{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:01:41Z","timestamp":1791144101812,"version":"4.1.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003214","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T21:56:12Z","timestamp":1362693372000},"page":"e1003214","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":94,"title":["Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection"],"prefix":"10.1371","volume":"9","author":[{"given":"Sebla B.","family":"Kutluay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perez-Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Bieniasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.immuni.2012.08.013","article-title":"Intrinsic Cellular Defenses against Human Immunodeficiency Viruses","volume":"37","author":"D Blanco-Melo","year":"2012","journal-title":"Immunity"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.coviro.2011.10.007","article-title":"Antiretroviral restriction factors","volume":"1","author":"T Hatziioannou","year":"2011","journal-title":"Curr Opin Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"a006940","DOI":"10.1101\/cshperspect.a006940","article-title":"HIV Restriction Factors and Mechanisms of Evasion","volume":"2","author":"MH Malim","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature02343","article-title":"The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys","volume":"427","author":"M Stremlau","year":"2004","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1093\/emboj\/20.9.2140","article-title":"The tripartite motif family identifies cell compartments","volume":"20","author":"A Reymond","year":"2001","journal-title":"EMBO J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nrmicro1248","article-title":"TRIM family proteins: retroviral restriction and antiviral defence","volume":"3","author":"S Nisole","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.tim.2008.08.013","article-title":"Restriction of retroviral replication by APOBEC3G\/F and TRIM5alpha","volume":"16","author":"H Huthoff","year":"2008","journal-title":"Trends Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/aid.2010.0367","article-title":"Recent insights into the mechanism and consequences of TRIM5alpha retroviral restriction","volume":"27","author":"J Sastri","year":"2011","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1128\/JVI.79.14.8870-8877.2005","article-title":"A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection","volume":"79","author":"EE Nakayama","year":"2005","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1128\/JVI.79.14.8969-8978.2005","article-title":"Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity","volume":"79","author":"D Perez-Caballero","year":"2005","journal-title":"J Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.0409853102","article-title":"Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain","volume":"102","author":"SL Sawyer","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1128\/JVI.79.5.3139-3145.2005","article-title":"Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction","volume":"79","author":"M Stremlau","year":"2005","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cub.2004.12.042","article-title":"A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction","volume":"15","author":"MW Yap","year":"2005","journal-title":"Curr Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"15567","DOI":"10.1128\/JVI.79.24.15567-15572.2005","article-title":"Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity","volume":"79","author":"D Perez-Caballero","year":"2005","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"11914","DOI":"10.1073\/pnas.162299499","article-title":"Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism","volume":"99","author":"S Cowan","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1073\/pnas.212400099","article-title":"A dominant block to HIV-1 replication at reverse transcription in simian cells","volume":"99","author":"C Munk","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1128\/JVI.77.1.726-731.2003","article-title":"Human and simian immunodeficiency virus capsid proteins are major viral determinants of early, postentry replication blocks in simian cells","volume":"77","author":"CM Owens","year":"2003","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11920","DOI":"10.1073\/pnas.172384599","article-title":"Restriction of lentivirus in monkeys","volume":"99","author":"C Besnier","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10571","DOI":"10.1128\/JVI.79.16.10571-10577.2005","article-title":"Capsid processing requirements for abrogation of Fv1 and Ref1 restriction","volume":"79","author":"MP Dodding","year":"2005","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"26933","DOI":"10.1074\/jbc.M502145200","article-title":"The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha","volume":"280","author":"H Javanbakht","year":"2005","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8725","DOI":"10.1128\/JVI.00497-11","article-title":"Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha","volume":"85","author":"M Lienlaf","year":"2011","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1073\/pnas.0402361101","article-title":"Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha","volume":"101","author":"T Hatziioannou","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1073\/pnas.0402474101","article-title":"The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities","volume":"101","author":"Z Keckesova","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1073\/pnas.0402876101","article-title":"Trim5alpha protein restricts both HIV-1 and murine leukemia virus","volume":"101","author":"MW Yap","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1073\/pnas.0403364101","article-title":"TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells","volume":"101","author":"MJ Perron","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"13324","DOI":"10.1073\/pnas.0404640101","article-title":"A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1","volume":"101","author":"S Nisole","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02777","article-title":"Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1","volume":"430","author":"DM Sayah","year":"2004","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1073\/pnas.0709003105","article-title":"Independent evolution of an antiviral TRIMCyp in rhesus