{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:16:33Z","timestamp":1791267393282,"version":"4.1.0"},"reference-count":107,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1002988","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T17:25:33Z","timestamp":1351790733000},"page":"e1002988","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis"],"prefix":"10.1371","volume":"8","author":[{"given":"Ram","family":"Viner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chetrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0966-842X(96)10041-X","article-title":"The molecular ecology of <italic>Legionellae<\/italic>","volume":"4","author":"BS Fields","year":"1996","journal-title":"Trends Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.158.4.1319","article-title":"Formation of a novel phagosome by the Legionnaires&apos; disease bacterium <italic>(Legionella pneumophila<\/italic>) in human monocytes","volume":"158","author":"MA Horwitz","year":"1983","journal-title":"J Exp Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/jcs.114.24.4637","article-title":"How the parasitic bacterium <italic>Legionella pneumophila<\/italic> modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane","volume":"114","author":"LG Tilney","year":"2001","journal-title":"J Cell Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1084\/jem.158.6.2108","article-title":"The Legionnaires&apos; disease bacterium (<italic>Legionella pneumophila<\/italic>) inhibits phagosome-lysosome fusion in human monocytes","volume":"158","author":"MA Horwitz","year":"1983","journal-title":"J Exp Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1172\/JCI109874","article-title":"Legionnaires&apos; disease bacterium (<italic>Legionella pneumophila<\/italic>) multiplies intracellularly in human monocytes","volume":"60","author":"MA Horwitz","year":"1980","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fmicb.2011.00208","article-title":"Comparative and functional genomics of <italic>legionella<\/italic> identified eukaryotic like proteins as key players in host-pathogen interactions","volume":"2","author":"L Gomez-Valero","year":"2011","journal-title":"Front Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-cellbio-100109-104034","article-title":"Modulation of host cell function by <italic>Legionella pneumophila<\/italic> type IV effectors","volume":"26","author":"A Hubber","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e00175","DOI":"10.1128\/mBio.00175-11","article-title":"Dot\/Icm type IVB secretion system requirements for <italic>Coxiella burnetii<\/italic> growth in human macrophages","volume":"2","author":"PA Beare","year":"2011","journal-title":"MBio"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.femsre.2004.07.001","article-title":"The Icm\/Dot type-IV secretion systems of <italic>Legionella pneumophila<\/italic> and <italic>Coxiella burnetii<\/italic>","volume":"29","author":"G Segal","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.1365-2958.2003.03626.x","article-title":"<italic>Coxiella burnetii<\/italic> express type IV secretion system proteins that function similarly to components of the <italic>Legionella pneumophila<\/italic> Dot\/Icm system","volume":"49","author":"DS Zamboni","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1128\/IAI.71.7.3714-3723.2003","article-title":"Functional similarities between the <italic>icm\/dot<\/italic> pathogenesis systems of <italic>Coxiella burnetii<\/italic> and <italic>Legionella pneumophila<\/italic>","volume":"71","author":"T Zusman","year":"2003","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2009.04515.x","article-title":"Intracellular life of <italic>Coxiella burnetii<\/italic> in macrophages","volume":"1166","author":"E Ghigo","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.tim.2007.06.006","article-title":"Effector proteins translocated by <italic>Legionella pneumophila<\/italic>: strength in numbers","volume":"15","author":"S Ninio","year":"2007","journal-title":"Trends Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e1000508","DOI":"10.1371\/journal.ppat.1000508","article-title":"Genome-scale identification of <italic>Legionella pneumophila<\/italic> effectors using a machine learning approach","volume":"5","author":"D Burstein","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1462-5822.2008.01249.x","article-title":"Large-scale identification of <italic>Legionella pneumophila<\/italic> Dot\/Icm substrates that modulate host cell vesicle trafficking pathways","volume":"11","author":"M Heidtman","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1462-5822.2010.01531.x","article-title":"The E Block motif is associated with <italic>Legionella pneumophila<\/italic> translocated substrates","volume":"13","author":"L Huang","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/j.1365-2958.2008.06124.x","article-title":"<italic>Legionella<\/italic> translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions","volume":"67","author":"T Kubori","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.0304916101","article-title":"Multiple substrates of the <italic>Legionella pneumophila<\/italic> Dot\/Icm system identified by interbacterial protein transfer","volume":"101","author":"ZQ Luo","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e17638","DOI":"10.1371\/journal.pone.0017638","article-title":"Comprehensive identification of protein substrates of the Dot\/Icm type IV transporter of <italic>Legionella pneumophila<\/italic>","volume":"6","author":"W