{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:35:08Z","timestamp":1784763308908,"version":"3.55.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003247","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T22:18:07Z","timestamp":1365113887000},"page":"e1003247","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":84,"title":["Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier"],"prefix":"10.1371","volume":"9","author":[{"given":"Tong-Bao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena L.","family":"Toffaletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseo","family":"Eugenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Perfect","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11908-000-0015-y","article-title":"Cryptococcal Meningitis in HIV-Infected Patients","volume":"2","author":"WG Powderly","year":"2000","journal-title":"Curr Infect Dis Rep"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"BJ Park","year":"2009","journal-title":"AIDS"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Casadevall A, Perfect JR (1998) Cryptococcus neoformans. Washington, DC: ASM press.","DOI":"10.1128\/9781555818241"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/14656566.9.4.551","article-title":"Epidemiology and management of cryptococcal meningitis: developments and challenges","volume":"9","author":"R Pukkila-Worley","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.idc.2006.07.001","article-title":"Cryptococcosis","volume":"20","author":"M Chayakulkeeree","year":"2006","journal-title":"Infect Dis Clin North Am"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1101\/gad.11.23.3206","article-title":"<italic>Cryptococcus neoformans<\/italic> mating and virulence are regulated by the G-protein alpha subunit <italic>GPA1<\/italic> and cAMP","volume":"11","author":"JA Alspaugh","year":"1997","journal-title":"Genes Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1086\/313603","article-title":"Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups","volume":"30","author":"JR Graybill","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.micro.62.081307.162753","article-title":"How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in <italic>Cryptococcus neoformans<\/italic>","volume":"63","author":"TL Doering","year":"2009","journal-title":"Annu Rev Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america","volume":"50","author":"JR Perfect","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Heitman J, Kozel TR, Kwon-Chung KJ, Perfect JR, and Casadevall A (2011) <italic>Cryptococcus<\/italic> from human pathogen to model yeast. Washington, DC: ASM press.","DOI":"10.1128\/9781555816858"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.chom.2007.05.005","article-title":"The human fungal pathogen <italic>Cryptococcus<\/italic> can complete its sexual cycle during a pathogenic association with plants","volume":"1","author":"C Xue","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.856001","article-title":"Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of <italic>C. neoformans<\/italic>","volume":"15","author":"C Luberto","year":"2001","journal-title":"Genes Dev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.mib.2006.06.003","article-title":"Lipid signaling in pathogenic fungi","volume":"9","author":"JM Shea","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"28547","DOI":"10.1074\/jbc.M503404200","article-title":"The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by <italic>Cryptococcus neoformans<\/italic>","volume":"280","author":"LJ Heung","year":"2005","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1128\/EC.00146-08","article-title":"PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"7","author":"KJ Gerik","year":"2008","journal-title":"Eukaryot Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0065-2318(08)60337-6","article-title":"The utilization of sugars by yeasts","volume":"32","author":"JA Barnett","year":"1976","journal-title":"Adv Carbohydr Chem Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/jcm.6.4.387-391.1977","article-title":"Diagnostic medium containing inositol, urea, and caffeic acid for selective growth of <italic>Cryptococcus neoformans<\/italic>","volume":"6","author":"ME Healy","year":"1977","journal-title":"J Clin Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.1016\/S0021-9258(18)99146-5","article-title":"Isolation and characterization of two distinct myo-inositol transporter genes of <italic>Saccharomyces cerevisiae<\/italic>","volume":"266","author":"J Nikawa","year":"1991","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1099\/mic.0.025718-0","article-title":"Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it","volume":"155","author":"TB Reynolds","year":"2009","journal-title":"Microbiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1128\/IAI.01514-07","article-title":"<italic>Candida albicans<\/italic> uses multiple mechanisms to acquire the essential metabolite inositol during infection","volume":"76","author":"YL Chen","year":"2008","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s002940050334","article-title":"Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in <italic>Schizosaccharomyces