{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:15Z","timestamp":1791262575952,"version":"4.1.0"},"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T00:00:00Z","timestamp":1357171200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003118","type":"journal-article","created":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T00:49:52Z","timestamp":1357260592000},"page":"e1003118","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":266,"title":["IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling"],"prefix":"10.1371","volume":"9","author":[{"given":"Helen M.","family":"Lazear","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Lancaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul S.","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Vick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Clepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Thackray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Brassil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert W.","family":"Virgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janko","family":"Nikolich-Zugich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlee V.","family":"Moses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Fr\u00fch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1002352","DOI":"10.1371\/journal.ppat.1002352","article-title":"Type 1 interferons and antiviral CD8 T-cell responses","volume":"8","author":"RM Welsh","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3527(06)69001-5","article-title":"The innate antiviral response: new insights into a continuing story","volume":"69","author":"A Paun","year":"2007","journal-title":"Adv Virus Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.it.2012.01.004","article-title":"The yin and yang of viruses and interferons","volume":"33","author":"BX Wang","year":"2012","journal-title":"Trends Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0952-7915(02)00354-0","article-title":"Links between innate and adaptive immunity via type I interferon","volume":"14","author":"A Le Bon","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1128\/JVI.05738-11","article-title":"Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion","volume":"86","author":"S Jensen","year":"2012","journal-title":"J Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.coviro.2011.04.004","article-title":"RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity","volume":"1","author":"HJ Ramos","year":"2011","journal-title":"Curr Opin Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coi.2009.12.003","article-title":"Recognition of viruses by cytoplasmic sensors","volume":"22","author":"C Wilkins","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.it.2012.05.008","article-title":"Cell-intrinsic innate immune control of West Nile virus infection","volume":"33","author":"MS Diamond","year":"2012","journal-title":"Trends Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"K Honda","year":"2006","journal-title":"Immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.biochi.2007.01.014","article-title":"The IRF family, revisited","volume":"89","author":"A Paun","year":"2007","journal-title":"Biochimie"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"LC Platanias","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri2314","article-title":"Interferon-inducible antiviral effectors","volume":"8","author":"AJ Sadler","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"JW Schoggins","year":"2011","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1128\/JVI.76.11.5532-5539.2002","article-title":"Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes","volume":"76","author":"N Grandvaux","year":"2002","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1006\/bbrc.2001.4913","article-title":"Gene induction pathways mediated by distinct IRFs during viral infection","volume":"283","author":"T Nakaya","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"18651","DOI":"10.1074\/jbc.M501289200","article-title":"Tissue-specific positive feedback requirements for production of type I interferon following virus infection","volume":"280","author":"A Prakash","year":"2005","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1128\/JVI.00918-08","article-title":"Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection","volume":"82","author":"S Daffis","year":"2008","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1189\/jlb.0603255","article-title":"Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells","volume":"74","author":"A Izaguirre","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses","volume":"434","author":"K Honda","year":"2005","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"42013","DOI":"10.1074\/jbc.M110.165936","article-title":"Transcription factor redundancy ensures induction of the antiviral state","volume":"285","author":"S Schmid","year":"2010","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1371\/journal.ppat.0030106","article-title":"Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms","volume":"3","author":"S Daffis","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000607","DOI":"10.1371\/journal.ppat.1000607","article-title":"Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7","volume":"5","author":"S Daffis","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1128\/JVI.00768-06","article-title":"Resistance to alpha\/beta interferon is a determinant of West Nile virus replication fitness and virulence","volume":"80","author":"BC Keller","year":"2006","journal-title":"J Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.1128\/JVI.00396-11","article-title":"Beta interferon controls West Nile virus infection and pathogenesis in mice","volume":"85","author":"HM Lazear","year":"2011","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"13350","DOI":"10.1128\/JVI.79.21.13350-13361.2005","article-title":"Alpha\/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival","volume":"79","author":"MA Samuel","year":"2005","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1128\/JVI.00935-08","article-title":"Toll-like receptor 3 has a protective role against West Nile virus infection","volume":"82","author":"S Daffis","year":"2008","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1000757","DOI":"10.1371\/journal.ppat.1000757","article-title":"IPS-1 is essential for the control of West Nile virus infection and immunity","volume":"6","author":"MS Suthar","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1128\/JVI.01026-10","article-title":"The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system","volume":"84","author":"KJ Szretter","year":"2010","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"T Wang","year":"2004","journal-title":"Nat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.immuni.2008.11.012","article-title":"Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing","volume":"30","author":"T Town","year":"2009","journal-title":"Immunity"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1128\/JVI.00232-11","article-title":"The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response","volume":"85","author":"S Daffis","year":"2011","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/eji.200838814","article-title":"The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection","volume":"39","author":"C Steinberg","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.4049\/jimmunol.1103185","article-title":"Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection","volume":"188","author":"C Schilte","year":"2012","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1128\/JVI.00956-12","article-title":"Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock","volume":"86","author":"PA Rudd","year":"2012","journal-title":"J Virol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"14295","DOI":"10.1074\/jbc.M800501200","article-title":"Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response","volume":"283","author":"A Paun","year":"2008","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature03308","article-title":"Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors","volume":"434","author":"A Takaoka","year":"2005","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1073\/pnas.0611559104","article-title":"Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression","volume":"104","author":"H Yanai","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"45194","DOI":"10.1074\/jbc.M400726200","article-title":"Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection","volume":"279","author":"BJ Barnes","year":"2004","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"17005","DOI":"10.1074\/jbc.M412584200","article-title":"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling","volume":"280","author":"A Schoenemeyer","year":"2005","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1002230","DOI":"10.1371\/journal.ppat.1002230","article-title":"Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection","volume":"7","author":"JD Brien","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1128\/JVI.02199-09","article-title":"Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections","volume":"84","author":"D Jiang","year":"2010","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"11557","DOI":"10.1128\/JVI.05519-11","article-title":"The interferon-inducible gene viperin restricts West Nile virus pathogenesis","volume":"85","author":"KJ Szretter","year":"2011","journal-title":"J Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.1128\/JVI.00733-12","article-title":"New PARP Gene with an Anti-Alphavirus Function","volume":"86","author":"S Atasheva","year":"2012","journal-title":"J Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1007\/s00018-002-8499-2","article-title":"Gene structure of the murine 2\u2032-5\u2032-oligoadenylate synthetase family","volume":"59","author":"S Eskildsen","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/nar\/gkg427","article-title":"Characterization of the 2\u2032-5\u2032-oligoadenylate synthetase ubiquitin-like family","volume":"31","author":"S Eskildsen","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1128\/JVI.01359-07","article-title":"Differential expression of interferon (IFN) regulatory factors and IFN-stimulated genes at early times after West Nile virus infection of mouse embryo fibroblasts","volume":"81","author":"SV Scherbik","year":"2007","journal-title":"J Virol"},{"key":"ref47","first-page":"730","article-title":"Microarray analysis of gene expression in West Nile virus-infected human retinal pigment epithelium","volume":"18","author":"L Munoz-Erazo","year":"2012","journal-title":"Mol Vis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1128\/JVI.78.14.7737-7747.2004","article-title":"The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway","volume":"78","author":"BL Fredericksen","year":"2004","journal-title":"J Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3201\/eid1104.041076","article-title":"Molecular mechanisms of West Nile virus pathogenesis in brain cell","volume":"11","author":"WL Koh","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1089\/jir.2006.26.804","article-title":"Blocking monoclonal antibodies specific for mouse IFN-alpha\/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection","volume":"26","author":"KC Sheehan","year":"2006","journal-title":"J Interferon Cytokine Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"9713","DOI":"10.1128\/JVI.78.18.9713-9720.2004","article-title":"Regulation of hepatitis C virus replication by interferon regulatory factor 1","volume":"78","author":"N Kanazawa","year":"2004","journal-title":"J Virol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1128\/JVI.66.7.4470-4478.1992","article-title":"Constitutive expression of an ISGF2\/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection","volume":"66","author":"R Pine","year":"1992","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.virol.2005.11.040","article-title":"West Nile virus infection of the placenta","volume":"347","author":"JG Julander","year":"2006","journal-title":"Virology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/vbz.2009.0067","article-title":"Infection, dissemination, and transmission of a West Nile virus green fluorescent protein infectious clone by Culex pipiens quinquefasciatus mosquitoes","volume":"10","author":"CE McGee","year":"2010","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.virol.2005.01.021","article-title":"An infectious West Nile virus that expresses a GFP reporter gene","volume":"334","author":"TC Pierson","year":"2005","journal-title":"Virology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/jir.2009.0069","article-title":"Mechanisms of evasion of the type I interferon antiviral response by flaviviruses","volume":"29","author":"MS Diamond","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1128\/JVI.79.17.11457-11466.2005","article-title":"Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis","volume":"79","author":"RS Klein","year":"2005","journal-title":"J Virol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature09489","article-title":"2\u2032-O methylation of the viral mRNA cap evades host restriction by