Zhu","year":"2011","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/j.1462-5822.2011.01710.x","article-title":"Manipulation of host vesicular trafficking and innate immune defence by <italic>Legionella<\/italic> Dot\/Icm effectors","volume":"13","author":"J Ge","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1149121","article-title":"A bifunctional bacterial protein links GDI displacement to Rab1 activation","volume":"318","author":"MP Machner","year":"2007","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature06336","article-title":"<italic>Legionella pneumophila<\/italic> proteins that regulate Rab1 membrane cycling","volume":"450","author":"A Ingmundson","year":"2007","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1126\/science.1192276","article-title":"The <italic>Legionella<\/italic> effector protein DrrA AMPylates the membrane traffic regulator Rab1b","volume":"329","author":"MP Muller","year":"2010","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10307","article-title":"<italic>Legionella pneumophila<\/italic> SidD is a deAMPylase that modifies Rab1","volume":"475","author":"Y Tan","year":"2011","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10335","article-title":"Modulation of Rab GTPase function by a protein phosphocholine transferase","volume":"477","author":"S Mukherjee","year":"2011","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/emboj.2012.16","article-title":"Reversible phosphocholination of Rab proteins by <italic>Legionella pneumophila<\/italic> effector proteins","volume":"31","author":"PR Goody","year":"2012","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"21212","DOI":"10.1073\/pnas.1114023109","article-title":"<italic>Legionella pneumophila<\/italic> regulates the small GTPase Rab1 activity by reversible phosphorylcholination","volume":"108","author":"Y Tan","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1002528","DOI":"10.1371\/journal.ppat.1002528","article-title":"Structural Insights into a Unique <italic>Legionella pneumophila<\/italic> Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State","volume":"8","author":"W Cheng","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1128\/JB.06306-11","article-title":"<italic>Legionella pneumophila<\/italic> LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1","volume":"194","author":"MR Neunuebel","year":"2012","journal-title":"J Bacteriol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2006.05.013","article-title":"Targeting of host rab GTPase function by the intravacuolar pathogen <italic>Legionella pneumophila<\/italic>","volume":"11","author":"MP Machner","year":"2006","journal-title":"Dev Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1001216","DOI":"10.1371\/journal.ppat.1001216","article-title":"<italic>Legionella<\/italic> metaeffector exploits host proteasome to temporally regulate cognate effector","volume":"6","author":"T Kubori","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1365-2958.2008.06453.x","article-title":"A Dot\/Icm-translocated ankyrin protein of <italic>Legionella pneumophila<\/italic> is required for intracellular proliferation within human macrophages and protozoa","volume":"70","author":"S Al-Khodor","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1462-5822.2010.01467.x","article-title":"The <italic>Legionella pneumophila<\/italic> F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication","volume":"12","author":"M Lomma","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/IAI.01450-09","article-title":"Indispensable role for the eukaryotic-like ankyrin domains of the ankyrin B effector of <italic>Legionella pneumophila<\/italic> within macrophages and amoebae","volume":"78","author":"CT Price","year":"2010","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20100771","article-title":"Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of <italic>Legionella pneumophila<\/italic>","volume":"207","author":"CT Price","year":"2010","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1212868","article-title":"Host proteasomal degradation generates amino acids essential for intracellular bacterial growth","volume":"334","author":"CT Price","year":"2011","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1128\/IAI.00344-10","article-title":"E3 ubiquitin ligase activity and targeting of BAT3 by multiple <italic>Legionella pneumophila<\/italic> translocated substrates","volume":"78","author":"AW Ensminger","year":"2010","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fmicb.2011.00076","article-title":"Effector glycosyltransferases in <italic>legionella<\/italic>","volume":"2","author":"Y Belyi","year":"2011","journal-title":"Front Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/BJ20091351","article-title":"Molecular mechanism of elongation factor 1A inhibition by a <italic>Legionella pneumophila<\/italic> glycosyltransferase","volume":"426","author":"R Hurtado-Guerrero","year":"2010","journal-title":"Biochem J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1462-5822.2009.01301.x","article-title":"Targeting eEF1A by a <italic>Legionella pneumophila<\/italic> effector leads to inhibition of protein synthesis and induction of host stress response","volume":"11","author":"X Shen","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1073\/pnas.0907200106","article-title":"A <italic>Legionella<\/italic> type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors","volume":"106","author":"J