{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:15:23Z","timestamp":1791296123053,"version":"4.1.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003152","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T21:54:53Z","timestamp":1359669293000},"page":"e1003152","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients"],"prefix":"10.1371","volume":"9","author":[{"given":"Emilie","family":"Tourneur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Ben Mkaddem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cilia","family":"Chassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle","family":"Bens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Goujon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pellefigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Aloulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Hertig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato C.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Girardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana J.","family":"Philpott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rondeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Elbim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Werts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vandewalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00042307-200203000-00007","article-title":"Urinary tract infections after renal transplantation","volume":"12","author":"S Schmaldienst","year":"2002","journal-title":"Curr Opin Urol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/ncpneph0781","article-title":"Urinary tract infection in the renal transplant patient","volume":"4","author":"RM de Souza","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1053\/j.ajkd.2004.04.040","article-title":"Late urinary tract infection after renal transplantation in the United States","volume":"44","author":"KC Abbott","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1600-6143.2006.01700.x","article-title":"Acute pyelonephritis represents a risk factor impairing long-term kidney graft function","volume":"7","author":"G Pelle","year":"2007","journal-title":"Am J Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1086\/320897","article-title":"Epidemiology of infections after solid-organ transplantation","volume":"33 Suppl 1","author":"DR Snydman","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.idc.2010.01.005","article-title":"Infection in organ transplantation: risk factors and evolving patterns of infection","volume":"24","author":"JA Fishman","year":"2010","journal-title":"Infect Dis Clin North Am"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1101\/gad.1102703","article-title":"Transcriptional regulation by calcium, calcineurin, and NFAT","volume":"17","author":"PG Hogan","year":"2003","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/369497a0","article-title":"NF-AT components define a family of transcription factors targeted in T-cell activation","volume":"369","author":"JP Northrop","year":"1994","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"O Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2362.2008.02005.x","article-title":"Innate and adaptive immune responses in the urinary tract","volume":"38 Suppl 2","author":"J Song","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1126\/science.1094351","article-title":"A toll-like receptor that prevents infection by uropathogenic bacteria","volume":"303","author":"D Zhang","year":"2004","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/embo-reports\/kve155","article-title":"CARD4\/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri","volume":"2","author":"SE Girardin","year":"2001","journal-title":"EMBO Rep"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/416194a","article-title":"RICK\/Rip2\/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems","volume":"416","author":"K Kobayashi","year":"2002","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/ni945","article-title":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid","volume":"4","author":"M Chamaillard","year":"2003","journal-title":"Nat Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"41702","DOI":"10.1074\/jbc.M307198200","article-title":"Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2","volume":"278","author":"SE Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"JP Hugot","year":"2001","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Y Ogura","year":"2001","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1084\/jem.20051229","article-title":"Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo","volume":"203","author":"J Masumoto","year":"2006","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1371\/journal.ppat.0030118","article-title":"Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing","volume":"3","author":"ES Lysenko","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nm.2087","article-title":"Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity","volume":"16","author":"TB Clarke","year":"2010","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/ndt\/gfg190","article-title":"Laboratory assessment of immune function in renal transplant patients","volume":"18","author":"P Hutchinson","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1093\/ndt\/gfi007","article-title":"Leukocyte phenotype and function predicts infection risk in renal transplant recipients","volume":"20","author":"M Blazik","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.177.7.4773","article-title":"Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways","volume":"177","author":"C Chassin","year":"2006","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nm994","article-title":"A new cell-permeable peptide allows successful allogeneic islet transplantation in mice","volume":"10","author":"H Noguchi","year":"2004","journal-title":"Nat Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1084\/jem.20071032","article-title":"Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin","volume":"204","author":"C Chassin","year":"2007","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.162.5.3037","article-title":"Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract","volume":"162","author":"L Hang","year":"1999","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1086\/315006","article-title":"Neutrophil recruitment and resistance to urinary tract infection","volume":"180","author":"M Haraoka","year":"1999","journal-title":"J Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1001042","DOI":"10.1371\/journal.ppat.1001042","article-title":"Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection","volume":"6","author":"TJ Hannan","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1681\/ASN.2007030273","article-title":"Dendritic cells in the kidney","volume":"18","author":"R John","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1053\/j.gastro.2009.12.008","article-title":"Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control","volume":"138","author":"S Dharancy","year":"2010","journal-title":"Gastroenterology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1073\/pnas.0736473100","article-title":"Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli","volume":"100","author":"JD Schilling","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1111\/j.1523-1755.2005.00729.x","article-title":"Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis","volume":"68","author":"PS Patole","year":"2005","journal-title":"Kidney Int"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1462-5822.2011.01614.x","article-title":"A role for collecting duct epithelial cells in renal antibacterial defences","volume":"13","author":"C Chassin","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.166.2.1148","article-title":"Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism","volume":"166","author":"JD Schilling","year":"2001","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.4049\/jimmunol.0903065","article-title":"Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury","volume":"184","author":"AA Shigeoka","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/sj.ki.5002436","article-title":"Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases","volume":"72","author":"HJ Anders","year":"2007","journal-title":"Kidney Int"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14896","DOI":"10.1073\/pnas.1015063108","article-title":"Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation","volume":"108","author":"JG Magalhaes","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1681\/ASN.2010101072","article-title":"Kidney dendritic cells induce innate immunity against bacterial pyelonephritis","volume":"22","author":"AP Tittel","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1440-1797.2012.01581.x","article-title":"Isolation of functional dendritic cells from murine kidneys for immunological characterization","volume":"17","author":"SA Teteris","year":"2012","journal-title":"Nephrology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/eji.200737069","article-title":"Nod1 and Nod2 induce CCL5\/RANTES through the NF-kappaB pathway","volume":"37","author":"C Werts","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1242\/jcs.000331","article-title":"Expression of the transcription factor NFAT2 in human neutrophils: IgE-dependent, Ca2+- and calcineurin-mediated NFAT2 activation","volume":"120","author":"A Vega","year":"2007","journal-title":"J Cell Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1084\/jem.20092531","article-title":"Calcineurin regulates innate antifungal immunity in neutrophils","volume":"207","author":"MB Greenblatt","year":"2010","journal-title":"J Exp Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1126\/science.285.5436.2129","article-title":"Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A","volume":"285","author":"J Aramburu","year":"1999","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"10884","DOI":"10.1074\/jbc.271.18.10884","article-title":"Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity","volume":"271","author":"C Loh","year":"1996","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7164\/antibiotics.36.1059","article-title":"Immunoactive peptides, FK-156 and FK-565. III. Enhancement of host defense mechanisms against infection","volume":"36","author":"Y Mine","year":"1983","journal-title":"J Antibiot (Tokyo)"},{"key":"ref46","first-page":"278","article-title":"Mycophenolate mofetil. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation","volume":"51","author":"B Fulton","year":"1996","journal-title":"Drugs"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1128\/IAI.65.8.3451-3456.1997","article-title":"Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration","volume":"65","author":"G Godaly","year":"1997","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1681\/ASN.V12162","article-title":"Cellular and molecular mechanisms of cyclosporin nephrotoxicity","volume":"1","author":"JB Kopp","year":"1990","journal-title":"J Am Soc Nephrol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.4049\/jimmunol.1003761","article-title":"Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen","volume":"186","author":"M Hasegawa","year":"2011","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/emmm.201100207","article-title":"Calcineurin\/NFAT signalling inhibits myeloid haematopoiesis","volume":"4","author":"J Fric","year":"2012","journal-title":"EMBO Mol Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"NA Gow","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.cellsig.2011.06.013","article-title":"Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes\/macrophages","volume":"23","author":"H Minematsu","year":"2011","journal-title":"Cell Signal"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2011.03.036","article-title":"Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages","volume":"1397","author":"R Yamaguchi","year":"2011","journal-title":"Brain Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.4049\/jimmunol.179.7.4598","article-title":"Calcineurin negatively regulates TLR-mediated activation pathways","volume":"179","author":"YJ Kang","year":"2007","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/1753425908100928","article-title":"Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo","volume":"15","author":"C Jennings","year":"2009","journal-title":"Innate Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","article-title":"Endotoxin tolerance: new mechanisms, molecules and clinical significance","volume":"30","author":"SK Biswas","year":"2009","journal-title":"Trends Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1128\/IAI.68.5.2566-2572.2000","article-title":"Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum","volume":"68","author":"J Hellman","year":"2000","journal-title":"Infect Immun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/eji.200526286","article-title":"Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists","volume":"35","author":"JH Fritz","year":"2005","journal-title":"Eur J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/IAI.72.3.1487-1495.2004","article-title":"Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors","volume":"72","author":"JG Kim","year":"2004","journal-title":"Infect Immun"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1432-2277.2000.tb01050.x","article-title":"Polymorphonuclear leukocyte functions as predictive markers for infections after organ transplantation","volume":"13","author":"G Egger","year":"2000","journal-title":"Transpl Int"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00007890-200102270-00016","article-title":"Improved phagocyte response by co-amoxiclav in renal transplant recipients","volume":"71","author":"AM Cuffini","year":"2001","journal-title":"Transplantation"},{"key":"ref62","first-page":"311","article-title":"Inhibition of phagocytes by cyclosporin in vitro","volume":"87","author":"SP Thorat","year":"1994","journal-title":"Q J Med"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1128\/AAC.38.12.2883","article-title":"In vitro and ex vivo effects of cyclosporin A on phagocytic host defenses against Aspergillus fumigatus","volume":"38","author":"E Roilides","year":"1994","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrmicro2745","article-title":"Modulating immunity as a therapy for bacterial infections","volume":"10","author":"RE Hancock","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ki.2011.129","article-title":"Homeostatic and pathogenic role of renal dendritic cells","volume":"80","author":"SA Teteris","year":"2011","journal-title":"Kidney international"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/nm1665","article-title":"CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation","volume":"13","author":"F Pinheiro da Silva","year":"2007","journal-title":"Nat Med"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.4049\/jimmunol.174.6.3633","article-title":"Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase\/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad","volume":"174","author":"S Francois","year":"2005","journal-title":"J Immunol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T03:12:25Z","timestamp":1688008345000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003152"}},"subtitle":[],"editor":[{"given":"Ralph R.","family":"Isberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,31]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003152","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,31]]}}}