pombe<\/italic>","volume":"33","author":"C Niederberger","year":"1998","journal-title":"Curr Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/EC.00327-10","article-title":"Two major inositol transporters and their role in cryptococcal virulence","volume":"10","author":"Y Wang","year":"2011","journal-title":"Eukaryot Cell"},{"key":"ref23","first-page":"e00084","article-title":"Role of an expanded inositol transporter repertoire in <italic>Cryptococcus neoformans<\/italic> sexual reproduction and virulence","volume":"1","author":"C Xue","year":"2010","journal-title":"mBio"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/genetics\/98.3.491","article-title":"Inositol mutants of <italic>Saccharomyces cerevisiae<\/italic>: mapping the Ino1 locus and characterizing alleles of the Ino1, Ino2 and Ino4 loci","volume":"98","author":"TF Donahue","year":"1981","journal-title":"Genetics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1128\/IAI.72.9.4985-4995.2004","article-title":"Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier","volume":"72","author":"YC Chang","year":"2004","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI41963","article-title":"Real-time imaging of trapping and urease-dependent transmigration of <italic>Cryptococcus neoformans<\/italic> in mouse brain","volume":"120","author":"M Shi","year":"2010","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1086\/341564","article-title":"Pathogenesis of cerebral <italic>Cryptococcus neoformans<\/italic> infection after fungemia","volume":"186","author":"F Chretien","year":"2002","journal-title":"J Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by <italic>Cryptococcus neoformans<\/italic>","volume":"77","author":"C Charlier","year":"2009","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI42949","article-title":"<italic>Cryptococci<\/italic> at the brain gate: break and enter or use a Trojan horse?","volume":"120","author":"A Casadevall","year":"2010","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/IAI.68.2.443-448.2000","article-title":"Urease as a virulence factor in experimental cryptococcosis","volume":"68","author":"GM Cox","year":"2000","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0002-9440(10)63734-0","article-title":"Urease expression by <italic>Cryptococcus neoformans<\/italic> promotes microvascular sequestration, thereby enhancing central nervous system invasion","volume":"164","author":"MA Olszewski","year":"2004","journal-title":"Am J Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/j.1462-5822.2012.01819.x","article-title":"<italic>Cryptococcus neoformans<\/italic> phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier","volume":"14","author":"R Maruvada","year":"2012","journal-title":"Cell Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1365-2958.2001.02236.x","article-title":"Extracellular phospholipase activity is a virulence factor for <italic>Cryptococcus neoformans<\/italic>","volume":"39","author":"GM Cox","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1099\/mic.0.051524-0","article-title":"Blood-brain barrier invasion by <italic>Cryptococcus neoformans<\/italic> is enhanced by functional interactions with plasmin","volume":"158","author":"J Stie","year":"2012","journal-title":"Microbiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"34761","DOI":"10.1074\/jbc.M111.219378","article-title":"Invasion of <italic>Cryptococcus neoformans<\/italic> into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3)","volume":"286","author":"SH Huang","year":"2011","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"15298","DOI":"10.1074\/jbc.M112.353375","article-title":"Hyaluronic acid receptor CD44 deficiency is associated with decreased <italic>Cryptococcus neoformans<\/italic> brain infection","volume":"287","author":"A Jong","year":"2012","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1462-5822.2008.01128.x","article-title":"Involvement of human CD44 during <italic>Cryptococcus neoformans<\/italic> infection of brain microvascular endothelial cells","volume":"10","author":"A Jong","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1046\/j.1471-4159.2002.01041.x","article-title":"Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance","volume":"82","author":"SK Fisher","year":"2002","journal-title":"J Neurochem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00971582","article-title":"Osmotic regulation of myo-inositol uptake in primary astrocyte cultures","volume":"19","author":"RE Isaacks","year":"1994","journal-title":"Neurochem Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1099\/jmm.0.05230-0","article-title":"<italic>Cryptococcus neoformans<\/italic> induces alterations in the cytoskeleton of human brain microvascular endothelial cells","volume":"52","author":"SH Chen","year":"2003","journal-title":"J Med Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/j.1462-5822.2008.01172.x","article-title":"Invasion of <italic>Cryptococcus neoformans<\/italic> into human brain microvascular endothelial cells requires protein kinase C-alpha activation","volume":"10","author":"A Jong","year":"2008","journal-title":"Cell Microbiol"},{"issue":"(Pt 8)","key":"ref42","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1099\/13500872-141-8-1829","article-title":"Unusual