Ge","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1462-5822.2010.01452.x","article-title":"LnaB: a <italic>Legionella pneumophila<\/italic> activator of NF-kappaB","volume":"12","author":"VP Losick","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1073\/pnas.0501315102","article-title":"Pathogen effector protein screening in yeast identifies <italic>Legionella<\/italic> factors that interfere with membrane trafficking","volume":"102","author":"N Shohdy","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/IAI.02060-05","article-title":"Members of a <italic>Legionella pneumophila<\/italic> family of proteins with ExoU (phospholipase A) active sites are translocated to target cells","volume":"74","author":"SM VanRheenen","year":"2006","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ejcb.2010.12.003","article-title":"Characterisation of <italic>Legionella pneumophila<\/italic> phospholipases and their impact on host cells","volume":"90","author":"C Lang","year":"2011","journal-title":"Eur J Cell Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1462-5822.2009.01328.x","article-title":"A <italic>Legionella<\/italic> effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria","volume":"11","author":"E Degtyar","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1074\/jbc.M807505200","article-title":"Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of <italic>Legionella pneumophila<\/italic>","volume":"284","author":"E Brombacher","year":"2009","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1371\/journal.ppat.0020046","article-title":"<italic>Legionella pneumophila<\/italic> exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole","volume":"2","author":"SS Weber","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1462-5822.2012.01761.x","article-title":"Domain organization of <italic>Legionella<\/italic> effector SetA","volume":"14","author":"T Jank","year":"2012","journal-title":"Cell Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1462-5822.2008.01266.x","article-title":"The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of <italic>Legionella<\/italic>, localizes to the replicative vacuole and binds to the bacterial effector LpnE","volume":"11","author":"SS Weber","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1099\/mic.0.2008\/019075-0","article-title":"The <italic>Salmonella<\/italic> SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid: cholesterol acyltransferase activity","volume":"154","author":"NS Lossi","year":"2008","journal-title":"Microbiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2958.2008.06142.x","article-title":"Esterification of cholesterol by a type III secretion effector during intracellular <italic>Salmonella<\/italic> infection","volume":"68","author":"P Nawabi","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1126\/science.1098188","article-title":"<italic>Salmonella<\/italic> modulates vesicular traffic by altering phosphoinositide metabolism","volume":"304","author":"LD Hernandez","year":"2004","journal-title":"Science"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1083\/jcb.200804131","article-title":"SopB promotes phosphatidylinositol 3-phosphate formation on <italic>Salmonella<\/italic> vacuoles by recruiting Rab5 and Vps34","volume":"182","author":"GV Mallo","year":"2008","journal-title":"J Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb854","article-title":"Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by <italic>Salmonella<\/italic>","volume":"4","author":"MR Terebiznik","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.181.1.257","article-title":"Characterization of the <italic>Mycobacterium tuberculosis<\/italic> phagosome and evidence that phagosomal maturation is inhibited","volume":"181","author":"DL Clemens","year":"1995","journal-title":"J Exp Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1073\/pnas.0409716102","article-title":"Mechanism of phagolysosome biogenesis block by viable <italic>Mycobacterium tuberculosis<\/italic>","volume":"102","author":"I Vergne","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e1002056","DOI":"10.1371\/journal.ppat.1002056","article-title":"The <italic>Coxiella burnetii<\/italic> Dot\/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication","volume":"7","author":"KL Carey","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"21755","DOI":"10.1073\/pnas.1010485107","article-title":"Large-scale identification and translocation of type IV secretion substrates by <italic>Coxiella burnetii<\/italic>","volume":"107","author":"C Chen","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e00226","DOI":"10.1128\/mBio.00226-11","article-title":"The <italic>Coxiella burnetii<\/italic> Dot\/Icm system creates a comfortable home through lysosomal renovation","volume":"2","author":"HJ Newton","year":"2011","journal-title":"MBio"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.1158160","article-title":"Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors","volume":"320","author":"X Pan","year":"2008","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1128\/JB.01359-10","article-title":"The <italic>Coxiella burnetii<\/italic> cryptic plasmid is enriched in genes encoding type IV secretion system substrates","volume":"193","author":"DE Voth","year":"2011","journal-title":"J Bacteriol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"20433","DOI":"10.1074\/jbc.M802903200","article-title":"An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth","volume":"283","author":"GS