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Strategies from poxviruses.","volume":"8","author":"MR Mohamed","year":"2009","journal-title":"Cell Cycle"},{"key":"ref57","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-384858-1.00012-6","article-title":"Polydnavirus gene products that interact with the host immune system.","author":"MR Strand","year":"2012"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"11426","DOI":"10.1073\/pnas.0505240102","article-title":"Inhibitor \u03baB-like proteins from a polydnavirus inhibit NF-\u03baB activation and suppress the insect immune response.","volume":"102","author":"H Thoetkiattikul","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1099\/vir.0.82306-0","article-title":"Characterization of the I\u03baB-like gene family in polydnaviruses associated with wasps belonging to different Braconid subfamilies.","volume":"88","author":"P Falabella","year":"2007","journal-title":"J Gen Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2240","article-title":"Phagocytosis and comparative innate immunity: learning on the fly.","volume":"8","author":"LM Stuart","year":"2008","journal-title":"Nature Rev Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1099\/vir.0.023853-0","article-title":"<italic>Varroa destructor<\/italic> is an effective vector of Israeli acute paralysis virus in the honeybee, <italic>Apis mellifera<\/italic>.","volume":"92","author":"G Di Prisco","year":"2011","journal-title":"J Gen Virol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1017\/S0031182011000072","article-title":"Salivary secretions from the honeybee mite, <italic>Varroa destructor<\/italic>: effects on insect haemocytes and preliminary biochemical characterization.","volume":"138","author":"EH Richards","year":"2011","journal-title":"Parasitology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF02765605","article-title":"Time-activity budgets and space structuring by the different life stages of <italic>Varroa jacobsoni<\/italic> in capped brood of the honey bee, <italic>Apis mellifera<\/italic>.","volume":"10","author":"G Donz\u00e9","year":"1997","journal-title":"J Insect Behav"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.ento.51.110104.151029","article-title":"Evolution of developmental strategies in parasitic hymenoptera.","volume":"51","author":"F Pennacchio","year":"2006","journal-title":"Annu Rev Entomol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.1166788","article-title":"Polydnaviruses of braconid wasps derive from an ancestral nudivirus.","volume":"323","author":"A B\u00e9zier","year":"2009","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1094\/MPMI-23-7-0835","article-title":"Disruption of two defensive signaling pathways by a viral RNA silencing suppressor.","volume":"23","author":"MG Lewsey","year":"2010","journal-title":"Mol Plant-Microbe Interact"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2491","article-title":"The good viruses: viral mutualistic symbioses.","volume":"9","author":"MJ Roossinck","year":"2011","journal-title":"Nature Rev Microbiol"},{"key":"ref68","article-title":"A Genetic Switch: Phage Lambda Revisited (3rd ed.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press.","author":"M Ptashne","year":"2004"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1101\/gad.909001","article-title":"NF-\u03baB signaling pathways in mammalian and insect innate immunity.","volume":"15","author":"N Silverman","year":"2001","journal-title":"Genes Dev"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"20853","DOI":"10.1073\/pnas.0906749106","article-title":"The immune response attenuates growth and nutrient storage in <italic>Drosophila<\/italic> by reducing insulin signaling.","volume":"106","author":"JR DiAngelo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0305-1978(91)90002-H","article-title":"Genetic discrimination of Italian bee, <italic>Apis mellifera ligustica<\/italic> versus Carniolan bee, <italic>Apis mellifera carnica<\/italic> by allozyme variability analysis.","volume":"19","author":"A Comparini","year":"1991","journal-title":"Biochem Syst Ecol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1051\/apido:19920201","article-title":"Morphometric analysis of honey bees from an area of racial hybridization in northeastern Italy.","volume":"23","author":"F Nazzi","year":"1992","journal-title":"Apidologie"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF01218569","article-title":"Reinfestation of an acaricide-treated apiary by <italic>Varroa jacobsoni<\/italic> Oud..","volume":"16","author":"M Greatti","year":"1992","journal-title":"Exp Appl Acarol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1051\/apido:2000107","article-title":"Colony evaluation is not affected by drifting of drone and worker honeybees (<italic>Apis mellifera<\/italic> L.) at a performance testing apiary.","volume":"31","author":"P Neumann","year":"2000","journal-title":"Apidologie"},{"key":"ref75","first-page":"41","article-title":"Il \u201cmetodo dei sesti\u201d per la valutazione numerica degli adulti in famiglie di <italic>Apis mellifera<\/italic> L..","volume":"1","author":"S Marchetti","year":"1985","journal-title":"Apicoltura"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"19635","DOI":"10.1073\/pnas.0609513103","article-title":"Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators.","volume":"103","author":"J Ju","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","article-title":"Honey bee pathology. London: Academic Press.","author":"LL Bailey","year":"1991"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(97)00337-6","article-title":"Identification and roles of non-pathogenic microflora associated with honey bees.","volume":"155","author":"M Gilliam","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jip.2003.08.007","article-title":"Bacterial diversity in worker adults of <italic>Apis mellifera capensis<\/italic> and <italic>Apis mellifera scutellata<\/italic> (Insecta: Hymenoptera) assessed using 16S rRNA sequences.","volume":"84","author":"A Jeyaprakash","year":"2003","journal-title":"J Invertebr Pathol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/AEM.72.1.606-611.2006","article-title":"Prevalence and transmission of honey bee viruses.","volume":"72","author":"YP Chen","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1743-422X-6-221","article-title":"Molecular approaches to the analysis of deformed wings virus replication and pathogenesis in honey bees, <italic>Apis mellifera<\/italic>.","volume":"6","author":"HF Boncristiani","year":"2009","journal-title":"Virol J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1051\/apido:19940608","article-title":"A technique for reproduction of <italic>Varroa jacobsoni<\/italic> Oud. under laboratory conditions.","volume":"25","author":"F Nazzi","year":"1994","journal-title":"Apidologie"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1098\/rspb.2007.0022","article-title":"Virus infection causes specific learning deficits in honeybee foragers.","volume":"274","author":"J Iqbal","year":"2007","journal-title":"Proc R Soc B"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq.","volume":"5","author":"A Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using Real-Time Quantitative PCR and the 2<sup>\u2212\u0394\u0394<italic>C<\/italic><sub>T<\/sub><\/sup> method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/00218839.2009.11101548","article-title":"Bee cups: Single-use cages for honey bee experiments.","volume":"48","author":"JD Evans","year":"2009","journal-title":"J Apic Res"},{"key":"ref87","article-title":"A biologist&apos;s guide to mathematical modeling in ecology and evolution. 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