effect of myo-inositol on phospholipid biosynthesis in <italic>Cryptococcus neoformans<\/italic>","volume":"141","author":"VL Vincent","year":"1995","journal-title":"Microbiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1567-1364.2006.00088.x","article-title":"Do major species concepts support one, two or more species within <italic>Cryptococcus neoformans<\/italic>?","volume":"6","author":"KJ Kwon-Chung","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1128\/IAI.69.7.4536-4544.2001","article-title":"Traversal of <italic>Candida albicans<\/italic> across human blood-brain barrier in vitro","volume":"69","author":"AY Jong","year":"2001","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1002305","DOI":"10.1371\/journal.ppat.1002305","article-title":"Mechanisms of <italic>Candida albicans<\/italic> trafficking to the brain","volume":"7","author":"Y Liu","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0165-022X(00)00069-5","article-title":"An enzymatic assay for myo-inositol in tissue samples","volume":"44","author":"N Ashizawa","year":"2000","journal-title":"J Biochem Biophys Methods"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/EC.00240-09","article-title":"Immortalized human brain endothelial cell line HCMEC\/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by <italic>Cryptococcus neoformans<\/italic>","volume":"8","author":"K Vu","year":"2009","journal-title":"Eukaryot Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0002-9440(10)62265-1","article-title":"Capsule structure changes associated with <italic>Cryptococcus neoformans<\/italic> crossing of the blood-brain barrier","volume":"166","author":"C Charlier","year":"2005","journal-title":"Am J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1128\/IAI.00551-10","article-title":"Survival defects of <italic>Cryptococcus neoformans<\/italic> mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis","volume":"78","author":"A Lee","year":"2010","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"15032","DOI":"10.1073\/pnas.0605143103","article-title":"Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism","volume":"103","author":"PM Brown","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2199-9-88","article-title":"Computational modeling and in silico analysis of differential regulation of myo-inositol catabolic enzymes in <italic>Cryptococcus neoformans<\/italic>","volume":"9","author":"EA Mackenzie","year":"2008","journal-title":"BMC Mol Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0959-440X(94)90271-2","article-title":"Mechanisms of enzymatic glycoside hydrolysis","volume":"4","author":"JD McCarter","year":"1994","journal-title":"Curr Opin Struct Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/EC.00120-07","article-title":"Identification and characterization of <italic>CPS1<\/italic> as a hyaluronic acid synthase contributing to the pathogenesis of <italic>Cryptococcus neoformans<\/italic> infection","volume":"6","author":"A Jong","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1128\/IAI.00089-06","article-title":"<italic>CPS1<\/italic>, a homolog of the <italic>Streptococcus pneumoniae<\/italic> type 3 polysaccharide synthase gene, is important for the pathobiology of <italic>Cryptococcus neoformans<\/italic>","volume":"74","author":"YC Chang","year":"2006","journal-title":"Infect Immun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1423-0127-19-19","article-title":"Lipid raft\/caveolae signaling is required for <italic>Cryptococcus neoformans<\/italic> invasion into human brain microvascular endothelial cells","volume":"19","author":"M Long","year":"2012","journal-title":"J Biomed Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1099\/mic.0.26644-0","article-title":"High-affinity myo-inositol transport in <italic>Candida albicans<\/italic>: substrate specificity and pharmacology","volume":"149","author":"JH Jin","year":"2003","journal-title":"Microbiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1128\/EC.4.1.190-201.2005","article-title":"Transcriptional network of multiple capsule and melanin genes governed by the <italic>Cryptococcus neoformans<\/italic> cyclic AMP cascade","volume":"4","author":"R Pukkila-Worley","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1128\/IAI.69.9.5217-5222.2001","article-title":"<italic>Escherichia coli<\/italic> translocation at the blood-brain barrier","volume":"69","author":"KS Kim","year":"2001","journal-title":"Infect Immun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0022-3476(74)80308-2","article-title":"Neonatal <italic>Escherichia coli<\/italic> septicemia\u2013bacterial counts in blood","volume":"85","author":"DE Dietzman","year":"1974","journal-title":"J Pediatr"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e1002047","DOI":"10.1371\/journal.ppat.1002047","article-title":"Phospholipids trigger <italic>Cryptococcus neoformans<\/italic> capsular enlargement during interactions with amoebae and macrophages","volume":"7","author":"CJ Chrisman","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1567-1364.2006.00039.x","article-title":"Phenotypic switching and its implications for the pathogenesis of <italic>Cryptococcus