{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:20Z","timestamp":1791308840012,"version":"4.3.1"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003063","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T12:36:15Z","timestamp":1357130175000},"page":"e1003063","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Blood Flukes Exploit Peyer's Patch Lymphoid Tissue to Facilitate Transmission from the Mammalian Host"],"prefix":"10.1371","volume":"8","author":[{"given":"Joseph D.","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Narang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Coles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Mountford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"B Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-3024.2009.01098.x","article-title":"Immunopathogenesis of human schistosomiasis","volume":"31","author":"ML Burke","year":"2009","journal-title":"Parasite immunology"},{"key":"ref3","first-page":"771","article-title":"Studies on the host-parasite relationship in Schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion","volume":"35","author":"M Doenhoff","year":"1978","journal-title":"Immunology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4269\/ajtmh.1993.48.496","article-title":"Biology and pathology of Schistosoma mansoni and Schistosoma japonicum infections in several strains of nude mice","volume":"48","author":"AW Cheever","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1074-7613(04)00107-4","article-title":"Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology","volume":"20","author":"DR Herbert","year":"2004","journal-title":"Immunity"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4269\/ajtmh.1962.11.201","article-title":"New approach to the screening of drugs in experimental schistosomiasis mansoni in mice","volume":"11","author":"J Pellegrino","year":"1962","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1017\/S0031182001007351","article-title":"The schistosome egg: development and secretions","volume":"122","author":"PD Ashton","year":"2001","journal-title":"Parasitology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses","volume":"206","author":"B Everts","year":"2009","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.20082462","article-title":"The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)","volume":"206","author":"S Steinfelder","year":"2009","journal-title":"J Exp Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1001323","DOI":"10.1371\/journal.ppat.1001323","article-title":"Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells","volume":"7","author":"PC Cook","year":"2011","journal-title":"PLoS pathogens"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"MS Wilson","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI36534","article-title":"Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression","volume":"119","author":"JJ Taylor","year":"2009","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4269\/ajtmh.1994.50.281","article-title":"Kinetics of egg production and egg excretion by Schistosoma mansoni and S. japonicum in mice infected with a single pair of worms","volume":"50","author":"AW Cheever","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e1269","DOI":"10.1371\/journal.pntd.0001269","article-title":"CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection","volume":"5","author":"JD Turner","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2008.05.001","article-title":"The biology of intestinal immunoglobulin A responses","volume":"28","author":"A Cerutti","year":"2008","journal-title":"Immunity"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1128\/IAI.01145-07","article-title":"Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp","volume":"76","author":"T Hashizume","year":"2008","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/003591576505800930","article-title":"Peyer's patches in the human gut","volume":"58","author":"JS Cornes","year":"1965","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.6.3.225","article-title":"Number, size, and distribution of Peyer's patches in the human small intestine: Part I The development of Peyer's patches","volume":"6","author":"JS Cornes","year":"1965","journal-title":"Gut"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4269\/ajtmh.1968.17.38","article-title":"A quantitative post-mortem study of Schistosomiasis mansoni in man","volume":"17","author":"AW Cheever","year":"1968","journal-title":"Am J Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ni.1605","article-title":"Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone","volume":"9","author":"E Scandella","year":"2008","journal-title":"Nature immunology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nri2414","article-title":"Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence","volume":"8","author":"T Junt","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molbiopara.2005.08.003","article-title":"Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs","volume":"144","author":"CM Fitzsimmons","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.4049\/jimmunol.178.10.6023","article-title":"Cutting edge: IPSE\/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo","volume":"178","author":"G Schramm","year":"2007","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.20061706","article-title":"CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo","volume":"204","author":"T Worbs","year":"2007","journal-title":"J Exp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.4049\/jimmunol.181.6.3947","article-title":"Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone","volume":"181","author":"M Bajenoff","year":"2008","journal-title":"Journal of immunology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.4049\/jimmunol.127.5.1906","article-title":"Heterogeneity of the granulomatous response in the liver, colon, ileum, and ileal Peyer's patches to schistosome eggs in murine schistosomiasis mansoni","volume":"127","author":"JV Weinstock","year":"1981","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0167-5699(98)01310-3","article-title":"Granulomatous inflammation and the transmission of infection: schistosomiasis\u2013and TB too?","volume":"19","author":"MJ Doenhoff","year":"1998","journal-title":"Immunology today"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T06:38:03Z","timestamp":1687934283000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003063"}},"subtitle":[],"editor":[{"given":"William C.","family":"Gause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003063","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717973254.793474005","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717973254.793469968","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}