium falciparum<\/italic> and <italic>Trypanosoma evansi<\/italic> and evaluation of its inhibitor as a candidate drug.","volume":"285","author":"R Pallavi","year":"2010","journal-title":"J Biol Chem"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1021\/jm901796s","article-title":"A repurposing strategy identifies novel synergistic inhibitors of <italic>Plasmodium falciparum<\/italic> heat shock protein 90.","volume":"53","author":"D Shahinas","year":"2010","journal-title":"J Med Chem"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.2174\/156802609789895656","article-title":"Strategies for stalling malignancy: targeting cancer&apos;s addiction to Hsp90.","volume":"9","author":"C 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