neoformans<\/italic>","volume":"6","author":"N Jain","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e35455","DOI":"10.1371\/journal.pone.0035455","article-title":"Capsule independent uptake of the fungal pathogen <italic>Cryptococcus neoformans<\/italic> into brain microvascular endothelial cells","volume":"7","author":"W Sabiiti","year":"2012","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/EC.3.6.1601-1608.2004","article-title":"<italic>UGD1<\/italic>, encoding the <italic>Cryptococcus neoformans<\/italic> UDP-glucose dehydrogenase, is essential for growth at 37 degrees C and for capsule biosynthesis","volume":"3","author":"F Moyrand","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"51669","DOI":"10.1074\/jbc.M408889200","article-title":"UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"279","author":"CL Griffith","year":"2004","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/15216540214931","article-title":"Functional characteristics and catalytic mechanisms of the bacterial hyaluronan synthases","volume":"54","author":"PH Weigel","year":"2002","journal-title":"IUBMB Life"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1104\/pp.119.1.165","article-title":"Myo-inositol-dependent sodium uptake in ice plant","volume":"119","author":"DE Nelson","year":"1999","journal-title":"Plant Physiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1242\/jeb.203.8.1299","article-title":"How do inositol and glucose modulate feeding in <italic>Manduca sexta<\/italic> caterpillars?","volume":"203","author":"JI Glendinning","year":"2000","journal-title":"J Exp Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1570-7458.1998.00362.x","article-title":"Inositol in two host plants of <italic>Manduca sexta<\/italic>","volume":"88","author":"N Nelson","year":"1998","journal-title":"Ehtomologia Experimentalis et Applicata"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1172\/JCI30006","article-title":"Role of a CUF1\/CTR4 copper regulatory axis in the virulence of <italic>Cryptococcus neoformans<\/italic>","volume":"117","author":"SR Waterman","year":"2007","journal-title":"J Clin Invest"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1523\/JNEUROSCI.5618-10.2011","article-title":"Cocaine hijacks sigma1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS","volume":"31","author":"H Yao","year":"2011","journal-title":"J Neurosci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"36147","DOI":"10.1074\/jbc.M112.389676","article-title":"<italic>Cryptococcus neoformans<\/italic> activates RhoGTPases followed by PKC, FAK and ezrin to enhance traversal across the blood-brain barrier","volume":"287","author":"J-C Kim","year":"2012","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Perfect JR (1999) Rabbit model of cryptococcal meningitis.. In: Zak O, Sande, M A., editor. Handbook of animal models of infection. London: Academic Press, Inc. pp. 721\u2013776.","DOI":"10.1016\/B978-012775390-4\/50226-8"},{"key":"ref73","first-page":"177","article-title":"Chronic cryptococcal meningitis: a new experimental model in rabbits","volume":"101","author":"JR Perfect","year":"1980","journal-title":"Am J Pathol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1128\/IAI.73.8.4922-4933.2005","article-title":"<italic>Cryptococcus neoformans<\/italic> {alpha} strains preferentially disseminate to the central nervous system during coinfection","volume":"73","author":"K Nielsen","year":"2005","journal-title":"Infect Immun"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/EC.3.5.1249-1260.2004","article-title":"Identification of <italic>Cryptococcus neoformans<\/italic> temperature-regulated genes with a genomic-DNA microarray","volume":"3","author":"PR Kraus","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1128\/EC.00120-09","article-title":"Remodeling of global transcription patterns of <italic>Cryptococcus neoformans<\/italic> genes mediated by the stress-activated HOG signaling pathways","volume":"8","author":"YJ Ko","year":"2009","journal-title":"Eukaryot Cell"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1074\/jbc.M600425200","article-title":"The <italic>Saccharomyces cerevisiae<\/italic> Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme","volume":"281","author":"GS Han","year":"2006","journal-title":"J Biol Chem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1074\/jbc.M410176200","article-title":"67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing <italic>Escherichia coli<\/italic> K1 into human brain microvascular endothelial cells","volume":"280","author":"KJ Kim","year":"2005","journal-title":"J Biol Chem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1523\/JNEUROSCI.1460-11.2011","article-title":"Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism","volume":"31","author":"EA Eugenin","year":"2011","journal-title":"J Neurosci"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T03:26:53Z","timestamp":1644722813000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003247"}},"subtitle":[],"editor":[{"given":"Robin Charles","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,4]]},"references-count":79,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003247","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,4]]}}}