macaques","volume":"105","author":"SJ Wilson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1073\/pnas.0709258105","article-title":"Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species","volume":"105","author":"CA Virgen","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.coviro.2012.02.003","article-title":"TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling","volume":"2","author":"MG Grutter","year":"2012","journal-title":"Curr Opin Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1128\/JVI.02318-06","article-title":"The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid","volume":"81","author":"MJ Perron","year":"2007","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1073\/pnas.0509996103","article-title":"Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor","volume":"103","author":"M Stremlau","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"11669","DOI":"10.1128\/JVI.01559-08","article-title":"Biochemical and biophysical characterization of a chimeric TRIM21-TRIM5alpha protein","volume":"82","author":"AK Kar","year":"2008","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11682","DOI":"10.1128\/JVI.01562-08","article-title":"Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication","volume":"82","author":"CR Langelier","year":"2008","journal-title":"J Virol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1128\/JVI.01052-06","article-title":"Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins","volume":"80","author":"JL Anderson","year":"2006","journal-title":"J Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"37025","DOI":"10.1074\/jbc.M606066200","article-title":"Trim5alpha accelerates degradation of cytosolic capsid associated with productive HIV-1 entry","volume":"281","author":"U Chatterji","year":"2006","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1073\/pnas.0510483103","article-title":"Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection","volume":"103","author":"X Wu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1083\/jcb.200706154","article-title":"Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5alpha","volume":"180","author":"EM Campbell","year":"2008","journal-title":"J Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1128\/JVI.05811-11","article-title":"RING domain mutations uncouple TRIM5alpha restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating","volume":"86","author":"A Roa","year":"2012","journal-title":"J Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.virol.2007.08.032","article-title":"Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp","volume":"369","author":"F Diaz-Griffero","year":"2007","journal-title":"Virology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.virol.2008.05.008","article-title":"A human TRIM5alpha B30.2\/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus","volume":"378","author":"F Diaz-Griffero","year":"2008","journal-title":"Virology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature09976","article-title":"TRIM5 is an innate immune sensor for the retrovirus capsid lattice","volume":"472","author":"T Pertel","year":"2011","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2007.04.034","article-title":"The ability of multimerized cyclophilin A to restrict retrovirus infection","volume":"367","author":"H Javanbakht","year":"2007","journal-title":"Virology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1742-4690-4-68","article-title":"Both TRIM5alpha and TRIMCyp have only weak antiviral activity in canine D17 cells","volume":"4","author":"J Berube","year":"2007","journal-title":"Retrovirology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1002011","DOI":"10.1371\/journal.ppat.1002011","article-title":"Novel escape mutants suggest an extensive TRIM5alpha binding site spanning the entire outer surface of the murine leukemia virus capsid protein","volume":"7","author":"S Ohkura","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/JVI.01228-12","article-title":"Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core","volume":"87","author":"Y Yang","year":"2012","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10951","DOI":"10.1128\/JVI.00682-09","article-title":"Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A","volume":"83","author":"Y Li","year":"2009","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/JVI.01406-10","article-title":"Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization","volume":"85","author":"J Shi","year":"2010","journal-title":"J Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1128\/JVI.72.3.2208-2212.1998","article-title":"Cytosolic Gag p24 as an index of productive entry of human immunodeficiency virus type 1","volume":"72","author":"V Marechal","year":"1998","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1128\/JVI.00410-08","article-title":"Primate lentivirus capsid sensitivity to TRIM5 proteins","volume":"82","author":"Z Kratovac","year":"2008","journal-title":"J Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1073\/pnas.1014522108","article-title":"Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription","volume":"108","author":"AE Hulme","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1073\/pnas.1013426108","article-title":"Hexagonal assembly of a restricting TRIM5alpha protein","volume":"108","author":"BK Ganser-Pornillos","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"29749","DOI":"10.1074\/jbc.M004670200","article-title":"Degradation of HIV-1 integrase by the N-end rule pathway","volume":"275","author":"LC Mulder","year":"2000","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"13125","DOI":"10.1073\/pnas.202480499","article-title":"Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1","volume":"99","author":"G Asher","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1002\/j.1460-2075.1996.tb01061.x","article-title":"Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo","volume":"15","author":"D Krappmann","year":"1996","journal-title":"EMBO J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4049\/jimmunol.157.2.617","article-title":"Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation","volume":"157","author":"MT Michalek","year":"1996","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/viro.2001.0966","article-title":"The NS2 protein generated by the parvovirus minute virus of mice is degraded by the proteasome in a manner independent of ubiquitin chain elongation or