IFIT family members","volume":"468","author":"S Daffis","year":"2010","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e1002698","DOI":"10.1371\/journal.ppat.1002698","article-title":"2\u2032-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo","volume":"8","author":"KJ Szretter","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1128\/JVI.01151-07","article-title":"West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis","volume":"81","author":"GR Medigeshi","year":"2007","journal-title":"J Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.182.1.466","article-title":"CHAC1\/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade","volume":"182","author":"IN Mungrue","year":"2009","journal-title":"J Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.4049\/jimmunol.1000864","article-title":"Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide","volume":"186","author":"SM Smith","year":"2011","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.cdd.4401833","article-title":"Viruses, endoplasmic reticulum stress, and interferon responses","volume":"13","author":"B He","year":"2006","journal-title":"Cell Death Differ"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1128\/JVI.02050-10","article-title":"West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasion","volume":"85","author":"RL Ambrose","year":"2011","journal-title":"J Virol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e1002708","DOI":"10.1371\/journal.ppat.1002708","article-title":"Induction of GADD34 Is Necessary for dsRNA-Dependent Interferon-beta Production and Participates in the Control of Chikungunya Virus Infection","volume":"8","author":"G Clavarino","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2005.07.013","article-title":"Gene expression in mice infected with West Nile virus strains of different neurovirulence","volume":"342","author":"M Venter","year":"2005","journal-title":"Virology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e24371","DOI":"10.1371\/journal.pone.0024371","article-title":"Gene expression analysis in the thalamus and cerebrum of horses experimentally infected with West Nile virus","volume":"6","author":"MA Bourgeois","year":"2011","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1128\/JVI.01122-06","article-title":"Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion","volume":"80","author":"MA Samuel","year":"2006","journal-title":"J Virol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e1001016","DOI":"10.1371\/journal.ppat.1001016","article-title":"Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling","volume":"6","author":"EJ Faul","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/MCB.22.16.5721-5740.2002","article-title":"Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes","volume":"22","author":"BJ Barnes","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ni.2307","article-title":"Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses","volume":"13","author":"H Negishi","year":"2012","journal-title":"Nat Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.immuni.2011.06.014","article-title":"Mapping a dynamic innate immunity protein interaction network regulating type I interferon production","volume":"35","author":"S Li","year":"2011","journal-title":"Immunity"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3201\/eid0704.017408","article-title":"Partial genetic characterization of West Nile virus strains, New York State, 2000","volume":"7","author":"GD Ebel","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1128\/JVI.77.4.2578-2586.2003","article-title":"B Cells and Antibody Play Critical Roles in the Immediate Defense of Disseminated Infection by West Nile Encephalitis Virus","volume":"77","author":"MS Diamond","year":"2003","journal-title":"Journal of Virology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3201\/eid0704.017420","article-title":"West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis","volume":"7","author":"SY Xiao","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1128\/JVI.00783-07","article-title":"Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence","volume":"81","author":"LB Thackray","year":"2007","journal-title":"J Virol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1128\/JVI.00141-08","article-title":"Antibody is critical for the clearance of murine norovirus infection","volume":"82","author":"KA Chachu","year":"2008","journal-title":"J Virol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"E898","DOI":"10.1073\/pnas.1118155109","article-title":"Spontaneous mutation of the Dock2 gene in Irf5\u2212\/\u2212 mice complicates interpretation of type I interferon production and antibody responses","volume":"109","author":"WE Purtha","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1128\/JVI.00489-06","article-title":"PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons","volume":"80","author":"MA Samuel","year":"2006","journal-title":"J Virol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nm1240","article-title":"Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus","volume":"11","author":"T Oliphant","year":"2005","journal-title":"Nat Med"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Smyth GK (2005) Limma: linear models for microarray data. In: Gentleman R, Carey V, Dudoit R, Irizarry R, Huber W, editors. Bioinformatics and Computational Biology Solutions using R and Bioconductor. New York: Springer. pp. 397\u2013420.","DOI":"10.1007\/0-387-29362-0_23"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1073\/pnas.0606699104","article-title":"Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2","volume":"104","author":"T Saito","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1128\/JVI.01593-08","article-title":"Novel characteristics of the function and induction of murine p56 family proteins","volume":"82","author":"V Fensterl","year":"2008","journal-title":"J Virol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"}],"updated-by":[{"DOI":"10.1371\/annotation\/4de7ddfd-52df-4f87-8ca4-d48afe646ca8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000}}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T19:42:29Z","timestamp":1595187749000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003118"}},"subtitle":[],"editor":[{"given":"Christopher F.","family":"Basler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,3]]},"references-count":84,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003118","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/4de7ddfd-52df-4f87-8ca4-d48afe646ca8","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,3]]}}}