Han","year":"2008","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"34537","DOI":"10.1074\/jbc.M606654200","article-title":"Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p\/Smp2p Mg2+-dependent phosphatidate phosphatase","volume":"281","author":"L O'Hara","year":"2006","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"11290","DOI":"10.1074\/jbc.M112.346023","article-title":"Pho85p-pho80p phosphorylation of yeast pah1p phosphatidate phosphatase regulates its activity, location, abundance, and function in lipid metabolism","volume":"287","author":"HS Choi","year":"2012","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/yea.747","article-title":"Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in <italic>Saccharomyces cerevisiae<\/italic>","volume":"18","author":"Y Kosodo","year":"2001","journal-title":"Yeast"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"20443","DOI":"10.1074\/jbc.M802866200","article-title":"Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase","volume":"283","author":"GS Han","year":"2008","journal-title":"J Biol Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.nutr.012809.104729","article-title":"Lipins: multifunctional lipid metabolism proteins","volume":"30","author":"LS Csaki","year":"2010","journal-title":"Annu Rev Nutr"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/sj.emboj.7600672","article-title":"The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth","volume":"24","author":"H Santos-Rosa","year":"2005","journal-title":"EMBO J"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.1600-0854.2009.00923.x","article-title":"Lipins, lipids and nuclear envelope structure","volume":"10","author":"S Siniossoglou","year":"2009","journal-title":"Traffic"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"37026","DOI":"10.1074\/jbc.M705777200","article-title":"The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity","volume":"282","author":"GS Han","year":"2007","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1007\/s00018-005-5195-z","article-title":"Phospholipase D: a lipid centric review","volume":"62","author":"GM Jenkins","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1021\/cr200296t","article-title":"Phospholipase D: enzymology, functionality, and chemical modulation","volume":"111","author":"PE Selvy","year":"2011","journal-title":"Chem Rev"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1093\/emboj\/16.15.4519","article-title":"Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity","volume":"16","author":"TC Sung","year":"1997","journal-title":"EMBO J"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1091\/mbc.E03-11-0844","article-title":"Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes","volume":"15","author":"S Carrasco","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1091\/mbc.E11-03-0247","article-title":"Diacylglycerol kinase zeta controls diacylglycerol metabolism at the immunological synapse","volume":"22","author":"SI Gharbi","year":"2011","journal-title":"Mol Biol Cell"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.140.3.485","article-title":"Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells","volume":"140","author":"E Oancea","year":"1998","journal-title":"J Cell Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1038\/sj.emboj.7601098","article-title":"Phospholipase Cgamma\/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling","volume":"25","author":"H Wang","year":"2006","journal-title":"EMBO J"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1083\/jcb.120.2.325","article-title":"Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor","volume":"120","author":"BL Tang","year":"1993","journal-title":"J Cell Biol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ncb1221","article-title":"Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function","volume":"7","author":"V Litvak","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"21746","DOI":"10.1074\/jbc.M702968200","article-title":"Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage","volume":"282","author":"M Zeniou-Meyer","year":"2007","journal-title":"J Biol Chem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1091\/mbc.E03-11-0798","article-title":"Positive and negative regulation of a SNARE protein by control of intracellular localization","volume":"15","author":"H Nakanishi","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abio.1997.2299","article-title":"Measurement of phospholipase D activity","volume":"252","author":"AJ Morris","year":"1997","journal-title":"Anal Biochem"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1152\/ajplung.00029.2002","article-title":"Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase","volume":"284","author":"M Nanjundan","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/CMR.00052-09","article-title":"Molecular pathogenesis of infections caused by <italic>Legionella pneumophila<\/italic>","volume":"23","author":"HJ Newton","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1207193","article-title":"De-AMPylation of the small GTPase Rab1 by the pathogen <italic>Legionella pneumophila<\/italic>","volume":"333","author":"MR Neunuebel","year":"2011","journal-title":"Science"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1139\/o03-079","article-title":"Phospholipase D","volume":"82","author":"M McDermott","year":"2004","journal-title":"Biochem Cell Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1111\/j.1462-5822.2008.01219.x","article-title":"The <italic>Legionella pneumophila<\/italic> phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole","volume":"10","author":"C Ragaz","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"G Van Meer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tcb.2010.10.002","article-title":"Coordination of Golgi functions by phosphatidylinositol 4-kinases","volume":"21","author":"TR Graham","year":"2010","journal-title":"Trends Cell Biol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/embor.2011.139","article-title":"Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology","volume":"12","author":"Y Fu","year":"2011","journal-title":"EMBO Rep"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tibs.2011.06.005","article-title":"Shaping up the membrane: diacylglycerol coordinates spatial orientation of signaling","volume":"36","author":"M Almena","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1128\/IAI.61.12.5361-5373.1993","article-title":"Identification of <italic>Legionella pneumophila<\/italic> genes required for growth within and killing of human macrophages","volume":"61","author":"AB Sadosky","year":"1993","journal-title":"Infect Immun"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1128\/JB.143.2.971-980.1980","article-title":"<italic>In vitro<\/italic> gene fusions that join an enzymatically active beta-galactosidase segment to amino-terminal fragments of exogenous proteins: <italic>Escherichia coli<\/italic> plasmid vectors for the detection and cloning of translational initiation signals","volume":"143","author":"MJ Casadaban","year":"1980","journal-title":"J Bacteriol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2","article-title":"Designer deletion strains derived from <italic>Saccharomyces cerevisiae<\/italic> S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications","volume":"14","author":"CB Brachmann","year":"1998","journal-title":"Yeast"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0092-8674(89)90584-9","article-title":"Elevated recombination rates in transcriptionally active DNA","volume":"56","author":"BJ Thomas","year":"1989","journal-title":"Cell"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature00935","article-title":"Functional profiling of the <italic>Saccharomyces cerevisiae<\/italic> genome","volume":"418","author":"G Giaever","year":"2002","journal-title":"Nature"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/j.1365-2958.2007.05604.x","article-title":"The response regulator PmrA is a major regulator of the <italic>icm<\/italic>\/<italic>dot<\/italic> type IV secretion system in <italic>Legionella pneumophila<\/italic> and <italic>Coxiella burnetii<\/italic>","volume":"63","author":"T Zusman","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2004.10.016","article-title":"Drag&amp;Drop cloning in yeast","volume":"344","author":"G Jansen","year":"2005","journal-title":"Gene"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/(SICI)1097-0061(199907)15:10B<963::AID-YEA399>3.0.CO;2-W","article-title":"Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines","volume":"15","author":"M Knop","year":"1999","journal-title":"Yeast"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1128\/JVI.02694-10","article-title":"The conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production","volume":"85","author":"Y Sabo","year":"2011","journal-title":"J Virol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1128\/IAI.65.12.5057-5066.1997","article-title":"Characterization of a new region required for macrophage killing by <italic>Legionella pneumophila<\/italic>","volume":"65","author":"G Segal","year":"1997","journal-title":"Infect Immun"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1128\/IAI.67.5.2117-2124.1999","article-title":"<italic>Legionella pneumophila<\/italic> utilize the same genes to multiply within <italic>Acanthamoeba castellanii<\/italic> and human macrophages","volume":"67","author":"G Segal","year":"1999","journal-title":"Infect Immun"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/yea.1018","article-title":"New \u2018marker swap\u2019 plasmids for converting selectable markers on budding yeast gene disruptions and plasmids","volume":"20","author":"WP Voth","year":"2003","journal-title":"Yeast"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0076-6879(02)50957-5","article-title":"Transformation of yeast by lithium acetate\/single-stranded carrier DNA\/polyethylene glycol method","volume":"350","author":"RD Gietz","year":"2002","journal-title":"Methods Enzymol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-1119(89)90358-2","article-title":"Site-directed mutagenesis by overlap extension using the polymerase chain reaction","volume":"77","author":"SN Ho","year":"1989","journal-title":"Gene"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0092-8674(82)90384-1","article-title":"Two differentially regulated mRNAs with different 5\u2032 ends encode secreted with intracellular forms of yeast invertase","volume":"28","author":"M Carlson","year":"1982","journal-title":"Cell"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1002988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T20:01:44Z","timestamp":1714507304000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1002988"}},"subtitle":[],"editor":[{"given":"Ralph R.","family":"Isberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":107,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1002988","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,1]]}}}