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Ljunggren","year":"1990","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"11737","DOI":"10.1073\/pnas.0306294101","article-title":"Tapasin enhances MHC class I peptide presentation according to peptide half-life","volume":"101","author":"M Howarth","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1073\/pnas.1201586109","article-title":"Promiscuous binding of extracellular peptides to cell surface class I MHC protein","volume":"109","author":"HN Eisen","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1074\/mcp.M500241-MCP200","article-title":"The turnover kinetics of major histocompatibility complex peptides of human cancer cells","volume":"5","author":"E Milner","year":"2006","journal-title":"Mol Cell 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