activation","volume":"285","author":"CL Miller","year":"2001","journal-title":"Virology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1097-2765(00)80435-9","article-title":"Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination","volume":"5","author":"RJ Sheaff","year":"2000","journal-title":"Mol Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1073\/pnas.0538058100","article-title":"Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein","volume":"100","author":"RF Kalejta","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1074\/jbc.272.4.2307","article-title":"Preferential binding of poly(A)-binding protein 1 to an inhibitory RNA element in the human immunodeficiency virus type 1 gag mRNA","volume":"272","author":"E Afonina","year":"1997","journal-title":"J Biol Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.1128\/JVI.65.11.5732-5743.1991","article-title":"Identification of posttranscriptionally active inhibitory sequences in human immunodeficiency virus type 1 RNA: novel level of gene regulation","volume":"65","author":"F Maldarelli","year":"1991","journal-title":"J Virol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1128\/JVI.68.5.2986-2993.1994","article-title":"Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA","volume":"68","author":"G Nasioulas","year":"1994","journal-title":"J Virol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0042-6822(92)90246-L","article-title":"Interaction of cellular factors with intragenic cis-acting repressive sequences within the HIV genome","volume":"191","author":"HS Olsen","year":"1992","journal-title":"Virology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1128\/JVI.71.7.4892-4903.1997","article-title":"Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag\/protease and particle formation","volume":"71","author":"R Schneider","year":"1997","journal-title":"J Virol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1128\/JVI.66.12.7176-7182.1992","article-title":"Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression","volume":"66","author":"S Schwartz","year":"1992","journal-title":"J Virol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/JVI.66.1.150-159.1992","article-title":"Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein","volume":"66","author":"S Schwartz","year":"1992","journal-title":"J Virol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.gene.2012.03.021","article-title":"The regulation of mRNA stability in mammalian cells: 2.0","volume":"500","author":"X Wu","year":"2012","journal-title":"Gene"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"22023","DOI":"10.1074\/jbc.270.37.22023","article-title":"Identification and initial characterization of a specific proteasome (prosome) associated RNase activity","volume":"270","author":"MN Pouch","year":"1995","journal-title":"J Biol Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1128\/JVI.80.8.4061-4067.2006","article-title":"Trim-cyclophilin A fusion proteins can restrict human immunodeficiency virus type 1 infection at two distinct phases in the viral life cycle","volume":"80","author":"MW Yap","year":"2006","journal-title":"J Virol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1128\/JVI.79.18.11580-11587.2005","article-title":"Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles","volume":"79","author":"LM Ylinen","year":"2005","journal-title":"J Virol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1128\/JVI.76.11.5667-5677.2002","article-title":"Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication","volume":"76","author":"BM Forshey","year":"2002","journal-title":"J Virol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1128\/JVI.73.10.8824-8830.1999","article-title":"Association of Nef with the human immunodeficiency virus type 1 core","volume":"73","author":"A Kotov","year":"1999","journal-title":"J Virol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1128\/JVI.74.3.1168-1177.2000","article-title":"Biochemical and structural analysis of isolated mature cores of human immunodeficiency virus type 1","volume":"74","author":"R Welker","year":"2000","journal-title":"J Virol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1099\/vir.0.81527-0","article-title":"Murine leukemia virus transmembrane protein R-peptide is found in small virus core-like complexes in cells","volume":"87","author":"KB Andersen","year":"2006","journal-title":"J Gen Virol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1128\/JVI.75.8.3626-3635.2001","article-title":"Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1","volume":"75","author":"A Fassati","year":"2001","journal-title":"J Virol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1128\/JVI.73.11.8919-8925.1999","article-title":"Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus","volume":"73","author":"A Fassati","year":"1999","journal-title":"J Virol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nsmb785","article-title":"The stoichiometry of Gag protein in HIV-1","volume":"11","author":"JA Briggs","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/emboj\/cdg042","article-title":"Restriction of multiple divergent retroviruses by Lv1 and Ref1","volume":"22","author":"T Hatziioannou","year":"2003","journal-title":"EMBO J"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1093\/nar\/30.2.e9","article-title":"High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells","volume":"30","author":"Y Durocher","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"12058","DOI":"10.1128\/JVI.78.21.12058-12061.2004","article-title":"APOBEC3G incorporation into human immunodeficiency virus type 1 particles","volume":"78","author":"V Zennou","year":"2004","journal-title":"J Virol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"H Niwa","year":"1991","journal-title":"Gene"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"e1001200","DOI":"10.1371\/journal.ppat.1001200","article-title":"Analysis of the initiating events in HIV-1 particle assembly and genome packaging","volume":"6","author":"SB Kutluay","year":"2010","journal-title":"PLoS Pathog"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:21:21Z","timestamp":1688084481000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003214"}},"subtitle":[],"editor":[{"given":"Michael","family":"Emerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":82,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003214","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]}}}